Treatments for secondary and tertiary hyperparathyroidism (SHPT/THPT) remain significant challenges in patients with end-stage renal disease. Thermal ablation (TA) has emerged as a minimally invasive, safe, and effective alternative to surgical resection (SR). However, technical variations and a lack of standardization have limited its widespread adoption. To address these challenges, an international expert panel developed consensus recommendations using a modified Delphi method, integrated with a systematic literature review. As a result, sixteen recommendations were formulated, addressing diagnosis, preoperative preparation, technical procedures, postoperative management, follow-up strategies, efficacy assessment, and complications associated with TA for SHPT/THPT. These recommendations aim to promote standardized treatment protocols, improve procedural safety, and provide evidence-based guidance for clinical practice and future research in ultrasound-guided TA for SHPT/THPT management.

This study investigated the association between fat-to-muscle ratio (FMR) and hypertension. A total of 1592 participants aged ≥ 40 years were included. Participants were divided into four groups by quartiles of FMR. Odds ratio (OR) and 95

OBJECTIVE:This preliminary comparative study assessed the effectiveness of three microwave ablation (MWA) techniques in managing cystic-solid thyroid nodules. METHODS:Patients who underwent MWA from January 2018 to October 2021 at the Second Affiliated Hospital of Shantou University Medical College were divided into three groups: Simple Aspiration Group (SAG) (cyst fluid drained before direct ablation), Epinephrine Solution Immersion Group (ESIG) (cyst fluid drained followed by soaking in epinephrine), and High-Power Ablation Group (HPAG) (immediate high-power ablation after drainage). Twenty patients were retrospectively analyzed in each group, comparing intraoperative intracapsular bleeding, ablation time of cystic-solid nodules, 12th-month nodule volume reduction rate (VRR), preoperative cosmetic and symptom scores, and postoperative scores. RESULTS:Significant differences were observed in intraoperative intracapsular rebleeding (≥50% cyst cavity volume) between ESIG and SAG (p = 0.029) and HPAG and SAG (p = 0.008), but not between ESIG and HPAG (p = 0.602). The ablation time for cystic-solid nodules was shorter in ESIG and HPAG compared to SAG (p = 0.003 and p = 0.006, respectively), with no significant difference between ESIG and HPAG (p = 0.689). However, the 12th-month outcomes-VRRs, symptom scores, and cosmetic scores-showed no statistical significance among the groups (p = 0.634, p = 0.329, and p = 0.717, respectively). CONCLUSION:ESIG and HPAG significantly reduced intraoperative intracapsular bleeding and ablation time of solid-cystic nodules compared with SAG, indicating enhanced procedural efficiency. Nevertheless, the long-term therapeutic outcomes (nodule shrinkage, symptom relief, and cosmesis) were similar across all methods. These findings underscore the potential of epinephrine immersion and high-power ablation in optimizing MWA for cystic-solid nodules.

OBJECTIVE:To construct a contrast-enhanced ultrasound thyroid imaging reporting and data system (CEUS TI-RADS) based on ACR TI-RADS (2017) without changing the initial scores of conventional ultrasound features and reduce unnecessary fine-needle aspiration (FNA) of thyroid nodules. METHODS:This retrospective study involved patients with thyroid nodules who underwent conventional ultrasound, CEUS, and FNA from October 2020 to June 2024 in three hospitals. Univariable and multivariable logistic regression analysis was employed to filter out useful CEUS features. A CEUS TI-RADS was constructed to differentiate thyroid nodules between benign and malignant and indicate the necessity of FNA. RESULTS:A total of 1275 patients with 1521 thyroid nodules were recruited in this study. Arterial phase intensity, wash-out speed, ring enhancement, and enhancement direction (P-value all<0.001) were independent risk factors for malignant nodules in the training cohort. CEUS TI-RADS outperformed in diagnostic efficacy compared to ACR TI-RADS (AUC[CEUS] =0.94, 0.94, 0.92 vs AUC[ACR]=0.92, 0.91, 0.80 in training, internal validation and external validation cohort respectively, P-value all<0.001). CEUS TI-RADS could achieve a lower unnecessary biopsy rate (UBR) of 43% (81 of 190 nodules) in the training cohort, compared with 59% (156 of 264 nodules) of UBR in ACR TI-RADS. Similar results were confirmed concerning the validation cohorts. CONCLUSION:The CEUS TI-RADS based on ACR TI-RADS (2017) without changing the initial scoring system of conventional ultrasound, was simple and effective in the differential diagnosis of thyroid nodules, which could reduce the unnecessary FNA rate of thyroid nodules than ACR TI-RADS.

