Rationale: There is no effective pharmacological treatment for acute lung injury (ALI). Statins are a potential new therapy because they modify many of the underlying processes important in ALI.Objectives: To test whether simvastatin improves physiological and biological outcomes in ALI.Methods: We conducted a randomized, double-blinded, placebo-controlled trial in patients with ALI. Patients received 80 mg simvastatin or placebo until cessation of mechanical ventilation or up to 14 days. Extravascular lung water was measured using thermodilution. Measures of pulmonary and nonpulmonary organ function were assessed daily. Pulmonary and systemic inflammation was assessed by bronchoalveolar lavage fluid and plasma cytokines. Systemic inflammation was also measured by plasma C-reactive protein.Measurements and Main Results: Sixty patients were recruited. Baseline characteristics, including demographics and severity of illness scores, were similar in both groups. At Day 7, there was no difference in extravascular lung water. By Day 14, the simvastatin-treated group had improvements in nonpulmonary organ dysfunction. Oxygenation and respiratory mechanics improved, although these parameters failed to reach statistical significance. Intensive care unit mortality was 30% in both groups. Simvastatin was well tolerated, with no increase in adverse events. Simvastatin decreased bronchoalveolar lavage IL-8 by 2.5-fold (P = 0.04). Plasma C-reactive protein decreased in both groups but failed to achieve significance in the placebo-treated group.Conclusions: Treatment with simvastatin appears to be safe and may be associated with an improvement in organ dysfunction in ALI. These clinical effects may be mediated by a reduction in pulmonary and systemic inflammation.Clinical trial registered with www.controlled-trials.com (ISRCTN70127774).

The authors present the findings of a special task group (STG) organized to explore effective training strategies for the practice guidelines focused on diverse populations. They provide a brief literature review and summarize survey data from academic training directors regarding current use of practice guidelines. The authors then describe the Integrative Training Model (ITM), developed by the STG, as a framework for students and professionals to incorporate the complex array of information contained in each set of guidelines. Unique challenges associated with incorporating the ITM are described, as well as pedagogical considerations for both students and current professionals. The authors believe the ITM may help students and professionals increase their diversity competence by developing a more holistic understanding of the various dimensions and social group experiences that affect their clients and themselves.

The estuary is a high-energy and very variable system, with a hypertidal, semidiurnal tidal regime. The amount and coarseness of the sediment trapped on filter papers, and the suspended silt concentration in the flood tidal front, were measured daily from mudflat and marsh stations at each of six sites during eight spring–neap cycles spread over a two-year period. Four of the cycles were associated with vernal equinoxes and four with autumnal equinoxes. River discharge, wind speed, tidal height and the suspended sediment concentration all affect the amount and texture of the trapped mud. Complex tidal patterns are unlikely to be registered other than very imperfectly in these tidal deposits. At any site, the silts deposited on the mudflats are slightly coarser than those accreted on the marshes. Both marsh and mudflat deposits tend to become less sandy but more clayey toward the mouth of the estuary. The sediments trapped on the mudflats and marshes during vernal equinoxes tend at a site to be sandier and less clayey than their autumnal counterparts. As the vernal and autumnal, equinoctial tidal regimes are virtually identical, and river discharge has a negligible influence, winter storminess and the substantial annual change in water temperature, affecting viscosity, may largely be the explanation, with biological factors possibly augmenting the effect.

Six sites monitored monthly on salt marshes and mudflats in the middle and outer Severn Estuary gave potentially predictive–retrodictive relationships between the vertical response of the sedimentary surface (erosion/accretion), a factor reflecting tidal heights, and the wind-wave power-supply. The continuing rise of relative sea level in the area, at the rate of a few millimetres annually, is providing accommodation space at a pace low enough to permit the continuing vertical build-up of the salt marshes throughout the estuary. On the mudflats, wind and tidal conditions during the survey maintained an accretionary regime in the middle estuary but an erosional one in the outer part. The Severn Estuary is a system in delicate balance which is likely to respond dramatically to modest changes in the tidal and/or wind regimes.

Menschenerythrocyten-Schatten wurden in Gegenwart von [3H]-Adenosin-3′ 5′-phosphat undurchlässig. Der Ausfluss der Nukleotide, in isotonischem Cholinchlorid, wurde von Hepes nicht beeinflusst.

Ca 2+ -ATPase activity, high affinity Ca 2+ binding in the presence and absence of ATP and low affinity Ca 2+ binding at added CaCl 2 concentrations of 1 μM, 100 μM and 10 mM were measured in isolated erythrocyte membranes from cystic fibrosis and control subjects. No significant difference was detected between the two groups for any of these measurements.

Conference Article| June 01 1974 Molecular Groups Responsible for the Binding of Calcium Ions in the Erythrocyte Membrane M. J. DUFFY; M. J. DUFFY 1Departments of Medical Biochemistry and Child Health, University of Manchester Medical School, Manchester M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar V. SCHWARZ V. SCHWARZ 1Departments of Medical Biochemistry and Child Health, University of Manchester Medical School, Manchester M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1974) 2 (3): 403–405. https://doi.org/10.1042/bst0020403 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation M. J. DUFFY, V. SCHWARZ; Molecular Groups Responsible for the Binding of Calcium Ions in the Erythrocyte Membrane. Biochem Soc Trans 1 June 1974; 2 (3): 403–405. doi: https://doi.org/10.1042/bst0020403 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1974 Biochemical Society1974 Article PDF first page preview Close Modal You do not currently have access to this content.

Conference Article| June 01 1974 The Effects of Adenosine 3′:5′-Cyclic Monophosphate and Adenosine Triphosphate on Calcium Ion Binding in Erythrocyte Membranes M. J. DUFFY; M. J. DUFFY 1Departments of Medical Biochemistry and Child Health, University of Manchester Medical School, Manchester M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar V. SCHWARZ V. SCHWARZ 1Departments of Medical Biochemistry and Child Health, University of Manchester Medical School, Manchester M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1974) 2 (3): 406–407. https://doi.org/10.1042/bst0020406 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation M. J. DUFFY, V. SCHWARZ; The Effects of Adenosine 3′:5′-Cyclic Monophosphate and Adenosine Triphosphate on Calcium Ion Binding in Erythrocyte Membranes. Biochem Soc Trans 1 June 1974; 2 (3): 406–407. doi: https://doi.org/10.1042/bst0020406 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1974 Biochemical Society1974 Article PDF first page preview Close Modal You do not currently have access to this content.

Cyclic AMP stimulated phosphorylation of the erythrocyte membrane was measured in cystic fibrosis and control subjects. No significant difference was detected.

Research Article| February 01 1972 Phosphorylation of the erythrocyte membrane: stimulation by adenosine 3′:5′-cyclic monophosphate M J Duffy; M J Duffy 1Department of Medical Biochemistry, University of Manchester, Manchester M13 9PL, U.K. Search for other works by this author on: This Site PubMed Google Scholar V Schwarz V Schwarz 1Department of Medical Biochemistry, University of Manchester, Manchester M13 9PL, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1972) 126 (3): 12P–13P. https://doi.org/10.1042/bj1260012Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation M J Duffy, V Schwarz; Phosphorylation of the erythrocyte membrane: stimulation by adenosine 3′:5′-cyclic monophosphate. Biochem J 1 February 1972; 126 (3): 12P–13P. doi: https://doi.org/10.1042/bj1260012Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 London: The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.