Infiltration and migration of c-fms+ myeloid cells in the tumor microenvironment. c-fms+ myeloid cells migrate at the border of a late carcinoma, whereas migration within the tumor mass mostly occurs along blood vessels and in stromal patches. c-fms+ cells (green) are seen migrating at the border of the carcinoma (blue) in the bottom of the field, along c-fms+-dense tracks that penetrate into the tumor mass and along blood vessels inside the mass in an MMTV-PyMT;ACTB-ECFP;c-fms-EGFP mouse. Few of the c-fms+ cells that have infiltrated the carcinoma mass migrate. c-fms+ cells are also seen flowing through blood vessels inside the lesion (black areas on the surrounding background of blue cancer cells). From Egeblad et al. (2008) Dis. Model. Mech., 1 155-167.
e bainbridge合作论文数7g peeters合作论文数7
Andrew J. Ewald合作论文数Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Johns Hopkins University7
Bryan E Welm合作论文数7
Hanne Askautrud合作论文数Division of Medicine, University of Oslo;Institute for Cancer Genetics and Informatics, Oslo University Hospital7
Mikala Egeblad合作论文数Departments of Cell Biology and Oncology, School of Medicine, Johns Hopkins University7
Zena Werb合作论文数Department of Anatomy, University of California, San Francisco7
Matthew F. Krummel合作论文数Krummel Lab, Department of Pathology, School of Medicine, University of California San Francisco;Biological Imaging Development Center, University of California San Francisco;Department of ImmunoX, University of California San Francisco7
