Magnesium alloys have excellent biocompatibility and the closest mechanical properties to that of natural cortical bone, making them a potential bone implant material. However, the rapid degradation of magnesium alloys might cause premature failure of the implant. In this work, magnesium gallate metal–organic framework (GA MOF) particles were in-situ grown on a micro-arc oxidation (MAO) base layer via a hydrothermal method to improve the corrosion resistance of the magnesium alloy. The results show that the GA-MOF can grow into a dense and uniform coating on the MAO layer, exhibiting a significant decrease of corrosion rate to that of the magnesium alloy. This coating effectively improves the corrosion resistance of the magnesium alloy, providing a new approach for the surface design of biodegradable metallic implant materials.

The die forging of large-sized complex structural components Mg-Gd-Y-Zr alloy plates remains challenging due to limited slip systems and strain distribution inhomogeneity inherent to the forming process. In this study, multidirectional forging was introduced as a pre-deformation step to eliminate as-cast defects, followed by die forging and subsequent aging treatment. The evolution of microstructure, mechanical properties, and corrosion behavior under this coupled process was systematically investigated. Results show that multidirectional forging refines grains to 22.14 μm, and die forging induces complete dynamic recrystallization that further reduces grain size to 19.13 μm. Peak aging at 225 °C for 20 h promotes dispersed nanoscale β′ precipitation, increasing tensile strength to 405 MPa and yield strength to 315 MPa while retaining 13.5% elongation, with a fatigue limit of 131 MPa. Regarding corrosion resistance, although the 20-h-aged specimen shows a slightly higher initial corrosion rate than the as-forged alloy, it forms a dense rare-earth oxide film that suppresses localized corrosion, resulting in a comparable long-term corrosion rate. This work provides a new approach for the integrated fabrication of large-scale complex forgings with high strength, high ductility, and high corrosion resistance.

Improving the corrosion resistance of magnesium-lithium (Mg-Li) alloys is pivotal for expanding their prospective utilization in lightweight structural materials. This research focused on evaluating the corrosion inhibition effectiveness of a composite corrosion inhibitor comprising sodium fluoride (NaF) and caffeic acid (CA) on the LAZ931 alloy in a 3.5 wt.% NaCl solution. The results demonstrated that NaF alone is insufficient to prevent localized corrosion of the alloy. Remarkably, the addition of 0.001 M caffeic acid to a 0.05 M NaF solution significantly increased the corrosion inhibition efficiency from 54.36 % to 88 %. This substantial improvement in corrosion resistance can be credited to the formation of the dense protective NaMgF3 deposition products on the sample surface. This study offers a novel approach to the design of corrosion inhibitors for duplex Mg alloys, emphasizing the synergistic effect between NaF and CA in augmenting corrosion protection.

This study systematically examined the microstructural and mechanical responses of 2055 Al-Li alloy to cryogenic rolling (CR) with varying reductions and subsequent short-term aging (STA), with emphasis on texture evolution, dislocation density, slip and precipitation behavior, and strengthening mechanism. The results revealed that texture intensity evolved from strong Cube {100}< 001 > and Goss {110}< 001 > textures to moderate Brass {011}<211>, Goss and S {123}<634> textures as the reduction increased from 10% to 90%. Meanwhile, Schmid factors (SF) gradually decreased, eventually leading to cooperative multi-slip with SF below 0.4 at a 90% reduction, which indicated greater difficulty in slip activation with increasing deformation. Dislocation density significantly increased, and narrower, aligned dislocation walls progressively developed beyond 30% reductions, accompanied by the formation of kink bands (KBs) with high boundary misorientation capable of absorbing dislocations. For T-1 precipitates, homogeneous nucleation driven by Mg/Ag clusters prevailed at 10% reduction, while higher deformation triggered a dual mechanism, namely, homogeneous nucleation outside dislocation walls and heterogeneous nucleation on dislocations within walls. The alloy achieved optimal strength-ductility synergy at a 70% reduction and 4-h STA, with ultimate tensile strength (UTS) of 515 MPa, yield strength (YS) of 425 MPa and elongation (EL) of 6.3%. Theoretical calculations indicated that precipitation strengthening dominated below 50% deformation and dislocation hardening dominated at higher reductions. The thermomechanical processing route presented in this study substantially reduced the aging time, offering a valuable reference for the efficient manufacturing of high-performance Al-Li alloys.

