Neurological syndromes secondary to acute aortic dissection (AAD) are uncommon and usually consist of focal deficits after an embolic cerebral infarction. This article reports the observation of an AAD with the chief complaint of transient acute memory impairment-that is, a non-usual stroke-like symptom.

The association of a pseudomyxoma peritonei with a mucinous tumor of the appendix and/or the ovary is regularly reported in the literature. However, in this context, endometrial. or endocervical lesions remain exceptional. We report the case of a 57-year-old patient, with pseudomyxoma peritonei associated with a low-grade mucinous neoplasia of appendix and both ovaries. The systematic sampling of endometrium and endocervix showed small segments of intestinal epithelium admixed with native epithelium. Histological and immunohistochemical characteristics of this epithelium were quite comparable to those observed in the appendix and ovaries. The endocervical. and endometrial lesions might represent an implantation of mucinous epithelium from appendix, emphasizing the capacity of this epithelium to implant at a distance from the original lesion. (C) 2009 Published by Elsevier Masson SAS.

Animal models are particularly useful for the study of many infectious diseases, including those caused by fungi. Invasive pulmonary aspergillosis is most frequently studied in mouse models. We present here an animal model of this disease based on undernourished immunocompromised rats infected with Aspergillus fumigatus spores by intra-tracheal nebulisation.

Purpose: To assess in vivo the corneal epithelial damage caused by a topical toxic medication using a 60-MHz ultrasound device. Material and methods: A solution of timolol with 0.01% benzalkonium chloride (BAC) was applied twice a day in the test eyes of ten rabbits, and a BAC-free solution of timolol in the control eyes, for 56 days. We used a 60-MHz ultrasound device to evaluate the epithelial damage in BAC-exposed eyes, compared to control eyes. The clinical and ultrasound examinations were performed every week, and the histological analysis at the end of the experiment. Results: The clinical findings were conjunctival redness, corneal staining and instability of the tear film. In vivo VHF ultrasound revealed a thinning of the epithelium of test eyes (from 40.9 +/- 1.6 mu m at DO to 31.8 +/- 3.4 mu m at D56; p = 0.0006 for DO vs D56), while the epithelium of control eyes remained unchanged. Ultrasound epithelial thickness was correlated with corneal staining (at D34 and D56; p = 0.0025 and 0.6377, respectively) and histological epithelial pachymetry (p = 0.0176 for control and 0.0505 for tested epithelium). Moreover, we report qualitative VHF ultrasound imaging of early epithelial damage. Conclusion: This new device could be very useful in ocular toxicity evaluation as a reproducible and reliable tool for multicentric clinical research.

HistopathologyVolume 49, Issue 4 p. 426-429 Florid marginal zone differentiation in follicular lymphoma mimicking marginal zone lymphoma of MALT type in the lung F Jourdan, F Jourdan Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this authorT J Molina, T J Molina Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author 1 A Le Tourneau, A Le Tourneau Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author 1 M C Machet, M C Machet Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author 2 A De Muret, A De Muret Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author 2 L Renjard, L Renjard Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this authorF Fetissof, F Fetissof Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author F Jourdan, F Jourdan Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this authorT J Molina, T J Molina Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author 1 A Le Tourneau, A Le Tourneau Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author 1 M C Machet, M C Machet Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author 2 A De Muret, A De Muret Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author 2 L Renjard, L Renjard Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this authorF Fetissof, F Fetissof Departments of Pathology, Hôpital Bretonneau Tours, 1Hôpital Hôtel Dieu, AP-HP, Paris and 2Hôpital Trousseau Tours, FranceSearch for more papers by this author First published: 15 September 2006 https://doi.org/10.1111/j.1365-2559.2006.02462.xCitations: 9Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Jaffes ES, Harris NL, Stein H, Vardiman JW eds. World Health Organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press 2001. 2 Maes B, De Wolf-Peeters C. Marginal zone cell lymphoma—an update on recent advances. Histopathology 2002; 40; 117–126. 3 Goodlad JR, Batstone PJ, Hamilton D, Hollowood K. Follicular lymphoma with marginal zone differentiation: cytogenetic findings in support of a high-risk variant of follicular lymphoma. Histopathology 2003; 42; 292–298. 4 Tzankov A, Hittmair A, Müller-Hermelink HK, Rüdiger T, Dirnhofer S. Primary gastric follicular lymphoma with parafollicular monocytoid B-cells and lymphoepithelial lesions, mimicking extranodal marginal zone lymphoma of MALT. Virchows Arch. 2002; 441; 614–617. 5 Abou-Ellela A, Shafer MT, Wan XY et al. Lymphomas with follicular and monocytoid B-cell components. Evidence for a common clonal origin from follicle center cells. Am. J. Clin. Pathol. 2000; 114; 516–522. 6 Nathwani BN, Anderson JR, Armitage JO et al. Clinical significance of follicular lymphoma with monocytoid B cells. Hum. Pathol. 1999; 30; 263–268. Citing Literature Volume49, Issue4October 2006Pages 426-429 ReferencesRelatedInformation

