Clinical Pharmacology & TherapeuticsVolume 95, Issue 6 p. 588-588 Letters to the Editor The Effect of Green Tea With Exceptionally High Catechin Content on Nadolol Plasma Concentration K Ide, K Ide Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanSearch for more papers by this authorM Park, M Park Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanSearch for more papers by this authorH Yamada, Corresponding Author H Yamada [email protected] Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanSearch for more papers by this author K Ide, K Ide Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanSearch for more papers by this authorM Park, M Park Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanSearch for more papers by this authorH Yamada, Corresponding Author H Yamada [email protected] Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanSearch for more papers by this author First published: 19 February 2014 https://doi.org/10.1038/clpt.2014.36Citations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Misaka, S. et al. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. Clin. Pharmacol. Ther. 95, 432–438 (2014). 2Genser, D. Food and drug interaction: consequences for the nutrition/health status. Ann. Nutr. Metab. 52 (suppl. 1), 29–32 (2008). 3Boullata, J.I. & Hudson, L.M. Drug-nutrient interactions: a broad view with implications for practice. J. Acad. Nutr. Diet. 112, 506–517 (2012). 4Nakagawa, S., Hoshi, T., Kubo, A., Yamato, S. Determination of tea polyphenols in bottled Japanese tea drinks and differences in polyphenol content in tea leaves from different variety [In Japanese]. Bunseki Kagaku 62, 51–55 (2013). Citing Literature Volume95, Issue6Advances in PharmacometricsJune 2014Pages 588-588 ReferencesRelatedInformation

This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the beta-blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 ml/day) or water for 14 days. Catechin concentrations in green tea and plasma were determined. Green tea markedly decreased the maximum plasma concentration (C-max) and area under the plasma concentration-time curve (AUC(0-48)) of nadolol by 85.3% and 85.0%, respectively (P < 0.01), without altering renal clearance of nadolol. The effects of nadolol on systolic blood pressure were significantly reduced by green tea. [H-3]-Nadolol uptake assays in human embryonic kidney 293 cells stably expressing the organic anion-transporting polypeptides OATP1A2 and OATP2B1 revealed that nadolol is a substrate of OATP1A2 (Michaelis constant (K-m)=84.3 mu mol/l) but not of OATP2B1. Moreover, green tea significantly inhibited OATP1A2-mediated nadolol uptake (half-maximal inhibitory concentration, IC50 = 1.36%). These results suggest that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine.