Objective To investigate the clinical features and related risk factors for nonalcoholic fatty liver disease(NAFLD)in Wuwei area.Methods Retrospective case-control study was performed to explore the clinical features and related risk factors for NAFLD by Logistic regression analysis.Results Level of serum ALT increased significantly in the patients with NAFLD and was 2-fold higher than that of the normal limit;serum AST increased mildly.Obesity,type 2 diabetes mellitus,heart and brain blood vessel disease and hyperlipidemia were syndromes of NAFLD.BMI,DBP,high lipid food,serum TG,serum ApoB were negatively correlated with the occurrence of NAFLD,while serum HDL was positively correlated with the occurance of NAFLD.Conclusion BMI,DBP,high lipid food,serum TG and serum ApoB may be independent risk factors for NAFLD,while serum HDL is prepective factor of NAFLD.To prevent NAFLD and its syndromes,periodical physical examination,changing unhealthy life styles and controlling obesity are the most important.