Schizophrenic patients struggle with figurative language, interpreting non-literal expressions in a literal way. This tendency, called concretism, is considered a schizophrenia core symptom. Despite being well-documented, concretism lacks a comprehensive review on methodological aspects, like stimuli and experimental designs. Following PRISMA guidelines, we conducted a literature review on behavioural studies comparing the comprehension of metaphorical and literal sentences between schizophrenic patients and healthy controls. Findings are limited and controversial, with only 12 articles identified. Studies show a substantial heterogeneity in stimuli and experimental designs. Notably, concretism was observed in only two studies, reflected in accuracy measures, but not reaction times. This review highlights a serious replicability issue, characterized by two intertwined factors. First, insufficient information provided by studies prevents their replication. Second, the lack of dedicated replication experiments, further complicates the findings validation. This considerable methodological heterogeneity likely leads to the involvement of different cognitive mechanisms in task performance, making findings difficult to compare. Although it was not our primary aim, we observed that concretism was not supported by findings which reveal only an overall linguistic impairment. Concretism, traditionally identified in relation to proverbs, has expanded to encompass all forms of figurative language, leading to a case of Epistemic Injustice, i.e., the potentially inaccurate presumption that schizophrenic patients interpret all figurative language literally. This conclusion should not be interpreted as evidence that concretism does not exist, but rather that current literature has yet to consistently and robustly demonstrate its presence.

IntroductionPrevious research has shown that experimentally manipulated physical states of instability negatively affect judgments and opinions. Based on this result, in the current study we want to investigate whether the processing of metaphorical expressions related to physical instability (e.g., “Our economy is shaky”) and underpinned by the conceptual metaphor EMOTIONAL STABILITY IS BALANCE negatively affects participants’ judgments.MethodsThree hundred participants were assigned to three experimental groups. Each group was presented with sentences containing, respectively, stable metaphors, unstable metaphors or unstable literal sentences. After reading the sentences, participants were asked to respond to six topical questions regarding current and future economic and life perspectives.ResultsData shows that across all six topical questions, reading stable metaphors led to more positive judgments compared to unstable sentences (both metaphors and literal ones). Moreover, in four questions out of six, reading unstable metaphorical sentences led to lower ratings compared to unstable literal sentences.DiscussionThese findings support the main claim of Conceptual Metaphor Theory, i.e., the idea that abstract and complex concepts are structured via metaphorical mappings from more concrete and simple ones and align with the Embodied Cognition Hypothesis. Furthermore, these findings suggest that metaphors can have a powerful influence on our perception of the world and contribute to our understanding of how metaphorical language can shape bodily experiences and attitudes.

For the past 25 years, it has been widely believed that humans react automatically to emotional stimuli, as such responses are thought to be crucial for survival. However, recent empirical evidence from studies with healthy individuals suggests that the emotional valence of stimuli influences motor behavior only when it aligns with the individual's goals. In this review, we focused on research examining whether, when, and how emotional facial expressions influence reactive motor inhibition and response readiness in healthy young adults depending on their relevance to current goals. Following PRISMA guidelines, we identified 52 studies using the Stop-signal tasks and Go/No-go where participants responded with their hands or arms. After excluding 10 low-quality studies, 42 articles were retained for inclusion in our review. By selecting this subset of studies, we aimed to ensure consistency and comparability in the research. Despite the presence of several confounding factors that limit the interpretability of the findings, our results suggest that emotional stimuli do not influence motor behavior when they are irrelevant to the task. In contrast, when the emotional content is relevant to the task, the valence of emotional expressions tends to impact behavior. This effect is particularly evident in studies that employed within-subjects designs allowing to control for interindividual variability (n = 7). While further research is certainly needed, the current evidence suggests that emotional expressions do not automatically elicit behavioral responses. Instead, individual's current goals appear to play a pivotal role in determining how people respond to facial emotions.

