Since 2001, capsule endoscopy has been the primary test used to diagnose small-intestinal diseases. However, video capsule endoscopy of the stomach was considered impractical because visualizing the entire stomach was deemed impossible and would require a steerable capsule. Magnetically controlled gastric capsule endoscopy has been increasingly used for the diagnosis of gastric diseases, with significant developments in China. This noninvasive, hygienic, and comfortable method has gained popularity as an alternative to traditional electronic gastroscopy owing to its disposable nature and recent hardware upgrades (resolution, brightness, and field of view). Important steps forward with artificial intelligence and robots allow for the automated detection and characterization of gastric lesions. As it was restricted in China, questions have been raised about its cost-effectiveness worldwide, particularly in countries where early gastric cancer is not a priority. In this paper, I review the initial trials with this innovative capsule and the important technical updates in the last 5 years: robots for capsule guidance and artificial intelligence for the detection and characterization of gastric lesions.

With incessant advances in information technology and its implications in all domains of our lives, artificial intelligence (AI) has emerged as a requirement for improved machine performance. This brings forth the query of how this can benefit endoscopists and improve both diagnostic and therapeutic endoscopy in each part of the gastrointestinal tract. Additionally, it also raises the question of the recent benefits and clinical usefulness of this new technology in daily endoscopic practice. There are two main categories of AI systems: computer-assisted detection (CADe) for lesion detection and computer-assisted diagnosis (CADx) for optical biopsy and lesion characterization. Quality assurance is the next step in the complete monitoring of high-quality colonoscopies. In all cases, computer-aided endoscopy is used, as the overall results rely on the physician. Video capsule endoscopy is a unique example in which a computer operates a device, stores multiple images, and performs an accurate diagnosis. While there are many expectations, we need to standardize and assess various software packages. It is important for healthcare providers to support this new development and make its use an obligation in daily clinical practice. In summary, AI represents a breakthrough in digestive endoscopy. Screening for gastric and colonic cancer detection should be improved, particularly outside expert centers. Prospective and multicenter trials are mandatory before introducing new software into clinical practice.

The distribution of close-in exoplanets is shaped by a complex interplay between atmospheric and dynamical processes. The Desert-Rim Exoplanets Atmosphere and Migration (DREAM) program aims at disentangling those processes through the study of the hot Neptune desert, whose rim hosts planets that are undergoing, or survived, atmospheric evaporation and orbital migration. In this first paper, we use the Rossiter-McLaughlin Revolutions (RMR) technique to investigate the orbital architecture of 14 close-in planets ranging from mini-Neptune to Jupiter-size and covering a broad range of orbital distances. While no signal is detected for the two smallest planets, we were able to constrain the sky-projected spin–orbit angle of six planets for the first time, to revise its value for six others, and, thanks to constraints on the stellar inclination, to derive the 3D orbital architecture in seven systems. These results reveal a striking three-quarters of polar orbits in our sample, all being systems with a single close-in planet but of various stellar and planetary types. High-eccentricity migration is favored to explain such orbits for several evaporating warm Neptunes, supporting the role of late migration in shaping the desert and populating its rim. Putting our measurements in the wider context of the close-in planet population will be useful to investigate the various processes shaping their architectures.

Objectives: The aim of this paper relies on our clinical experience in a single center with an evaluation of feasibility, clinical benefits, and safety in daily practice based on diagnosis and therapeutic yield using a newly designed Motorized Spiral Enteroscope (MSE) marked by Olympus. Method: All examinations were conducted in the usual endoscopy suite with patients in the left lateral position with deep propofol sedation monitored by an anesthesiologist (bolus 2 mg/kg then 0.5 mg/kg on demand with mean total dose 300 mg (225.6-386 mg). For the anal route, MSE was performed on the X-ray table in order to monitor colonic passage and ileocecal intubation. Inflation was carried out with CO2 used. Results: From June 2019 to July 2022, 204 procedures have been carried out. 188 patients were involved as repeated MSE was required due to multiple bleeding (male 111, 57.1%, female 87, 46.2%). In all cases, we considered a successful MSE when the enteroscope was deeply inserted in the ileum and achieved diagnosis or therapeutic indications as an endpoint (195 patients, 95.5%). Diagnostic yield was achieved in 134 procedures (65.7%). Time to deep insertion was 11:36 f 05.05 min, and the total procedure time was 22:07 f 07:25 min. Minor mucosal damage occurred in 59 patients (28.9%). Conclusions: In our 204 procedures MSE is a safe and useful new tool in routine clinical practice with an overall benefit for our patients.

