Oxidative DNA damage markers (8OHdG, comet assay, gammaH2AX) are becoming widely used in clinical cardiology research. To conduct this review of DNA damage in relation to hypertension in humans, we used databases (e.g. PubMed, Web of Science) to search for English-language publications up to June 30, 2022 and the terms: DNA damage, comet assay, gammaH2AX, 8OHdG, strand breaks, and arterial hypertension. Exclusion criteria were: children, absence of relevant controls, extra-arterial hypertensive issues, animal, cell lines. From a total of 79526, 15 human studies were selected. A total of 902 hypertensive patients (pts): (comet: N=418 pts; 8OHdG: N=484 pts) and 587 controls (comet: N=203; 8OHdG: N=384) were included. DNA damage was significantly higher in hypertensive pts than healthy controls (comet 26.6±11.0 vs 11.7±4.07 arbitrary units /A.U./; P<0.05 and="" 8ohdg="" 13="" 1="" 4="" 12="" vs="" 6="" 97="" 2="" 67="" ng="" mg="" creatinine="" i=""> P<0.05) confirmed with meta-analysis for both. Greater DNA damage was observed in more adverse cases (concentric cardiac hypertrophy 43.4±15.4 vs 15.6±5.5; sustained/untreated hypertension 31.4±12.1 vs 14.2±5/35.0±5.0 vs 25.0 ±5.0; non-dippers 39.2±15.5 vs 29.4±11.1 A.U.; elderly 14.9±4.5 vs 9.3±4.1 ng/mg creatinine; without carvedilol 9.1±4.2 vs 5.7±3.9; with coronary heart disease 0.5±0.1 vs 0.2±0.1 ng/mL) (P<0.05) confirmed with meta-analysis. DNA damage correlated strongly positively with serum glycosylated haemoglobin (r=0.670; P<0.05) and negatively with total antioxidant status (r=-0.670 to -0.933; P<0.05). This is the first systematic review with meta-analysis showing that oxidative DNA damage was increased in humans with arterial hypertension compared to controls.

A new insight into oxidative stress is based on oxidative deoxyribonucleic acid (DNA) damage. DNA is the pivotal biopolymer for life and health. Arterial hypertension (HT) is a globally common disease and a major risk factor for numerous cardiovascular (CV) conditions and non-cardiac complications, making it a significant health and socio-economic problem. The aetiology of HT is multifactorial. Oxidative stress is the main driver. Oxidative DNA damage (oxidised guanosine (8OHdG), strand breaks (SSBs, DSBs)) seems to be the crucial and initiating causal molecular mechanism leading to HT, acting through oxidative stress and the resulting consequences (inflammation, fibrosis, vascular remodelling, stiffness, thickness, and endothelial dysfunction). In light of the current European Society of Cardiology (ESC) guidelines with defined gaps in the evidence, this manuscript, for the first time, (1) summarizes evidence for oxidative DNA damage in HT and other CV risk factors, (2) incorporates them into the context of known mechanisms in HT genesis, (3) proposes the existing concept of HT genesis innovatively supplemented with oxidative DNA damage, and (4) mentions consequences such as promising new targets for the treatment of HT (DNA damage response (DDR) pathways).

Objective: This study aimed to investigate whether out-of-hospital cardiac arrest (OHCA) may induce severe DNA damage measured using comet assay in successfully resuscitated humans and to evaluate a short-term prognostic role.Methods: In this prospective, controlled, blinded study (1/2013-1/2014), 41 patients (age, 63 +/- 14 years) successfully resuscitated from non-traumatic OHCA and 10 healthy controls (age, 53 +/- 17 years) were enrolled. DNA damage [double-strand breaks (DSBs) and single-strand breaks (SSBs)] was measured using comet assay in peripheral lymphocytes sampled at admission. Clinical data were recorded (according to Utstein style). A good short-term prognosis was defined as survival for 30 days.Results: Among the patients, there were 71% (29/41) short-term survivors. After OHCA, DNA damage (DSBs and SSBs) was higher (11.0 +/- 7.6% and 0.79 +/- 2.41% in tail) among patients than among controls (1.96 +/- 1.63% and 0.02 +/- 0.03% in tail), and it was more apparent for DSBs (p< 0.001 and p=0.085). There was no difference in the DNA damage between patients with cardiac and non-cardiac etiology, or between survivors and nonsurvivors. Among Utstein style parameters, ventricular fibrillation, asystole, and early electrical defibrillation influenced DSBs; none of the factors influenced SSBs. Factors influencing survival were SSBs, ventricular fibrillation, length of cardiopulmonary resuscitation by professionals =15 min, cardiogenic shock, and postanoxic encephalopathy. In contrast to DSBs [area under the curve (AUC)=0.520], SSBs seem to have a potential in prognostication (AUC=0.639).Conclusion: This study for the first time demonstrates revelation of DNA damage using comet assay in patients successfully resuscitated from OHCA. Whether DNA damage measured using comet assay may be a prognostic marker remains unknown, although our data may encourage some suggestions.

