British Journal of HaematologyVolume 38, Issue 1 p. 85-97 Immunological Diagnosis of Leukaemia and Lymphoma: A World Health Organization/International Union of Immunological Societies Technical Report D. Belpomme, D. BelpommeSearch for more papers by this authorL. Borella, L. BorellaSearch for more papers by this authorR. Braylan, R. BraylanSearch for more papers by this authorM. Greaves, M. GreavesSearch for more papers by this authorR. Herberman, R. HerbermanSearch for more papers by this authorW. Hitzig, W. HitzigSearch for more papers by this authorJ. Kersey, Corresponding Author J. KerseyProfessor John H. Kersey, Departments of Paediatrics and Laboratory Medicine, University of Minnesota, Box 609, Mayo Memorial Building, University Hospital, Minneapolis, Minnesota 55455, U.S.A. Reprints of this report will not be available.Search for more papers by this authorR. Petrov, R. PetrovSearch for more papers by this authorR. Ritts, R. RittsSearch for more papers by this authorM. Seligmann, M. SeligmannSearch for more papers by this authorL. Sobin, L. SobinSearch for more papers by this authorS. Thierfelder And, S. Thierfelder AndSearch for more papers by this authorG. Torrigiani, G. TorrigianiSearch for more papers by this author D. Belpomme, D. BelpommeSearch for more papers by this authorL. Borella, L. BorellaSearch for more papers by this authorR. Braylan, R. BraylanSearch for more papers by this authorM. Greaves, M. GreavesSearch for more papers by this authorR. Herberman, R. HerbermanSearch for more papers by this authorW. Hitzig, W. HitzigSearch for more papers by this authorJ. Kersey, Corresponding Author J. KerseyProfessor John H. Kersey, Departments of Paediatrics and Laboratory Medicine, University of Minnesota, Box 609, Mayo Memorial Building, University Hospital, Minneapolis, Minnesota 55455, U.S.A. Reprints of this report will not be available.Search for more papers by this authorR. Petrov, R. PetrovSearch for more papers by this authorR. Ritts, R. RittsSearch for more papers by this authorM. Seligmann, M. SeligmannSearch for more papers by this authorL. Sobin, L. SobinSearch for more papers by this authorS. Thierfelder And, S. Thierfelder AndSearch for more papers by this authorG. Torrigiani, G. TorrigianiSearch for more papers by this author First published: January 1978 https://doi.org/10.1111/j.1365-2141.1978.tb07111.xCitations: 20 Report of a meeting held in Munich, 31 October 1976 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume38, Issue1January 1978Pages 85-97 RelatedInformation

Scandinavian Journal of ImmunologyVolume 3, Issue 5 p. 521-532 Identification, Enumeration, and Isolation of B and T Lymphocytes from Human Peripheral Blood Report of a WHO/IARC-Sponsored Workshop on Human B and T Cells, London, 15-17 July 1974 F. Aiuti, F. AiutiSearch for more papers by this authorJ.C. Cerottini, J.C. CerottiniSearch for more papers by this authorR. R. A. Coombs, R. R. A. CoombsSearch for more papers by this authorM. Cooper, M. CooperSearch for more papers by this authorH. B. Dickler, H. B. DicklerSearch for more papers by this authorS. Froland, S. FrolandSearch for more papers by this authorH. H. Fudenberg, H. H. FudenbergSearch for more papers by this authorM. F. Greaves, M. F. GreavesSearch for more papers by this authorH. M. Grey, H. M. GreySearch for more papers by this authorH. G. Kunkel, H. G. KunkelSearch for more papers by this authorJ. B. Natvig, J. B. NatvigSearch for more papers by this authorJ.L. Preu?homme, J.L. Preu?hommeSearch for more papers by this authorE. Rabellino, E. RabellinoSearch for more papers by this authorR. E. Ritts, R. E. RittsSearch for more papers by this authorD. S. Rowe, D. S. RoweSearch for more papers by this authorM. Seligmann, M. SeligmannSearch for more papers by this authorF. P. Siegal, F. P. SiegalSearch for more papers by this authorJ. Stjernswärd, J. StjernswärdSearch for more papers by this authorW. D. Terry, W. D. TerrySearch for more papers by this authorJ. Wybran, J. WybranSearch for more papers by this author F. Aiuti, F. AiutiSearch for more papers by this authorJ.C. Cerottini, J.C. CerottiniSearch for more papers by this authorR. R. A. Coombs, R. R. A. CoombsSearch for more papers by this authorM. Cooper, M. CooperSearch for more papers by this authorH. B. Dickler, H. B. DicklerSearch for more papers by this authorS. Froland, S. FrolandSearch for more papers by this authorH. H. Fudenberg, H. H. FudenbergSearch for more papers by this authorM. F. Greaves, M. F. GreavesSearch for more papers by this authorH. M. Grey, H. M. GreySearch for more papers by this authorH. G. Kunkel, H. G. KunkelSearch for more papers by this authorJ. B. Natvig, J. B. NatvigSearch for more papers by this authorJ.L. Preu?homme, J.L. Preu?hommeSearch for more papers by this authorE. Rabellino, E. RabellinoSearch for more papers by this authorR. E. Ritts, R. E. RittsSearch for more papers by this authorD. S. Rowe, D. S. RoweSearch for more papers by this authorM. Seligmann, M. SeligmannSearch for more papers by this authorF. P. Siegal, F. P. SiegalSearch for more papers by this authorJ. Stjernswärd, J. StjernswärdSearch for more papers by this authorW. D. Terry, W. D. TerrySearch for more papers by this authorJ. Wybran, J. WybranSearch for more papers by this author First published: October 1974 https://doi.org/10.1111/j.1365-3083.1974.tb01285.xCitations: 253 Reprints may be ordered from Scandinavian Journal of Immunology, Universitetsforlaget, P.O. Box 307, Blindern, Oslo 3, Norway, and cost N. kr. 10.