ADVERTISEMENT RETURN TO ISSUEPREVArticleUnbleachable rhodopsin with an 11-cis-locked eight-membered ring retinal: The visual transduction process. [Erratum to document cited in CA120(7):74157z]Shuanghua Hu, Paul J. Franklin, Jun Wang, Arh Hwang Chen, Beatriz E. Ruiz Silva, Fadila Derguini, and Koji NakanishiCite this: Biochemistry 1994, 33, 16, 4994Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://doi.org/10.1021/bi00182a030RIGHTS & PERMISSIONSArticle Views21Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (48 KB) Get e-Alerts Get e-Alerts

The triggering process of rhodopsin activation leading to visual transduction has remained a key problem in the chemistry of vision. In order to provide probes to explore this process, retinal analogs ret8 3 and ret9 4, with the 11-ene cis-locked by 8- and 9-membered rings, have been synthesized. These could lead to pigment analogs which might accomodate a transoid chromophore upon irradiation, thus providing unique models for rhodopsin activation studies. Enzyme assays and flash photolysis of rhodopsin analogs incorporating ret8 and other retinal analogs showed that the triggering process requires complete 11-cis to trans isomerization involving the entire polyene moiety. The syntheses of ret8 3 and ret9 4 double bond isomers are described.