We present the discovery and characterization of a transiting sub-Neptune orbiting with a 16.20 day period around a nearby (28 pc) and bright(V=8.37) K0V star HD207897 (TOI-1611). This discovery is based on photometric measurements from the Transiting Exoplanet Survey Satellite(TESS) mission and radial velocity (RV) observations from the SOPHIE, Automated Planet Finder (APF) and HIRES high precision spectrographs. We used EXOFASTv2 for simultaneously modeling the parameters of the planet and its host star, combining photometric and RV data to determine the planetary system parameters. We show that the planet has a radius of 2.50+/-0.08 RE and a mass of either 14.4+/-1.6 ME or 15.9+/-1.6 ME with nearly equal probability; the two solutions correspond to two possibilities for the stellar activity period. Hence, the density is either 5.1+/-0.7 g cm^-3 or 5.5^+0.8_-0.7 g cm^-3, making it one of the relatively rare dense sub-Neptunes. The existence of such a dense planet at only 0.12 AU from its host star is unusual in the currently observed sub-Neptune (2<RE<4) population. The most likely scenario is that this planet has migrated to its current position.

Distinguishing classes within substellar objects and understanding their formation and evolution need larger samples of substellar companions such as exoplanets, brown dwarfs, and low-mass stars. In this paper, we look for substellar companions using radial velocity surveys of FGK stars with the SOPHIE spectrograph at the Observatoire de Haute-Provence. We assign here the radial velocity variations of 27 stars to their orbital motion induced by low-mass companions. We also constrained their plane-of-the-sky motion using HIPPARCOS and Gaia Data Release 1 measurements, which constrain the true masses of some of these companions. We report the detection and characterization of six cool Jupiters, three brown dwarf candidates, and 16 low-mass stellar companions. We additionally update the orbital parameters of the low-mass star HD 8291 B, and we conclude that the radial velocity variations of HD 204277 are likely due to stellar activity despite resembling the signal of a giant planet. One of the new giant planets, BD+631405 b, adds to the population of highly eccentric cool Jupiters, and it is presently the most massive member. Two of the cool Jupiter systems also exhibit signatures of an additional outer companion. The orbital periods of the new companions span 30 days to 11.5 years, their masses 0.72 Jupiter mass to 0.61 Solar mass, and their eccentricities 0.04 to 0.88. These discoveries probe the diversity of substellar objects and low-mass stars, which will help constrain the models of their formation and evolution.

Aims. Since 2011, the SOPHIE spectrograph has been used to search for Neptunes and super-Earths in the northern hemisphere. As part of this observational program, 290 radial velocity measurements of the 6.4 V magnitude star HD 158259 were obtained. Additionally, TESS photometric measurements of this target are available. We present an analysis of the SOPHIE data and compare our results with the output of the TESS pipeline.Methods. The radial velocity data, ancillary spectroscopic indices, and ground-based photometric measurements were analyzed with classical and l(1) periodograms. The stellar activity was modeled as a correlated Gaussian noise and its impact on the planet detection was measured with a new technique.Results. The SOPHIE data support the detection of five planets, each with m sin i approximate to 6 M-circle plus, orbiting HD 158259 in 3.4, 5.2, 7.9, 12, and 17.4 days. Though a planetary origin is strongly favored, the 17.4 d signal is classified as a planet candidate due to a slightly lower statistical significance and to its proximity to the expected stellar rotation period. The data also present low frequency variations, most likely originating from a magnetic cycle and instrument systematics. Furthermore, the TESS pipeline reports a significant signal at 2.17 days corresponding to a planet of radius approximate to 1.2 R-circle plus. A compatible signal is seen in the radial velocities, which confirms the detection of an additional planet and yields a approximate to 2 M-circle plus mass estimate.Conclusions. We find a system of five planets and a strong candidate near a 3:2 mean motion resonance chain orbiting HD 158259. The planets are found to be outside of the two and three body resonances.