BackgroundSerum uric acid (SUA) has been suggested as a contributor of hypertension. However, reports on the relationship between changes in SUA and hypertension are limited. Hence, we aimed to investigate the potential impact of SUA, especially its change over time, on hypertension incidence.MethodsThis dynamic cohort included 6052 participants without hypertension at baseline. Participants were categorized into six grades based on whether baseline SUA was high and whether changes in SUA progressed to hyperuricemia or decreased to normal levels. Grades 1 to 6 represented the participants’ SUA control from best to worst. Logistic regression and restricted cubic spline (RCS) models were used to explore the association of the grades of SUA control and hypertension incidence.ResultsDuring a median follow-up of 6 years, 2550 (42.1%) participants developed hypertension. After adjusting confounding factors, compared to grade 1 with the best control of SUA, the odds ratios for grades 2 to 6 with worse control were 1.347 (1.109-1.636), 1.138 (0.764-1.693), 1.552 (1.245-1.934), 1.765 (1.170-2.663), and 2.165 (1.566-2.993), respectively. RCS indicated a linear correlation between the risk of hypertension and changes in SUA, and an elevated risk in participants with baseline hyperuricemia. Subgroup analyses showed that grades of SUA control had an interaction with systolic (P = 0.003) and diastolic blood pressure (P < 0.001). Sensitivity analyses further determined the robustness of the result that participants with poor SUA control have a higher risk of developing hypertension.ConclusionPoor SUA control, an increase in SUA over time, rises the risk of developing hypertension regardless of whether the initial SUA is normal or not. Initial hyperuricemia will exacerbate this risk. Effective SUA control should be an important measure for primary prevention of hypertension.

Multiple evidence indicates that perinatal factors make impact on immune development and affect offspring allergic rhinitis (AR) risk. In this systematic review and meta-analysis, we examined available published studies to clarify the relationship between cesarean section (C-section) and offspring AR in children. To explore the relationship between C-section, especially the special attention was paid to different cesarean delivery mode, and the risk of AR in children. Articles were searched using PubMed, Web of Science, EMBASE, Cochrane Library, China knowledge Network, Wanfang, and China Science and Technology Journal databases. A meta-analysis of 22 studies published before August 1, 2022, which included 1,464,868 participants, was conducted for statistical analysis with RevMan5.4. The correlation strength between C-section and offspring AR was determined by combining odds ratio ( OR ) and 95% confidence interval ( 95% CI ). Meta-regression and subgroup analyses were used to explore potential sources of heterogeneity. Publication bias was detected using the funnel chart and Egger tests. Meta-analysis revealed that there was a significant correlation between C-section and children AR ( OR = 1.19, 95% CI : 1.12–1.27, P < 0.001), especially C-section with a family history of allergy ( OR = 1.82, 95% CI : 1.36–2.43, P < 0.001). Moreover, elective C-section (without genital tract microbe exposure) had the higher risk of offspring AR ( OR = 1.24, 95% CI : 1.05–1.46, P = 0.010) compared with the whole study. Meta-regression demonstrated that sample size explained 38.0% of the variability between studies, and year of publication explained 18.8%. Delivery by C-section, particularly elective C-section and C-section with a family history of allergy can increase the risk of AR in children.

BACKGROUND The inadequacy samples caused by the internal characteristic structure of thyroid nodules are difficult to be solved. OBJECTIVE To evaluate the ultrasound features affecting the sample adequacy after fine-needle aspiration (FNA) of thyroid nodules with different risk stratification. METHODS 592 thyroid nodules that underwent ultrasound-guided FNA were included in this retrospective study. The sample obtained by FNA were classified as inadequacy and adequacy according to the cytopathological results. Ultrasound features (ie., size, position, cystic predominance, composition, echo, shape, margin, and superficial annular calcification status) of the nodules were recorded and compared between the inadequacy sample group and adequacy sample group. RESULTS Multiple logistic regression shows that preponderant cystic proportion (OR, 0.384; P = 0.041), extremely hypoechogenicity and hypoechogenicity (OR, 6.349; P = 0.006) were the independent influencing factors of inadequate samples after FNA in benign expected nodules. In addition, nodule size ≤10 mm (OR, 1.960; P = 0.010) and superficially annular calcification (OR, 4.600; P <  0.001) were independent influencing factors for inadequate samples after FNA in malignant expected nodules. CONCLUSION The ultrasound features of hypoechogenicity or high cystic proportion in benign expected nodules and that of small size or annular calcification in malignant expected nodules were the risk factors for inadequacy samples by US-guided FNA.

