目的 探讨人绒毛膜促性腺激素(hCG)注射日血清抗米勒管激素(AMH)、雌二醇(E2)、孕酮(P)/获卵数水平对体外受精-胚胎移植(IVF-ET)术后妊娠失败的预测价值.方法 回顾性分析在郑州大学第一附属医院接受IVF-ET治疗的80例不孕症患者的临床资料,根据妊娠结局分为妊娠成功组和妊娠失败组.统计患者妊娠失败率,对比妊娠失败组与妊娠成功组hCG注射日血清AMH、E2及P/获卵数水平,并采用受试者工作特征(ROC)曲线分析hCG注射日血清AMH、E2、P/获卵数对患者IVF-ET术后妊娠失败的预测价值.结果 不孕症患者IVF-ET术后的妊娠失败率为52.50％,妊娠失败组hCG注射日血清AMH水平低于妊娠成功组(P<0.05),E2、P/获卵数水平均高于妊娠成功组(P<0.05);血清AMH、E2、P/获卵数水平预测患者IVF-ET术后妊娠失败的cut-off值分别为3.69μg·L-1、989.00 pmol·L-1、0.28,三者联合预测患者IVF-ET术后妊娠失败的灵敏度、特异度、曲线下面积(AUC)分别为95.24％、86.84％、0.866,AUC均高于单独预测,差异有统计学意义(P<0.05).结论 IVF-ET术后妊娠失败患者hCG注射日血清AMH水平较低,E2、P/获卵数水平较高,血清AMH、E2、P/获卵数水平联合对患者IVF-ET术后妊娠失败的预测价值高,可用于指导治疗.

目的 分析穴位按摩联合穴位贴敷对痰热郁肺型COPD(慢阻肺)患者的护理效果.方法 选择该院2017年12月-2018年12月接收治疗80例痰热郁肺型COPD患者作为该次研究的对象,以数字随机法将其分作两组,各组40例.其中甲组患者采取穴位按摩法进行护理,乙组患者采取穴位按摩联合穴位贴敷进行护理,对比两组患者的护理效果.结果 经过护理后,两组患者肺功能FEVl、FEVl/FVC改善情况均优于护理前,但乙组患者改善情况更好;两组患者mMRC评分都有所降低,但乙组患者呼吸困难程度改善情况明显优于甲组,差异有统计学意义(P＜0.05).结论 针对痰热郁肺型COPD患者采取穴位按摩联合穴位贴敷护理效果由于单一使用穴位按摩的效果,能够改善患者肺功能及呼吸困难的情况,临床上值得推广及应用.

BACKGROUND:It has beenreportedthat tissue-engineered acelular matrix can induce and promote epithelial cels and smooth muscle celstoevolveinto a part of bodyin vivocompared with the normal extracelular matrix. <br> OBJECTIVE:To investigate the effect of tissue-engineered acelular matrix in articular cartilage repair. <br> METHODS:Totaly 30 New Zealand rabbits were randomly alottedto fibroid tissue andacelular matrix groups (n=15 per group), and then articular cartilage defect models,4mmin diameter,were established at the white rabbitfemoral condyle. Acelular cartilage matrix scaffold was prepared using bovine knee cartilage, and model rats in the acelular matrix group were repaired with acelular cartilage matrix scaffold and the others in the fibroid tissue group repaired with fibroid tissues. Finaly, repair effects between two groups were compared. <br> RESULTS AND CONCLUSION:The dark blue and porous tissue-engineered acelular matrix material could be found, with a diameter of 5mm and moderate hardness, and exhibited certain flexibility after cross-linking. Hematoxylin-eosin staining showed that cel debris,blue-stainednuclear materials and residual extracelular matrix disappeared. Toluidine blue staining found that the porosity of the blue scaffold was 90%, and the sweling ratio was (1314±337)%. The absorbance value in the acelular matrix group was significantly higher than that in the fibroid tissue group at 1, 3, 5, 7 and 9 days (P< 0.05). In the fibroid tissue group,defectsfiled withnewborn fibrous scars were overt. By contrast, in the acelularmatrix group, the white tissuescovered the defect regionwith smooth surface,and the woundwas basicaly healed,withanunclearboundaryafter 12weeks. Moreover, blue-stained, smal flattened cels appeared, subchondral bone structurewasconnected wel with the cartilage, and the scaffold was directly degraded. In conclusion, the tissue-engineered acelular matrix material exhibits good biocompatibility, cel adsorption and hydrophilicity, and can promote the defect repairafterarticular cartilage injury.Therefore, it is a suitable substitute for articular cartilage repair.