OBJECTIVES:To determine whether an open science checklist can be useful for predicting the reproducibility of publications resulting from these grant proposals when used by grant referees assessing them. STUDY DESIGN AND SETTING:This is a comparative accuracy study design using funded grant proposals obtained from online sources (i.e., Open Grants, RIO Journal, NIH, and Grantome). Two independent groups of mock referees assessed open science practices in the proposals and predicted whether the resulting publications would be reproducible, with one group using an open science checklist as an intervention, and the other without. Then we attempted to reproduce the primary findings of a resulting publication from the grant proposal. Sensitivity, specificity, predictive values, and overall accuracy were calculated from 2 × 2 tables, comparing predicted vs. actual reproducibility. The primary outcome is the level of reproducibility, measured by the predictive value, the proportion of (non)reproducible study findings that are accurately predicted. This study was conducted between April and September 2025. RESULTS:Of seven out of 101 publications (6.9%, 95% CI: 2.8%-13.8%), the primary results could be reproduced. When using the checklist, only 16.8% of the proposals were expected to be reproducible, whereas without the checklist 75.2% were expected to be reproducible. When using the checklist, 17 proposals were expected to be reproducible, whereas only 2 out of these 17 could actually be reproduced (positive predictive value (PPV) 11.8% (95% CI: 3.3%-34.3%). Without using the checklist, 76 proposals were thought to be reproducible, whereas only six out of 76 could actually be reproduced (PPV 7.9% [95% CI: 3.7-16.2%]). Sensitivity analysis by research field was not conducted because of small sample sizes in most categories. CONCLUSION:The open science checklist has a low positive predictive value, as expected given the low reproducibility prevalence in our sample. Although the differences between the group using the checklist and the group that did not use the checklist may also have been caused by their level of knowledge of reproducibility and open science, neither group could predict which proposals would or would not be reproducible.

Objective: To assess whether the open science practices promised in grant proposals are subsequently implemented in the resulting publications. Study Design and Setting: We conducted an observational study cohort design using a dataset including 101 grant proposals, each matched with a subsequent publication. All grant proposals were collected from online sources, published in English, and between 1999 and 2024. We assessed which open science practices were mentioned and promised in the proposals using an open science checklist. We used the same checklist to score the subsequent publication and compared the open science scores in the grant and publication and assessed whether there were any discrepancies. Results: Open science practices are reported more frequently in publications than in grant proposals. The majority of open science practices implemented in publications is open access (81 out of 101), whereas a quarter of grants (26 out of 101) include these practices. Open materials, open data, and data citation are also more prevalent in publications than in grant proposals. Other practices, such as protocol availability, study registration, open code, code availability, software and tools, citation of materials or code, transparent reporting, preprints, and registered reports, are infrequently reported in both grants and publications. Notably, registered reports are absent from all publications. Among grants that planned open science practices, the actual implementation rate in funded publications is low. Of all grant proposals that promised to adhere to a certain open science practice between 1.0% and 21.8% of the subsequent articles committed to this practice. Conclusion: Open science practices are being implemented more frequently in publications than at the grant proposals. These findings suggest an opportunity for funders to strengthen policies of open science practices throughout the research lifecycle, from proposal submission to publication.

INTRODUCTION:Effective prevention and intervention strategies for tinnitus rely on identifying risk factors and understanding its progression over time. However, longitudinal data on these aspects are limited. This study therefore aimed to (1) assess the incidence of tinnitus and identify risk factors associated with tinnitus development, and (2) assess the impact of tinnitus and change in impact over time and identify factors associated with this change. METHODS:Data from the Busselton Healthy Ageing Study, a population-based cohort of individuals born between 1946-1964, were used. Information on tinnitus presence and impact, general health, ear-related health and mental health was collected from 3863 participants through questionnaires and physical measurements at two time points with a six-year interval. Logistic regression analysis was used to examine risk factors for tinnitus development. Multinomial logistic regression analysis was used to examine factors associated with changes in impact. RESULTS:The 6-year incidence of tinnitus was 12.1%. Statistically significant risk factors for developing tinnitus included male gender, higher BMI, larger waist circumference, fair subjective health, hearing loss, occupational noise exposure with occasional use of hearing protection, hyperacusis, migraine, and diagnosed anxiety disorder. Among participants with pre-existing tinnitus, 21.4% reported an increase in tinnitus impact over time, while 16.5% experienced a decrease. Changes in impact were influenced by general health and ear-related health factors. CONCLUSION:The high incidence of tinnitus and its notable impact on daily life emphasize the importance of gaining a better understanding of the broad range of identified risk factors for developing tinnitus and change in impact. The multifaceted nature of these factors, comprising hearing-related issues, general health conditions and psychological aspects, underscore the complexity of tinnitus etiology and impact. By gaining more insight into these factors, we can inform future research efforts aimed at developing targeted prevention and intervention strategies tailored to specific demographic groups.

