Aim: We aim to explore how the basal LH/FSH ratio and basal E2 levels correlate with the quality and number of oocytes and embryos, as well as with clinical pregnancy outcomes in patients with polycystic ovary syndrome. Materials and Methods: Cases with polycystic ovary syndrome between the ages of 18-35 were involved in the study. The characteristic features of the cases, laboratory values, total stimulation duration and dose, endometrium thickness and dominant follicle number on the ovulation trigger day, maturity and number of oocytes, quality and number of embryos, number of transferred embryos, implantation rate and clinical pregnancy rates were recorded from the hospital registry system and files. SPSS version 26.0 is used for analyzing the data. Results: The average number of oocytes obtained from all cases was 15, MII oocyte rate was 84.6%, embryo number was 8 and high quality embryo rate was 66%. MII oocyte rate and embryo number were higher in group 2 (p=0.005 and p=0.003). A negative relation was found between basal E2 levels and M2 oocyte rates (r=-0.1, p=0.02). No notable correlation was detected between basal E2 levels and good quality embryo rate (r=0.05, p=0.5). Conclusion: It was found that in polycystic ovary syndrome cases with a basal LH/FSH ratio ≥ 1.5, mature oocyte ratio was higher and basal E2 level was inversely related to mature oocyte ratio. However, it was determined that these effects were not reflected in embryo quality and clinical pregnancy results.

Background/Aim: This study examines the difference of serum CRP and CA 125 levels between the menstrual and non-menstrual phases of the menstrual cycle (days 2 and 14) and aims to investigate the diagnostic value of these markers for the early diagnosis of endometriosis.Methods: There were 36 patients in the study group and 30 patients in the control group (n = 66) in this prospective case-control study.The patients in the study group, who were prediagnosed with endometriosis, were tested for serum CA 125 and CRP on the 2 nd and 14 th days of menstrual cycle preoperatively (during menstruation and non-menstrual phase) and underwent surgery.The women in the control group were patients who visited the outpatient clinic for a regular checkup without any gynecological complaints. Results:The CA 125 levels were significantly higher on the 2 nd day of the menstrual cycle than the 14 th day in the study group [108.15(90.33)U/mL and 58.60 (39.53)U/mL, respectively, P < 0.001].In the control group, the CA 125 levels were also significantly higher on the 2 nd day than the 14 th day [22.97 (15.42)U/mL and 13.82 (6.82) U/mL, respectively, P < 0.001].When the comparison was made between the CRP levels on the 2 nd and 14 th day for the study group [4.52 (4.45) mg/L and 2.82 (3.79) mg/L, respectively], the levels were significantly higher on the 2 nd day (P < 0.001).The difference of CA 125 and CRP levels between the days [for the study group: ΔCA 125 = 49.55(56.89)U/mL, ΔCRP = 1.69(3.45)mg/L and for the control group ΔCA 125 = 9.14 (11.95) U/mL, ΔCRP = 1.42 (4.74) mg/L] were higher for both markers in the study group, and the differences with the control group were statistically significant (P < 0.001 for ΔCA 125 and P = 0.033 for ΔCRP). Conclusion:Our data indicates that it may be possible to support the diagnosis with the evaluation of CA 125 levels during different phases of menstruation separately.

Burns are serious life-threatening health problems. This study was performed to determine the effect of educated platelets on burn wound healing process. 28 female wistar albino 200-220 gr rats were randomly divided into four groups. Group A1 rats(n:7) were the first-line burnt group from which blood samples are extracted to develop platelet-rich plasma(PRP) with the educated platelets that have a response to burn injury. Group B1 rats(n:7) were the unburnt group with ordinary platelets. Group A2 rats(n:8) were the second-line burnt group which was given PRP with educated platelets. Group B2 rats(n:6), as control group, were the second-line burnt group which was given PRP with ordinary platelets. Photos of rats' dorsum were taken by digital camera on the first day and 21st day of the study. Wound healing was determined by scar surface area. In the study group (Group A2) mean wound area was  53±37 mm², in the control group (Group B2) mean wound area was 114±55 mm² on the last day of the experiment. The sizes of the wounded areas were significantly lower in the study group compared with the control group (p: 0.039). Educated platelets seem to facilitate the recovery period of burn wound healing in rats.

