Aims. Several studies showed that genetic risk of developing celiac disease can be stratified in five risk classes according to the HLA-DQ genotype. DQ2 genotype can be divided in three groups: the first group is characterized by two copies of DQB1*02 (group G1) in linkage with DR3/3-3/7; the second by one copy of DQB1*02 in trans with DQA1*05 (group G2) in linkage with DR5/7; the third by one copy of DQB1*02 in cis with DQA1*05 (group G3) in linkage with DR3/X. DQ2-negative individuals are classified in two groups: the fist group has two copies of DQB1*02 or two copies of DQ8 or one copy of each of the previous (group G4) in linkage with DR7/7-DR7/4-DR4/4; the second group has any DQ-DR haplotype different from the previous ones (group G5). In the Italian population the relative risk for individuals belonging to the different groups G1, G2, G3, G4 and G5 is respectively 1, 0.68, 0.23, 0.10 and 0.02.
Aims. ‘Prevent celiac disease’ is a multicentric 3-year project whose aim is to study the natural history of celiac disease and the immune response after exposure to gluten in children with high genetic risk.
Aim. Several studies have shown a higher prevalence of CD in sibs of CD patients compared with the general population, with risk estimates ranging from 8 to 12%, but this risk is not the same for all sibs. The aim of the present study is to evaluate the real risk in the Italian population that a sib of symptomatic patient will develop CD and to provide to the parents of a child with CD the most precise estimate of the risk for any future child.
Aim. Several studies have shown a higher prevalence of CD in sibs of CD patients compared with the general population, with risk estimates ranging from 8 to 12%, but this risk is not the same for all sibs. The aim of the present study is to evaluate the real risk in the Italian population that a sib of symptomatic patient will develop CD and to provide to the parents of a child with CD the most precise estimate of the risk for any future child.
Aims. To evaluate the global (health, education, social integration) well-being of coeliac children at the teenagers time.
C. Natale合作论文数6M.G. Limongelli合作论文数5
Leopoldo Greco合作论文数Department of Pediatrics, University of Naples “Federico II5Augusto Pianese合作论文数4S. Storchi合作论文数4O. Esposito合作论文数4R. Di Mase合作论文数4A. Del Mastro合作论文数4G. Terrone合作论文数4Riccardo Troncone合作论文数3S. Errichiello合作论文数3
Renata Auricchio合作论文数Department of Translational Medical Sciences, School of Medicine and Surgery, University of Naples Federico II3C. Marano合作论文数2E. Piccolo合作论文数2Anna Coruzzo合作论文数2
Mario D'Aniello合作论文数University of Naples;Dept of Structural Engineering;Dept of Structural Engineering, University of Naples2
Pietro Strisciuglio合作论文数University “Magna Graecia” of Catanzaro Department of Pediatrics c/o Ospedale Civile A. Pugliese2L. Timpone合作论文数2M.G. Limongell合作论文数1Mathieu Bourgey合作论文数Department of Paediatrics;University of Naples;Department of Paediatrics, University of Naples1Françoise Clerget-Darpoux合作论文数Unité de Recherche d'Epidemiologie Genetique (I.N.S.E.R.M. U 155),, Dominique Campion1
