In this study, a series of bis amide thiazolidine derivatives (Q1-Q6) were synthesized and their anticancer activity was evaluated against prostate (PC3) and breast (MCF7) cancer cells and normal cells line activity was evaluated against breast (MCF10), prostate (PNT1A) and living human cells (HUVEC) cancer cells. The thiazolidine rings were built from penicillamine and aromatic aldehydes (A1-A6), then converted to acetyl thiazolidines (B1-B6) using acetic anhydride, and finally linked with phenylene diamine to form the final compounds (Q1-Q6). Notably, compounds Q1 and Q3 displayed the highest activity against PC3, with IC50 values of 81 and 89 mu g/ml, respectively. Docking simulations were performed for Q1, Q4, and Q5 against protein structures related to cancer (2FVD and 1SJ0). Additionally, DFT calculations were used to determine various molecular properties like HOMO/LUMO energies, band gap, and other descriptors, providing insights into the compounds' stability and reactivity.

new pyrazole derivatives were synthesized through a cyclization reaction of chalcones derivatives with hydrazine hydrate under acidic catalysis and characterization by different techniques. The MTT assay was used to examine the cytotoxic activity of the produced compounds against the tumor cell lines MCF-7 and MDA-MB-231. Morphological screening images by using the IC50 values of 2-[3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]quinoline at various concentrations to the cancer cell lines MCF-7 and MDA-MB-231 were done. Molecular docking for the most active compound inside the active sites of the (PDB: 1M17) was done. The geometry optimization and reactivity descriptors, such as energy band gap (ΔE), chemical potential (μ), electronegativity (χ), chemical hardness (η), chemical softness (S), electrophilicity (ω), and least unoccupied molecular orbital (LUMO), were also analyzed using the DFT calculation performed using DFT/B3LYP/6-311+G(d,p). Additionally, a thorough in silico prediction of the compounds physicochemical ADME profile was completed.

New pyrimidine derivatives were synthesized through domino Knoevenagel–Michael cyclization reactions of aryl aldehydes, ethyl cyanoacetate, and guanidine hydrochloride or urea under a basic catalysis. Cytotoxic activity of the prepared compounds against MCF-7 and HepG2 tumor cell lines was investigated by the MTT test. Compound geometry analysis was performed using the B3LYP functional with a 6-311+G(d,p) basis set. The estimated geometries were very similar to the experimental ones.

Cancer is a leading cause of death worldwide. Osteoporosis is a bone condition that causes the bones to become porous and lose density. Discovering, searching, and develop for a drug against cancer and at the same time preventing osteoporosis is very important. Chalcone and epoxy have an interest as potential drug candidates due to their easy synthesis. The present study target compounds were screened for potential anti-cancer against different cell lines (HepG2, MDA-MB-231, A375, A549, MCF-7, and HCT116) and anti-osteoporosis against cell line (MC3T3-E1). A new series of compounds evaluation by MTT assay to determine the IC50, and study apoptosis and docking study. The most potent activities were the effects of the compounds CH2, CH3, and CH4 on the MDA-MB-231 cells and those of the compounds CH7 and CH9 on the HepG2. The CH7 compound proved non-cytotoxicbut was antiproliferative and caused cell cycle arrest at the G0/G1 and G2/M phases. Also, the CH7, CH9, and E1 compounds displayed excellent anti-osteoporosis activity. The docking analysis showed good binding energy. The compounds CH2, CH3, and CH4 exhibited activity towards MDA-MB-231 cells and CH7 against HepG2, with induced apoptosis and cell cycle arrest, others compounds showed no significant cytotoxic activity. While compounds CH7, CH8, CH9, and E1 showed good toxicity against MC3T3-E1. The molecular docking study revealed that there was evidence of good interactions and the most stable complex for inhibition.

In this study, new chalcone and epoxy chalcone synthesized by condensation of 4-acetylbiphenyl with the appropriate aldehydes. The epoxy chalcone prepared via the reaction chalcone with alkaline hydrogen peroxide in methanol. We characterized their mass spectra and H-1, C-13-NMR, and 2D-HSQC spectra to confirm their structure and absolute configuration. The target compounds were then screened for their potential antibacterial and antifungal activities. Most of the tested chalcone compounds had better activity against the fungal strains Fusarium and Aspergillus niger.