Mg alloys have become a new generation of biodegradable medical materials due to their good biocompatibility. However, their rapid corrosion rate in physiological environments and the mismatch between their degradation rate and tissue reconstruction pose challenges for clinical applications. To improve the corrosion resistance and biocompatibility of Mg alloys, drug-loaded corrosion resistant coating has gradually become a research hotspot. In this work, a uniform pH-responsive ZIF-14 coating was in situ synthesized on the surface of Mg alloy via a solvothermal method. Using rapamycin, an anti-restenosis drug, as a model compound, the drug release behavior and biocompatibility of the rapamycin-loaded ZIF-14 coating were evaluated under different pH conditions. ZIF-14 coating exhibited rapid drug release under both acidic and alkaline conditions. The rapamycin-loaded ZIF-14 coating effectively inhibited the excessive proliferation of smooth muscle cells, thereby preventing vascular restenosis after device implantation. Notably, theoretical calculations and experimental characterizations revealed that Zn2+ ions in ZIF-14 precursor solution can coordinate with both imidazole ligands and Mg from the substrate, leading to the formation of a stable ZIF precursor on Mg surface. In addition, ZIF-14 coating enhanced the corrosion resistance of Mg alloy, effectively prolonging its service life. This work provides a new strategy for the design of multifunctional smart coatings on Mg alloy surfaces and shows great potential for applications in biomedical Mg alloy implants. STATEMENT OF SIGNIFICANCE: This study presents a significant advancement in addressing the limitations of biodegradable Mg alloy stents by developing a uniform, and pH-responsive ZIF-14 coating via one-step in situ solvothermal synthesis. Integrating DFT calculations with experimental validation, this research elucidates the intricate coordination mechanism among Zn2+, imidazole ligands, and Mg, offering fundamental insights into MOFs growth on reactive metal surfaces. This coating exhibits dual-trigger pH-responsive drug release, accelerating drug release under both acidic (local inflammation) and alkaline (Mg corrosion) conditions, thus providing a smart solution for localized therapeutic intervention. Furthermore, this nanostructured coating enhances the corrosion resistance and biocompatibility of Mg alloy. This work proposes a strategy for designing multifunctional smart coatings on biodegradable implants, holding potential for biodegradable implants.

This paper investigates the microstructure of Mg-4Al-0.5Mn-xSc (x=0, 0.2, 0.6, and 1.0wt.%) alloys and their differentiated corrosion behavior in 0.9wt.% NaCl solution and Hanks' solution. With increasing Sc content, dendritic segregation in the alloy intensifies, and the secondary phases transition from Al11Mn14 to Al-Sc-Mn phase. During immersion in 0.9wt.% NaCl solution, the stability of the corrosion product layer is enhanced by oxides such as Sc2O3, Al2O3, and MnO/MnO2, leading to a significantly improved corrosion resistance of the alloy with the highest Sc content (Mg-4Al-0.5Mn-1.0Sc alloy). In Hanks' solution, due to the deposition of Ca-P salts and the reduced susceptibility of secondary phases to galvanic corrosion, the corrosion rates of the alloys are significantly decreased as compared to those in NaCl solution, with the slowest corrosion of the Mg-4Al-0.5Mn-0.2Sc alloy. This study provides a theoretical foundation for the differential customization of magnesium alloys based on various service environments.

Biodegradable magnesium alloys exhibit significant potential for application in bone defect repair owing to their excellent mechanical properties and biocompatibility. Low-intensity pulsed ultrasonography (LIPUS) is a potential intervention for promoting bone repair. However, when magnesium alloys were used with LIPUS, their degradation was accelerated, which may have a negative impact on bone repair. In this study, a bio-piezoelectric coating was prepared on a porous magnesium alloy scaffold, and the degradation behavior of the porous scaffolds with a bio-piezoelectric coating under LIPUS intervention was studied while evaluating their synergistic effect on bone defect regeneration. In vitro studies revealed that the charge generation induced by the piezoelectric effect accelerated CaP deposition, which in turn decelerated the degradation of the coated scaffold. Meanwhile, the synergistic effect promoted the M2 transformation of macrophages, thereby enhancing osteogenic differentiation. In vivo studies showed that a transition layer of MgO and Mg₃(PO₄)₂ appeared at the bone–scaffold interface, which was beneficial for tissue repair. In addition, a large amount of Ca-P layer above served as an osteoconductive interface to promote tissue repair. Histological staining indicated that this synergistic effect accelerated bone formation and mineral deposition. Immunohistochemical staining demonstrated that the synergistic effect promoted OCN expression while suppressing TRAP expression, thereby promoting bone repair. These findings demonstrate that, under a synergistic effect, new bone formation synchronizes with magnesium degradation, consequently providing an innovative clinical strategy for bone defect regeneration.