Décrire la stratégie de prise en charge des macrobiopsies mammaires dans notre établissement. Le recrutement des patientes s’effectue par le biais des services de radiologie et de gynécologie. Après la consultation radiologique pré-macrobiopsie, les dossiers sont présentés à la réunion multidisciplinaire (gynécologues, pathologistes et radiologues) hebdomadaire de sénologie, pour validation de l’indication. Une consultation radiologique post-macrobiopsie après la procédure est également réalisée. Puis tous les dossiers complets sont représentés à la réunion multidisciplinaire hebdomadaire de sénologie pour décision de la conduite à tenir ultérieure. La consultation pré-macrobiopsie permet une étude de la faisabilité du geste, une information orale et écrite de la procédure. En fin de procédure un deuxième document d’information post macrobiopsie est remis aux patientes. La consultation post-macrobiopsie dix jours après la procédure consiste en un examen sénologique du sein biopsie et une annonce des résultats le plus souvent. La stratégie de prise en charge des patientes bénéficiant d’une macrobiopsie mammaire est protocolée et fait l’objet d’une concertation multidisciplinaire indispensable à la prise en charge des lésions mammaires infra-cliniques.

We report a case of mullerian "inclusions" within an intra-mammary lymph node. Discovered on a routine mammography, the inclusions appeared in the right breast as a focus of microcalcifications. The 63-year-old patient was asymptomatic. Microcalcifications were associated with benign appearing epithelial formations which were positive for estrogen receptor antibodies and negative for thyroglobulin, calretinin and smooth muscle actin antibodies. Three years later, the patient developed a peritoneal low-grade serous carcinoma.Mullerian inclusions within lymph nodes are rather frequent below the diaphragm but exceptional above. Even in a supra-diaphragmatic localization, they con be associated with a pelvic serous tumor.

PURPOSE:To assess in vivo the corneal epithelial damage caused by a topical toxic medication using a 60-MHz ultrasound device.MATERIAL:and methods: A solution of timolol with 0.01% benzalkonium chloride (BAC) was applied twice a day in the test eyes of ten rabbits, and a BAC-free solution of timolol in the control eyes, for 56 days. We used a 60-MHz ultrasound device to evaluate the epithelial damage in BAC-exposed eyes, compared to control eyes. The clinical and ultrasound examinations were performed every week, and the histological analysis at the end of the experiment.RESULTS:The clinical findings were conjunctival redness, corneal staining and instability of the tear film. In vivo VHF ultrasound revealed a thinning of the epithelium of test eyes (from 40.9+/-1,6 microm at D0 to 31.8+/-3.4 microm at D56; p=0.0006 for D0 vs D56), while the epithelium of control eyes remained unchanged. Ultrasound epithelial thickness was correlated with corneal staining (at D34 and D56; p=0.0025 and 0.0377, respectively) and histological epithelial pachymetry (p=0.0176 for control and 0.0505 for tested epithelium). Moreover, we report qualitative VHF ultrasound imaging of early epithelial damage.CONCLUSION:This new device could be very useful in ocular toxicity evaluation as a reproducible and reliable tool for multicentric clinical research.