IntroductionThis study explores how drone movements and human bodily gestures influence spectators’ perceptions, focusing on physical and emotional involvement, aesthetic appreciation, and time perception.MethodsInspired by the iconic staircase scene from the Soviet film The Cranes Are Flying (1957), a set of 81 naturalistic video stimuli was created using a drone-mounted camera, varying in Drone Movement (Ascending, Descending, Still), Human Presence (Female, Male, None), and Image Speed (Normal, Low, Very Slow). Participants evaluated each video based on Liking, Perceived Movement, Physical Involvement, Emotional Involvement and Perceived Duration.Results and discussionResults showed that ascending movements elicited the highest levels of perceived movement, aesthetic appreciation and emotional engagement, outperforming descending and still movements. These results could be explained by a stronger sense of effort and exertion associated with ascending movements, aligning with the embodied simulation of upward motion against gravity. Human presence significantly enhanced ratings across all metrics compared to videos without human figures, thus suggesting that bodily movements play a crucial role in evoking stronger viewer involvement. Additionally, the Female condition received higher aesthetic ratings. Notably, normal image speed yielded greater perceived movement and physical involvement than slowed footage, highlighting a stronger connection to the natural rhythm of bodies in motion. Furthermore, ascending and descending conditions were perceived as lasting longer than still, corroborating prior research on time perception distortions with dynamic stimuli. Correlation analysis highlighted a strong link between physical involvement, emotional engagement, and aesthetic appreciation, underscoring the interplay between bodily and emotional responses. This study emphasizes the potential of drone-based cinematography to evoke embodied and emotional responses, reinforcing the role of embodied simulation theory in cinematic experiences.

IntroductionThe widespread use of surgical masks during the COVID-19 pandemic has posed challenges in interpreting facial emotions. As the mouth is known to play a crucial role in decoding emotional expressions, its covering is likely to affect this process. Recent evidence suggests that facial expressions impact behavioral responses only when their emotional content is relevant to subjects’ goals. Thus, this study investigates whether and how masked emotional faces alter such a phenomenon.MethodsForty participants completed two reaching versions of the Go/No-go task in a counterbalanced fashion. In the Emotional Discrimination Task (EDT), participants were required to respond to angry, fearful, or happy expressions by performing a reaching movement and withholding it when a neutral face was presented. In the Gender Discrimination Task (GDT), the same images were shown, but participants had to respond according to the poser’s gender. The face stimuli were presented in two conditions: covered by a surgical mask (masked) or without any covering (unmasked).ResultsConsistent with previous studies, valence influenced behavioral control in the EDT but not in the GDT. Nevertheless, responses to facial emotions in the EDT exhibited significant differences between unmasked and masked conditions. In the former, angry expressions led to a slowdown in participants’ responses. Conversely, in the masked condition, behavioral reactions were impacted by fearful and, to a greater extent, by happy expressions. Responses to fearful faces were slower, and those to happy faces exhibited increased variability in the masked condition compared to the unmasked condition. Furthermore, response accuracy to masked happy faces dramatically declined compared to the unmasked condition and other masked emotions.DiscussionIn sum, our findings indicate that surgical masks disrupt reactions to emotional expressions, leading people to react less accurately and with heightened variability to happy expressions, provided that the emotional dimension is relevant to people’s goals.

Several studies demonstrated that explicit forms of negation processing (e.g., “I don’t know”) recruits motor inhibitory mechanisms. However, whether this is also true for implicit negation, in which the negative meaning is implicated but not explicitly lexicalized in the sentence (e.g., “I ignore”), has never been studied before. Two Go/No-Go studies, which differed only for the time-windows to respond to the Go stimulus, were carried out. In each, participants (N = 86 in experiment 1; N = 87 in experiment 2) respond to coloured circle while reading task-irrelevant affirmative, explicit negative and implicit negative sentences. We aimed to investigate whether: (i) the processing of implicit negations recruits inhibitory mechanisms; (ii) these inhibitory resources are differently modulated by implicit and explicit negations. Results show that implicit negative sentences recruit the inhibitory resources more strongly when compared to explicit ones, probably due to their inferential nature, likely requiring deeper processing of the negative meaning. Implicit and inferential meaning (i.e., pragmatic information) are grounded too in the same mechanisms that integrate action with perception. Such findings provide further evidence to the embodied account of language, showing that even abstract aspects, like implicit negation, are grounded in the sensory-motor system, by means of functional link between language and motor activity.

Recent research indicates that emotional faces affect motor control only when task-relevant. However, these studies utilized a single-face presentation, which does not accurately mirror real-life situations wherein we frequently engage with multiple individuals simultaneously. To overcome this limitation, we gave 40 participants two versions of a novel Flanker-Go/No-go task, where we presented three-face stimuli with a central target and two task-irrelevant flankers that could be congruent or incongruent with the target for valence and gender. In the Emotional Discrimination Task (EDT), participants had to respond to fearful or happy targets and refrain from moving with neutral ones. In the Gender Discrimination Task (GDT), the same images were shown, but participants had to respond according to the target's gender. In line with previous studies, we found an effect of valence only in EDT, where fearful targets increased reaction times and omission error rates compared to happy faces. Notably, the flanker effect, i.e., slower and less accurate responses in incongruent than congruent conditions, was not found. This likely stems from the higher perceptual complexity of faces than that of stimuli traditionally used in the Eriksen Flanker task (letters or signs), leading to a capacity limit in face feature processing.

