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When sequences of digits are visually presented within a numerical keypad on a screen, memory span increases, this effect was named visuospatial bootstrapping. The aim of the first experiment was to know if this effect could emerge without presenting a keypad on the screen. For this purpose, a three-phase experiment was designed. During phase 1, the immediate serial recall of two groups of participants was compared (pre-training): the first group saw sequences of one-digit numbers displayed on a screen within a keypad (the keypad group) whereas the second group heard the (same) sequences (the auditive group). During phase 2, all participants underwent a training session to help them visualise in their mind a keypad. Finally, in the third phase, participants were tested again with an immediate serial recall task (post-training). Results showed that both groups had comparable performance in post-training indicating that the visuospatial bootstrapping could be obtained without displaying a numerical keypad. The second experiment also involved a keypad group and an auditive group and was designed to investigate their spatial representation. Results showed that both groups spatialised the digits following the keypad spatial configuration: digits 1-4-7 were associated to left, 2-5-8 to middle and 3-6-9 to right.

Palatable sweet/fatty foods overconsumption is a major risk factor for obesity and eating disorders, also having an impact on neuro-behavioural hedonic and cognitive components comparable to what is described for substance abuse. We hypothesized that Yucatan minipigs would show hedonic, cognitive, and affective neuro-behavioral shifts when subjected to western diet (WD) exposure without weight gain, after the onset of obesity, and finally after weight loss induced by caloric restriction with (RYGB) or without (Sham) gastric bypass. Eating behavior, cognitive and affective abilities were assessed with a spatial discrimination task (holeboard test) and two-choice feed tests. Brain responses to oral sucrose were mapped using 18F-FDG positron emission tomography. WD exposure impaired working memory and led to an “addiction-type” neuronal pattern involving hippocampal and cortical brain areas. Obesity induced anxiety-like behavior, loss of motivation, and snacking-type eating behavior. Weight loss interventions normalized the motivational and affective states but not eating behavior patterns. Brain glucose metabolism increased in gustatory (insula) and executive control (aPFC) areas after weight loss, but RYGB showed higher responses in inhibition-related areas (dorsal striatum). These results showed that diet quality, weight loss, and the type of weight loss intervention differently impacted brain responses to sucrose in the Yucatan minipig model.