PURPOSE:This study aimed to evaluate the diagnostic value of combined fine-needle aspiration (FNA) with core needle biopsy (CNB) in thyroid nodules. METHODS:FNA and CNB were performed simultaneously on 703 nodules. We compared the proportions of inconclusive results and the diagnostic performance for malignancy among FNA, CNB, and combined FNA/CNB for different nodule sizes. RESULTS:Combined FNA/CNB showed lower proportions of inconclusive results than CNB for all nodules (2.8% vs. 5.7%, P<0.001), nodules ≤1.0 cm (4.9% vs. 7.3%, P=0.063), nodules >1.0 cm (2.0% vs. 5.0 %, P<0.001), nodules ≤1.5 cm (3.8% vs. 7.9 %, P<0.001), and nodules >1.5 cm (2.1% vs. 3.9 %, P=0.016). The sensitivity of combined FNA/CNB in predicting malignancy was significantly higher than that of CNB (89.0% vs. 80.0%, P<0.001) and FNA (89.0% vs. 58.1%, P<0.001) for all nodules. Within American College of Radiology Thyroid and Imaging Reporting and Data System grades 4-5, in the subgroup of nodules ≤1.5 cm, combined FNA/ CNB showed the best sensitivity in predicting malignancy (91.4%), significantly higher than that of CNB (81.0%, P<0.001) and FNA (57.8%, P<0.001). However, in the subgroup of nodules >1.5 cm, the difference between combined FNA/CNB and CNB was not significant (84.2% vs. 78.9%, P=0.500). CONCLUSION:Regardless of nodule size, combined FNA/CNB tended to yield lower proportions of inconclusive results than CNB or FNA alone and exhibited higher performance in diagnosing malignancy. The combined FNA/CNB technique may be a more valuable diagnostic method for nodules ≤1.5 cm and nodules with a risk of malignancy than CNB and FNA alone.

Purpose To investigate the feasibility of percutaneous intrauterine instillation of chilled saline to protect the endometrium during microwave ablation (MWA) treating types 1-3 uterine fibroids. Materials and methods Twenty-six patients with types 1-3 uterine fibroids were prospectively enrolled in an intrauterine saline instillation group (study group). The same number of patients with types 1-3 uterine fibroids who previously received MWA without endometrial protection were retrospectively included in a control group. Endometrial impairment was evaluated by hysteroscopy and magnetic resonance imaging (MRI). Results In the study group, hysteroscopy revealed an intact endometrium in 17 patients, congestion and reddening of the endometrium due to heat in 8 patients, and a burnt necrosis with a size < 1 cm on the functional layer of the endometrium in 1 patient. On MRI, in the study group, there were 17 (65.4%), 6 (23.1%), and 3 (11.5%) patients with grades 0, 1, and 2 endometrial impairment, respectively, but no grade 3 endometrial impairment. In the control group, there were 8 (30.8%), 8 (30.8%), 7 (26.9%), and 3 (11.5%) patients with grades 0, 1, 2, and 3 endometrial impairment, respectively. Endometrial impairment in the study group was significantly better than that in the control group (p = 0.006). One patient had puncture tunnel bleeding and no other complications occurred in the study group. Conclusion Intraoperative percutaneous intrauterine instillation of chilled saline may be effective and safe in reducing the thermal damage to the endometrium caused by MWA for treating types 1-3 uterine fibroids.