Uterine fibroids are the most common benign tumors in women in the reproductive age group. The incidence of fibroids during pregnancy varies between 1.6 and 10.7%. In 10% of these cases, fibroids lead to complications. The management in symptomatic patients is conservative, and the surgical treatment is delayed until after birth due to its risks. In the last two decades, it has been shown that myomectomy can be an alternative treatment in selected cases, especially in second-trimester pregnancies. However, the data on the success of myomectomies performed earlier in pregnancy are limited. In this case report, we present two cases who were admitted to our clinic during the first trimester of pregnancy and had complicated fibroids. The diagnosis, the follow up and the treatment are presented with the review of the literature.

In December 2019, in Wuhan, China, scientists observed a sudden and sharp increase in the number of cases of pneumonia and acute respiratory distress syndrome of an unknown origin. By the end of January 2020, the outbreak had spread to Asia, Europe, America, and Australia. In this article, we have outlined the pandemic action plan of our university hospital.

Background: The aim of this study is to evaluate the importance of ischemia changed albumin, in foreseeing fetal asphyxia and comparing it between normal and preeclamptic pregnant. Method: We planned our study as a prospective case-controlled study between May 2011 and June 2013. We recruited 104 pregnant women complicated by preeclampsia and 110 healthy pregnant women in the study. Doppler ultrasonography, non-stress test and fetal biometric measurements were performed. Venous blood samples taken to measure ischemia modified albumin (IMA). The presence of fetal hypoxia/acidosis was analyzed by conducting post-natal cord blood gas examination and 1.-5. minutes APGAR scoring. Results: IMA levels in the preeclamptic group were found statistically high (p<0,0001). The correlations between umbilical artery doppler systolic/diastolic (S/D) ratio, brain sparing effect, non stress test and IMA analyzed. We have found IMA statistically high when S/D ratio is above 2 standard deviations (preeclampsia; 11.83±1.33 vs 19.62±1.56 p<0.001, control; 10.28±1.57 vs 18.09±2.13 p<0.001) or brain sparing effect started (preeclampsia; 25.59±2.48 vs 9.16±1.99 p<0.001, control; 16.37±1.97 vs 6.72± 1.53 p<0.001) or abnormal NST findings occurred (preeclampsia; 10.69±1.92 vs 20.72±1.15 p<0.001, control; 7,42±1,94 vs 9,72±2,19 p<0.001). Conclusions: Maternal IMA levels are found high in preeclamptic pregnant women and it can be used as a biomarker for determining fetal wellbeing. What’s already known about this topic? Hypertensive disease of pregnancy is the most frequently complication of pregnancy, being 5-10%. It is the most important reason for perinatal morbidity and mortality. Preeclampsia develops in an abnormal hypoxic intrauterine environment characterized by reperfusion and oxidative stress. To determine the fetal wellbeing, various tests were suggested, yet many of them provided a few benefits. What does this article add? The detected elevations in serum concentrations of IMA propose that measurements of this biomarker may be useful in assessing fetal hypoxia and predicting pregnancies which preeclampsia may develop

Parasitic myomas occur especially after laparoscopic myomectomy and its incidence increases due to the use of morcellators. Parasitic myomas can rarely occur at the port entry site, being more commonly seen on the intestines, the omentum, the ureter, the bladder, and the diaphragm in different periods after surgery, the average duration being 24 months. In this article, we present the case of parasitic myoma developing secondary to the port site in a 45-year-old nulliparous woman after the use of laparoscopic myomectomy and morcellation 8 years ago. The patient presented with complaints of pelvic pain and a palpable mass in the left trocar incision line, and an appearance compatible with multiple myomas in the subcutaneous tissue of the left trocar incision line. Besides, myomas were also observed in the mesentery of the rectosigmoid colon and at the uterus in the present study. Numerous and large myomas were observed in the uterus, in the mesentery of the rectosigmoid colon, on the left pelvic peritoneum, and under the skin corresponding to the port entrance. The pathological examination of the myomas excised was reported as leiomyoma. In this article, the diagnosis, the treatment, the possible risk factors, and the complications of myomas were discussed in the light of the literature.