In the last decades, the embodied approach to cognition and language gained momentum in the scientific debate, leading to evidence in different aspects of language processing. However, while the bodily grounding of concrete concepts seems to be relatively not controversial, abstract aspects, like the negation logical operator, are still today one of the main challenges for this research paradigm. In this framework, the present study has a twofold aim: (1) to assess whether mechanisms for motor inhibition underpin the processing of sentential negation, thus, providing evidence for a bodily grounding of this logic operator, (2) to determine whether the Stop-Signal Task, which has been used to investigate motor inhibition, could represent a good tool to explore this issue. Twenty-three participants were recruited in this experiment. Ten hand-action-related sentences, both in affirmative and negative polarity, were presented on a screen. Participants were instructed to respond as quickly and accurately as possible to the direction of the Go Stimulus (an arrow) and to withhold their response when they heard a sound following the arrow. This paradigm allows estimating the Stop Signal Reaction Time (SSRT), a covert reaction time underlying the inhibitory process. Our results show that the SSRT measured after reading negative sentences are longer than after reading affirmative ones, highlighting the recruitment of inhibitory mechanisms while processing negative sentences. Furthermore, our methodological considerations suggest that the Stop-Signal Task is a good paradigm to assess motor inhibition’s role in the processing of sentence negation.

concepts are relevant to a wide range of disciplines, including cognitive science, linguistics, psychology, cognitive, social, and affective neuroscience, and philosophy. This consensus paper synthesizes the work and views of researchers in the field, discussing current perspectives on theoretical and methodological issues, and recommendations for future research. In this paper, we urge researchers to go beyond the traditional abstract-concrete dichotomy and consider the multiple dimensions that characterize concepts (e.g., sensorimotor experience, social interaction, conceptual metaphor), as well as the mediating influence of linguistic and cultural context on conceptual representations. We also promote the use of interactive methods to investigate both the comprehension and production of abstract concepts, while also focusing on individual differences in conceptual representations. Overall, we argue that abstract concepts should be studied in a more nuanced way that takes into account their complexity and diversity, which should permit us a fuller, more holistic understanding of abstract cognition.

Embodied music cognition predicts that our understanding of human-made sounds relates to our experience of making the same or similar movements and sounds, which involves imitation of the source of visual and auditory information. This embodiment of sound may lead to numerous kinetic cross-modal correspondences (CMCs). This article investigates music experience in participants with a non-professionally trained music background across three musical dimensions: Contour (Ascending, Descending, Flat), Vertical Density (Low, Medium, High), and Note Pattern (Binary, Ternary, Quaternary). In order that stimuli should reflect contemporary musical usage yet be subject to a high degree of experimental control, 27 ten-second digital piano tracks were created in collaboration with a film composer. In Study 1, participants were asked to rate the stimuli for perceived Direction, Rotation, Movement, and Emotional and Physical Involvement. We test the effects of these factors in terms of the following theories: general and vocal embodied responses to music, the Ecological Theory of Rotating Sounds, and the Shared Affective Motion Experience model of emotion induction. Results for Study 1 were consistent with theories of general and vocal embodied responses to music, as well as with theories of embodied emotional contagion in music. Study 1 also revealed potential confounds in the stimuli, which were further investigated in Study 2 with a new set of participants rating the stimuli for perceived Pitch, Loudness, and Speed. Results for Study 2 served to dissociate intrinsic features of the stimuli from CMCs. Taken together, the two studies reveal a range of embodied CMCs. Although there are limitations to a perceptual study such as this, these stimuli stand to benefit future research in further investigating the embodiment of musical motion.