目的:探讨非断离(Uncut)Roux-en-Y吻合技术在全腹腔镜远端胃癌根治术中的应用价值.方法:回顾性分析上饶市立医院在2019年10月-2021年7月收治的64例行胃癌根治术的患者资料,根据消化道重建方式,将32例使用Uncut Roux-en-Y吻合技术的患者设为非断离组,将32例使用常规Roux-en-Y吻合技术的患者设为常规组.比较两组手术时间、消化道重建时间、术中出血量、淋巴结清扫数目、胃管留置时间、首次排气时间、进食流食时间及住院时间.术前及术后6个月,比较两组患者白蛋白(ALB)、前白蛋白(PA)、血红蛋白(Hb)、CD4+、CD8+及CD4+/CD8+水平.比较两组并发症发生情况.结果:两组术中淋巴结清扫数目比较,差异无统计学意义(P>0.05),非断离组手术时间、消化道重建时间均短于常规组(P<0.05),术中出血量少于常规组(P<0.05);两组胃管留置时间及住院时间比较,差异均无统计学意义(P>0.05),非断离组首次排气时间及进食流食时间均短于常规组(P<0.05).术前,两组ALB、PA及Hb水平比较,差异均无统计学意义(P>0.05),术后,非断离组ALB、PA及Hb水平均高于常规组(P<0.05).术前及术后,两组CD4+、CD8+及CD4+/CD8+水平比较,差异均无统计学意义(P>0.05);非断离组Roux滞留综合征发生率低于常规组(P<0.05).结论:在全腹腔镜远端胃癌根治术中选择Uncut Roux-en-Y吻合技术进行消化道重建,可缩短重建与手术时间、减少术中出血量,并且有助于早期进食,促进术后胃肠功能恢复,同时,还减少了Roux滞留综合征的发生率,从而促进患者营养恢复.

PURPOSE:To compare the effectiveness and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) for the treatment of benign thyroid nodules (BTNs).METHODS:PubMed, Embase and Cochrane databases were searched up to September 11, 2020. Volume reduction rate (VRR), symptomatic and cosmetic scores analysed by standardized mean difference (SMD), and complications analysed by risk difference (RD) were performed to evaluate the efficacy and safety of RFA and MWA for treating BTNs.RESULTS:Five eligible studies were included. 899 patients with 956 BTNs and 869 patients with 938 BTNs received RFA and MWA, respectively. RFA and MWA have the similar pooled 3-month (56.0% vs. 53.9%, p = .668) and 6-month (80.8% vs. 74.9%, p = .080) VRRs. But RFA showed a significantly higher VRR than MWA after 12 months (86.2% vs. 80.0%, p = .036). The pooled symptomatic and cosmetic scores decreased significantly after 6 and 12 months in both RFA and MWA. The improvements of symptoms were equivalent between two groups at 6 (SMD: 1.17 vs. 1.12, p = .930) and 12 (SMD: 1.46 vs. 1.45, p = .930) months. No significant differences in cosmetic scores were found between two groups at 6 (SMD: 0.87 vs. 0.94, p = 0. 334) and 12 (SMD: 1.21 vs. 1.15, p = 0. 872) months. Major (RD = -0.02, P = .107) and minor (RD = 0.00, p = .661) complications did not significantly differ between RFA and MWA.CONCLUSIONS:RFA and MWA are effective and safe treatment modalities for BTNs. But RFA showed a superior 12-month VRR. RFA may have a better long-term effect on volume reduction of nodules compared with MWA.

Objective. Respiratory failure is the leading cause of mortality in COVID-19 patients, characterized by a generalized disbalance of inflammation. The aim of this study was to investigate the relationship between immune-inflammatory index and mortality in PSI IV-V patients with COVID-19. Methods. We retrospectively reviewed the medical records of COVID-19 patients from Feb. to Apr. 2020 in the Zhongfa Xincheng Branch of Tongji Hospital, Wuhan, China. Patients who presented high severity of COVID-19-related pneumonia were enrolled for further analysis according to the Pneumonia Severity Index (PSI) tool. Results. A total of 101 patients diagnosed with COVID-19 were identified at initial research. The survival analysis revealed that mortality of the PSI IV-V cohort was significantly higher than the PSI I-III group ( p = 0.0003 ). The overall mortality in PSI IV-V patients was 32.1% (9/28). The fatal cases of the PSI IV-V group had a higher level of procalcitonin ( p = 0.022 ) and neutrophil-to-lymphocyte ratio ( p = 0.033 ) compared with the survivors. Procalcitonin was the most sensitive predictor of mortality for the severe COVID-19 population with area under receiver operating characteristic curve of 0.78, higher than the neutrophil-to-lymphocyte ratio (0.75) and total lymphocyte (0.68) and neutrophil (0.67) counts. Conclusion. Procalcitonin and neutrophil-to-lymphocyte ratio may potentially be effective predictors for mortality in PSI IV-V patients with COVID-19. Increased procalcitonin and neutrophil-to-lymphocyte ratio were associated with greater risk of mortality.

