There is much evidence that gliomas are caused by progressive ischemia, followed by increasing and prolonged hypoxia very close to the subventricular zone. In this way, hypoxia on immature glial cells is the primary cause in gliomas genesis. The ischemic process caused by atherosclerosis, anatomical variants of the arteries in the affected area and associated with carcinogenic agents are the harmful factors. While cytotoxic hypoxia triggers a reactive oxygen species (ROS) overproduction in the glial progenitor cells. Consequently, cellular impairment caused by ROS alters the cell cycle phases and provokes genesis of low-grade glioma. Subsequently, its progression causes angiogenesis and higher-grade cancer cells. Then, the vascular recanalization through aspirin is the indicated therapy to reduce the ischemic process by increasing blood flow and oxygen in the affected zone. Therefore, we must fight against the genesis of atherosclerosis and thus decrease the incidence of “neurodegenerative” diseases and cancer.

BACKGROUND:To date all researchers conclude that the etiology of Amyotrophic lateral sclerosis (ALS) is not known. On the contrary, since August 2009, we believe that disease is of ischemic origin in the anterior surface of the medulla oblongata.MATERIAL AND METHOD:We present our surgical experience into 45 patients with ALS (bulbar form in 36 cases and spinal form in 9). Preoperative MRI scans revealed microinfarcts in the medulla oblongata and/or cervical cord. During surgery we found: 1) poor quality of omentum in most cases; 2) degenerative changes in the cervical spine; 3) anatomical anomalies at the V4 segments of the vertebral arteries; 4) moderate to severe atherosclerosis at both V4 segments; 5) unilateral absence or stenosis in the anterior-ventral spinal arteries (AVSAs). All patients received omentum on the anterior, lateral and posterior surface of the medulla oblongata, and in 9 cases, an additional segment at the C5-C6 level.RESULTS:Neurological improvement was better during the first days or weeks after surgery than in the following months or years, in all patients. However, 13 patients suffered neurological impairment in about 4 months later, due to greater deterioration of the cervical spine, by contrast, 7 patients with mild ALS have experienced neurological improvement by 80 to 100% during a follow-up of 4 and 6 years.CONCLUSIONS:These results confirm that ALS is of ischemic origin in the intraparenchymal territory of the AVSAs and/or in anterior spinal artery caused by atherosclerosis and associated to anatomical variants in the V4 segments of the vertebral arteries. Because in contrast to this, its revascularization by means of omentum can cure (mild degree) or improve this disease.

Author reports to a 42-year-old man who suffered motor impairment in his limbs since 17- years of age, and five years later he presented central pain. In August 2011, a preoperative MRI scans showed syringobulbia and a giant intramedullary tumor, which occupied 70% of the cervical cord. The neoplasm was surgically removed and the histological study was recognized as cellular ependymoma. At present, 56 months after surgery the patient can walk with or without assistance and persists with central pain. This patient confirms previous observations that in dyscomplete transection there are axons in function and that could improve after a decompression or revascularization. Moreover, this patient confirms that there is a huge tolerance of the spinal cord to chronic injuries.

To demonstrate that amyotrophic lateral sclerosis (ALS) is not a neurodegenerative disease. The patient, a 33-year-old man began with symptoms of the bulbar form of ALS, characterized by burning pain in both feet during two months and then, he presented right crural monoparesis, fasciculations, slight dysarthria and he walked with help of orthopedic devices. A preoperative MRI scans showed atherosclerosis at the V4 segment of the left vertebral artery. On May 2012, he received an omental transplantation on the anterior, left lateral and posterior surface of the medulla oblongata. About 48 hours after surgery, the dysarthria disappeared and the voluntary movement of the right foot improved. Three days later, he walked without aid of orthopedic device. At present, four years after operation he present complete reversal of symptoms. In conclusión, this patient confirms that bulbar ALS is of ischemic origin and therefore, mild ALS can be cured.

Clinical, neurosurgical and autopsy findings show that type 2 diabetes mellitus is caused by progressive ischemia in the anterior hypothalamus and endocrine pancreas due to atherosclerosis, and associated with insulin resistance. The hypothalamic ischemia provokes neuroendocrinological disorders through descending projections, and the pancreatic ischemia causes an inappropriate insulin secretion. Both ischemic structures can be improved by means of omental implantation (omental transplantation or transposition) or with anti-inflammatory drugs. Likewise, experimental and clinical observations suggest that insulin resistance is caused by inflammatory action of tumor necrosis factor alpha and resistin in the insulin receptor. Because, in contrast to this, high-dose aspirin or resveratrol can reduce hyperglycemia to normal or near normal in diabetic patients. That is, both drugs are almost specific for the treatment of insulin resistance. Finally, the use of clonazepam at night can have a beneficial effect on glucose homeostasis, because it can reduce the effects of stressful stimuli and normalize the sleep disorders or loss. J Endocrinol Metab. 2016;6(1):1-11 doi: http://dx.doi.org/10.14740/jem333e

