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M. Valle | AMiner学者主页 | AMiner

M. Valle

15Papers / 论文

352Citations / 引用

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论文（15）

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1Domain-wise fitting of the crystal structure of T.thermophilus EF-G into the low resolution map of the release complex.Puromycin.EFG.GDPNP of E.coli 70S ribosome.

M. Valle,A. Zavialov,J. Sengupta,U. Rawat,M. Ehrenberg, J. Frank

2003

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2Coordinates of the A/T Site Trna Model Fitted into the Cryo-Em Map of EF-Tu Ternary Complex (gdp.kirromycin) Bound 70S Ribosome

M. Valle,A. Zavialov, W. Li,S.M. Stagg,J. Sengupta,R.C. Nielsen,P. Nissen,S.C. Harvey,M. Ehrenberg, J. Frank

2003

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3Coordinates of S12, SH44, LH69 and SRL Separately Fitted into the Cryo-Em Map of EF-Tu Ternary Complex (gdp.kirromycin) Bound 70S Ribosome

M. Valle,A. Zavialov, W. Li,S.M. Stagg,J. Sengupta,R.C. Nielsen,P. Nissen,S.C. Harvey,M. Ehrenberg, J. Frank

2003

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4Real space refined coordinates of the 30S subunit fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome

H. Gao,J. Sengupta,M. Valle,A Korostelev,N. Eswar,S.M. Stagg,P. Van Roey,R.K. Agrawal,S.T. Harvey,A. Sali,M.S. Chapman,J. Frank

2003

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5Coordinates of L11 with 58nts of 23S rRNA fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome

M. Valle,A. Zavialov, W. Li,S.M. Stagg,J. Sengupta,R.C. Nielsen,P. Nissen,S.C. Harvey,M. Ehrenberg, J. Frank

2003

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6Coordinates of the A-site tRNA model fitted into the cryo-EM map of 70S ribosome in the pre-translocational state

M. Valle,A. Zavialov, W. Li,S.M. Stagg,J. Sengupta,R.C. Nielsen,P. Nissen,S.C. Harvey,M. Ehrenberg, J. Frank

2003

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7Real space refined coordinates of the 30S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome

H. Gao,J. Sengupta,M. Valle,A Korostelev,N. Eswar,S.M. Stagg,P. Van Roey,R.K. Agrawal,S.T. Harvey,A. Sali,M.S. Chapman,J. Frank

2003

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8Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome

H. Gao,J. Sengupta,M. Valle,A Korostelev,N. Eswar,S.M. Stagg,P. Van Roey,R.K. Agrawal,S.T. Harvey,A. Sali,M.S. Chapman,J. Frank

2003

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9Coordinates of S12, L11 proteins and E-site tRNA from 70S crystal structure separately fitted into the Cryo-EM map of E.coli 70S.EF-G.GDPNP complex. The atomic coordinates originally from the E-site tRNA were fitted in the position of the hybrid P/E-site tRNA.

M. Valle,A. Zavialov,J. Sengupta,U. Rawat,M. Ehrenberg, J. Frank

2003

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10Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome

H. Gao,J. Sengupta,M. Valle,A Korostelev,N. Eswar,S.M. Stagg,P. Van Roey,R.K. Agrawal,S.T. Harvey,A. Sali,M.S. Chapman,J. Frank

2003

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11Coordinates of S12, L11 proteins and P-tRNA, from the 70S X-ray structure aligned to the 70S Cryo-EM map of E.coli ribosome

M. Valle,A. Zavialov,J. Sengupta,U. Rawat,M. Ehrenberg, J. Frank

2003

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12Coordinates of L11 with 58nts of 23S rRNA fitted into the cryo-EM map of the 70S ribosome

M. Valle,A. Zavialov, W. Li,S.M. Stagg,J. Sengupta,R.C. Nielsen,P. Nissen,S.C. Harvey,M. Ehrenberg, J. Frank

2003

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13Separate Fitting of the Anticodon Loop Region of Trna (nucleotide 26-42) in the Low Resolution Cryo-EM Map of an EF-Tu Ternary Complex (GDP and Kirromycin) Bound to E. Coli 70S Ribosome

M. Valle,J. Sengupta,N.K. Swami,R.A. Grassucci,N. Burkhardt,K.H. Nierhaus,R.K. Agrawal,J. Frank

2002

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14Fitting of EF-Tu and tRNA in the Low Resolution Cryo-EM Map of an EF-Tu Ternary Complex (GDP and Kirromycin) Bound to E. coli 70S Ribosome

M. Valle,J. Sengupta,N.K. Swami,R.A. Grassucci,N. Burkhardt,K.H. Nierhaus,R.K. Agrawal,J. Frank

2002

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15Cryo-EM Reveals an Active Role for Aminoacyl-Trna in the Accommodation Process.

Mikel Valle,Jayati Sengupta,Neil K. Swami,Robert A. Grassucci,Nils Burkhardt,Knud H. Nierhaus,Rajendra K. Agrawal,Joachim Frank

During the elongation cycle of protein biosynthesis, the specific amino acid coded for by the mRNA is delivered by a complex that is comprised of the cognate aminoacyl‐tRNA, elongation factor Tu and GTP. As this ternary complex binds to the ribosome, the anticodon end of the tRNA reaches the decoding center in the 30S subunit. Here we present the cryo‐ electron microscopy (EM) study of an Escherichia coli 70S ribosome‐bound ternary complex stalled with an antibiotic, kirromycin. In the cryo‐EM map the anticodon arm of the tRNA presents a new conformation that appears to facilitate the initial codon–anticodon interaction. Furthermore, the elbow region of the tRNA is seen to contact the GTPase‐associated center on the 50S subunit of the ribosome, suggesting an active role of the tRNA in the transmission of the signal prompting the GTP hydrolysis upon codon recognition.

2002The EMBO Journal（2002）引用：352

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作者统计

合作学者

合作机构

D-Core

合作者
学生
导师

Sengupta Jayati

Sengupta Jayati合作论文数14

S.M. Stagg

S.M. Stagg合作论文数9

Andrey Zavialov合作论文数International Center for Aging and Cancer, Hainan Medical University8

Mans Ehrenberg

Mans Ehrenberg合作论文数8

Rajendra K. Agrawal合作论文数Department of Biomedical Sciences, State University of New York at Albany6

S.C. Harvey

S.C. Harvey合作论文数5

R.C. Nielsen

R.C. Nielsen合作论文数5

Poul Nissen合作论文数Department of Molecular Biology and Genetics, Aarhus University;Faculty of Natural Sciences, Aarhus University5

M.S. Chapman

M.S. Chapman合作论文数4

A. Sali

A. Sali合作论文数4

S.T. Harvey

S.T. Harvey合作论文数4

P. Van Roey

P. Van Roey合作论文数4

Andrei A Korostelev合作论文数Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, RNA Therapeut Inst, Worcester, MA 01605 USA4

Narayanan Eswar

Narayanan Eswar合作论文数4

U. Rawat

U. Rawat合作论文数3

N.K. Swami

N.K. Swami合作论文数2

J. Frank

J. Frank合作论文数2

H. Gao

H. Gao合作论文数2

Knud H. Nierhaus合作论文数Institute of Medical Physics and Biophysics, Charité Universitätsmedizin Berlin;Max-Planck-Institut fur Molekulare Genetik2

Robert A. Grassucci

Robert A. Grassucci合作论文数Wadsworth Center, Empire State Plaza, Albany, NY 12201 USA2

Nils Burkhardt

Nils Burkhardt合作论文数2

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