We report a case of mullerian "inclusions" within an intra-mammary lymph node. Discovered on a routine mammography, the inclusions appeared in the right breast as a focus of microcalcifications. The 63-year-old patient was asymptomatic. Microcalcifications were associated with benign appearing epithelial formations which were positive for estrogen receptor antibodies and negative for thyroglobulin, calretinin and smooth muscle actin antibodies. Three years later, the patient developed a peritoneal low-grade serous carcinoma. Mullerian inclusions within lymph nodes are rather frequent below the diaphragm but exceptional above. Even in a supra-diaphragmatic localization, they can be associated with a pelvic serous tumor.

Docetaxel (Taxotere ® ), alone or in combination with other anticancer agents, has proven efficacy in the first- and second-line treatment of metastatic breast cancer. This phase II study investigated the efficacy and tolerability of docetaxel as neoadjuvant chemotherapy in women with stage II–III primary operable breast cancer. Patients ( n =88) were treated with six cycles of docetaxel at 100 mg m −2 every 21 days, followed by definitive surgery and radiotherapy. After six cycles of docetaxel, the overall clinical response rate was 68.4% (CI 95%: 58.1–78.7%), including 19.0% complete remissions. Breast conservation was achieved in 72.4% of patients. A high pathological complete response (pCR) rate in breast was confirmed in 15 patients (19.8% (CI 95%: 10.8–28.8%)) on Chevallier's classification restricted to breast and in 27 patients (35.5% (CI 95%: 24.7–46.3%)) on Sataloff's classification. After a median follow-up of 30.8 months, 19 recurrences were documented with a median time to first recurrence of 17.3 months. Patients with stage III tumours had more recurrences than patients with stage II tumours ( P =0.02). The principal toxicity of docetaxel is myelosuppression and 70.5% of patients developed grade III or IV neutropenia with 13.6% developing neutropenic sepsis. There was no case of severe cardiac toxicity, thrombocytopenia or any other serious adverse events. In conclusion, neoadjuvant docetaxel induces a high pCR and breast-conservation rate. Docetaxel monotherapy is a highly effective regimen that merits formal comparison with currently used combination regimens in a randomised phase III study.

Objective. To distinguish various types of local recurrence after conserving treatment of breast cancer and to evaluate their predictive value.

OBJECTIVES:Evaluate management of patients with a borderline ovarian tumor.MATERIALS AND METHODS:A multicentric retrospective survey was conducted in 137 patients with borderline ovarian tumor diagnosed between January 1, 19975 and December 31, 1995.RESULTS:Mean follow-up was 6.5 years, mean age was 50 years. Initial surgery was cystectomy, unilateral salpingo-oophorectomy and total hysterectomy with bilateral salpingo-oophorectomy in 22, 40 and 75 cases respectively. Eleven patients had residual disease. Serous, mucinous and Brenner tumors were observed in 67, 69 and 1 cases respectively. Staging was I, II, III in 117, 3, and 17 cases respectively with two pseudomyxomas. Adjuvant therapy was given in 15 patients. There was a recurrence in 15 patients and 14 died. The 5-year survival rate was 89.3%. Prognosis factors with an impact on survival rate were age, recurrence and type of surgery. Factors with a negative impact on recurrence were adjuvant therapy and residual disease after surgery.CONCLUSION:Careful staging followed by complete and radical surgery is essential. Unilateral salpingo-oophorectomy with omentectomy and multiple peritoneal biopsies may be indicated in younger patients undergoing radical surgery after pregnancy. Aduvant therapy is necessary for invasive implants.