The basis of the mechanism of ischemic brain tissue are hematological disorders. It is known that divalent ions influence the formation and structure of fibrin. In connection with this fact, a change in macro- and microelement balance serves as a marker of neurotrophic disturbances in the brain long before their clinical manifestations. The imbalance of metal-ligand homeostasis is an unfavorable background for the debut of ischemic stroke. In a multifactorial coagulation system, specific proteins - Protein C and D-dimers - occupy a key place. Many macro- and microelements are mediators of homeostasis and thrombosis: violations of elemental homeostasis are the molecular basis of the ischemic process. In a study conducted in a clinical setting, the combined dynamics of protein C and D-dimers and a complex of macro- and microelements are shown with a high degree of certainty. Using Spearman correlation analysis, reliable correlations were revealed between the concentrations of protein C, D-dimers and macro- and microelements in patients diagnosed with ischemic insult. In the final part of the mathematical processing of the results, multiple regression analysis was used, with the help of which a reliable relationship between protein C, a component of the blood coagulation system, and the concentration of a complex of macro- and microelements contributing to the central mechanism of etiopathogenesis of ischemic stroke is shown: R = 0.95938848, R2 = 0.92042626.

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