Mg-Gd-Y-Zr alloys, with strong age-hardening and thermal stability, are ideal for lightweight load-bearing components, yet forming large complex parts is limited by high sensitivity to hot deformation parameters. This work investigates the hot deformation behavior and microstructure evolution of a Mg-9Gd-4Y-0.5Zr (wt.%) alloy via hot compression at 400 to 510 °C and strain rates of 0.001 to 10 s−1. An Arrhenius constitutive equation with an activation energy Q of 158.63 kJ/mol was established, and a hot processing map was constructed. EBSD characterization revealed the dynamic recrystallization, grain size evolution, and texture transition. The results show that flow stress depends strongly on temperature and strain rate. At strain rates of 0.001~1 s−1, a dynamic balance between work hardening and dynamic softening is achieved, and the post-peak flow stress gradually stabilizes. At a high strain rate of 10 s−1, the flow stress continues to decrease because the competition between softening from dynamic recrystallization and work hardening is disrupted by deformation-induced heating. Low strain rates (≤0.01 s−1) and high temperatures (≥470 °C) promote dynamic recrystallization and significant grain refinement. Two optimal processing windows were determined: 400 to 430 °C at 0.001 to 0.01 s−1, giving fully recrystallized fine equiaxed grains, and 440 to 460 °C at 0.01 to 0.1 s−1 with a power dissipation efficiency η of 0.43 to 0.51, balancing processing efficiency and microstructural uniformity. This work provides systematic theoretical and data support for optimizing hot forming parameters of large Mg-Gd-Y-Zr load-bearing components and offers guidance for applying high-strength magnesium alloys in high-end equipment.

Biodegradable iron (Fe)-based alloys represent a promising class of biomaterials due to their exceptional mechanical properties and biocompatibility. However, their clinical translation is hindered by slow degradation rates resulting from the formation of protective oxide layers. This study addresses this challenge by investigating Fe-36.8Mn-6Si alloy fabricated via mechanical alloying and spark plasma sintering (SPS) at low temperatures (650–750°C). The study systematically evaluates the effects of sintering temperature on microstructure, mechanical performance, and corrosion behavior in Hanks’ Balanced Salt Solution. Microstructural analysis reveals that elevated sintering temperatures enhance atomic diffusion, promoting densification through sintering neck growth and pore elimination. At 750°C, the alloy achieves a relative density above 98 % and exhibits optimal mechanical properties. Higher sintering temperatures reduce corrosion current density and mass loss rates of sintered alloys. Surface characterization after immersion reveals that lower-temperature sintered alloys develop thick, porous corrosion product layers rich in calcium phosphates and hydroxides, whereas higher-temperature specimens form sparse, localized deposits. This work underscores the potential of low-temperature SPS in engineering biodegradable metals with tailored microstructures for enhanced performance.

In this study, Mg-30wt.%Sc alloy wires were fabricated via multi-pass cold drawing and annealing. By controlling the processing parameters, an "alpha-shell/(alpha + beta)-core" structure was obtained. The structure consists of an alpha-phase (hexagonal close-packed) surface layer that transitions into an alpha + beta(body-centred cubic) dual-phase core. This specific structure is primarily attributable to the synergistic effect of the radial strain gradient introduced during drawing and subsequent annealing. During the initial corrosion stage, the alpha-phase surface undergoes uniform corrosion, which effectively suppresses localized attack. The exposed beta phase network subsequently provides a corrosion-resistant framework. These two aspects synergistically maintain mechanical integrity. Overall, this work presents a microstructure-guided approach that balances predictable corrosion behavior and prolonged structural stability in biodegradable implants. (c) 2026 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.

Precision magnesium alloy minitubes are key raw materials used in the manufacture of magnesium alloy vascular stents. However, the poor room-temperature formability of magnesium alloys limits the production of high-performance precision minitubes through conventional cold drawing methods. In this study, a combined process of cyclic extrusion compression (CEC) and hot drawing was proposed to manufacture the Mg alloy minitubes. The results show that CEC produces a fine grain with an average size of approximately 1.96 µm, and providing a favorable microstructure for subsequent hot drawing. As the temperature rises from 25 °C to 250 °C, the deformation mechanism of CEC processed ZE21B magnesium alloy transitions from basal slip and twin to prismatic and pyramidal slips, further activating two {101¯2} tensile twin variants, thereby, the cross-section reduction rate (CRR) during one pass increases from 21.45 % to 46.24 %. The minitubes with a wall thickness of 0.14 mm are fabricated using only four drawing passes and one final annealing via hot drawing at 250 °C, whereas conventional cold drawing requires six passes and five annealing passes. Moreover, the final hot drawn minitubes containing two twin variants induce an S-shaped stress-strain curve with ultimate tensile strength (UTS) of 273.5 ± 6.6 MPa, an elongation (EL) of 22.7 ± 0.2 %, its yield ratio (YR) is approximately 0.5 indicating better suitability for subsequent stent deformation. Meanwhile, a high density of twin boundary suppresses preferential grain boundary corrosion, result in a uniform corrosion morphology and improve the corrosion resistance. This study offers theoretical foundation and a novel processing route for the manufacture of biodegradable Mg alloy stents.

Osteosarcoma (OS) poses a severe threat to human health, and the standard clinical treatment involves prosthetic replacement after surgical removal combined with radiotherapy and chemotherapy. However, the recurrence of residual tumors and extensive bone defects leads to a poor prognosis for patients. Zoledronic acid (ZA) is clinically used for tumor treatment and osteoclast inhibition. Nevertheless, intravenous infusion of ZA has poor targeting and significant toxicity to normal tissues. Biodegradable Mg alloys have excellent mechanical and biological compatibility, making them ideal for orthopedic implants. However, their application is limited due to poor corrosion resistance. This work applied a multi-composite layered double hydroxide (LDH)-ZA/PDA coating to the surface of ZE21C alloy. The composite coating adsorbed ZA in weakly alkaline or neutral conditions and released ZA under near-infrared (NIR) irradiation in the tumor microenvironment (TME). The stimuli-responsive release of ZA was confirmed to be related to the NIR-TME-triggered change in LDH interlayer spacing. In vitro and in vivo experiments showed that this multi-composite coating improved corrosion resistance, responded to TME and NIR stimuli to release ZA and reactive oxygen species, effectively targeting and killing tumor cells and osteoclasts through the AKT/GSK-3β signaling pathway. It also transformed OS from “cold tumors” into “hot tumors”, reactivated macrophage-mediated tumor immunity, and promoted osteogenesis. The chemo-thermal-therapeutic approach of the composite coating achieves a “three-birds-with-one-stone” effect. This study offers new insights into applying Mg alloys in prosthetic replacements after OS surgery.

Magnesium alloys have attracted significant attention as biodegradable implant materials due to their low density, high specific strength, and elastic modulus close to that of natural bone. However, their rapid corrosion rate and limited mechanical reliability remain major challenges for load-bearing applications. In this study, the effects of cyclic extrusion compression (CEC) processing on the microstructure, mechanical properties, and corrosion behavior of Mg-Zn-Y-Nd-Sc alloys were systematically investigated. The alloy was processed by CEC at temperatures ranging from 350 to 380 degrees C with 3-7 passes. Microstructural characterization revealed pronounced grain refinement and texture evolution induced by CEC. Optimal processing at 360 degrees C with 5 passes produced a fine-grained structure with an average grain size of similar to 3.72 mu m, resulting in an excellent combination of tensile strength (225.0 +/- 3.4 MPa) and elongation (40.6 +/- 2.8%). Corrosion tests conducted in Hanks' balanced salt solution showed a time-dependent decrease in corrosion rate for the CEC-processed alloy, reaching 0.14 mm & centerdot;y(-)& sup1; after 168 h, whereas the as-cast alloy exhibited non-monotonic corrosion behavior. The enhanced corrosion resistance is attributed to the formation of a dense and uniform protective surface film consisting of Mg(OH)(2) and rare-earth oxides. These results demonstrate that CEC processing is an effective approach to tailoring the microstructure and optimizing the mechanical and degradation performance of Mg-Zn-Y-Nd-Sc alloys, making them promising candidates for load-bearing biodegradable implant applications.