Out-of-hospital cardiac arrest (OHCA) is a highly stressful event with a transient common ischaemic — reperfusion injury in successfully resuscitated victims. Survival rate of patients resuscitated from OHCA remains too low (10%) [ [1] Strömsöe A. Svensson L. Axelsson Å.B. et al. Improved outcome in Sweden after out-of-hospital cardiac arrest and possible association with improvements in every link in the chain of survival. Eur. Heart J. 2015; 36: 863-871 Crossref PubMed Scopus (112) Google Scholar ]. It has been shown that stress induces the most severe form of deoxyribonucleic acid (DNA) damage — double strand breaks (DSBs) [ 2 Vilasová Z. Rezácová M. Vávrová J. et al. Changes in phosphorylation of histone H2A.X and p53 in response of peripheral blood lymphocytes to gamma irradiation. Acta Biochim. Pol. 2008; 55: 381-390 PubMed Google Scholar , 3 Zhang G. Li Y. Wang M. et al. Effect of prolonging interval time between coronary angiography and percutaneous coronary intervention on X-ray-induced DNA double-strand breaks in blood lymphocytes. Chin. Med. J. 2014; 127: 2058-2062 PubMed Google Scholar , 4 Ivashkevich A. Redon C.E. Nakamura A.J. Martin R.F. Martin O.A. Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Lett. 2012; 327: 123-133 Abstract Full Text Full Text PDF PubMed Scopus (294) Google Scholar , 5 Šalovská B. Fabrik I. Ďurišová K. et al. Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis. Int. J. Mol. Sci. 2014; 15: 12007-12026 Crossref PubMed Scopus (21) Google Scholar ]. The reliable marker of DNA DSB damage, respectively its reparation is the phosphorylated histone H2AX (γH2AX), which reaches maximum levels in peripheral blood lymphocytes between 10 and 60 min following cell exposure [ 3 Zhang G. Li Y. Wang M. et al. Effect of prolonging interval time between coronary angiography and percutaneous coronary intervention on X-ray-induced DNA double-strand breaks in blood lymphocytes. Chin. Med. J. 2014; 127: 2058-2062 PubMed Google Scholar , 4 Ivashkevich A. Redon C.E. Nakamura A.J. Martin R.F. Martin O.A. Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Lett. 2012; 327: 123-133 Abstract Full Text Full Text PDF PubMed Scopus (294) Google Scholar , 5 Šalovská B. Fabrik I. Ďurišová K. et al. Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis. Int. J. Mol. Sci. 2014; 15: 12007-12026 Crossref PubMed Scopus (21) Google Scholar , 6 Kuo L.J. Yang L.X. Gamma-H2AX — a novel biomarker for DNA double-strand breaks. In Vivo. 2008; 22: 305-309 PubMed Google Scholar , 7 Kinner A. Wu W. Staudt C. Iliakis G. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res. 2008; 36: 5678-5694 Crossref PubMed Scopus (811) Google Scholar , 8 Corbucci G.G. Perrino C. Donato G. et al. Transient and reversible deoxyribonucleic acid damage in human left ventricle under controlled ischemia and reperfusion. J. Am. Coll. Cardiol. 2004; 43: 1992-1999 Abstract Full Text Full Text PDF PubMed Scopus (34) Google Scholar ]. The effect of OHCA on DNA integrity has not been described. Thus the aim of the authors was to describe in patients successfully resuscitated from OHCA the occurrence of DNA DSB damage and evaluate γH2AX short-term prognostic (30-day survival) role.

