Adequate, gradual, regular and locomotive diversified physical activities and training is at present a substantial part of treatment virtually in all patients with both type 1 and type 2 diabetes mellitus (T1DM and T2DM). In postgraduate conceived lecture authors explained meaning and indications of physical activities in primary and secondary prevention of metabolic syndrome and its complications. The lecture is focused also on relative contraindications of physical activities and sports in patients with T1DM and T2DM.

Proarytmie (PA) znamena vznik nove arytmie nebo zhorseni již existujici poruchy srdecniho rytmu během antiarytmicke terapie. Podminkou je, že nejsou překroceny lecebne koncentrace antiarytmika, nejde tedy o jeho toxický efekt (9, 13). Skutecnost, že každe antiarytmikum může být arytmogenni a že nově vznikla arytmie může podstatne zhorsit prognozu nemocneho a být i přicinou jeho nahle smrti, je z kazuistických praci znama již desitky let. V posledni době potvrdila rozpornost mezi supresivnim antiarytmickým ucinkem preventivně podavaneho antiarytmika a umrtnosti pacientů take řada velkých epidemiologických studii (1, 2)....

The authors evaluated after 4-year interval the results of coronarographic and spiroergometric examination after a work load on a bicycle ergometer up to the limiting work syndrome in 51 all patients with the aim to reveal "risk factors" of sudden death in CHD patients. The following parameters were recorded: age, duration of treatment number of cigarettes smoked, systolic blood pressure at rest and the daily dose of the most frequently used drugs. After the work load the limiting values of pulse rate, systolic blood pressure, oxygen consumption, blood lactate level and the work ECG were evaluated. In the group of 7 sudden deaths of CHD patients the authors found statistically significant (p less than 0.001) a lower mean limiting value of oxygen consumption/kg and a deeper (p less than 0.0001) mean depression of the S-T segment in the work ECG when compared with 35 CHD patients surviving for 4 years. Both indicators are considered the main "risk factors" for sudden death.

The authors compared two groups of men: the group with minimal sclerotic wall changes (n = 18) and the group with a normal coronary angiographic finding (n = 32). All the examinations were repeated after 5 to 10 years (mean 8.4 years). The two groups did not differ in the occurrence of the main IHD risk factors, complaints, kind and amount of principal drugs and working history. No statistically significant differences were found between the groups in the reasons for discontinuing bicycle ergometric test or in the exercise ECG finding. The two groups studied did not differ in the mean values of limiting metabolic and cardiologic parameters (oxygen consumption, lactate, pulse rate, RPP index) either. The conclusion can be made that in the functional and clinical prognosis the group of symptomatic men with minor sclerotic wall changes does not differ practically from individuals with completely normal coronary angiography.

Mit der spiroergometrischen Methode wurden die Einwirkungen von 0,05 g Dexfenmetrazin (DEX) bzw. 0,02 g Psychoton (PS) auf 8 Studenten bei Ruhe, bei Arbeit auf dem Fahrradergometer (75–85% des maximalen O2-Verbrauchs) sowie während einer 10 min dauernden Erholung nach der Arbeit verfolgt. Es wurden O2-Verbrauch, Atemminutenvolumen, Atem- und Pulsfrequenz, Milchsäurespiegel im arterialisierten Capillarblut verfolgt, ferner die mögliche Arbeitsdauer beim höchsten Belastungsgrad sowie die gesamte bei dieser Belastung geleistete Arbeit ermittelt.