Biodegradable magnesium (Mg) alloys are promising orthopedic implants. However, the synergistic effects of their degradation and physiological loading on fracture healing require further investigation. This study evaluated Mg-Zn-Y-Nd alloy intramedullary (IM) nails in a rat tibiofibular fracture model under 10 N axial loading. A combined approach of finite element analysis (FEA) and in vivo experiments was utilized to assess stress distribution, degradation kinetics and biological response. FEA validated a dynamic load-sharing mechanism, where maximum callus strain decreased from 1530 to 233 με as mineralization progressed, effectively shifting mechanical load from the IM nail to the regenerated bone and mitigating stress-shielding. In vivo, the Mg-Zn-Y-Nd nail exhibited controlled degradation (peaking at 0.74 mm per year) synchronized with healing phases, without premature stress-corrosion failure. Radiographic and micro-CT analyses revealed that Mg-based implants significantly accelerated healing compared to stainless steel, with the Mg-load group exhibiting superior bone volume fraction and trabecular architecture. Mechanistically, FITC staining showed that early-stage high strain (1530 με) modulated osteocyte morphology into a spindle-shaped alignment (aspect ratio reached 2.5), which is essential for establishing structural anisotropy and bone quality.The Mg-Zn-Y-Nd IM nail acts as a bioactive interface where Mg release and mechanical loading synergistically promote rapid, high-quality bone regeneration. This study provides a robust biomechanical foundation for the clinical translation of load-bearing biodegradable fixations.

The effects of three corrosion inhibitors on Mg-Zn-Y-Nd alloy corrosion fatigue were investigated. Salicylic acid (SA) induces uniform but rapid corrosion, limiting fatigue life improvement. 2, 6-pyridinedicarboxylic acid (2,6-PDCA) delays crack initiation under low stress yet fails to fully suppress localized corrosion. Paeonol condensed cysteine Schiff base (PCCys) significantly inhibits both uniform corrosion and localized attacks, enhancing corrosion fatigue life. Localized corrosion behavior, rather than isolated corrosion rate metrics, critically determines mechanical performance under combined corrosive-dynamic stress conditions. A multi-parameter evaluation framework integrating localized corrosion, corrosion rate, and stress effects is proposed for practical screening of corrosion inhibitors for magnesium alloys.

Mg alloy thin sheets have broad application prospects, but conventional rolling processes often fail to achieve both high strength and ductility, and the scope for property optimization is limited. In this work, ZE21B Mg alloy thin sheets with a thickness of 0.2 mm were fabricated by asymmetric extrusion combined with two-stage cross rolling. The effect of hot rolling temperature (350, 400, and 450°C) on the final microstructure and mechanical properties was investigated. The results show that the asymmetrically extruded sheet exhibits fine equiaxed grains and a weak basal texture, providing a favorable microstructure for subsequent rolling. As the hot rolling temperature increases, the grain size of the hot rolled sheets grows from 7.75 to 48.76 μm. Under the same subsequent warm rolling and annealing conditions, the sheet hot rolled at 350°C undergoes pronounced recrystallization, forming a mixed structure of recrystallized and deformed grains with high dislocation density, achieving an elongation of 28.03% ± 2.1% and an ultimate tensile strength of 356.7 ± 5.3 MPa. In contrast, recrystallization is strongly suppressed in the sheets hot rolled at 400 and 450°C, and the microstructures are dominated by irregular dislocation walls and regular sub-grains, respectively, resulting in the ultimate tensile strength increasing to 387.6 ± 4.3 and 405.3 ± 6.9 MPa, respectively, but the elongation dropping to 18.60% ± 1.3% and 6.50% ± 2.6%. Simply by adjusting the hot rolling temperature, the strength and ductility can be continuously adjusted, enabling on-demand tailoring of mechanical properties within a certain range.

Magnesium alloys are widely used as biodegradable biomedical materials. This study investigates the corrosion behavior of cross-rolled magnesium alloy thin sheets in simulated physiological environments to evaluate their suitability as biodegradable guided bone regeneration (GBR) membranes. Through a two-stage thermomechanical processing route (hot rolling at 350-450 degrees C followed by warm rolling at 200 degrees C), the alloy achieved optimal mechanical properties. Microstructural analysis revealed that specimens processed at 400 degrees C exhibited the most homogeneous second-phase particle distribution and uniform equiaxed grain structures, which correlated with superior corrosion resistance. Electrochemical and immersion tests in Hanks' Balanced Salt Solution (HBSS) and artificial saliva (AS) demonstrated pronounced solution-dependent degradation kinetics. 400 degrees C processed samples in AS formed calcium-phosphate layers, yielding the lowest corrosion rates, while HBSS induced localized corrosion with rates higher than that in AS due to chloride-induced film breakdown. These findings underscore the importance of microstructural control and environmental interactions in optimizing the performance of magnesium alloys for biomedical applications, offering a scientific basis for tailoring their degradation behavior in oral implant devices.