Coarctation of the aorta is a congenital aortopathy with a narrowed aortic segment as the typical entity that is localized mostly between the left subclavian artery and the ligamentum arteriosum. The obstruction to aortic blood flow through this narrowed segment is serious, and emergency life-threatening complications may arise (heart failure, refractory arterial hypertension, hypertensive crisis, aortic complications including dissection or rupture, infective endocarditis, cerebrospinal hemorrhagic or ischemic complications, and cardiac arrest). Because the vast majority of coarctations are diagnosed and frequently corrected during childhood, native coarctations identified for the first time in adulthood are rare, especially when the adult presentation is emergent. However, the frequency of emergencies in adults due to previously unrecognized coarctation remains unknown (1). Thus, we provided this retrospective study based on a hospital database screen using the code for coarctation of the aorta Q 25.1. From a total of 2 105 000 inpatients (40 500 inpatients/year), there were 9 adults (34±19 years; 56% men) in the 52-year period (1960–2012) under the care of the University Hospital (catchment region of 19 235 km2 and 2 019 804 inhabitants) because of emergencies in adulthood due to unrecognized and significant coarctation (upper–lower body blood pressure gradient and/or invasive peak to peak pressure gradient and/or Doppler systolic mean coarctation gradient ≥20 mm Hg and/or coarctation segment narrowing to 0–8 mm). The frequency of emergencies in adults due to unrecognized coarctation was once per 6 years and the types of emergency were as follows: acute heart failure (34% both genders), spinal complications (33% men), hypertensive crisis (22% women), and aortic complications (11% man). The mean age of adults in all emergencies due to unrecognized coarctation was 34±19 years, with a trend to be lower in men (25 years) than in women (46 years). Amongst women, 75% had a maternity history, all prior to the emergency diagnosis of coarctation. All 9 adults are still alive (recent age 54±20 years); significant cardiac residues persist in 44% and intra-cardiac metallic material is present in 33%. Thus, the authors conclude that professionals in centers providing non-pediatric general cardiovascular services may see emergencies in adults due to unrecognized coarctation sporadically, on average, once every 6 years. Unfortunately, there are no relevant comparable data because this is the first cohort-based study (apart from case reports and necropsies). However, Oliver et al. (2) retrospectively found 4 adults with aortic complications due to known native mild coarctation during the 13-year period (1990–2002), which equates to a frequency of once every 3 years. Hannoush et al. (3) in his retrospective analysis of adults hospitalized in the 20-year period (1980–2000) for various health problems found 3 coarctations that had been diagnosed in adulthood representing a frequency of once per 6.7 years, ignoring manifestations. Acknowledgements: SupportPRVOUK P37/03 [Faculty of Medicine in Hradec Králové, Charles University in Prague, Czech Republic]; MH CZ DRO (UHHK, 00179906) [Ministry of Health, Czech Republic].

Introduction. The aim of this multicentre prospective study was to describe the seven-year survival of patients, from the region of East Bohemia, after out-of-hospital cardiac arrest (OHCA), occurring between 2002 and 2004. The main focus of this study was on the survival of patients with ST-segment elevated myocardial infarction (STEMI). Patients and Methods. A total 718 patients with OHCA were included in the study. Of these patients, 149 were admitted to hospital. The main cohort of our study consisted of 53 patients (41 men; median 59; average 58±13), who survived acute hospitalization. In these patients, STEMI was the main cause of OHCA in 15 cases (28%), whereas without STEMI was found in 38 cases (72%). Patients who survived hospitalization were periodically followed-up at six-monthly intervals. Results. In the first follow-up year, 42 patients survived (79% of 53 patients), in the third year 38 patients (72%), in the fifth year 33 patients (62%) and in the seventh year 31 patients (59%). Ninety-four percent of patients were in good neurological condition after the seventh follow-up year. The whole period of seven years was survived by 12 (80%) out of 15 patients with STEMI, and by 19 (50%) out of 38 patients without STEMI. In patients who survived the seventh year after STEMI, direct percutaneous coronary intervention was performed in 11 cases. Conclusions. Fifty-nine percent of patients discharged from hospital after OHCA survived until the seventh year. The highest rate of survival during this period was seen in patients with STEMI, i.e. in 80%. MILOSLAV PLESKOT ( ) •