Importance:Open science practices are essential for improving transparency, reproducibility, and trust in biomedical research. Journals play a critical role in promoting these practices through editorial policies, yet implementation and impact remain unclear. Objective:To evaluate the open science policies of leading medical journals and assess implementation and detectability of practices using automated tools. Design, Setting, and Participants:This cross-sectional study of journal policies and open science practices evaluated research articles published in 10 leading general medical journals from January 2020 to December 2023. Additionally, the diagnostic accuracy of automated tools was validated against manual extraction. Exposures:Journal policies regarding open science practices and article-level implementation of 13 core practices including registration, protocol sharing, and intention to share data. Main Outcomes and Measures:Journal policies were assessed using the Transparency and Openness Promotion guidelines (TOP2025). At the article level, 13 core open science practices were examined. Additionally, 9 validated automated tools were applied to detect these practices, and their performance was compared with manual extraction of articles. Results:Overall, 15 624 research articles published in 10 general medical journals were analyzed (validation subset, 312 articles: 103 randomized clinical trials [RCTs], 98 meta-analyses, and 111 with other designs). At the journal level, TOP2025 evaluation identified substantial heterogeneity in policies, primarily applied to clinical trials. At the article level, open science practices were more frequently implemented in RCTs than other designs: registration (RCTs: 99% [95% CI, 97%-100%]; meta-analyses: 69% [95% CI, 56%-79%]; other designs: 16% [95% CI, 9%-26%]), protocol sharing (RCTs: 96% [95% CI, 93%-98%]; meta-analyses: 67% [95% CI, 54%-78%]; other designs: 20% [95% CI, 12%-33%]), and intention to share data (RCTs: 79% [95% CI, 67%-87%]; meta-analyses: 65% [51%-77%]; other designs: 70% [95% CI, 57%-81%]). Automated tools showed variable performance (F1 scores, 0.06-1.00) and generally underestimated practices. Conclusions and Relevance:In this cross-sectional study of 15 624 articles in 10 leading medical journals, journal policies were only partially aligned with TOP2025, and article-level open science practices were more frequently reported for RCTs than for other designs, supporting the need for stronger journal policies.

Various open science practices have been proposed to improve the reproducibility and replicability of scientific research, but not for all practices, there may be evidence they are indeed effective. Therefore, we conducted a scoping review of the literature on interventions to improve reproducibility. We systematically searched Medline, Embase, Web of Science, PsycINFO, Scopus and Eric, on 18 August 2023. Any study empirically evaluating the effectiveness of interventions aimed at improving the reproducibility or replicability of scientific methods and findings was included. We summarized the retrieved evidence narratively and in evidence gap maps. Of the 105 distinct studies we included, 15 directly measured the effect of an intervention on reproducibility or replicability, while the remainder addressed a proxy outcome that might be expected to increase reproducibility or replicability, such as data sharing, methods transparency or pre-registration. Thirty studies were non-comparative and 27 were comparative but cross-sectional observational designs, precluding any causal inference. Despite studies investigating a range of interventions and addressing various outcomes, our findings indicate that in general the evidence base for which various interventions to improve reproducibility of research remains remarkably limited in many respects.

BackgroundCochlear implant fixation in pediatric patients can be challenging due to the thin cranial bone. The dura matter can be exposed by drilling a bony recess leading to possible complications. A minimally invasive newer fixation method might avoid such risks.ObjectivesThe study focus is to assess the feasibility of drilling a bony well adequate for cochlear implant receiver/stimulator device embedment in pediatric patients of different age groups. We also aim report the occurred complications and device failure rates using different surgical techniques for cochlear approach and fixation of the implant.MethodsComputed tomography (CT) scans of 96 pediatric patients (192 ears) were acquired. An optimal location was found within a predetermined area of the temporal bone, using an in-house designed algorithm in Materialise Python API. The feasibility of drilling a bony well was assessed by digitally removing a ramped shaped bony well. Skull thickness descriptive data were calculated, before and after the removal of the bone. Clinical data of pediatric CI patients receiving their cochlear implant between 1996 and 2021 in our tertiary center, were retrospectively collected.ResultsIn 153 ears (79.7%) it was not feasible to create a bony well without exposing the dura mater. In young children aged 0-4 years, drilling a bony well was not feasible in almost all patients (n=69, 98.6%). Mean minimum bone thickness of the location determined by the algorithm, in different age groups, varied from 1.84 mm in the 0-4 years, to 3.31 mm in the 15-17 years age group. We included 344 cochlear implants in 230 patients with a mean age of 3 years. Most implants were placed using the mastoidectomy with posterior tympanotomy (MPTA) approach technique (n=256, 74.4%) and fixated with the bony well fixation technique with or without bony tie-down sutures (n=293, 85.1%). Major complications occurred in all surgical techniques groups. Device related complications occurred in both the bony well and the tight pocket groups.ConclusionDrilling a bony well for fixation of the cochlear implant without exposing the dura matter is not feaible in children. No difference in complication rates was reported regarding device failure between subgroups.

