OBJECTIVE We aimed to identify the oxidative stress effects of the ischemic priapism on cavernosal tissues and to assess the biochemical and histopathological effects of curcumin in rats. MATERIALS AND METHODS 26 adult male Sprague Dawley rats were randomly divided into three groups. Group 1 (Control, n = 8): only penectomy was performed and 3 ml blood samples were obtained from the vena cava inferior (VCI). Group 2 (ischemia-reperfusion group; n= 8): penectomy was performed after 1 hour ischemic priapism + 30 min reperfusion and 3 ml blood samples were obtained from the VCI. Group III (IR + CURC group, n = 10): 200 mg/kg/day curcumin per orally before surgery for 7 days + penectomy after 1 hour ischemic priapism + 30 min reperfusion and 3 ml blood samples from the VCI. Total oxidant status (TAS), total antioxidant status (TAS) and paraoxonase (PON1) levels were measured. Tissue samples were investigated and scored histopathologically in terms of bleeding, edema and necrosis. RESULTS TOS levels were higher (p = 0.002), and TAS levels were lower (p = 0.001) in the IR group compared to the control group. As a result of curcumin treatment, TAS levels were increased (p = 0.003), and TOS levels were decreased (p = 0.004) in the IR + CURC group compared to the IR group. In the treatment group (IR + CURC) TAS and TOS levels were similar to levels in the control group. PON1 levels were increased with ischemia-reperfusion (p = 0.21) and decreased with curcumin treatment (p = 0.53), however these changes were not statistically significant. There was no significant difference in the effects of curcumin on histopathological changes. CONCLUSIONS This study showed that curcumin has preventive effects on oxidative stress parameters against ischemia-reperfusion injury.

INTRODUCTION:The pathophysiology of erectile dysfunction (ED) may be vasculogenic, hormonal, anatomical, neurogenic, drug-induced and/or psychogenic in origin. Neuropathic pain (NP) may facilitate ED, because it is frequently associated with anxiety, depression, and its drug, pregabalin, may also contribute ED.AIM:The objective of this study was to determine whether pregabalin treatment for patients with neuropathic pain promotes erectile dysfunction.METHODS:The study sample consisted of a total of 102 male subjects that were subdivided into three groups. Group 1 patients (n = 31) had a pre-existing diagnosis of NP and was treated with 300 mg/day of pregabalin for at least 3 months. Group 2 patients (n = 34) were diagnosed with NP for at least 3 months; however, neither were they treated with pregabalin nor did they received physical therapy throughout the study. Lastly, healthy age-matched control subjects comprised group 3 (n = 37).MAIN OUTCOME MEASURES:Patients in all groups completed the International Index for Erectile Function (IIEF) questionnaire.RESULTS:Mean age and mean body mass index did not differ significantly between each of the three groups. The cause of NP and the mean duration of having a diagnosis of NP did not differ significantly in groups 1 and 2. However, IIEF scores were significantly lower for group 1 when compared to group 2 in terms of erectile function, orgasmic function, overall satisfaction and total score. Yet groups 1 and 2 did not diverge significantly in the intercourse satisfaction and sexual desire scores. Overall IIEF scores for group 3 were significantly higher than those of group 2 except for mean erectile function scores.CONCLUSION:Taking pregabalin for the treatment of neuropathic pain poses an increased risk for developing ED in male patients. Thus, clinicians prescribing pregabalin to patients diagnosed with neuropathic pain should assess for ED before and during treatment with this medication.

OBJECTIVE:Deafness may be one of the factors that leads to a change in sexual function. This study aimed to assess sexual function, in particular erectile dysfunction, in male patients with hearing loss.MATERIALS AND METHODS:We studied two groups: (1) adult men with acquired, bilateral, sensorineural hearing loss, and (2) healthy, adult, married men demonstrated to have normal hearing levels, as the control group. Sexual function was assessed using the International Index of Erectile Functions questionnaire, and quality of life using the 36-Item Short-Form Health Survey.RESULTS:There was a statistically significant difference between the groups regarding the International Index of Erectile Functions questionnaire results (p <0.001), both for each of the five questionnaire domain scores and for the total score.CONCLUSION:Our results indicate that men with mild or moderate sensorineural hearing loss have poorer sexual health.