Pharmacorefractory chronic heart failure is a serious world-wide problem of systolic dysfunction not improving despite evidence based chronic heart failure pharmacotherapy. With the aim to reverse the poor pharmacorefractory chronic heart failure prognosis, severe sophisticated technical therapeutic approaches (from cardiac resynchronization usually with implantable cardioverter-defibrillator to heart transplantation) have been clinically adopted and detached at least for the most eligible pharmacorefractory chronic heart failure patients. However, both significant limitations of these highly specialised therapeutic techniques (cost, uncertain individual effect, complication, adverse effect, waiting list) and the pharmacorefractory chronic heart failure hopelessness for unfit patients make the effort to stop the pharmacorefractory chronic heart failure genesis never ending longing. Regarding growing knowledge on differences in pharmacokinetics, authors assume that the relative undertreatment despite fixed doses may explain the pharmacorefractory chronic heart failure genesis. If this hypothesis proves to be correct, the evidence based chronic heart failure pharmacotherapy innovatively personalized according to steady state drug serum level may reduce the pharmacorefractory chronic heart failure epidemiology with the lower need for cost-consuming techniques and be the promising strategy for patients left on individually ineffective evidence based chronic heart failure pharmacotherapy.

We sought to investigate specific hemostasis activation markers during electrophysiologic study (EPS) with consequent radiofrequency catheter ablation (RFA). Sixty patients were studied prospectively during routine EPS with RFA for paroxysmal supraventricular tachycardia. Blood samples were drawn before the insertion of venous sheaths (T0), at the end of EPS (T1), and 30 min after completion of RFA (T2). To study coagulation and fibrinolytic and platelet activity, we measured concentrations of thrombin–antithrombin III (TAT), D-dimers (DD), plasminogen activator inhibitor type 1 (PAI-1), tissue-type plasminogen activator (t-PA), and circulating platelet aggregates. The results are expressed as median and show 95% confidence levels. Levels of DD increased from 0.24 mg/L at T0 to 0.37 mg/L at T1 (P < 0.001) and to 0.59 mg/L at T2 (P < 0.001). TAT levels increased from 5.29 μg/L at T0 to 35.80 μg/L at T1 (P < 0.001) and decreased to 26.30 μg/L at T2 (P < 0.001). PAI-1 concentration decreased from 30.10 μg/L at T0 to 26.4 μg/L at T1 (P < 0.001). t-PA at T2 increased to 5.10 μg/L from 4.75 μg/L at T1 (P = 0.001). No other differences between corresponding medians were statistically significant (P > 0.05). We found that concentrations of DD at T2 versus T1 depended on the number of radiofrequency energy applications (rS = 0.387; P = 0.002). Marked platelet activation was observed from the start of the procedure, without changes during the procedure.

OBJECTIVES:Electrogastrography (EGG) is a non-invasive investigation of gastric myoelectrical activity. The aim of study was to evaluate the impact of erythromycin on EGG in gastrointestinal toxic injury induced by dextran sodium sulphate (DSS) in experimental pigs.METHODS:The experiments were carried out on 12 adult pigs (weighing 30-35 kg). EGG was recorded using Digitrapper equipment (Synectics Medical AB, Stockholm). Running spectrum activity was used for EGG evaluation. There were two groups of animals: Group I: 6 controls with erythromycin administration (1,600 mg intragastrically); Group II: 6 animals treated with DSS (for 5 days, 0.25 g/kg per day in a dietary bolus) followed by erythromycin administration. Baseline and subsequent six separate 30-minute EGG-recordings (from time 0 to 360 min) were accomplished in each animal.RESULTS AND CONCLUSION:A total of 84 records were analysed. Baseline dominant frequency of slow waves was fully comparable in both groups. In Group I, there was a significant increase in dominant frequency after erythromycin administration (maximum between 240-360 min). There was a flat non-significant and delayed increase in dominant frequency after erythromycin administration in Group II. The difference between Group I and II at particular time intervals was not significant but a diverse trend was evident. EGG recording enables us to register a gastric myoelectrical effect of prokinetic drugs. Erythromycin induced a significant increase in the dominant frequency of slow waves. DSS caused toxic injury to the porcine gastrointestinal tract responsible for the delayed and weaker myoelectrical effect of erythromycin in experimental animals.