INTRODUCTION:Tinnitus in children remains an underexplored area of research, with limited knowledge about its prevalence and impact on daily lives. Current assessments of the impact of tinnitus in children predominantly rely on open-ended questioning during clinical interviews, inconsistent use of structured tools, and data reported by adult proxies. These methods often fail to fully capture the child's personal experience of tinnitus, underscoring the need for a standardized, child-centered measure to more accurately assess its impact and improve understanding of children's experience. To address this gap, this study proposes the development of a validated PROM set using the Patient-Reported Outcomes Measurement Information System (PROMIS). METHODS:The proposed study is a monocenter, mixed-methods, multi-phase observational study. The study will consist of six consecutive steps: (1) identifying patient-important outcomes through focus groups with children aged 8-18 years; (2) defining the underlying constructs of the outcomes and linking them to relevant PROMIS domains; (3) gathering input form an expert panel to refine the outcomes and domains; (4) discussing the PROM set with the focus groups and assess its feasibility; (5) assessing content validity in the expert panel; and (6) assessing the reliability in a sample of children with tinnitus. DISCUSSION:By using the generic PROMIS framework to develop a condition-specific measure, the proposed study aims to create a standardized, child-centered PROM set that captures the specific impact of pediatric tinnitus, while maintaining the ability to compare outcomes across different conditions and populations. This PROM set could ultimately be used in both clinical care and research to evaluate tinnitus impact and assess the effects of treatments.

Objectives To assess whether treatment with drugs that activate the Wnt pathway leads to an increased risk of cancer.Design Systematic review reported using Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) reporting guidelines.Data sources PubMed, Embase and the Cochrane Library were searched through 1 November 2024.Eligibility criteria All primary research articles reporting clinical studies, including observational and experimental studies, were included in this review. All studies were eligible for inclusion if they included the exposure of interest, that is, compounds which have been described to activate the Wnt pathway, and the outcome of interest, that is, cancer prevalence. No language restrictions were performed.Data extraction and synthesis This study was reported according to the PRISMA reporting guidelines. The search string, objectives, and study protocol methods were defined before the study was initiated.Results A total of 48 studies investigating drugs that activate the Wnt pathway (valproic acid, lithium, cimetidine, olanzapine, clozapine, haloperidol) were included in this systematic review. The results from this systematic review show that, at least for the included compounds in the currently used systemic dosage, cancer prevalence does not significantly increase.Conclusions The current study found that the use of drugs that activate the Wnt pathway was not associated with an increased risk of cancer. As a promising agent in the regenerative therapy field, further research into Wnt activation as a treatment option should be explored.PROSPERO registration number CRD42021286193.

BACKGROUND:Excessively loud music is frequently played at leisure activities, posing significant health risks. However, the lack of consensus on consumers' preferred music settings makes it difficult to implement preventive measures against high noise levels. Therefore, our objective is to systematically evaluate how different musical characteristics influence the experiences and behaviors of individuals engaged in leisure activities. METHODS:We conducted a search for studies examining the effects of musical characteristics on individuals at leisure activities where the musical experience is of primary focus. The search was performed using the Medline Pubmed, Embase Elsevier, Cochrane, PsychInfo, and ClinicalTrial.gov databases. The exclusion criteria included: leisure activities related to sports, studies evaluating music as a treatment, lab settings, case studies, and participants below 15 years old. The NOS, RoB2, and ROBINS-I tools were used to assess risk of bias. Results relevant to our outcomes of interest were extracted and summarized in tables. RESULTS:We identified 2503 studies, of which 37 studies were included for data extraction. The total number of participants in this systematic review was 16843. Among the 37 studies, 23 were observational with the remainder being experimental control trials. Risk of bias in the studies was high. Our findings indicate that musical characteristics such as low frequencies, high groove, high tempo, and live performance enhanced participants' movements and emotions. Excessively high levels, such as those found in nightclubs, were deemed unnecessary by those exposed. These extreme volumes also caused discomfort and posed a risk to hearing health. INTERPRETATION:The high risk of bias makes it difficult to draw conclusions based on the data in this systematic review. Therefore, and in order to inform policy makers, we need adequate randomized controlled trials in order to assess the effects of different levels of loudness on music experience. Registration: PROSPERO registration: CRD42023412634.