New time-resolved photometric observations of three close but detached white dwarf/red dwarf binaries have enabled an in-depth analysis of their properties, combining new data with known information. For HZ 9, time-resolved photometric data have not been published previously. Our data reveal sinusoidal variations, with the orbital period showing unusual phase shifts between expected and observed light maximum epochs when combining our photometry with the precise radial velocity ephemeris. There are also variations of the photometric amplitude between 0.04 and 0.11 mag. Phase shifts and amplitude variations could be the result of a relatively strong magnetic activity of the secondary M star component, which seems to superimpose the usual reflection effect. This effect is dominant in the two remaining targets of our study. We improve the accuracy of the photometric ephemeris of KV Vel, complementing published data with light curves from the All-Sky Automated Survey (ASAS) and ASAS-SN and with our own observations. Finally, we also add new data for the central star of the planetary nebula Abell 65, complementing and confirming its previously published photometric ephemeris.

We present the detection of a warm Neptune orbiting the M dwarf Gl 378, using radial velocity measurements obtained with the SOPHIE spectrograph at the Observatoire de Haute-Provence. The star was observed in the context of the SOPHIE exoplanet consortium's sub-programme dedicated to finding planets around M dwarfs. Gl 378 is an M1 star, of solar metallicity, at a distance of 14.96 pc. The single planet detected, Gl 378 b, has a minimum mass of 13.02 M-Earth and an orbital period of 3.82 days, which place it at the lower boundary of the hot Neptune desert. As one of only a few such planets around M dwarfs, Gl 378 b provides important clues to the evolutionary history of these close-in planets. In particular, the eccentricity of 0.1 may point to a high-eccentricity migration. The planet may also have lost part of its envelope due to irradiation.

Whereas thousands of transiting giant exoplanets are known today, only a few are well characterized with long orbital periods. Here we present KOI-3680b, a new planet in this category. First identified by the Kepler team as a promising candidate from the photometry of the Kepler spacecraft, we establish here its planetary nature from the radial velocity follow-up secured over 2 yr with the SOPHIE spectrograph at Observatoire de Haute-Provence, France. The combined analysis of the whole dataset allows us to fully characterize this new planetary system. KOI-3680b has an orbital period of 141.2417 ± 0.0001 days, a mass of 1.93 ± 0.20 M Jup , and a radius of 0.99 ± 0.07 R Jup . It exhibits a highly eccentric orbit ( e = 0.50 ± 0.03) around an early G dwarf. KOI-3680b is the transiting giant planet with the longest period characterized so far around a single star; it offers opportunities to extend studies which were mainly devoted to exoplanets close to their host stars, and to compare both exoplanet populations.

Brown-dwarfs are substellar objects with masses intermediate between planets and stars within about 13-80Mjup. While isolated BDs are most likely produced by gravitational collapse in molecular clouds down to masses of a few Mjup, a non-negligible fraction of low-mass companions might be formed through the planet formation channel in protoplanetary disks. The upper mass limit of objects formed within disks is still observationally unknown, the main reason being the strong dearth of BD companions at orbital periods shorter than 10 years, a.k.a. the BD desert. To address this question, we aim at determining the best statistics of secondary companions within the 10-100Mjup range and within 10 au from the primary star, while minimising observational bias. We made an extensive use of the RV surveys of FGK stars below 60pc distance to the Sun and in the northern hemisphere performed with the SOPHIE spectrograph at the Observatoire de Haute-Provence. We derived the Keplerian solutions of the RV variations of 54 sources. Public astrometric data of the Hipparcos and Gaia missions allowed constraining the mass of the companion for most sources. We introduce GASTON, a new method to derive inclination combining RVs Keplerian and astrometric excess noise from Gaia DR1. We report the discovery of 12 new BD candidates. For 5 of them, additional astrometric data led to revise their mass in the M-dwarf regime. Among the 7 remaining objects, 4 are confirmed BD companions, and 3 others are likely in this mass regime. We also report the detection of 42 M-dwarfs within 90Mjup-0.52Msun. The resulting Msin(i)-P distribution of BD candidates shows a clear drop in the detection rate below 80-day orbital period. Above that limit, the BD desert reveals rather wet, with a uniform distribution of the Msin(i). We derive a minimum BD-detection frequency around Solar-like stars of 2.0+/-0.5

