Background: Vitiligo is a common, acquired, discoloration of the skin, characterized by well circumscribed, ivory or chalky white macules which are flush to the skin surface. Although majority of cases are managed by medical therapies, surgical methods are reserved for lesions not responding to medical treatment and are stable in nature. The basic principle surgical method is the transfer of melanocytes from uninvolved skin to the stable vitiligo patch in the form of either tissue graft or cellular graft. Purpose: To evaluate the effects of topical corticosteroids and PUVAsol in repigmentation of vitiligo patch following split-thickness skin grafting. Methods: Twenty patients of stable vitiligo having total 30 patches were included in the study of which 15 completed it. Each patch is subjected to split-thickness skin grafting and then randomly divided into two groups of fifteen each. Group A received PUVAsol therapy while other received topical steroid therapy started 4 weeks after surgery. During the follow-up of 6 months, five patients were lost to follow-up; fifteen patients were evaluated for pigment spread and side effects at 1st, 4th, 8th, and 24th week. Results: Eight patients (61.53%) in PUVA sol group and seven patients (58.3%) in steroid group had excellent (>90%). Color matching of grafted area was observed to be better with steroid therapy (83.3%), then PUVAsol (76.9%). Conclusion: Although the extent of repigmentation was more in Group A (PUVAsol) then in Group B, the color matching and the side effect profile were improved in Group B (topical steroid). The use of topical corticosteroid is much less cumbersome, cheaper, and easy to administer at home. The limitation of our study was short follow-up and small sample size.
Lupus vulgaris (LV) is a chronic and progressive form of cutaneous tuberculosis. The lesions may sometimes be associated with extensive destruction of tissue resulting in marked disfigurement and morbidity. A high index of suspicion is crucial for early diagnosis and treatment and thereby prevention of cosmetic deformity. Lupus vulgaris presenting as disseminated mutilating lesions in a child is uncommon, especially in today's era. Herein, we report an unusual case of lupus vulgaris with coexistence of multiple ulcerative mutilating lesions over face and classical plaque over distant site (right thigh) in a 9 year old girl.
A 36-year-old mother and her 9-year-old daughter presented with multiple facial papules. In both cases, the papules had started to develop at about the age of 8-9 years. Biopsy of one of the mother′s papules revealed a trichoepithelioma. Both mother and daughter were otherwise well. However, there have been rare reports of multiple trichoepitheliomas being associated with systemic conditions. Multiple trichoepitheliomas are inherited in an autosomal dominant manner and have been mapped to chromosome 9p21.
Verrucous epidermal nevi are congenital, noninflammatory, cutaneous hamartomas composed of keratinocytes. To the best of our knowledge, only single case of lichen planus (LP) arising in an inflammatory linear verrucous epidermal nevus has been reported. We herewith report a case of 10-year-old boy who developed LP over linear epidermolytic verrucous epidermal nevus.
Background: Reports from different parts of the country have revealed wide variation in the clinical profile of childhood vitiligo. Variations exist with respect to age, sex, family history, Koebner phenomena and presence of other cutaneous disease. Aim: The aim of the following study is to assess the clinical profile and other cutaneous disease in childhood vitiligo. Materials and Methods: This study was designed to find the clinical characteristics of childhood vitiligo (in the age group < 12 years) in the Outpatient Department of Dermatology, Venereology and Leprology, Government medical college, Kota, between July 2012 and June 2013. A total of 35 childhood vitiligo patients were examined. Results: Out of 35 children, 20 patients (57.14%) were female and 15 patients (42.86%) were male. In most of the patients, disease onset was < 10 year of age and mean age of onset was 6.64 1 year. The most common pattern observed in childhood vitiligo was vitiligo vulgaris (17 patients) followed by focal (9 patient). Other less common pattern were segmental (4 patients), mucosal (2 patients), mixed (1 patient), contact (1 patient), acrofacial (1 patient). Out of 35 patients, 6 patients had a family history, 12 patients had Koebner phenomena, and 3 patients had leucotrichia. Other cutaneous dermatoses was found in 4 patients out of which 3 patients had halo nevus and 1 patient had atopic dermatitis.Conclusion: Childhood vitiligo in Hadoti region showed a preponderance in females and most common pattern were vitiligo vulgaris followed by focal vitiligo.
Child abuse is a major public health crisis and is on the rise. Dermatologists are frequently involved in its evaluation in differentiating abusive injuries from accidental injuries and in excluding pathological conditions that may mimic abuse. Munchausen syndrome by proxy (MSBP) is a rare form of child abuse where the parents or caretaker, intentionally causes an illness in the child for her own self-serving psychological needs. A 6-year-old orphan girl presented with spontaneous ulcers over bilateral lower limbs since last 6 months. The girl was investigated thoroughly in detail for possible causes of ulcers but nothing came out. Diagnosis of MSBP was firmly established in the case.
Netherton syndrome (NS) is a rare disorder consisting of ichthyosis, hair shaft abnormalities and atopic dermatitis. It is inherited in an autosomal recessive pattern. Patients with NS have been found to have a mutation in a gene named serine protease inhibitor, Kazal type-5. Here, we report a female child with NS.