Background: Infantile cerebral palsy (ICP) is currently one of the major diseases that cause paralysis and mental retardation in children. The stem cell treatment is a promising alternative for this disease. Material and method: Twenty-eight patients with ICP and epilepsy (12 cases) since 4.5 to 24 years received omental transplantation on the carotid bifurcation, anterior perforated space (APS), optic chiasm, and the temporal lobes. During surgery we found : 1) small and thin omentum in 13 cases, 2) adhesive arachnoiditis in the chiasmatic cistern and surrounding areas in 18 cases, 3) ischemic microinfarcts and atrophy in the surgical area; 4) vascular anomalies in the anterior perforating arteries; 5) several collapsed and exsanguinated perforating arteries, and 6) arachnoid cyst in 3 cases. Of all patients, thirteen cases received only, omentum on the APS, because the omentum was small. Results: Neurological improvement occurred since the first days after surgery in 21 patients. The epileptic seizures were reduced or aborted. Currently, 10 to 26 months after the operation, the patients have improved in different degrees. Likewise, the clinical data in 10 patients with minimal brain dysfunction were reversed. Conclusions: These results indicate that omental transplantation against ICP is effective. Because the omentum provoke revascularization and provide mesenchymal stem cells to the injured area, Moreover, the omentum favors the proliferation and migration of neural stem cells from the subventricular zone of the adult human brain.

Al contrario de la hipótesis sobre una predisposición genética en la patogénesis de la enfermedad de Parkinson, propuesta por muchos investigadores, nosotros creemos que un deterioro del flujo sanguíneo a la sustancia negra es la clave en el proceso patológico primario de esta enfermedad, sin estar relacionado, necesariamente, con el envejecimiento. Conclusión: Basado en hallazgos histopatológicos y neuroquímicos en las neuronas dopaminérgicas, la enfermedad de Parkinson se debe a una reducción subóptima y crónica del flujo sanguíneo arterial al mesencéfalo. Por tanto, la revascularización a los núcleos catecolaminérgicos es una meta por resolver.

Background: Since 1990 and to date, four therapeutic methods have been used against aging. All of them, to increase the plasma growth hormone levels. Material and Method: We choose 38 patients to analyse the postoperative rejuvenation. Previously, all of them have been received omental transplantation on the optic chiasma, the carotid bifurcation and the anterior perforated space. Patients with stroke in 14 cases, Alzheimer´s disease (AD) in 23 and Huntington´s disease (HD) in 1. The clinical data of rejuvenation were obtained by observation, videotape and photography. Results: Neurological improvement in patients with stroke, AD and HD were better during the first weeks after surgery than in the following months or years. Besides this, between 1 to 4 months after surgery, 32 patients (84.21%) showed rejuvenation and in the rest, there were not changes. These 6 last patients presented dilation of the third ventricle. Conclusions: These results indicate that the primary cause of aging is of ischemic origin, in the arcuate nucleus of the hypothalamus. Because, in contrast to this, its revascularization by means of omental tissue produce rejuvenation. Therefore, our surgical method improve the function of the residual arcuate nucleus and adjacent zones.

Up to date, almost all researchers consider that there is still no effective therapy for neurodegenerative diseases (NDDs) and therefore, these diseases are incurable. However, since May 1998, we know that a progressive ischemia in the medial temporal lobes and subcommissural regions can cause Alzheimer's disease; because, in contrast to this, its revascularization by means of omental tissue can cure or improve this disease. Likewise we observed that the aging process, Huntington's disease, Parkinson's disease, and Amyotrophic lateral sclerosis; all of them are of ischemic origin caused by cerebral atherosclerosis, associated with vascular anomalies and/or environmental chemicals. On the contrary, an omental transplantation on the affected zone can stop and improve these diseases. For these reasons, I believe that NDDs, are wrongly classified as neurodegenerative disorders.

Resumen es: Introduccion: Desde 1990, hemos postulado que la causa primaria de la enfermedad de Parkinson (EP) es de origen isquemico iniciado en el tegmento mesence...

Objective: Up to date, the cause of amyotrophic lateral sclerosis (ALS) is not known. Several factors have been etiologically linked with this disease, but none of them with ischemia in the anterior horns of the spinal cord, in the pyramids and in bulbar nuclei of the cranial nerves. The goal of the present study was to place omentum on the medullo-spinal junction to a patient with severe ALS Method: A 60-year-old man with a bulbar form of ALS received an omental transplantation on the anterior and right lateral surface of the medulla oblongata. During surgery we found: 1) vascular anomalies; 2) atherosclerosis in both V4 segments of the vertebral arteries; 3) several exsanguinated perforating arteries over the surface of the pyramids, and 4) hypotrophy of the anterior surface of the pyramids. Result: Subjective and objective clinical improvement occurred beginning the first day after surgery. This improvement was better during the first days or weeks after operation than in the following months. At present, fourteen months after surgery, the bulbar symptoms have improved by 90% and he can walk at a slow pace with or without assistance. Conclusions: These observations suggests that the bulbar form of ALS is caused by progressive ischemia in the intraparenchymal territory of the anterior-ventral spinal arteries. Because, in contrast to this, its revascularization by means of omentum produced neurological improvement.