OBJECTIVETo explore the incidence of enteral feeding intolerance and its risk factors in patients with malignant oral and maxillofacial tumors.METHODSWe conducted a retrospective analysis of 122 patients with malignant oral and maxillofacial tumor admitted in a general hospital for enteral nutrition between March, 2018 and March, 2021. The incidence of intolerance to enteral nutrition was analyzed, and the two groups of patients with and without intolerance were compared for age, gender, height, weight, pathological staging, types of enteral nutrition preparations, clinical treatment (physical hypothermia and nasal delivery), drug usage (sedatives, vasoactive drugs, acid suppressant, potassium preparation, antibiotics and hormones) and biochemical parameters (serum total protein, serum albumin, blood glucose and serum potassium concentration). Logistic regression analysis was used to analyze the influencing factors of enteral nutritional feeding intolerance in patients.RESULTSOf the 122 patients, 52 had enteral feeding intolerance with an incidence rate of 42.6%. Logistic regression analysis showed that potassium preparation (OR=4.125, P=0.027, 95%CI: 1.178-14.444), sedatives (OR=4.125, P=0.000, 95%CI: 2.007-11.765) and hypoproteinemia (OR=3.557, P=0.010, 95%CI: 1.351-9.366) were independent risk factors of feeding intolerance in patients with malignant oral and maxillofacial tumors, while adding dietary fiber was a protective factor (OR= 0.108, P=0.015, 95%CI: 0.018-0.643).CONCLUSIONThe incidence of enteral feeding intolerance is high in patients with malignant oral and maxillofacial tumors. Enteral nutrition preparations with dietary fiber are recommended for these patients. The patients with potassium preparations, sedatives and hypoproteinemia should be closely monitored for enteral feeding intolerance, and timely intervention should be administered to reduce its incidence.

Objective: This prospective study was designed to compare the effect of painless childbirth under combined spinal-epidural anesthesia (CSEA) and normal delivery. Methods: We enrolled 86 parturients with full-term singleton pregnancies who were admitted to the Department of Obstetrics and Gynecology in Hengyang Maternal and Child Health Care hospital from June 2018 to December 2019. Among them, 43 parturients with painless delivery were randomly selected into the CSEA group and 43 parturients with normal delivery were put into the non-CSEA group. After anesthesia in the CSEA group, the parturients of both groups at each stage of labor were clinically evaluated in terms of the analgesic efficiency, degree of motor block, delivery mode, labor duration, blood loss at 2 hours and 24 hours after delivery and Apgar scores of the newborns. Results: The analgesic efficiency was significantly higher, and the blood loss at 2 h and 24 h after delivery was much less in the CSEA group than in the non-CSEA group (all P<0.05). Meanwhile, the total length of labor revealed no significant difference between the two groups (P>0.05); however, the duration of the first stage of labor was significantly shorter, while the duration of the second stage of labor was much more prolonged in the CSEA group than in the non-CSEA group (all P<0.05). Otherwise, no significant differences were identified in spontaneous delivery rates and Apgar scores between the two groups (both P>0.05). Conclusion: CSEA can exert an obvious analgesic effect, decrease the rate of cesarean section and assisted delivery, as well as reduce the length of the first stage of labor and postoperative bleeding in the process of delivery, thus greatly alleviating maternal pain and fetal distress and promoting the health of mothers and infants. As a result, the CSEA technique is worthy of promotion and application during delivery.

目的 探讨精准康复护理对患舌癌术后患者生活质量的效果.方法 采用随机的方法将我院2019年1～4月住院的口腔科48例舌癌患者分为实验组和对照组各24例.对照组按照常规护理的方式,实验组在常规护理的基础上给予精准康复护理干预.结果 实验组与对照组相比,干预后生活质量总评分明显提高,差异具有统计学意义(P≤0.05).结论 精准康复护理可以提高舌癌患者术后生活质量,间接提高护理满意度.