- (U.S. $2.00), including air mail postage. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Additional references can be found in: T and B lymphocytes in humans. Transplant. Rev. 16, 1973. 1 Böyum, A.. Scand. J. clin. Lab. Invest. 21, 77, 1968. 10.3109/00365516809076979 CASPubMedWeb of Science®Google Scholar 2 Brown, G. & Greaves, M. F.. Scand. J. Immunol. 3, 161, 1974. 10.1111/j.1365-3083.1974.tb01244.x CASPubMedWeb of Science®Google Scholar 3 Dickler, H. B. & Kunkel, H. G.. J. exp. Med. 136, 191, 1972. 10.1084/jem.136.1.191 PubMedWeb of Science®Google Scholar 4 Frøland, S. S. & Natvig, J. B.. Transplant. Rev. 16, 114, 1973. 10.1111/j.1600-065X.1973.tb00119.x PubMedWeb of Science®Google Scholar 5 Frøland, S. S., Wisløff, F. & Michaelsen, T. E.. Int. Arch. Allergy 47, 124, 1974. 10.1159/000231207 CASPubMedWeb of Science®Google Scholar 6 Giuliano, V. J., Jasin, H. E., Hurd, E. R. & Ziff, M.. J. Immunol. 112, 1494, 1974. CASPubMedWeb of Science®Google Scholar 7 Hallberg, T., Gurner, B. W. & Coombs, R. R. A.. Int. Arch. Allergy 44, 500, 1973. 10.1159/000230956 PubMedWeb of Science®Google Scholar 8 Hallberg, T., Haegert, D., Clein, G. P., Coombs, R. R. A., Feinstein, A. & Gurner, B. W.. J. Immunol. Methods 4, 317, 1974. 10.1016/0022-1759(74)90074-X CASPubMedWeb of Science®Google Scholar 9 Preu?homme, J.L. & Flandrin, G.. J. Immunol. In press, 1974. Google Scholar 10 Ross, G. D., Polley, M. J., Rabellino, E. M. & Grey, H. M.. J. exp. Med. 138, 798, 1973. 10.1084/jem.138.4.798 CASPubMedWeb of Science®Google Scholar 11 Ross, G. D., Rabellino, E. M., Polley, M. J. & Grey, H. M.. J. clin. Invest. 52, 377, 1973. 10.1172/JCI107194 CASPubMedWeb of Science®Google Scholar 12 Wernet, P., Feizi, T. & Kunkel, H. G.. J. exp. Med. 136, 650, 1972. 10.1084/jem.136.3.650 CASPubMedWeb of Science®Google Scholar 13 Wybran, J. & Fudenberg, H. H.. J. clin. Invest. 52, 106, 1973. 10.1172/JCI107267 PubMedWeb of Science®Google Scholar Citing Literature Volume3, Issue5October 1974Pages 521-532 ReferencesRelatedInformation

1. Two registries are to be established in association with WHO, with the object of gathering and recording information on cases of immunodeficiency from all over the world. One registry will comprise cases of primary immunodeficiency that have received transplants of any immunologically competent organ, cell, or cell product, e.g., bone marrow, thymus, or transfer factor. It will be organized by W. Hitzig and M. Seligmann. The other will comprise cases of malignant tumour found in patients with primary immunodeficiency; it will be organized by R. A. Good, who will also arrange for pathological material to be submitted for study by selected pathologists. The organizers will collate and periodically report on the material in both registries. 2. Standardization of diagnostic procedures and additional studies related to diagnostic tests are required. a. There is a need for standard preparations of antigens for assessing antibody formation as described. A sufficiently large batch of such antigens should be prepared, and aliquots should be sent, on request, for use by clinicians investigating immunodeficiency. b. Methods for measuring serum antibodies need to be standardized, and in vitro tests for the measurement of cell-mediated immunity, such as tests for cytotoxicity and macrophage migration inhibition factors, need to be further developed. 3. Therapeutic procedures should be standardized and assessed. a. Aggregates in immunoglobulin preparations for intramuscular or intravenous injection should be looked for with tests such as those recommended. b. National agencies responsible for immunoglobulin production should develop stable aggregate-free intact IgG, without fragments and with relatively normal in vivo survival, for the treatment of patients with immunodeficiency. c. It would be of value to determine the relative effectiveness of therapy with immunoglobulin and with plasma. Clinical trials might be designed for this purpose. d. Immunoglobulin preparations having high contents of specific antibodies would, if available, be valuable for treatment of patients with specific infections. e. Further research is required to develop new methods of destroying the biological activity of lymphocytes in whole blood. f. Pools of immunoglobulin, prepared as Cohn FII from donors with absence of One genetic allotype, may be valuable for the treatment of patients with immunodeficiency who have anti-allotype antibodies.