Atmospheric neutrinos are one of the most relevant natural neutrino sources that can be exploited to infer properties about Cosmic Rays and neutrino oscillations. The Jiangmen Underground Neutrino Observatory (JUNO) experiment, a 20 kton liquid scintillator detector with excellent energy resolution is currently under construction in China. JUNO will be able to detect several atmospheric neutrinos per day given the large volume. A study on the JUNO detection and reconstruction capabilities of atmospheric νe and νμ fluxes is presented in this paper. In this study, a sample of atmospheric neutrinos Monte Carlo events has been generated, starting from theoretical models, and then processed by the detector simulation. The excellent timing resolution of the 3” PMT light detection system of JUNO detector and the much higher light yield for scintillation over Cherenkov allow to measure the time structure of the scintillation light with very high precision. Since νe and νμ interactions produce a slightly different light pattern, the different time evolution of light allows to discriminate the flavor of primary neutrinos. A probabilistic unfolding method has been used, in order to infer the primary neutrino energy spectrum from the detector experimental observables. The simulated spectrum has been reconstructed between 100MeV and 10GeV, showing a great potential of the detector in the atmospheric low energy region.

How the breast cancer genome evolves during malignant progression has been highly debated. To gain insight into the landscape of genomic aberrations occurring in breast cancers from the onset to metastasis, we compared the molecular profile of matched primary and relapsed tumors, focusing on the additional alterations developed in metastases. The study population included a mono-institutional cohort of 128 patients with breast cancers (n=72 Luminal B - LUM, n=56 Triple-negative - TN) and with at least one recurrence in a timeframe of 17 years. 289 samples, comprising primary tumors (P) and matched metastases (M), were subjected to a comprehensive genomic profile using Next-Generation Sequencing (NGS) panels (FoundationeOne Dx or Oncomine Comprehensive Cancer Assay v.3). Genomic data were available for 106 P and 82 M that reached the NGS quality parameters. The most recurrent genomic alterations were TP53 mutations (P=49%, M=49%), PIK3CA mutations (P=33%, M=30%) and MYC copy number gain (P=25%, M=23%). TP53, PIK3R1, and NF1 aberrations were more frequently identified in TN breast cancer whereas ESR1 mutations and CCND1, FGF3, FGF19, and FGFR1 copy number gains in LUM cases (p-value < 0.05). The total number of P alterations, TP53 mutations, and MYC amplification were significantly and independently associated with a shorter time to relapse (p-value < 0.05). Considering matched P and M samples, we found a molecular subtype change in 10 of 128 (7.8%) cases. 55.8% of driver alterations were shared between P and matched M, including the most frequently mutated genes. In 27/61 (44.3%) cases 65 driver alterations were detected in M only, including 20 alterations classified as level1-level4 by OncoKB ranking and affecting mostly ESR1 (n=8) and PIK3CA (n=8) genes. Prognostic biomarkers associated with time to relapse could be identified in primary tumors. A core of driver alterations was shared between P and M samples but novel and clinically relevant alterations could be identified in M only.

The OPERA neutrino detector in the underground Gran Sasso Laboratory (LNGS) has been designed to perform the first detection of neutrino oscillations in direct appearance mode through the study of the νμ → ντ channel. The hybrid apparatus consists of an emulsion/lead target complemented by electronic detectors and it is placed in the high energy long-baseline CERN to LNGS beam (CNGS) 730 km away from the neutrino source. Runs with CNGS neutrinos were successfully carried out in 2008 and 2009. After a brief description of the beam, the experimental setup and the procedures used for the analysis of the neutrino events, we describe the topology and kinematics of a first candidate ντ charged-current event satisfying the kinematical selection criteria. The background calculations and their cross-check are explained in detail and the significance of the event is assessed.

