The human skin is a unique organ that embeds multiple functions that no artificial systems can currently replicate. Advances in materials science and engineering are driving the design of electronic skins—large-area sensor arrays that mimic some sensory modalities and have the soft, elastic form of natural skin. Here, we focus on electronic skins designed to be worn on the human body for healthcare monitoring or prosthetic applications. The primary sensing modalities are mechanical, thermal, and electrophysiological. We review key materials and associated designs needed to manufacture electronic devices that can conform to the human body and move along with it. Electronic skins offer exciting opportunities for human–machine interfaces.

Integrated wearable electronics capable of transducing and transmitting biophysical information on complex and dynamic systems are attracting high interest across the consumer electronics, clinical, and research domains. Gallium and gallium‐based liquid metals (LMs) emerge as promising conductor technology for wearables due to their excellent combination of electrical conductivity and mechanical compliance. However, LMs feature complex physical and chemical properties that pose significant manufacturability challenges. Herein, a microtechnology approach is presented to fabricate deformable, microscale LM conductors with high surface density and over large surface areas. Based on a combination of soft lithography, directional patterning, and thermal evaporation of gallium, this new technology enables a range of designs and geometries that can be used to form LM‐based stretchable electronic conductors. The versatility of the technology enables a palette of circuit designs that can offer unrivaled transparency ( T > 89%) or large metallization density (2/5 µm line/gap).

Wearable electronic circuits based on the films of gallium and its alloys offer promising implementations in health monitoring and gaming sensing applications. However, the complex rheology of liquid metals makes it challenging to manufacture thin gallium‐based devices with reliable, reproducible, and stable properties over time. Herein, the surface coating and topography of silicone substrates are engineered to enable precisely defined, micrometer‐thick liquid metal patterns over large (>10 cm2) surface areas, and high design versatility. Control over the film microstructure meets manufacturing conditions that enable gallium films with a precise, repeatable, and durable electromechanical performance. The robustness and applicability of this technology in a virtual‐reality scenario is demonstrated by implementing thin, soft, and stretchable gallium‐based sensors to accurately monitor human hand kinematics.

Soft robotic systems are composed of active and passively deformable structures which are intrinsically compliant, flexible, and elastic. Although these features offer benefits of adaptability, robustness, and safety, controlling these types of robots is a significant challenge, in part from the difficulty of obtaining feedback from sensors which provide state information without hindering the advantageous material properties which grant these systems their unique mechanical behavior. We demonstrate here the first integration of a flexible, stretchable, liquid metal-based strain sensor with vacuum-powered soft pneumatic actuators (V-SPAs) for simultaneous controlled feedback of the soft actuators as well as user input and soft robotic device interaction. The soft sensors which are encapsulated within a Polydimethylsiloxane (PDMS) membrane are directly embedded in the outer body skin of the soft actuators, and can be used to correlate the deformation of the body under vacuum actuation to overall actuator strain or to detect external disturbances. This information is used to compute and control the angle of a rotational 3-DoF actuator module, as well as detect implicit user input control signals by direct interaction without the need for an external control interface. The dual use of embedded sensing shown in this work provides a fundamental strategy for soft collaborative robot applications.

Emerging applications of the Internet of Things in healthcare, wellness, and gaming require continuous monitoring of the body and its environment, fueling the need for wearable devices able to maintain intimate, reliable, and unobtrusive contact with the human body. This translates in the necessity to develop soft and deformable electronics that match the body's mechanics and dynamics. In recent years, various strategies have been proposed to form stretchable circuits and more specifically elastic electrical conductors embedded in elastomeric substrate using either geometrical structuring of solid conductors or intrinsically stretchable materials. Gallium (Ga)-based liquid metals (LMs) are an emerging class of materials offering a particularly interesting set of properties for the design of intrinsically deformable conductors. They concomitantly offer the high electrical conductivity of metals with the ability of liquids to flow and reconfigure. The specific chemical and physical properties of Ga-based LMs differ fundamentally from those of solid conductors and need to be considered to successfully process and implement them into stretchable electronic devices. In this Account, we report on how the key physical and chemical properties of Ga-based LMs can be leveraged to enable repeatable manufacturing and precise patterning of stretchable LM conductors. A comprehensive understanding of the interplay between the LM, its receiving substrate chemistry and topography, and the environmental conditions is necessary to meet the reproducibility and reliability standards for large scale deployment in next-generation wearable systems. In oxidative environments, a solid oxide skin forms at the surface of the LM and provides enough stiffness to counterbalance surface tension, and prevent the LM from beading up to a spherical shape. We review techniques that advantageously harness the oxide skin to form metastable structures such as spraying, 3D printing, or channel injection. Next, we explore how controlling the environmental condition prevents the formation or removes the oxide skin, thereby allowing for selective wetting of Ga lyophilic surfaces. Representative examples include selective plating and physical vapor deposition. The wettability of LMs can be further tuned by engineering the surface chemistry and topology of the receiving substrate to form superlyophobic or superlyophilic surfaces. In particular, our group developed Ga-superlyophilic substrates by engineering the surface of silicone rubber with microstructures and a gold coating layer. Thermal evaporation of Ga on such engineered substrates allows for the formation of smooth LM films with micrometric thickness control and design freedom. The versatility of the available deposition techniques facilitates the implementation of LM conductors in a wide variety of wearable devices. We review various epidermal electronic systems using LM conductors as interconnects to carry power and information, transducers and sensors, antennas, and complex hybrid (soft-rigid) electronic circuits. In addition, we highlight the limitations and challenges inherent to the use of Ga LM conductors that include electromigration, corrosion, solidification, and biocompatibility.

Periodontitis affects the attachment of natural teeth, and infection or inflammation associated with periodontitis may affect peri-implant tissues. Enamel matrix derivative (EMD) proteins provide stimulation for self-regeneration of the damaged tissue when applied to wide intrabony defects as part of a mixture with bone graft material. As a first step of the process enhancing cell proliferation and ligament formation, we demonstrated that EMD protein precipitation depends strongly on the physical and chemical characteristics of the bone grafts used in the mixture. To guarantee optimum protein-stimulated self-regulation, the pH of the initial EMD formulation must therefore be adjusted between 3.9 and 4.2 in order to compensate the change in pH induced by the bone graft. Moreover, the interaction between the two components resulted in precipitates of different shape and size differently covering the grafts. This outcome might potentially have clinical implications on cell attachment and periodontal ligament extension, which deserve further in vitro and in vivo tests.

This study demonstrates soft, epidermal resistive strain gauges capable of tracking finger joint angle during dexterous manipulation tasks. Intrinsically stretchable, biphasic, gallium-based metal films embedded in an elastomeric substrate allow for extremely thin (<50 µm) and skin-conforming wearable sensors with outstanding robustness. The sensors sustain repeated cycling to 50% strain and are insensitive to normal pressure up to 100 kPa. Following a calibration phase, we recorded flexions of a human finger using the soft sensors and compared their joint angle estimation to that of a commercial marker-based visual motion tracking system. The accuracy of our system (defined as the mean angular deviation between our sensors' output and the reference system) was below 9° over a set of 11 different grasping and motion tasks. We demonstrate the scalability and wearability of our technology with a three-finger sensing system used to track the fine movements of a pianist hand. Our soft technology is a promising candidate for implementation of truly wearable proprioceptive sensing systems.