Motor inhibitory control, a core component of cognitive control, is impaired in Parkinson's disease, dramatically impacting patients' abilities to implement goal-oriented adaptive strategies. A progressive loss of the midbrain's dopamine neurons characterizes Parkinson's disease and causes motor features responsive to dopaminergic treatments. Although such treatments restore motor symptoms, their impact on response inhibition is controversial. Most studies failed to show any effect of dopaminergic medicaments, although three studies found that these drugs selectively improved inhibitory control in early-stage patients. Importantly, all previous studies assessed only one domain of motor inhibition, i.e. reactive inhibition (the ability to react to a stop signal). The other domain, i.e. proactive inhibition (the ability to modulate reactive inhibition pre-emptively according to the current context), was utterly neglected. To re-examine this issue, we recruited cognitively unimpaired Parkinson's patients under dopaminergic treatment in the early (Hoehn and Yahr, 1-1.5, n = 20), intermediate (Hoehn and Yahr 2, n = 20), and moderate/advanced (Hoehn and Yahr, 2.5-3, n = 20) stages of the disease. Using a cross-sectional study design, we compared their performance on a simple reaction-time task and a stop-signal task randomly performed twice on dopaminergic medication (ON) and after medication withdrawal (OFF). Normative data were collected on 30 healthy controls. Results suggest that medication effects are stage-dependent. In Hoehn and Yahr 1-1.5 patients, drugs selectively impair reactive inhibition, leaving proactive inhibition unaffected. In the ON state, Hoehn and Yahr two patients experienced impaired proactive inhibition, whereas reactive inhibition is no longer affected, as it deteriorates even during the OFF state. By contrast, Hoehn and Yahr 2.5-3 patients exhibited less efficient reactive and proactive inhibition in the OFF state, and medication slightly improved proactive inhibition. This evidence aligns with the dopamine overdose hypothesis, indicating that drug administration may overdose intact dopamine circuitry in the earliest stages, impairing associated cognitive functions. In later stages, the progressive degeneration of dopaminergic neurons prevents the overdose and can exert some beneficial effects. Thus, our findings suggest that inhibitory control assessment might help tailor pharmacological therapy across the disease stage to enhance Parkinson's disease patients' quality of life by minimizing the hampering of inhibitory control and maximizing the reduction of motor symptoms. Mirabella et al. examined the impact of dopaminergic treatment (DT) on motor inhibition in Parkinson's patients. They found that DT's effects vary depending on the disease stage. DT hinders inhibitory control in early-stage patients. These results emphasize the importance of carefully adjusting DT in the initial stages of the disease. Graphical Abstract

A classical theoretical frame to interpret motor reactions to emotional stimuli is that such stimuli, particularly those threat-related, are processed preferentially, i.e., they are capable of capturing and grabbing attention automatically. Research has recently challenged this view, showing that the task relevance of emotional stimuli is crucial to having a reliable behavioral effect. Such evidence indicated that emotional facial expressions do not automatically influence motor responses in healthy young adults, but they do so only when intrinsically pertinent to the ongoing subject's goals. Given the theoretical relevance of these findings, it is essential to assess their generalizability to different, socially relevant emotional stimuli such as emotional body postures. To address this issue, we compared the performance of 36 right-handed participants in two different versions of a Go/No-go task. In the Emotional Discrimination task, participants were required to withhold their responses at the display of emotional body postures (fearful or happy) and to move at the presentation of neutral postures. Differently, in the control task, the same images were shown, but participants had to respond according to the color of the actor/actress' t-shirt, disregarding the emotional content. Results showed that participants made more commission errors (instances in which they moved even though the No-go signal was presented) for happy than fearful body postures in the Emotional Discrimination task. However, this difference disappeared in the control task. Such evidence indicates that, like facial emotion, emotional body expressions do not influence motor control automatically, but only when they are task-relevant.

The meaning of music may rely upon perceived motion (Zuckerkandl, 1971). Recently, the framework of embodied music cognition, which draws on the discovery of mirror neurons and the theory of embodied simulation (Gallese, 2007), makes the claim that our understanding of human-made sounds draws upon our experience of making the same or similar movements and sounds, which involves imitation of the source of visual and auditory information (Cox, 2011). This paper investigates perceived motion and embodied music experience in non-musicians across three musical dimensions: melodic contour (ascending, descending and flat), melodic complexity (low, medium, high) and, following from Hanson and Huron (2019), note pattern (binary, ternary, quaternary). As part of an initiative to adhere to a high aesthetic standard, 27 ten-second piano tracks were created in collaboration with a film composer. In the computer task, participants rated stimuli on a Visual Analogue Scale (VAS) ranging from 0 to 100 for perceived Direction, Rotation, Movement, and Emotional and Physical Involvement. Results showed that: 1) Quaternary conditions were perceived as having significantly more Rotation, Movement and being more Physically Involving than Ternary and Binary, 2) High Complexity conditions were perceived as evoking significantly more Movement and being more Emotionally Involving than Low and Medium, and 3) Ascending conditions were perceived as having significantly more Movement, Rotation and being more Emotionally and Physically Involving than Descending and Flat. Results indicate that greater embodiment evoked by musical ascent may be modulated by greater perceived exertion or ‘effort’ to reach higher pitches, in line with the mimetic subvocalization hypothesis (Cox, 2017). Future studies are needed to investigate whether perceived rotation is driven by note pattern (i.e. metre) or note density and pitch., and how musical contour and rotation impact sensorimotor activation in the brain.

