Acta Medica ScandinavicaVolume 176, Issue S425 p. 88-91 On the Standardization of the Histo-Pathologic Reading of the Kveim Test J. Ringsted, J. Ringsted Danish Tuberculosis Index, Copenhagen, and the Pathology Institute, Holbæk, DenmarkSearch for more papers by this authorJ. B. Ferebee, J. B. Ferebee Danish Tuberculosis Index, Copenhagen, and the Pathology Institute, Holbæk, DenmarkSearch for more papers by this author J. Ringsted, J. Ringsted Danish Tuberculosis Index, Copenhagen, and the Pathology Institute, Holbæk, DenmarkSearch for more papers by this authorJ. B. Ferebee, J. B. Ferebee Danish Tuberculosis Index, Copenhagen, and the Pathology Institute, Holbæk, DenmarkSearch for more papers by this author First published: January/December 1964 https://doi.org/10.1111/j.0954-6820.1964.tb05706.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume176, IssueS425January/December 1964Pages 88-91 RelatedInformation

The Kveim reaction was studied in vivo in 50 patients with sarcoidosis. Commonwealth Serum Laboratories Kveim material and a new Danish Kveim material gave 14 and 8 positive reactions respectively, as well as 6 and 8 equivocal reactions. Forty-six of the patients were also tested in vitro for cell mediated immunity to the Danish Kveim material, using both the leucocyte migration agarose technique and the capillary technique. No significant migration inhibition or stimulation were found. A tuberculin skin test was performed in 49 of the patients, and in 45 a dinitrochlorobenzene sensitivity titer was determined. Both tests revealed a depression of the cell mediated immunity. The serum levels of immunoglobulins IgG, IgA, IgM, IgD, and IgE were determined. The serum of each patient was also examined to determine if organ-non-specific and granulocyte-specific antinuclear factors of IgG class, antibodies against native DNA, rheumatoid factor, mitochondrial antibodies, antibodies against thyroid cytoplasm, and parietal cell antibodies were present. IgG levels were above normal in 28 patients; IgE was above normal in 10 patients, 4 of whom were atopics or had an atopic disposition. Organ-non-specific antinuclear factors were present in 17 patients.

We found it valuable to separate the heterogeneous types of sarcoidosis into more homogeneous groups on the basis of activity and duration of the disease. This view is supported in the present study by the finding of a marked depression of T-cell function in patients with chronic-active sarcoidosis. Patients with acute or chronic-inactive disease had only moderately depressed T-cell function as measured by tuberculin skin test and DNCB index. These results are in agreement with those of some previous investigations. The remainder of the abnormal findings, particularly low total number of circulation T lymphocytes, elevated serum IgG levels, and presence of autoantibodies, could not be correlated to disease activity, extent of the disease, or T-cell function. We have found no explanation for the presence of autoantibodies but suspect that they may be nonspecifically related to the disease process.

No migration inhibition was observed in the 46 patients or the 12 controls when the Danish Kveim antigen was used in the LMAT. No migration inhibition was found in 23 of the same patients when the LMT was employed using the same antigens (Table 3).

ABSTRACT An elderly woman exhibited severe hypoglycaemic attacks. Whipple's triad and characteristic electroencephalographic changes were present. After removal of a large retroperitoneal fibrosarcoma, the hypoglycaemia ceased. On the basis of this case and of 11 reported in the literature, the authors emphasize the following characteristics: (1) The tumour is located retroperitoneally, more rarely intrathoracically, just above the diaphragm. (2) The tumours are very large, ranging in weight from 700 to 4700 g. (3) The tumours appear to be fibrosarcomas of low-degree malignancy; histologically they do not resemble insulomas. (4) The pancreas is normal. Insulin was not demonstrable in the tumour in the present case. It is suggested that perhaps the tumour produces an unknown substance exerting an insulin-like activity.

Acta Pharmacologica et ToxicologicaVolume 16, Issue 1 p. 6-9 Mercurial Diuretics and the Nephrotic Syndrome in the Rat. O. Munck, O. Munck Research Laboratories of Pharmacia Ltd., Copenhagen, Denmark. ) 30, Ved Kaeret, Gentofte, Denmark.Search for more papers by this authorJ. G. A. Pedersen, J. G. A. Pedersen Research Laboratories of Pharmacia Ltd., Copenhagen, Denmark.Search for more papers by this authorJ. Ringsted, J. Ringsted Research Laboratories of Pharmacia Ltd., Copenhagen, Denmark.Search for more papers by this authorF. Speggers, F. Speggers Research Laboratories of Pharmacia Ltd., Copenhagen, Denmark.Search for more papers by this author O. Munck, O. Munck Research Laboratories of Pharmacia Ltd., Copenhagen, Denmark. ) 30, Ved Kaeret, Gentofte, Denmark.Search for more papers by this authorJ. G. A. Pedersen, J. G. A. Pedersen Research Laboratories of Pharmacia Ltd., Copenhagen, Denmark.Search for more papers by this authorJ. Ringsted, J. Ringsted Research Laboratories of Pharmacia Ltd., Copenhagen, Denmark.Search for more papers by this authorF. Speggers, F. Speggers Research Laboratories of Pharmacia Ltd., Copenhagen, Denmark.Search for more papers by this author First published: October 1959 https://doi.org/10.1111/j.1600-0773.1959.tb01181.xCitations: 2 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume16, Issue1October 1959Pages 6-9 RelatedInformation

Acta Pathologica Microbiologica ScandinavicaVolume 32, Issue 4 p. 465-467 INOCULATION OF TUBERCLE BACILLI INTO CORTISONE TREATED GUINEA PIGS An Attempt at Improving the Routine Diagnosis of Tuberculosis J. Balslev Jørgensen, J. Balslev Jørgensen PATHOLOGICAL INSTITUTE OF BISPEBJERG HOSPITAL, COPENHAGEN (DIRECTOR: PROSECTOR BJ. VIMTRUP, M.D.)Search for more papers by this authorJ. Ringsted, J. Ringsted PATHOLOGICAL INSTITUTE OF BISPEBJERG HOSPITAL, COPENHAGEN (DIRECTOR: PROSECTOR BJ. VIMTRUP, M.D.)Search for more papers by this author J. Balslev Jørgensen, J. Balslev Jørgensen PATHOLOGICAL INSTITUTE OF BISPEBJERG HOSPITAL, COPENHAGEN (DIRECTOR: PROSECTOR BJ. VIMTRUP, M.D.)Search for more papers by this authorJ. Ringsted, J. Ringsted PATHOLOGICAL INSTITUTE OF BISPEBJERG HOSPITAL, COPENHAGEN (DIRECTOR: PROSECTOR BJ. VIMTRUP, M.D.)Search for more papers by this author First published: July 1953 https://doi.org/10.1111/j.1699-0463.1953.tb00274.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume32, Issue4July 1953Pages 465-467 RelatedInformation