Purpose. A study was designed to compare differences in insulin aerosol deposition profiles in healthy male and female subjects, as well as examine the effect of mouthpiece cross-sectional shape, volume, and taper on deposition profiles using a developmental AERx pulmonary delivery system.
X-ray fluorescence (XRF) has been used to determine in vivo the percutaneous absorption of 5-iodouracil (5IU) in dimethyl sulfoxide (DMSO) on female Sprague-Dawley rats. An average absorption rate constant of 122 ± 34 µg/cm2-hr was obtained from the XRF measurements on four rats. A comparative study was performed with radiolabeled (125I) 5IU in which the absorption rate constant was determined to be 126 ± 20 µg/cm2-hr. The XRF system described provides a simple, noninvasive means of measuring the percutaneous absorption rate of select compounds by the surface disappearance method.
Dave Hasegawa合作论文数1J Schuster合作论文数1Jerry Okikawa合作论文数1boyd brooks m合作论文数1Peter Noymer合作论文数1Simon Warren合作论文数1Jay Michael合作论文数1
J. David Robertson合作论文数Department of Chemistry, College of Arts and Science, University of Missouri1Liu Kui合作论文数1
Glyn Taylor合作论文数The Welsh School of Pharmacy, University of Wales College of Cardiff1Igor Gonda合作论文数1
Stephen Farr合作论文数1Dennis J. Stalker合作论文数1