The COVID-19 pandemic has dramatically changed the nature of our social interactions. In order to understand how protective equipment and distancing measures influence the ability to comprehend others’ emotions and, thus, to effectively interact with others, we carried out an online study across the Italian population during the first pandemic peak. Participants were shown static facial expressions (Angry, Happy and Neutral) covered by a sanitary mask or by a scarf. They were asked to evaluate the expressed emotions as well as to assess the degree to which one would adopt physical and social distancing measures for each stimulus. Results demonstrate that, despite the covering of the lower-face, participants correctly recognized the facial expressions of emotions with a polarizing effect on emotional valence ratings found in females. Noticeably, while females’ ratings for physical and social distancing were driven by the emotional content of the stimuli, males were influenced by the “covered” condition. The results also show the impact of the pandemic on anxiety and fear experienced by participants. Taken together, our results offer novel insights on the impact of the COVID-19 pandemic on social interactions, providing a deeper understanding of the way people react to different kinds of protective face covering.

According to embodied simulation theory, humans tacitly ‘simulate’ the actions of the other by mapping them in the sensorimotor cortex of the brain. According to the framework of embodied cinema, the meaning-making process in film is considered to be inextricably linked to the interrelation between the brain, body and environment of the viewer. Athough there are a growing number of theoretical and technological studies on the embodied nature of drone flight, to date no studies have investigated the effect of drone footage with and without human bodily movement on spectators’ cognitive behavioral mechanisms. Thus, the present study investigates the relationship between Drone Movement (Ascending, Descending, Still) , Actor Presence (Female, Male, None) and Image Speed (Normal, Slow, Very Slow) on perceived motion, appeal and involvement measures. To achieve these aims, a custom-made, naturalistic set of video stimuli modeled after the staircase scene in the Soviet film The Cranes Are Flying (Kalatozov, 1957) was created using a DJI Phantom Pro 4 Drone. In the experimental task (carried out at the computer), participants were asked to rate video stimuli using a Visual Analogue Scale (VAS) ranging from 0 to 100 for perceived Duration, Liking, Movement, and Emotional and Physical Involvement. Results demonstrate that: 1) Ascending and Descending had significantly higher ratings for perceived Duration, Movement and Physical and Emotional Involvement than Still; 2) Ascending had significantly higher ratings for perceived Duration, Movement and Emotional Involvement than Descending; 3) Female and Male had significantly higher ratings for Movement, Physical Involvement and Emotional Involvement than None (No Actor); 4) Normal Image Speed had significantly higher ratings for Movement, Physical Involvement and Emotional Involvement with respect to Slow and Very Slow. Results indicate that drone/actor ascent may evoke more motion and involvement due to perceived exertion or ‘effort’ to climb up the stairs, and that participants resonate more with conspecifics and familiar repertoires, in support of embodied simulation theory. Results also indicate that movement in the drone/actor image modulates perceived time. Neuroimaging studies are needed to investiate the impact of drone movement with or without human bodily movement on cortical sensorimotor activation in the brain.