Context. Since 1998, a planet-search around main sequence stars within 50~pc in the southern hemisphere has been carried out with the CORALIE spectrograph at La Silla Observatory. Aims. With an observing time span of more than 20 years, the CORALIE survey is able to detect long term trends in data with masses and separations large enough to select ideal targets for direct imaging. Detecting these giant companion candidates will allow us to start bridging the gap between radial velocity detected exoplanets and directly imaged planets and brown dwarfs. Methods. Long-term precise Doppler measurements with the CORALIE spectrograph reveal radial velocity signatures of massive planetary companions and brown dwarfs on long-period orbits. Results. In this paper we report the discovery of new companions orbiting HD~181234, HD~13724, HD~25015, HD~92987 and HD~50499. We also report updated orbital parameters for HD~50499b, HD~92788b and HD~98649b. In addition, we confirm the recent detection of HD~92788c. The newly reported companions span a period range of 15.6 to 40.4 years and a mass domain of 2.93 to 26.77 $M_{\mathrm{Jup}}$, the latter of which straddles the nominal boundary between planets and brown dwarfs. Conclusion. We have reported the detection of five new companions and updated parameters of four known extrasolar planets. We identify at least some of these companions to be promising candidates for imaging and further characterisation.

Context. Since 1998, a planet-search around main sequence stars within 50 pc in the southern hemisphere has been underway with the CORALIE spectrograph at La Silla Observatory. Aims. With an observing time span of more than 20 yr, the CORALIE survey is able to detect long-term trends in data with masses and separations large enough to select ideal targets for direct imaging. Detecting these giant companion candidates will allow us to start bridging the gap between radial-velocity-detected exoplanets and directly imaged planets and brown dwarfs. Methods. Long-term precise Doppler measurements with the CORALIE spectrograph reveal radial-velocity signatures of massive planetary companions and brown dwarfs on long-period orbits. Results. In this paper, we report the discovery of new companions orbiting HD 181234, HD 13724, HD 25015, HD 92987 and HD 50499. We also report updated orbital parameters for HD 50499b, HD 92788b and HD 98649b. In addition, we confirm the recent detection of HD 92788c. The newly reported companions span a period range of 15.6-40.4 yr and a mass domain of 2.93-26.77 M-Jup, the latter of which straddles the nominal boundary between planets and brown dwarfs. Conclusions. We report the detection of five new companions and updated parameters of four known extrasolar planets. We identify at least some of these companions to be promising candidates for imaging and further characterisation.

Kepler-419 is a planetary system discovered by the Kepler photometry which is known to harbour two massive giant planets: an inner 3 M-J transiting planet with a 69.8-day period, highly eccentric orbit, and an outer 7.5 M-J non-transiting planet predicted from the transit-timing variations (TTVs) of the inner planet b to have a 675-day period, moderately eccentric orbit. Here we present new radial velocity (RV) measurements secured over more than two years with the SOPHIE spectrograph, where both planets are clearly detected. The RV data is modelled together with the Kepler photometry using a photodynamical model. The inclusion of velocity information breaks the MR-3 degeneracy inherent in timing data alone, allowing us to measure the absolute stellar and planetary radii and masses. With uncertainties of 12 and 13% for the stellar and inner planet radii, and 35, 24, and 35% for the masses of the star, planet b, and planet c, respectively, these measurements are the most precise to date for a single host star system using this technique. The transiting planet mass is determined at better precision than the star mass. This shows that modelling the radial velocities and the light curve together in systems of dynamically interacting planets provides a way of characterising both the star and the planets without being limited by knowledge of the star. On the other hand, the period ratio and eccentricities place the Kepler-419 system in a sweet spot; had around twice as many transits been observed, the mass of the transiting planet could have been measured using its own TTVs. Finally, the origin of the Kepler-419 system is discussed. We show that the system is near a coplanar high-eccentricity secular fixed point, related to the alignment of the orbits, which has prevented the inner orbit from circularising. For most other relative apsidal orientations, planet b's orbit would be circular with a semi-major axis of 0.03 au. This suggests a mechanism for forming hot Jupiters in multiplanetary systems without the need of high mutual inclinations.