Prematür ovaryen yetmezlik, kadınlarda 40 yaşından önce gonadotropin yüksekliğine, düşük östrojen seviyesinin eşlik ettiği erken ovaryen fonksiyon kaybıdır

Epithelioid trophoblastic tumors (ETTs) are extremely rare gestational trophoblastic neoplasia and a subtype of the placental site trophoblastic tumors (PSTTs). To our knowledge, there have been only 110 patients diagnosed with the ETT. ETT is generally seen in the reproductive period, following term pregnancy. Generally, as in PSTT, β-HCG levels are normal or slightly elevated. The most common complaint is abnormal vaginal bleeding. At the time of diagnosis, findings of metastasis can be seen in 50% of the cases. Transvaginal ultrasonography (TV-USG) and computed tomography (CT) are used for imaging in the literature. Surgical treatment and follow-up are sufficient in the early stages. We present a case of a 37-year-old ETT patient who suffered from irregular vaginal bleeding.

INTRODUCTION: Chromosome anomalies are one of the major causes of premature ovarian failure and the importance of chromosome analysis in reproductive management has been confirmed. Numerical and structural chromosome anomalies, especially structural anomalies of the X chromosome, X-autosome translocations and X-chromosome aneuploidies, are the chromosome anomalies most commonly described in the literature. In this study, we aimed to evaluate the frequency and type of chromosomal anomalies in the patients with premature ovarian failure admitted to our clinic and to discuss the findings in the light of current literature and to provide guidance to new studies. METHODS: The files of the patients, who were diagnosed with premature ovarian failure between 2002 and 2017, were screened from the archive of the division of reproductive endocrinology and infertility in the department of obstetrics and gynecology at our center. 65 patients were included in the study. Information about age, smoking, alcohol use, age at menarche and menapose, hormone replacement therapy usage, additional disease and obstetric history were obtained from files. The laboratory results of the patients were obtained from files. FSH, LH, estradiol, prolactin, TSH, fT3, fT4, Anti-TPO, Anti-TG, TRAB, cortisol, ANA, Insulin, fasting blood glucose, LDL, HDL, triglyceride, total cholesterol, anti-Mullerian hormone levels were recorded from files. The karyotype results were recorded from files. RESULTS: The mean age at diagnosis was 32.6 years.The mean body mass index was 23.4(kg/m²). 60(92.3%) had normal karyotype(46+XX). 5(7.7%) had abnormal karyotype(4 had 46+XX/45+X and 1 had 46+XY/45+X). The mean value of fT3 is significantly higher in cases with normal karyotype(p: 0.019). DISCUSSION AND CONCLUSION: Considering the high rate of X chromosome loss in patients with premature ovarian failure, we can say that premature ovarian failure manifests itself in a wide spectrum. In conclusion, it can be said that cytogenetic studies should be evaluated routinely in cases with premature ovarian failure regardless of age.

The aim of this study is to evaluate the presence of residual tubal tissue and endosalpingiosis on the ovarian surface after salpingectomy. A total of 105 ovarian tissues of 54 patients who underwent abdominal total hysterectomy with bilateral or unilateral salpingo-oophorectomy for benign indications between January 2019 and December 2019 were included in the study. Salpingectomy was performed prior to oophorectomy in all patients. The adhesion grade score was calculated for each case. Persistent tubal epithelium was found in 16 (29.6%) of the patients. There was a significant difference in adhesion scores between the persistent tubal epithelium negative and persistent tubal epithelium - positive patients (p = 0.041). In conclusion, permanent tubal epithelium may remain in the ovaries after salpingectomy. Persistent tubal epithelium is more common in cases with intra-abdominal adhesions. Opportunistic and risk-reducing salpingectomy is effective to prevent ovarian cancer, although it is not a definitive solution.