Patient's age belongs to the independent prognostic factors of patients after out-of-hospital cardiac arrest (OHCA). This study aimed to evaluate the influence of age on 5-year survival in professionally cardio-pulmonary resuscitated patients with “primary cardiac” etiology OHCA. In this analysis of prospective multi-centric study, from April 1, 2002 until August 31, 2004, a total of 560 patients were included (aged 16–97 years) from the East Bohemian region, for whom a professional cardio-pulmonary resuscitation for OHCA was attempted. In the age subgroup <70 years there were 307 patients and in the age subgroup ≥70 years there were 253 patients. Of the subgroup <70 years, 29 patients (10%) survived to year 5 (58% from the 50 patients surviving to day 30), and in the subgroup ≥70 years, we had 4 patients surviving to year 5 (2%) (29% from the 14 patients surviving to day 30), respectively (Fisher‘s exact test; comparison in the all resuscitated patients: p<0.001, in the population surviving to day 30: p=0.071). In conclusion, there was a trend towards a worse outcome in 5-year survival following OHCA in the patients aged ≥70 years. Nevertheless, these data support that prognosis OHCA of elders is not associated with universal dismal outcome.

Radek Pudil*, Martina Vašatová, Juraj Lenčo, Miloš Tichý, Vı́t Řeháček, Alena Fučı́ková, Jan M. Horáček, Jan Vojáček, Miloslav Pleskot, Jiřı́ Stulı́k and Vladimı́r Palička 1 Faculty of Medicine Hradec Kralove, First Department of Medicine, Charles University Prague, Hradec Kralove, Czech Republic 2 Faculty of Medicine Hradec Kralove, Institute of Clinical Biochemistry and Diagnostics, Charles University Prague, Hradec Kralove, Czech Republic 3 Faculty of Military Health Sciences, Department of Molecular Pathology, University of Defence, Hradec Kralove, Czech Republic

Two cases (a 23-year-old man and a 33 year-old-woman) with Bland-White-Garland (BWG) syndrome (an anomalous origin of the left coronary artery from the pulmonary artery) are presented. Their first symptom was survived sudden cardiac death. Both patients underwent surgical repair. One patient received an implantable defibrillator because of serious structural changes in the left ventricle and symptomatic non-sustained ventricular tachycardia; the second patient is free of therapy. During long-term follow-up (10.5 and 4.5 years, respectively), ventricular tachyarrhythmias did not recur. Both cases show good long-term prognosis in resuscitated adult patients after surgical repair for BWG syndrome regardless of the presence of structural changes.

AIM:To describe the 3-year survival of patients after out-of-hospital cardiac arrest (OHCA) taking into account the presence of ST-segment elevation myocardial infarction (STEMI) and evaluating prognostic factors associated with pre-hospital and hospital care. PATIENT GROUP:Over a period of 29 months and with the aid of a questionnaire supplied to 24 rescue stations, we prospectively included 560 individuals (415 men; aged 16-97 years, median 68) for whom cardio-pulmonary resuscitation (CPR) for OHCA of confirmed cardiac etiology was attempted. RESULTS:Of 149 hospitalized individuals, 28.2% survived 1 year and 25.5% survived 3 years after OHCA. In the subgroup of patients with STEMI (26 individuals; 17.5%), 57.7% survived 1 year and 53.9% survived 3 years. In the subgroup of patients without STEMI (n=123), 22% survived 1 year and 19.5% survived 3 years. The strongest predictors for long-term survival by logistic regression analysis were: age under 70 years, ventricular fibrillation as initial rhythm, CPR without atropine, and STEMI. OHCA occurrence at a public place was an indicator of better survival in the subgroup with STEMI. In the subgroup of patients without STEMI, long-term angiotensin-converting enzyme inhibitor treatment, CPR without atropine, a Glasgow Coma Scale upon hospital admission over 3, no presence of cardiogenic shock, and no manifestations of postanoxic encephalopathy (Fisher's exact test, chi(2) test) were indicators of better survival. CONCLUSION:Among 560 individuals with "primary cardiac" etiology OHCA and initiation of professional CPR, 8% survived 1 year and 7% survived 3 years. A higher survival rate among patients with STEMI was documented.

