AC is a rare skin cancer with a primarily locoregional recurrence pattern. In our experience, adjuvant RT was associated with improved LC which, depending on the tumor location, may help prevent morbid or cosmetically-impactful salvage surgery. Patients with AC would benefit from radiation oncology referral to discuss adjuvant treatment.

Staging systems for cutaneous squamous cell carcinoma (cSCC) produce inconsistent risk stratification.

Journal of the European Academy of Dermatology and VenereologyVolume 30, Issue 1 p. 172-174 Letter to the Editor Recurrent nodule on the scalp: a differential diagnosis of a nodule on the scalp M.E. Martínez-Escala, Corresponding Author M.E. Martínez-Escala Department of Dermatology, Parc de Salut Mar, Universitat Autónoma de Barcelona, Institut Municipal d'Investigació mèdica de Barcelona (IMIM), Barcelona, SpainCorrespondence: M.E. Martínez-Escala. E-mail: [email protected]Search for more papers by this authorV.G. Prieto, V.G. Prieto Departments of Pathology and Dermatology, MD Anderson Cancer Center, Houston, Texas, USASearch for more papers by this authorD. Ivan, D. Ivan Departments of Pathology and Dermatology, MD Anderson Cancer Center, Houston, Texas, USASearch for more papers by this author M.E. Martínez-Escala, Corresponding Author M.E. Martínez-Escala Department of Dermatology, Parc de Salut Mar, Universitat Autónoma de Barcelona, Institut Municipal d'Investigació mèdica de Barcelona (IMIM), Barcelona, SpainCorrespondence: M.E. Martínez-Escala. E-mail: [email protected]Search for more papers by this authorV.G. Prieto, V.G. Prieto Departments of Pathology and Dermatology, MD Anderson Cancer Center, Houston, Texas, USASearch for more papers by this authorD. Ivan, D. Ivan Departments of Pathology and Dermatology, MD Anderson Cancer Center, Houston, Texas, USASearch for more papers by this author First published: 29 August 2014 https://doi.org/10.1111/jdv.12679Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Shnitka TK, Bain GO. Cutaneous meningioma (psammoma). Autopsy findings in a previously reported case. Arch Dermatol 1959; 80: 410–412. 10.1001/archderm.1959.01560220020004 CASPubMedWeb of Science®Google Scholar 2Lopez DA, Silvers DN, Helwig EB. Cutaneous meningiomas–a clinicopathologic study. Cancer 1974; 34: 728–744. 10.1002/1097-0142(197409)34:3<728::AID-CNCR2820340332>3.0.CO;2-U PubMedWeb of Science®Google Scholar 3Battistella M, Guedj N, Fallet-Bianco C, Bodemer C, Brousse N, Fraitag S. The histopathological spectrum of cutaneous meningeal heterotopias: clues and pitfalls. Histopathology 2011; 59: 407–420. 10.1111/j.1365-2559.2011.03968.x CASPubMedWeb of Science®Google Scholar 4Battistella M, Verola O, Moulonguet I, Janin A. Cutaneous heterotopic meningeal nodules. Ann Pathol 2009; 29: 130–133. 10.1016/j.annpat.2008.10.002 PubMedWeb of Science®Google Scholar 5Zeikus P, Robinson-Bostom L, Stopa E. Primary cutaneous meningioma in association with a sinus pericranii. J Am Acad Dermatol 2006; 54(2 Suppl): S49–S50. 10.1016/j.jaad.2004.08.058 Web of Science®Google Scholar 6Ouazzani A, de Fontaine S, Berthe JV. Extracranial meningioma and pregnancy: a rare diagnosis. J Plast Reconstr Aesthet Surg 2007; 60: 622–625. 10.1016/j.bjps.2006.01.054 CASPubMedWeb of Science®Google Scholar 7Shaw R, Kissun D, Boyle M, Triantafyllou A. Primary meningioma of the scalp as a late complication of skull fracture: case report and literature review. Int J Oral Maxillofac Surg 2004; 33: 509–511. 10.1016/j.ijom.2003.08.007 Google Scholar Volume30, Issue1January 2016Pages 172-174 ReferencesRelatedInformation

Extramammary Paget disease (EMPD) is an infrequent skin cancer sometimes representing a secondary event caused by extension of an underlying carcinoma. Her‐2/neu overexpression in breast cancer is correlated with a more aggressive behavior, but anti‐Her‐2/neu therapy improves survival in these patients. We investigated Her‐2/neu expression by immunohistochemistry in cases of EMPD with and without underlying malignancy to try to correlate with tumor recurrence, progression and possible targeted therapy. Forty‐seven cases were analyzed (6 from the scrotum, 7 perianal region, 1 axilla and 33 vulva). Two cases had invasive EMPD (one from vulva and one from scrotum). The overall Her‐2/neu expression was 31.9%. Of the noninvasive EMPD of the vulva (32 cases), Her‐2/neu was shown in 38%. The case of invasive vulvar EMPD was negative. All six scrotal EMPD lacked Her2/neu expression. Her‐2/neu was expressed in two of seven perianal cases (33.3%). The EMPD on the axilla (one case) was negative. Eighteen cases had recurrence, and of these, 44.4% expressed Her‐2/neu in the initial lesion. A high proportion of EMPD showed Her‐2/neu expression (31.9%), indicating that these patients may benefit from targeted therapy. The proportion of positive cases was higher in lesions that had recurred at last follow up (44.4%), suggesting a more aggressive behavior.