Purpose:Research on the association between hearing loss and cognition has primarily focused on speech-range hearing frequencies (i.e., 0.5-4 kHz), as these frequencies are most relevant to everyday functioning. However, age-related hearing loss (ARHL) tends to impact higher-frequency hearing first, and more severely. Despite this, limited research has investigated the relationship between high-frequency (i.e., >4 kHz) hearing loss and cognitive impairment. In the current study, we aimed to assess whether high-frequency hearing loss predicts non-verbal cognitive functions (i.e., visuospatial executive function, learning, and memory tasks) above and beyond speech-frequency hearing loss. Materials and methods:Participants were 241 English-speaking adults, aged 40-88 years, with hearing loss. Audiometrically assessed better-ear, speech-frequency (0.5, 1, 2 & 4 kHz; BE4PTA) and high-frequency (6 & 8 kHz; BE2PTA) hearing loss were compared to cognitive functions measured using non-verbal tests from the Cambridge Neuropsychological Test Automated Battery; covariates included hearing-loss asymmetry, age, sex, premorbid IQ, and mental health measured with the short-form Depression Anxiety Stress Scales. Results:While correlation analyses demonstrated that all measured cognitive faculties were associated with both BE4PTA and BE2PTA, hierarchical linear regression analyses demonstrated that only BE4PTA predicted cognitive flexibility and working-memory ability after controlling for covariates; age primarily accounted for BE2PTA's cognitive effects. Conclusion:While both speech and higher-frequency hearing loss were associated with poorer cognition, only the former demonstrated effects beyond those of ageing. However, the present study only investigated two frequencies in the higher range, encouraging broader investigation of higher-frequency hearing's cognitive effects in the future.

Dizziness and imbalance are common symptoms among patients visiting healthcare providers. Current knowledge about their prevalence, impact on daily life, and associated factors is primarily based on selected samples from individuals seeking medical help, particularly older individuals. This study aimed to estimate the prevalence, symptoms, and impact of dizziness or imbalance symptoms, and to assess the association between these symptoms and their characteristics with demographic, general health, and mental health factors in middle-aged men and women from a representative, general population sample. Cross-sectional data were collected from participants aged 45 to 70 years in the Busselton Healthy Ageing Study (BHAS), recruited in the City of Busselton, Western Australia. The data included physical tests and health-related questionnaires covering demographics, medical history, general and mental health, including any dizziness and imbalance symptoms and their impact on daily life. Estimates were made of the prevalence, patterns, and impact of dizziness and imbalance symptoms. Logistic regression was employed to calculate the association between demographic, mental and general health (independent variables) and the presence of dizziness or imbalance symptoms (dependent variable). Adjustments were made for sex and age as confounding factors. Of the 5086 participants, 1216 (23.9

Background:Many interventions, especially those linked to open science, have been proposed to improve reproducibility in science. To what extent these propositions are based on scientific evidence from empirical evaluations is not clear. Aims:The primary objective is to identify Open Science interventions that have been formally investigated regarding their influence on reproducibility and replicability. A secondary objective is to list any facilitators or barriers reported and to identify gaps in the evidence. Methods:We will search broadly by using electronic bibliographic databases, broad internet search, and contacting experts in the field of reproducibility, replicability, and open science. Any study investigating interventions for their influence on the reproducibility and replicability of research will be selected, including those studies additionally investigating drivers and barriers to the implementation and effectiveness of interventions. Studies will first be selected by title and abstract (if available) and then by reading the full text by at least two independent reviewers. We will analyze existing scientific evidence using scoping review and evidence gap mapping methodologies. Results:The results will be presented in interactive evidence maps, summarized in a narrative synthesis, and serve as input for subsequent research. Review registration:This protocol has been pre-registered on OSF under doi https://doi.org/10.17605/OSF.IO/D65YS.