The exclusive electroproduction of two pions in the mass range 0.4 < Mππ < 2.5 GeV has been studied with the ZEUS detector at HERA using an integrated luminosity of 82 pb−1. The analysis was carried out in the kinematic range of 2 < Q2 < 80 GeV2, 32 < W < 180 GeV and |t | < 0.6 GeV2, where Q2 is the photon virtuality, W is the photon-proton centre-of-mass energy and t is the squared four-momentum transfer at the proton vertex. The Eur. Phys. J. C (2012) 72:1869 Page 3 of 12 two-pion invariant-mass distribution is interpreted in terms of the pion electromagnetic form factor, |F(Mππ)|, assuming that the studied mass range includes the contributions of the ρ, ρ′ and ρ′′ vector-meson states. The masses and widths of the resonances were obtained and the Q2 dependence of the cross-section ratios σ(ρ′ → ππ)/σ(ρ) and σ(ρ′′ → ππ)/σ(ρ) was extracted. The pion form factor obtained in the present analysis is compared to that obtained in e+e− → π+π−. a e-mail: levy@alzt.tau.ac.il ASupported by the US Department of Energy BSupported by the Italian National Institute for Nuclear Physics (INFN) CSupported by the German Federal Ministry for Education and Research (BMBF), under contract No. 05 H09PDF DSupported by the Science and Technology Facilities Council, UK ESupported by an FRGS grant from the Malaysian government FSupported by the US National Science Foundation. Any opinion, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation GSupported by the Polish Ministry of Science and Higher Education as a scientific project No. DPN/N188/DESY/2009 HSupported by the Polish Ministry of Science and Higher Education and its grants for Scientific Research ISupported by the German Federal Ministry for Education and Research (BMBF), under contract No. 05h09GUF, and the SFB 676 of the Deutsche Forschungsgemeinschaft (DFG) JSupported by the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and its grants for Scientific Research KSupported by the Korean Ministry of Education and Korea Science and Engineering Foundation LSupported by FNRS and its associated funds (IISN and FRIA) and by an Inter-University Attraction Poles Programme subsidised by the Belgian Federal Science Policy Office MSupported by the Spanish Ministry of Education and Science through funds provided by CICYT NSupported by the Natural Sciences and Engineering Research Council of Canada (NSERC) OPartially supported by the German Federal Ministry for Education and Research (BMBF) PSupported by RF Presidential grant N 4142.2010.2 for Leading Scientific Schools, by the Russian Ministry of Education and Science through its grant for Scientific Research on High Energy Physics and under contract No.02.740.11.0244 QSupported by the Netherlands Foundation for Research on Matter (FOM) RSupported by the Israel Science Foundation bNow at University of Salerno, Italy cNow at Queen Mary University of London, United Kingdom dAlso funded by Max Planck Institute for Physics, Munich, Germany eAlso Senior Alexander von Humboldt Research Fellow at Hamburg University, Institute of Experimental Physics, Hamburg, Germany

Cross sections for e^+p neutral current deep inelastic scattering have been measured at a centre-of-mass energy of sqrt{s}=318 GeV with the ZEUS detector at HERA using an integrated luminosity of 63.2 pb^-1. The double-differential cross section, d^2sigma/dxdQ^2, is presented for 200 GeV^2"200 GeV^2. The effect of Z-boson exchange is seen in dsigma/dx measured for Q^2>10000 GeV^2. The data presented here were combined with ZEUS e^+p neutral current data taken at sqrt{s}=300 GeV and the structure function F_2^{em} was extracted. All results agree well with the predictions of the Standard Model."

We present a measurement of the decay amplitudes in B--\u003eJ/psi K^*(892) channels using 20.7 fb-1 of data collected at the Upsilon(4S) resonance with the BABAR detector at PEP-II. We measure a P-wave fraction R_perp = (16.0+/-3.2+/-1.4)% and a longitudinal polarization fraction (59.7+/-2.8+/-2.4)%. The measurement of a relative phase that is neither 0 nor pi, phi_ll = 2.50+/-0.20+/-0.08 radians, favors a departure from the factorization hypothesis. Although the decay B--\u003eJ/psi Kpi proceeds mainly via K^*(892), there is also evidence for K^*_2(1430) and Kpi S-wave contributions.