UNLABELLED:Health care associated with cardiac arrest exhibits a significant economic burden, rather than effectiveness.HYPOTHESIS:The time of the out-of-hospital cardiac arrest (OHCA) onset during a diurnal period alters the survival chance. Professionally resuscitated patients for witnessed OHCA (n = 495) from the study were prospectively followed for 12 months. The distribution of the onset of cardiac arrest during the 24-hour period was tested in the survivors (the total group, the other groups). In the ultrashort-term survivors (n = 136, follow-up = admission to hospital) the highest incidence was seen between 18:01-22:00 h. The same trend was seen in both the short-term (n = 48, follow-up = discharge from hospital) and the long-term survivors (n = 39, follow-up = 1 year). Furthermore, when the ultrashort-, short-, and long-term survivors were analysed according to indicators of prehospital care (early electrical defibrillation < or =5 min, bystander cardiopulmonary resuscitation, ambulance response time < or =10 min; locations of arrest; initial cardiac rhythms) an OHCA peak was observed for early defibrillation and ambulance response time (ultrashort-term survivors, 18:01-22:00 h) and/or in the case of OHCA that occurred in a public place (short-term survivors, 18:01-22:00 h). The lowest incidence of cardiac arrest was between 22:01-06:00 h in all groups. The evening incidence of OHCA reflects a higher chance of survival in our study area (East Bohemian region).

Úvod:V animální studii zvýšilo hemodynamické přetížení o velikosti 8 mm Hg množství uvolněného B-typu natriuretického peptidu (BNP) do 4 hodin. Cíl:Určit, zda zhoršení hemodynamických parametrů o 2,0 až 4,8 mm Hg (tlak v zaklíněné plicnici) způsobené změnou chronické biventrikulární stimulace (BiVP) na stimulaci izolované pravé komory (RVP) zvyšuje v lidském organismu plazmatickou hodnotu BNP. Metodika:18 pacientů s dlouhodobě optimalizovanou terapií srdečního selhání včetně BiVP (16,7 ± 13,8 měsíců) bylo randomizováno v poměru 1 : 1 do 4hodinové periody testovaného typu srdeční resynchronizace (reaktivovaná BiVP nebo RVP). Následující den byla ve zkříženém schématu doplněna aktivace zbývajícího typu resynchronizace (reaktivovaná BiVP, nebo RVP). V mezidobí bylo obnoveno původní nastavení kardiostimulátoru. Hodnocena byla plazmatická koncentrace BNP a její dynamika (2 vzorky před aktivací a 6 po aktivaci). Výsledky:V porovnání s vyrovnaným horizontálním trendem BNP, zachyceným při reaktivované BiVP, byl během RVP detekován setrvalý vzestup BNP (p < 0,007). Ve srovnání s výchozí hodnotou došlo během RVP k signifikantnímu zvýšení ve 3. hodině (+5,71 %, p < 0,008) a více ve 4. hodině (+12,8 %, p < 0,0003), zatímco během reaktivované BiVP byla hodnota BNP srovnatelná s hodnotou výchozí. Závěr:U reálných pacientů zvyšuje reprogramace kardiostimulátoru z chronické BiVP na RVP plazmatickou hodnotu BNP do 4 hodin.

Background: Early reperfusion by direct percutaneous coronary intervention (PCI) in patients with ST segment elevation acute myocardial infarctions (STEMI) with an out-of-hospital cardiac arrest (OHCA) reduces hospital and longterm mortality. Aims: Evaluating the significance of direct PCI for the short-term (discharge from acute hospitalization) and 1-year survival in patients with acute STEMI after OHCA. Methods: In this prospective study, from April 1, 2002 up to August 31, 2004, a total of 26 hospitalized individuals (22 men, 4 women, aged 35–79 years, median 58.5) from the East Bohemian region with OHCA (primary group of 718 individuals) with acute STEMI were included. Urgent coronary angiography was performed in 20 individuals, and direct PCI was done in 19 of them. The remaining 6 patients did not undergo angiography. Results: Fifteen patients (57.7%) survived acute hospitalization, of whom 11 were without neurological deficits. In the subgroup with urgent coronary angiography 14 patients (70%) survived hospitalization, and in the subgroup without coronarography only 1 patient survived hospitalization (16.7%). In the subgroup with PCIs, 13 out of the 19 patients survived (68.4%). None of the patients died during the 1-year follow-up after being discharged from acute hospitalization. According to the urgent coronarography the artery most commonly responsible for the infarction was the left anterior descending artery (50%). Initial TIMI flow grade 0–I was found in 17 patients and grade II–III in 3 individuals. After PCI, irrespective of stent implantation, an optimal angiographic success (TIMI flow grade II–III) was obtained in 17 cases. Conclusion: Short-term survival of patients after OHCA with STEMI treated with direct PCI was found to be 68.4%. Out of 6 patients not receiving reperfusion therapy 1 survived (16.7%). Over the course of the 1-year follow-up none of the patients died.