OBJECTIVE To investigate the change of drug resistance of extended-spectrum β-lactamases(ESBLs)-producing Klebsiella pneumoniae from pediatric patients,to provide evidence for clinical reasonable use of antibiotics.METHODS In accordance with the NCCLS standard operating,cefotaxime,cefotaxime/clavulanic acid susceptibility disk diffusion method was used to isolates of test the hospital from Jan 2010 to Dec 2010 of ESBLs prodcing and their resistance of K.pneumoniae were compared with 2008.RESULTS From Jan.to Dec.2010,the isolated ESBLs-producing K.pneumoniae accounted for 57.2%,36.8% in 2008,the difference was significant(P0.05).The susceptibility rate of ESBLs-producing K.pneumoniae to aztreonam was 19.3% in 2010,47.8% in 2008,presenting a significant decrease(P0.05).ESBLs-producing K.pneumoniae maintained high susceptibility to sulfamethoxazole/trimethoprim and rifamycin,there was no significant change during the three years.ESBLs-producing K.pneumoniae remained the susceptibility rate of 100.0% to imipenem.CONCLUSION In recent years,ESBLs-producing K.pneumoniae shows a significant increase both in number and the detection rate as well as the drug resistance,management of antibiotic use in department of pediatrics should be further strengthened.

目的探讨解脲支原体感染(UU)与反复自然流产(RSA)的关系。方法随机抽取我院门诊77例RSA患者(观察组)和52例健康妇女(对照组),取其宫颈分泌物进行UU分离培养。结果观察组UU阳性率40.2%,对照组UU阳性率9.6%,2者比较差异有统计学意义(P<0.01)。结论反复自然流产与解脲支原体感染有密切关系。

目的:分析黏液脓性宫颈炎的病原检测情况。方法:选择具有黏液脓性宫颈炎的观察组221例,对照组205例进行病原检测,比较两者主要病原谱的异同。结果:观察组221例黏液脓性宫颈炎病例中,病原体检出率88.69%(196/221),与对照组205例相比,有统计学差异(P<0.05)。结论:黏液脓性宫颈炎其主要病原体为淋球菌、沙眼衣原体和支原体,其混合感染率高。

Objective: To analyse pathogens and their susceptibility test of patients with mucopurulent cervicitis(MPC) attending gynecological clinics and to probe into the therapeutic effect. Methods: The pathogens detected by laboratory testing were then compared with those of normal control. 221 cases with MPC and 205 normal ones were adopted in the study and control group respectively. Results: The results showed that the pathogen positive rate in 221 cases with cervical mucopurulent discharge was 88.69%, Neisseria gonorrhoeae was 14.48%, Bedsonia trachomatis was 57.74%, and the mix infection was 61.99%. It was statistically significant(P 0.005) compared with that of normal control and no significant difference of the positive rate of ureaplasma urealytricum was found between tow groups(P 0.05). Conclusion: Patients with Mucopurulent Cervicitis attending gynecological clinics have high Infection rate of mix pathogens and the major pathogens were Neisseria gonorrhoeae, Bedsonia trachomatis neisseriag and mycoplasma. The highest susceptible curative drugs were minocycline, clarithromycin, josamycin, chlormycetin and vibramycin. Ofloxacin, azithromycin, ciprofloxacin were middle sensitive, and erythrocin, acetylspiramycin, achromycin has high resistance.