Since 1969 the Swiss Academy of Medical Sciences (SAMS) has issued many guidelines and directives on medical problems and guiding principles on ethical behaviour for doctors, which have been well accepted by the various population groups concerned. In 1981 the Senate of the SAMS set up a Permanent ''Central Medical-ethical Committee'' which, with the help of sub-committees and experts, draws up guidelines and guiding principles which before implementation are considered by the Senate in two readings.In order to obtain the opinion of the medical profession and after their approval by the Senate, our guidelines are published in German and French in the ''Schweizerische Arztezeigung''. They are also included in the ''Vademecum for Swiss Doctors''. They are also frequently requested by institutions and other interested parties outside the medical profession as well as from abroad in the form of individual brochures, an there has recently been an increased demand for English versions. We are very grateful to the Editors of the Schweizerische Medizinische Wochenschrift (SMW) that in order to considerably broaden the readership we shall in future also be able to publish these guidelines in that journal in three languages(1).The attached ''Medical-ethical Guidelines on Genetic Investigation in Humans'' appeared in the ''Schweizerische Arztezeitung'' on 22. 9. 1993. They are the result of about four years' work by several sub-committees.

In a prospective multicenter study 42 thrombocytopenic (<30×109 platelets/l) children with chronic idiopathic thrombocytopenic purpura (ITP) or with acute ITP, dependent on or refractory to corticosteroids, were given 0.4 g i.v. IgG/kg body weight/day on 5 consecutive days and thereafter once a week if the platelet count fell to <20×109/l or if the patient bled. After the initial 5 days of i.v. IgG the platelets rose within a mean of 7–8 days to >30×109/l in all and to >150×109/l in 33 of 42 patients (79%). After a mean observation time of 26.6 months 26 of 42 patients (62%) showed a satisfactory long-term effect, i.e. no need for treatment for at least 6 months without bleeding and with no platelet counts below 20×109/l. No difference in response rate was found between children with chronic and those with previously treated acute ITP. These results indicate that i.v. IgG could be used to control emergency situations, e.g. to stop bleeding or to prepare a patient for surgery. I.v. IgG also represents a good alternative to treatment modalities, such as splenectomy and/or the administration of cytostatic immunosuppressants with potentially serious side effects. In addition to the expected transient rise in serum IgG levels, i.v. IgG induced a more prolonged elevation of serum IgM. Platelet associated IgG, elevated before therapy, was correlated with the clinical long-term outcome.

British Journal of HaematologyVolume 38, Issue 1 p. 85-97 Immunological Diagnosis of Leukaemia and Lymphoma: A World Health Organization/International Union of Immunological Societies Technical Report D. Belpomme, D. BelpommeSearch for more papers by this authorL. Borella, L. BorellaSearch for more papers by this authorR. Braylan, R. BraylanSearch for more papers by this authorM. Greaves, M. GreavesSearch for more papers by this authorR. Herberman, R. HerbermanSearch for more papers by this authorW. Hitzig, W. HitzigSearch for more papers by this authorJ. Kersey, Corresponding Author J. KerseyProfessor John H. Kersey, Departments of Paediatrics and Laboratory Medicine, University of Minnesota, Box 609, Mayo Memorial Building, University Hospital, Minneapolis, Minnesota 55455, U.S.A. Reprints of this report will not be available.Search for more papers by this authorR. Petrov, R. PetrovSearch for more papers by this authorR. Ritts, R. RittsSearch for more papers by this authorM. Seligmann, M. SeligmannSearch for more papers by this authorL. Sobin, L. SobinSearch for more papers by this authorS. Thierfelder And, S. Thierfelder AndSearch for more papers by this authorG. Torrigiani, G. TorrigianiSearch for more papers by this author D. Belpomme, D. BelpommeSearch for more papers by this authorL. Borella, L. BorellaSearch for more papers by this authorR. Braylan, R. BraylanSearch for more papers by this authorM. Greaves, M. GreavesSearch for more papers by this authorR. Herberman, R. HerbermanSearch for more papers by this authorW. Hitzig, W. HitzigSearch for more papers by this authorJ. Kersey, Corresponding Author J. KerseyProfessor John H. Kersey, Departments of Paediatrics and Laboratory Medicine, University of Minnesota, Box 609, Mayo Memorial Building, University Hospital, Minneapolis, Minnesota 55455, U.S.A. Reprints of this report will not be available.Search for more papers by this authorR. Petrov, R. PetrovSearch for more papers by this authorR. Ritts, R. RittsSearch for more papers by this authorM. Seligmann, M. SeligmannSearch for more papers by this authorL. Sobin, L. SobinSearch for more papers by this authorS. Thierfelder And, S. Thierfelder AndSearch for more papers by this authorG. Torrigiani, G. TorrigianiSearch for more papers by this author First published: January 1978 https://doi.org/10.1111/j.1365-2141.1978.tb07111.xCitations: 20 Report of a meeting held in Munich, 31 October 1976 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume38, Issue1January 1978Pages 85-97 RelatedInformation

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