Objective To explore the effect of early comprehensive interventions on oral feeding difficulties in preterm infants.Methods Totally,64preterm infants with oral feeding difficulties were randomly divided into a control group of 33,and an intervention group of 31.Both groups were given parenteral nutrition and/or nasogastric tube feeding,routine care,massage,etc.The intervention group were additionally given oral sensorimotor interventions with appropriate feeding skills.Duration of dependence on parenteral nutrition,duration of nasogastric feeding,lengths of hospital stay,the time for infants to oral feeding,time to achieve complete oral feeding,time to return to their birth weight,the rates of weight gain after return to their birth weight,were compared between the 2groups.Results The duration of dependence on parenteral nutrition,duration of nasogastric feeding,length of hospital stay,were significantly shorter in the intervention group than in the control group(P<0.05,P<0.01).The intervention group had significantly shorter time to oral feeding,shorter time to achieve complete oral feeding,more rapid return to their birth weight,and higher rate of weight gain after return to their birth weight,than the control group(P<0.05,P<0.01).Conclusion Early comprehensive interventions could combat oral feeding difficulties in premature infants,and boost the transition to oral feeding.This method is safe and effective.