Amac: Dicle Universitesi Tip Fakultesinde urolojik laparoskopik cerrahi yapilan ilk 100 olgunun sonuclarini sunmaktir. Gerec ve yontem: Temmuz 2010 ve Ekim 2011 tarihleri arasinda klinigimizde yapilan laparoskopik operasyonlari retrospektif olarak inceledik. Bulgular: Ameliyat edilen hastalarin, Erkek/Kadin orani 57/43 seklinde iken ortalama hasta yasi 48,65±8,94 yil idi. Doksan bir olguda transperitoneal, 9 olguda retroperitoneal yaklasim tercih edildi. Toplam 100 hastanin, otuz dordune basit nefrektomi, 22\'sine radikal nefrektomi, 21\'ine bobrek kisti eksizyonu, 7\'sine orsiektomi, 4\'une ureterolitotomi, 4\'une adrenalektomi, 3\'une orsiopeksi, 2\'sine piyeloplasti, 1\'ine nefroureterektomi ve el yardimli sistektomi, 1\'ine nefroureterektomi ve el yardimli parsiyel sistektomi, 1\'ine nefroureterektomi yapildi. Toplam 100 vakanin 6\'sinda (%6) acik operasyona gecildi. Aciga gecis nedenleri ise; 3 hastada bobrek pedikulune ulasilamadi, 2 hastada bobrek etrafindaki dokulara ve kolona yapisikti, 1 hastada splenik arter yaralandi. Hastalari 3\'unde kan transfuzyonu ihtiyaci oldu. Bunun disinda hicbir hastada major komplikasyon veya mortalite gorulmedi. Sag basit nefrektomi, radikal nefrektomi ve surrenalektomi vakalarinda karaciger ekartasyonu gereken vakalarda 4 port kullanilirken, diger tum vakalarda 3 port kullanildi. Ortalama hastanede kalis suresi 1.7 (1-8) gun idi. En sik yapilan operasyonlarin ortama sureleri dakika (aralik) olarak; basit Nefrektomi 95 (70-135), radikal nefrektomi 148 (125-190), kist eksizyonu 45 (20-80), orsiektomi 41 (30-45), ureterolitotomi 104 (95-135), orsiopeksi 85 (80-100), surrenalektomi 148 (110-180), pyeloplasti 170 (160-180) ve nefroureterektomi 150 seklinde idi. Sonuc: Klinigimizdeki ilk 100 laparoskopik operasyon sonuclarinin basari ve komplikasyon oranlari literaturle uyumlu bulundu. Laparoskopik cerrahi, teknolojinin gelisimi ve yayginligin artmasiyla acik cerrahiye alternatif olarak kabul gormeye devam eden guvenli ve uygulanabilir bir tekniktir.

There is a gap in the literature about psychological status of patients following penile fracture surgery. We aimed to assess the long-term psychological status of penile fracture patients who have been treated by immediate surgical repair. A total of 32 patients with penile fracture have been treated surgically at our center. These 32 patients and 30 healthy control subjects were included in the study. All participants have completed the Hospital Anxiety and Depression Scale (HADS), Glombok-Rust Inventory of Satisfaction Scale (GRISS), and the premature ejaculation diagnostic tool (PEDT). The mean age of patients was 30.4 years and the mean body mass index was 27.3 kg m −2 . Sexual intercourse was the most common cause of the fracture. Immediate surgical repair was performed in all cases using a circumferential subcoronal incision and none of the patients had urethral injury intraoperatively. All tears were unilateral with a mean size of 1.5 cm. Only two patients had superficial dorsal vein rupture. At the day of assessment, the mean time elapsed after penile trauma was 15.9±6.3 months (range: 6–23). Only three patients had complications due to penile fracture including minimal penile curvature, penile nodule, and penile pain during intercourse. The mean scores obtained from PEDT, HADS, and GRISS did not show any statistically significant difference between groups. Anxiety, depression, premature ejaculation, and sexual dyssatisfaction levels were similar in both penile fracture patients who underwent immediate surgical repair and healthy control subjects. Immediate surgical repair of corporal ruptures have not shown any harmful psychogenic sequelae on patients with penile fracture.