Background Many interventions, especially those linked to open science, have been proposed to improve reproducibility in science. To what extent these propositions are based on scientific evidence from empirical evaluations is not clear. Aims The primary objective is to identify Open Science interventions that have been formally investigated regarding their influence on reproducibility and replicability. A secondary objective is to list any facilitators or barriers reported and to identify gaps in the evidence. Methods We will search broadly by using electronic bibliographic databases, broad internet search, and contacting experts in the field of reproducibility, replicability, and open science. Any study investigating interventions for their influence on the reproducibility and replicability of research will be selected, including those studies additionally investigating drivers and barriers to the implementation and effectiveness of interventions. Studies will first be selected by title and abstract (if available) and then by reading the full text by at least two independent reviewers. We will analyze existing scientific evidence using scoping review and evidence gap mapping methodologies. Results The results will be presented in interactive evidence maps, summarized in a narrative synthesis, and serve as input for subsequent research. Review registration This protocol has been pre-registered on OSF under doi https://doi.org/10.17605/OSF.IO/D65YS

Background: Excessively loud music is frequently played at leisure activities, posing significant health risks. However, the lack of consensus on consumers’ preferred music settings makes it difficult to implement preventive measures against high noise levels. Therefore, our objective is to systematically evaluate how different musical characteristics influence the experiences and behaviors of individuals engaged in leisure activities. Methods: We conducted a search for studies examining the effects of musical characteristics on individuals at leisure activities where the musical experience is of primary focus. The search was performed using the Medline Pubmed, Embase Elsevier, Cochrane, PsychInfo, and ClinicalTrial.gov databases. The exclusion criteria included: leisure activities related to sports, studies evaluating music as a treatment, lab settings, case studies, and participants below 15 years old. The NOS, RoB2, and ROBINS-I tools were used to assess risk of bias. Results relevant to our outcomes of interest were extracted and summarized in tables. Results: We identified 2503 studies, of which 37 studies were included for data extraction. The total number of participants in this systematic review was 16843. Among the 37 studies, 23 were observational with the remainder being experimental control trials. Risk of bias in the studies was high. Our findings indicate that musical characteristics such as low frequencies, high groove, high tempo, and live performance enhanced participants' movements and emotions. Excessively high levels, such as those found in nightclubs, were deemed unnecessary by those exposed. These extreme volumes also caused discomfort and posed a risk to hearing health. Interpretation: The high risk of bias makes it difficult to draw conclusions based on the data in this systematic review. Therefore, and in order to inform policy makers, we need adequate randomized controlled trials in order to assess the effects of different levels of loudness on music experience. Funding: Dorhout Mees Stichting Registration: PROSPERO registration CRD42023412634 ### Competing Interest Statement The authors have declared no competing interest. ### Clinical Protocols ### Funding Statement Yes ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data extraction files are available from the Zenodo database: https://doi.org/10.5281/zenodo.14211840

PURPOSE:Laryngeal cleft (LC) is an anatomical defect of the larynx, where there is a gap (or cleft) between the arytenoids. Milder types can be treated with injection laryngoplasty (IL), involving injection with a filler, resulting in a decreased depth of the cleft and thereby reducing tracheal penetration or aspiration. The effect, however, is temporary. The aim of this study was to investigate the possible indications and the efficacy of IL for LC. METHODS:Patients who underwent IL for LC between March 2018 and June 2023 were retrospectively evaluated. The following parameters were studied: incidence of LC symptoms and objective swallowing evaluations before and after IL, the duration of possible symptom improvement, complications, and the number of subsequent suture repairs. RESULTS:Eighty-five patients were included. Before IL, 81 (96 %) patients had symptoms of aspiration during feeding, compared to 41 (54 %) patients after IL (p ≤ 0.001). In 42 (49 %) patients, temporary symptom relief occurred, in 22 (26 %) patients symptoms persisted, in 16 (19 %) patients symptoms decreased permanently. Mild complications such as cough and desaturations in the direct postoperative period occurred. CONCLUSION:This study shows a statistically significant decrease in the number of parents/caretakers reporting swallowing symptoms after injection laryngoplasty, and a decrease in the average percentage of parents/caretakers reporting various other symptoms. Based on our results, injection laryngoplasty can be recommended as a diagnostic tool in the treatment of laryngeal cleft. Furthermore, it can be used as bridge therapy (i.e. until patients outgrow their symptoms, or until suture repair).