BACKGROUND:Breast cancer is one of the most frequent malignancies in women, and it is a major cause of cancer death worldwide, as well as one of the leading causes of cancer mortality. Traditional herbal therapy has been widely used in some developing countries as a complementary and alternative technique. Because of their low toxicity, medicinal edible plants have been allowed to minimize the risk of breast cancer and other diseases. The heart of Phoenix dactylifera is a well-known, safe, and common edible part of the P. dactylifera plant (Hilawi variety). The biological properties of heart of P. dactylifera are unclear, and the appeal warrants further investigation. The aim of this study is to look into the chemical compositions, antioxidant and anticancer properties of heart of P. dactylifera extract obtained via microwave-assisted extraction.METHODS:Microwave-assisted extraction, ethanol solvent, gas chromatography-mass spectroscopy (GC-MS) analysis, DPPH assay, MTT assay, acridine orange/ethidium bromide staining, cell cycle, reactive oxygen species, and apoptosis were all used to evaluate the activity of heart of P. dactylifera.RESULTS:GC-MS was used to identify the chemical compositions of heart of P. dactylifera extract, which revealed about 15 bioactive compounds. The antioxidant activity of heart of P. dactylifera extract was determined to have an IC50 value of 114.2 µg/ml. The cytotoxicity was measured using MCF-7 cells, and the IC50 was reported to be 620.1 µg/ml. The cell cycle was arrested at the G1 gate, resulting in the formation of reactive oxygen species and apoptosis.CONCLUSION:The findings suggested that regular consumption of P. dactylifera heart components is important for nutrition and immune system support in the prevention of breast cancer, and that more research into molecular apoptotic pathways is needed.

Background: Vegetables with edible parts like flowers, fruits, stems, leaves, fibers, roots, and seeds are rich sources of essential vitamins, minerals, and trace elements with various medical functions. Many diseases such as osteoporosis, diabetes, high cholesterol, obesity, heart diseases, and stroke are caused by poor, healthy lifestyle or nutrition. Therefore, generation of new biological functions from vegetables will increase the interests of scientific research and applications. Main body: Okra is an edible vegetable which contains vitamins, fiber, carbohydrates, protein, and minerals. The bioactive compounds of okra possess various biological activities such as anti-inflammation, antibacterial, anticancer, and antifungal. Polysaccharides from vegetables or medicinal plants are important large molecules with various biological applications. In this review, we will focus on the biological properties and nanoparticle uses of polysaccharides isolated from okra and the extraction methods of polysaccharides. Conclusion: This review will enhance the scientific research findings of okra polysaccharides and recommend future prospective of polysaccharides for biological uses.

Microwave-assisted extraction (MAE) is a highly selective method that reduces the time and number of solvents used, has high efficiency, and is environmentally friendly. This study aimed to evaluate the antioxidant, anticancer, and antibacterial activities of Iraqi Terfezia claveryi desert truffle extract and silver nanoparticles by MAE using water and hexane as extraction solvents. Chemical compositions were identified by gas chromatography-mass spectrometry. Silver nanoparticles were characterized by field emission scanning electron microscopy. Antioxidant activity was assessed with the 2,2-diphenyl-1-picrylhydrazyl method. Antibacterial activity was evaluated against four types of pathogenic bacteria, and anticancer activity was also assessed. The T. claveryi hexane extract showed approximately 18 bioactive compounds, with an antioxidant half-maximal inhibitory concentration of 6.896 μg/mL. This extract also had significant antibacterial action against Escherichia coli and Pseudomonas aeruginosa. A cytotoxicity test of the hexane extract showed moderate toxicity against hepatocellular carcinoma mouse (HCAM) liver cancer cells. Acridine orange/ ethidium bromide staining showed apoptosis and DNA damage in HCAM cells treated with the hexane extract. The results of this study suggest that components of the T. claveryi wild desert truffle could have important nutrition functions that might support the immune system in fighting liver diseases when taken in daily regular doses.