Biodegradable porous magnesium alloy (pMg) scaffolds hold significant potential for repair of bone defects owing to favorable mechanical properties and biocompatibility. However, a critical challenge remains in matching the degradation rate of pMg scaffolds with the pace of bone regeneration. Low-intensity pulsed ultrasound (LIPUS) has emerged as a promising therapeutic strategy to enhance bone repair. In this study, femoral bone defects in Sprague–Dawley rats were implanted with pMg scaffolds, and LIPUS was applied to the defect sites post-operatively. This study primarily investigated the degradation behavior of pMg scaffolds in vivo experiments, as well as their reparative effects on bone defects under LIPUS intervention. In vivo analysis revealed that LIPUS intervention accelerated the degradation of pMg scaffolds by loosening the degradation layer, making it more susceptible to erosion. Concurrently, LIPUS enhanced the accumulation of beneficial calcium and phosphorus compounds on the surface of the pMg scaffolds. Furthermore, the pMg + LIPUS group exhibited enhanced bone formation and mineralization around the degradation site compared to the pMg group alone, attributed to the increasing osteocalcin (OCN) and type I collagen (COL-I) as well as reduction in osteolysis by pMg and LIPUS-induced osteogenesis effect. At the 24-week post-surgery, the hardness value (HV) of regeneration bone in the pMg + LIPUS group had a 15% increase compared to the pMg group and approached the HV of healthy bone. In conclusion, the promotion of bone tissue growth rate under the intervention of LIPUS in conjunction with the degradation rate of pMg scaffolds offers a novel clinical strategy for the repair of bone defects.

In this study, two Al-Cu alloys, one conventionally cast (exhibiting coarse grains) and the other ultrasonically processed (featuring refined grains and elevated Cu content in Al matrix), were hot rolled at 400 degrees C, 420 degrees C, and 440 degrees C followed by solution aging. For both samples, the average grain size, continuity and thickness of secondary phase at grain boundaries first decreased and then increased again as rolling temperature increased. However, the conventional alloy showed greater sensitivity to rolling temperature in terms of grain size fluctuations, whereas the ultrasonicated alloy showed marked variations in 9'/9''-Al2Cu precipitates volume fraction with increasing rolling temperature. Smaller grains and thinner secondary phase in the ultrasonicated sample were beneficial for dynamic recovery (DRV) and dynamic recrystallization (DRX) during hot rolling, resulting in significant increases in subgrains content and dislocation density. Meanwhile, the texture intensity (anisotropy) was reduced compared with the conventional sample. Static recrystallization (SRX) dominated during solution aging, yielding recrystallized grains of 115.1 mu m in conventional sample versus 87.5 mu m in ultrasonicated sample after 420 degrees C rolling. The nano-sized precipitated particles were densest and most evenly distributed in the ultrasonicated sample after 420 degrees C rolling and solution aging, whereas 440 degrees C rolling triggered abnormal coarsening in precipitates. After solution aging, the deformation S texture generated during rolling was attenuated, and Cube and Goss textures were intensified. The ultrasonicated sample after 420 degrees C rolling followed by solution aging exhibited superior mechanical properties: ultimate tensile strength (UTS) of 420 MPa, yield strength (YS) of 260 MPa, and elongation (EL) of 14.3 %.

Magnesium (Mg) alloys hold significant promise as biodegradable orthopedic biomaterials due to their biocompatibility, controlled degradability, and mechanical properties. However, their rapid degradation in physiological environments and its induced poor biocompatibility limit the clinical translation. This study proposes a micro-arc oxidation (MAO) coating strategy that incorporates tantalum pentoxide (TaaO5) nano-particles (NPs) to enhance the biocompatibility and osteointegration of magnesium alloys without significantly compromising their corrosion resistance. Surface characterization revealed concentration-dependent micro-structural modifications, including reduced porosity (from 4.89 % to 2.97 %) and improved coating uniformity. X-ray diffraction and photoelectron spectroscopy confirmed TaaO5 integration without phase alterations. The 10 g & sdot;L-1 TaaO5-modified coating exhibited optimal performance, with enhanced hydrophilicity, adhesive strength and wear resistance. While short-term corrosion resistance was modestly reduced due to micro-galvanic effects, the coating demonstrated accelerated osteogenic activity, promoting MC3T3-E1 cell adhesion, proliferation, and cytoskeleton reorganization. This study demonstrates that TaaO5 NPs-modified MAO coatings achieve a balance between corrosion resistance and bioactivity, offering a viable strategy for Mg alloy-based orthopedic applications.