Objective To explore the differences in autophagic expression levels between hypertrophic scar (HS) tissue and normal skin tissue,and further investigate the relationship between hypertrophic scar formation and autophagy protein expression through the rabbit ear hypertrophic scar model.Methods 30 patients with hypertrophic scar were collected.One hypertrophic scar tissue and one normal skin tissue were harvested.The relative expressions of LC3,P62 and Beclin-1 in each tissue specimen were detected by immunohistochemistry and Western blot.Western blot was used to detect the autophagic-associated protein LC3 (MAPLC3),P62 and Beclin-1 in the hypertrophic scar tissue of rabbit ear and the corresponding normal tissue of rabbit ears at 4 weeks,8 weeks,12 weeks,and 24 weeks,and further explore their clinical significance.Results In vivo,the expression of hypertrophic scar tissue protein LC3 and Beclin-1 was significantly stronger than that in normal skin tissue (P ＜ 0.05).The expression of P62 was significantly weaker than that in normal skin tissue (P ＜ 0.05).In animal experiments,during the process of HS formation,the protein expression of LC3 gradually increased,while the protein expression of P62 gradually decreased;the protein expression of Beclin-1 was higher than that of normal rabbit ears tissue,with statistically significant differences (P ＜ 0.05).Conclusions The expression of LC3 and Beclin-1 in human hypertrophic scar tissues is higher than that in normal tissues.While the expression of P62 is lower than that in normal tissues.That is,the expression of autophagy in human hypertrophic scar tissue showed an upward trend in a certain period of time,and was significantly higher than that in normal tissue.

Objective By taking usage of bioinformatics screening methods,this medical research aimed at exploring how the miRNAs in endothelial progenitor cell exosomes relate to the regulation of angiogenesis.Methods miRNAs in endothelial progenitor cells exosomes and angiogenesis-related miRNA was intersected from the existing database to obtain the candidates of miRNA molecules related to angiogenesis in endothelial progenitor exosomes.Results 160 and 50 miRNAs in endothelial progenitor cell candidates were obtained through experimental data analysis and literature searching respectively.600 candidates of angiogenesis-related miRNAs were obtained through literature searching;the top 20 with the highest frequency were selected out.Finally,9 miRNA candidates (miR-126,miR-21,miR-221,miR-92a,miR-199a,miR-210,miR-214,miR-155,miR-146a) that may be highly expressed in endothelial progenitor exosomes and associated with angiogenesis were obtained for the following research.Conclusions Based on data analysis and literature searching,bioinformatics could screen out the target miRNAs for follow-up studies easily and reliably,it is worthy to be widely applied and popularized.

With the development of modern medical technology,accurate resection of tumor and timely repair and repair of defective tissues and organs are important concerns in the field of tumor research.The precise excision of tumor,refers to the preoperative assessment of systemic and local detection based on detailed to personalized surgical planning,the use of precise operation in operation,ensure as much as possible while minimizing surgical trauma to patients after removal of the lesions,creating the optimal conditions of recovery for trauma patients.Repair and regeneration of defective tissues and organs refers to the deletion or damage of tissues and organs,and gradually resume its anatomical structure and function process under the action of a variety of cells,extracellular mechanisms and related regulatory factors.Then from the tumor resection,tumor resection and accurate regeneration after three point repair technology to change rapidly in the tissue of tumor plastic organ regeneration in tissue of origin.

Negative-pressure wound therapy (NPWT) is one of the most advanced therapeutic methods in the treatment of various hard-to-heal acute and refractory chronic wounds. Recent emerging evidence points to a role of the microRNA-mediated regulation of angiogenesis in ischemic tissues, and a series of microRNAs associated with angiogenesis have been successively identified. In this study, we found that miR-195 expression was significantly upregulated and the microvessel density (MVD) was increased in granulation tissue collected 7 days after NPWT compared with those in the pre-NPWT tissue. Moreover, the expression of NLRX1, the potential target gene of miR-195, was down-regulated in post-NPWT compared with that in pre-NPWT tissue. Significant negative correlations were detected between miR-195 and NLRX1 expression levels (r = -.856, P < .001) and between NLRX1 expression and MVD (r = -.618, P < .05), whereas miR-195 expression was positively correlated with MVD in the granulation tissue (r = .630, P < .05). In summary, NPWT may suppress NLRX1 expression through the upregulation of miR-195 expression, thus efficaciously promoting angiogenesis in the granulation tissue to enhance wound healing.