Decapryn Succinate, a new histamine antagonist, was well tolerated by dogs, rats, and monkeys when administered several times daily over a period of approximately two months. No accumulation occurred with repeated doses, and results in rats indicated repeated doses do not produce signs of toxicity unless doses employed approach acutely lethal ones.

Experiments in rats and dogs, employing various dosage regimes, demonstrate urinary elimination accounts for roughly only 10 to 30 per cent of administered Decapryn Succinate. The antihistamine does not accumulate in various body tissues, and it is concluded that the bulk of administered Decapryn Succinate is destroyed in the body.

The subcutaneous injection in rabbits of purified pyrogen prepared from Proteus vulgaris produces a fever which lasts several hours. The elevated temperature can be reduced to normal or below by aminopyrine, acetanilid, or acetylsalicylic acid. The rise in temperature can be arrested with aceto‐phenetidin, but this antipyretic does not bring the temperature back to normal. The results may be important in connection with treatment of pyrogen‐induced fevers, and they form the basis of a method for evaluating antipyretic activity.

The acute subcutaneous toxicities in mice of Ephedrine, Propadrine, and Amphetamine were increased by the elevation of environmental temperature while those of Tuamine, Vonedrine, and Privine were not significantly altered. Intravenous administrations indicate these effects were not due to alterations in rates of absorption. Ephedrine had a greater and more persistent temperature-raising action than Vonedrine following subcutaneous injection in rats, and Ephedrine toxicity was increased more than that of Vonedrine in this species. Thus, altered toxicity at different temperatures appears to be correlated with effects of the amines on body temperature. Effects of environmental temperature on the toxicity of various vasopressor amines were modified by weight (age) of animals and the species employed.

A method is described for evaluating the emetic activity of quinacrine and quinacrine derivatives following oral administration of the compounds to pigeons. The assay method was designed to detect large differences and the data were not treated statistically. Results, however, which indicated a fair degree of sensitivity are presented.