Brain vascular damage accumulate in aging and often manifest as white matter hyperintensities (WMHs) on MRI. Despite increased interest in automated methods to segment WMHs, a gold standard has not been achieved and their longitudinal reproducibility has been poorly investigated. The aim of present work is to evaluate accuracy and reproducibility of two freely available segmentation algorithms. A harmonized MRI protocol was implemented in 3T-scanners across 13 European sites, each scanning five volunteers twice (test-retest) using 2D-FLAIR. Automated segmentation was performed using Lesion segmentation tool algorithms (LST): the Lesion growth algorithm (LGA) in SPM8 and 12 and the Lesion prediction algorithm (LPA). To assess reproducibility, we applied the LST longitudinal pipeline to the LGA and LPA outputs for both the test and retest scans. We evaluated volumetric and spatial accuracy comparing LGA and LPA with manual tracing, and for reproducibility the test versus retest. Median volume difference between automated WMH and manual segmentations (mL) was -0.22[IQR = 0.50] for LGA-SPM8, -0.12[0.57] for LGA-SPM12, -0.09[0.53] for LPA, while the spatial accuracy (Dice Coefficient) was 0.29[0.31], 0.33[0.26] and 0.41[0.23], respectively. The reproducibility analysis showed a median reproducibility error of 20%[IQR = 41] for LGA-SPM8, 14% [31] for LGA-SPM12 and 10% [27] with the LPA cross-sectional pipeline. Applying the LST longitudinal pipeline, the reproducibility errors were considerably reduced (LGA: 0%[IQR = 0], p < 0.001; LPA: 0% [3], p < 0.001) compared to those derived using the cross-sectional algorithms. The DC using the longitudinal pipeline was excellent (median = 1) for LGA [IQR = 0] and LPA [0.02]. LST algorithms showed moderate accuracy and good reproducibility. Therefore, it can be used as a reliable cross-sectional and longitudinal tool in multi-site studies.

Abstract The COVID-19 pandemic has dramatically changed the nature of our social interactions. In order to understand how protective equipment and distancing measures influence the ability to comprehend others’ emotions and, thus, to effectively interact with others, we carried out an online survey across the Italian population during the first pandemic peak. Participants were shown static facial expressions (Angry, Happy and Neutral) covered by a sanitary mask or by a scarf. They were asked to evaluate the expressed emotions as well as to assess the degree to which one would adopt physical and social distancing measures for each stimulus. Results demonstrate that, despite the covering of the lower-face, participants correctly recognized the facial expressions of emotions with a polarizing effect on emotional valence ratings found in females. Noticeably, while females’ ratings for physical and social distancing were driven by the emotional content of the stimuli, males were influenced by the “covered” condition. The results also show the impact of the pandemic on anxiety and fear experienced by participants. Taken together, our results offer novel insights on the impact of the COVID-19 pandemic on social interactions, providing a deeper understanding of the way people react to different kinds of protective face covering.

Vascular damage increases with normal aging and appear as WMH signals on FLAIR images. Recently, fully automatic tools to segment the WMHs have been developed (for a review see Caligiuri, 2015). These tools aim to replace manual segmentation, gaining time and reducing the variability given by different raters. Up for now, a shared gold standard for an automatic tool has not been achieved. The aim of this preliminary study was to investigate the WMHs segmentation obtained by different algorithms in terms of i) volumetric accuracy compared to manual segmentation and ii) effect of different scanner. Five healthy local volunteers (55-90 years) were enrolled for 13 sites across Europe. Each participant underwent 3T MRI (Siemens, GE, Philips) protocol including 2D Flair. The manual segmentation was performed using FSL (version 5.0.3), a library of analysis tools for MRI data for analyzing brain images, while the automatic segmentation by two algorithms of the Lesion Segmentation Toolbox (LST, version 2.0.15, Schmidt, 2012) implemented in Statistic Parametric Mapping (SPM12): Lesion growth algorithm (LGA) and Lesion prediction algorithm (LPA). Intraclass Correlation Coefficients (ICC) was performed to evaluate the agreement between volume of each automatic and manual segmentation. Wilcoxon rank test was applied to test for difference between each automatic and manual methods. Kruskal-Wallis test on coefficient of variation (CV) was computed to investigate the scanner effect on the LST accuracy. Both LGA and LPA showed high volumetric agreement with the manual segmentation (LGA-ICC: 0.80; LPA-ICC: 0.81). Moreover, Wilcoxon rank test reveals that LGA volumes (mean±SD=1565±2992) were significantly different than manual volumes (mean±SD=2119±4006, p=0.007) while LPA (mean±SD=1860±3924) and manual volumes were comparable (p=0.201). There was no significant scanner effect on accuracy of both algorithms (LGA: p=0.167; LPA: p=0.097). Although both the tested algorithms show high agreement with manual segmentation and were not influenced by scanner type, but LPA seems to be more accurate to evaluate vascular damage. Pharmacog is funded by the EU-FP7 for the Innovative Medicine Initiative (grant n°115009).