Objective To evaluate the performance of chronic kidney disease epidemiology collaboration ( CKD-EPI) equations, Chinese estimated glomerular filtration rate (eGFR) investigation collaboration equations and FQ-eGFR equations in the early diagnosis of chronic kidney disease (CKD).Methods Serum cystatin C(Cys C) and creatinine (Cr) concentrations were detected in 283 inpatients with CKD and 9 307 outpatients, and the eGFR of 3 CKD-EPI equations ( Cr-, Cys C-and Cys C-C equations ) , 2 Chinese eGFR investigation collaboration equations ( Cys C-and Cys C-C equations) and 2 FQ-eGFR equations (Cys C-and Cys C-C equations) were calculated as the order of eGFR1-eGFR7.Plasma 99mtechnetium-diethylene triamine pentacetic acid (99mTC-DTPA) clearance rate as measured glomerular filtration rate ( mGFR ) was detected in 283 inpatients with CKD , and was used as a gold standard for evaluating difference, consistency and performance of eGFR .The incidence rate ratio (IRR) of each eGFR predicting CKD was analyzed retrospectively in 9 307 outpatients .Results There were significant differences between eGFR 2 and eGFR3 with mGFR (P=0.000).The concordance correlation coefficients (ρc)of eGFR4, eGFR6 and eGFR7 with mGFR were all significantly higher than that of eGFR1 (P<0.01).For the patients with mGFR <60mL/(min· 1.73 m2 ), the deviation, precision and accuracy of eGFR4, eGFR6 and eGFR7 had quite correspondence ( P >0.05), and had significant differences with those of eGFR1(P<0.05).In contrast, the deviation of eGFR4 was smaller [median (M)=0.3 mL/( min · 1.73 m2 )], the precision of eGFR6 was higher [ standard interquartile range ( IQR) =7.7 mL/(min· 1.73 m2)], and the accuracy of eGFR7 was better (1-P30 =13.8%).The incidence rates of predicting CKD by eGFR4, eGFR6 and eGFR7 were higher than that by eGFR1 (P<0.01), and were greatly higher in&nbsp;elderly (>65 years old) compared with in under 65 years old (P=0.000).Conclusions CKD-EPI equations could not provide an accurate assessment of kidney function for Chinese adult patients with CKD , whose GFR <60 mL/(min· 1.73 m2).In contrast, it would be more appropriate for the screening of diseases and early diagnosing used Cys C-equation, FQ-eGFR Cys C-equation or FQ-eGFR Cys C-C equation of Chinese eGFR investigation collaboration equations , in which it is as far as possible to prevent leak-diagnosis or misdiagnosis when FQ-eGFR Cys C-equation is used for the screening of diseases .

目的:探讨Sysmex XE-2100血细胞分析仪测定有MPV值和无MPV值样本电阻法与激光法血小板计数(PLT)结果的可比性.方法:在XE-2100血细胞分析仪上使用网织红细胞模式测定两组抗凝血样本,获得相应激光法和电阻法血小板计数(PLT)值,分别对电阻法结果(PLT_I)和激光法结果(PLT_O)做配对t检验、曲线拟合统计分析,得出PLT_O预测值与PLT_I初步的曲线方程,并做验证试验.结果:无MPV组的PLT_I与PLT_O总体间有统计性差异(P<0.05);而有MPV组的PLT_I与PLT_O总体间无统计学差异(p0.05).无MPV组PLT_O预测值与PLT_I的方程为:PLT_O预测值=0.851*PLT_I+29.938;有MPV组的PLT_O与PLT_I的方程为:PLT_O预测值=0.927*PLT_I+15.325.验证实验中,有MPV组和无MPV组中PLT_O预测值与PLT_O实测值间做配对t检验,PLT_O预测值与PLT_O实测值总体间均无统计学意义(P0.05).结论:在Sysmex XE-2100检测中,对于电阻法未报告MPV的样本,可选择网织红细胞模式激光法对血小板计教进行复查;电阻法与激光法计数血小板结果间具有相关性,在无相应网织红细胞试剂的特殊情况下,可以使用激光法PLT计算方程,由电阻法PLT结果进行相应换算,其可作为一种简便经济的血小板复查方法.

目的:探讨胆固醇(TC)、甘油三酯(TG)在中、老年中的分布和高血脂的发病状况.方法:用酶法检测928名中、老年人的血清TC和TG水平.结果:TC水平在年龄和性别上无统计学意义((P0.05));TG在性别上和中年男、女之间有统计学意义(P＜0.01),高血脂发病率高峰在中年男性(57.4％)和老年女性(57.7％),前者是以单纯甘油三酯升高为主(33.7％),后者两项均升高,发病率明显高于是中年女性(P＜0.05).结论:中、老年人,特别是中年男性和老年女性要注重饮食结构,减少脂肪的摄入,加强身体锻炼,预防代谢性疾病的发生.

Objective To explore the serum high sensitivity C-response protein of patients with brain hemorrhage and clinical significance.Methods 35 patients with brain hemorrhage were checked the serum hs-CRP(experimental group)and 46 healthy people were sampled as control group, To analyzed the relationship between the two groups.Results Serum levels of hs-CRP were significantly higher in patients(mean 2.41±1.62mg/L) than in those(mean 0.71±0.62mg/L)of normal ones ,but the levels of Hs-CRP have no relationship with quantity of brain hemorrhage(r=0.064,p0.05).Conclusions The Serum hs-CRP of the patients with brain hemorrhage will rise, but rising degree has no relationship with quantity of brain hemorrhage.