IntroductionDevelopmental language disorder (DLD) is a common childhood condition negatively influencing communication and psychosocial development. An increasing number of pathogenic variants or chromosomal anomalies possibly related to DLD have been identified. To provide a base for accurate clinical genetic diagnostic work-up for DLD patients, understanding the specific genetic background is crucial. This study aims to give a systematic literature overview of pathogenic variants or chromosomal anomalies causative for DLD in children.MethodsWe conducted a systematic search in PubMed and Embase on available literature related to the genetic background of diagnosed DLD in children. Included papers were critically appraised before data extraction. An additional search in OMIM was performed to see if the described DLD genes are associated with a broader clinical spectrum.ResultsThe search resulted in 15,842 papers. After assessing eligibility, 47 studies remained, of which 25 studies related to sex chromosome aneuploidies and 15 papers concerned other chromosomal anomalies (SCAs) and/or Copy Number Variants (CNVs), including del15q13.1–13.3 and del16p11.2. The remaining 7 studies displayed a variety of gene variants. 45 (candidate) genes related to language development, including FOXP2, GRIN2A, ERC1, and ATP2C2. After an additional search in the OMIM database, 22 of these genes were associated with a genetic disorder with a broader clinical spectrum, including intellectual disability, epilepsy, and/or autism.ConclusionOur study illustrates that DLD can be related to SCAs and specific CNV's. The reported (candidate) genes (n = 45) in the latter category reflect the genetic heterogeneity and support DLD without any comorbidities and syndromic language disorder have an overlapping genetic etiology.

OBJECTIVES:Tinnitus in children and adolescents is relatively unexplored territory. The available literature is limited and the reported prevalence of tinnitus suffering varies widely due to the absence of a definition for pediatric tinnitus. The impact on daily life seems to be lower than in the adult population. It is unclear if children who suffer from tinnitus, like adults, also experience psychological distress like anxiety or depressive symptoms. A better understanding of tinnitus in children and its impact on daily life could provide more insight into the actual size of the problem and could give direction for future studies to investigate the cause of progression of tinnitus. DESIGN:A cross-sectional study was performed using the Dutch Lifelines population-based cohort of people living in the north of the Netherlands. A total of 4964 children (4 to 12 years of age) and 2506 adolescents (13 to 17 years of age) were included. The presence of tinnitus suffering and behavioral outcomes were assessed with a single-item question and the Child Behavioral Checklist or the Youth Self Report questionnaire respectively. The associations of behavioral outcomes and tinnitus suffering were analyzed using univariate binary regressions. RESULTS:The prevalence of tinnitus suffering in children was 3.3 and 12.8% in adolescents. Additionally, 0.3% of the children and 1.9% of the adolescents suffered a lot or extremely of their tinnitus. Externalizing and internalizing problems were associated with tinnitus in adolescents. Internalizing problems were associated with tinnitus in children. CONCLUSIONS:The prevalence of tinnitus suffering in this sample of the general population is comparable to other population-based studies. A low percentage of children (0.3%) or adolescents (1.9%) suffered a lot or extremely of their tinnitus. Tinnitus suffering is associated with all behavioral outcome subscales in adolescents and with internalizing problems in children, although the effect sizes were very small. Future research should focus on achieving a consensus for the definition of pediatric tinnitus and on the development of a validated outcome measure.

Various interventions – especially those related to open science – have been proposed to improve the reproducibility and replicability of scientific research. To assess whether and which interventions have been formally tested for their effectiveness in improving reproducibility and replicability, we conducted a scoping review of the literature on interventions to improve reproducibility. We systematically searched Medline, Embase, Web of Science, PsycINFO, Scopus and Eric, on August 18, 2023. Grey literature was requested from experts in the fields of reproducibility and open science. Any study empirically evaluating the effectiveness of interventions aimed at improving the reproducibility or replicability of scientific methods and findings was included. An intervention could be any action taken by either individual researchers or scientific institutions (e.g., research institutes, publishers and funders). We summarized the retrieved evidence narratively and in an evidence gap map. Of the 104 distinct studies we included, 15 directly measured the effect of an intervention on reproducibility or replicability, while the other research questions addressed a proxy outcome that might be expected to increase reproducibility or replicability, such as data sharing, methods transparency or preregistration. Thirty research questions within included studies were non-comparative and 27 were comparative but cross-sectional, precluding any causal inference. Possible limitations of our review may be the search and selection strategy, which was done by a large team including researchers from different disciplines and different expertise levels. Despite studies investigating a range of interventions and addressing various outcomes, our findings indicate that in general the evidence-base for which various interventions to improve reproducibility of research remains remarkably limited in many respects.