Tanatoforik displazi, genelde perinatal donemde olumle sonuclanan ve kisa ekstremiteler ile kendini gosteren yenidoganin cucelik sendromlarindan biridir. Makrosefali, belirgin alin, dar toraks, vertebralarda duzlesme, ekstremitelerde kisalik, femurda egrilme ile karakterizedir. Fibroblast buyume faktoru reseptoru 3 ( FGFR3) genindeki mutasyonlardan kaynaklanir ve otozomal dominant kalitim modeli gosterir. Bu makalede, prenatal donemde anormal USG bulgulari olan, amniyosentez materyalinden yapilan FGFR3 gen analizi ile p.R248C mutasyonu saptanan bir olgu anlatilmistir.

To evaluate whether uterine artery (UtA) Doppler velocimetry during peak uterine contraction is a useful marker for the prediction of preterm delivery.

Objective: To demonstrate a correlation between neuroendocrine hormone changes in menopause and obstructive sleep apnea syndrome (OSAS), excluding risk factors, i.e., depression, and treatment of cases where the disease has been diagnosed.Methods: This was a case study (2009-2010) of 194 menopausal patients, excluding surgically induced cases, performed at the Obstetrics and Gynocology Clinic of Dokuz Eylul University School of Medicine Hospital.Results: Patients were queried on their demographic data, menopause and OSAS symptoms, and Epworth Sleepiness Scale (ESS) results. Fourteen patients having 10 points and above in the ESS were hospitalized for one night in Dokuz Eylul University Sleep Center and underwent polysomnography (PSG). In our study, OSAS prevalence for postmenopausal patients was found in 6.21% of the patients. Further, 28.6% of 12 patients having OSAS were found to have mild and 57.2% were found to have moderate-severe OSAS. By PSG, 14 patients were detected to have 398.5 min of average sleep time and 23.9 of Apnea-Hypopnea Index. Three patients were suggested to undergo the palliative care and 9 were suggested to undergo continuous positive airway pressure (CPAP) therapy. The average CPAP was 7.1 mmHg. A correlation was found between body mass index and LH, prolactin, E2, and free testosterone levels and OSAS.Conclusion: OSAS risk increases during menopause. Menopause is an independent risk factor for OSAS; therefore, detailed research with PSG is suggested to be performed when required.

"Polypoid endometriosis presenting as a mass at the pouch of Douglas." Journal of Obstetrics and Gynaecology, 35(8), pp. 861–862

Our objective was to determine the underlying pathophysilogy of preterm labor by comparing the placental pathologies in patients with preterm labor symptoms and their matched controls. Additionally, the second purpose was to determine the relationship between the placental pathologies and uterine artery (UtA) Doppler findings. 172 patients with singleton pregnancies between 24 and 35 weeks who presented with signs of preterm labor and 169 healthy pregnant women with correlative properties who admitted for routine pregnancy visits were recruited for the study. UtA blood flows were evaluated with Doppler ultrasonography during uterine inertia for both patients having preterm labor signs and for the control group. Each patient followed until the birth and delivery in 48 hours/7 days/14 days were recorded. The placental pathologies were interpreted (Redline 2007) and the relationship between the Doppler findings and placental pathologies were investigated. Placental pathologies were found to be higher in the study group compared to their controls (P = 0.002). According to placental pathology patterns; the study group had significantly higher subclinical chorioamnionitis (P = 0.014), maternal vascular maldevelopment (P = 0.000) and maternal vascular loss of integrity (P = 0.021) than the control group. In the study group, the patients' who delivered in 48 hours/7 days/14 days, presence of abnormal placental pathologies were also found to be higher (P = 0.001/P = 0.000/P = 0.000) than the patients who did not deliver. The study group with abnormal placental pathologies had substantially higher UtA PI (0.98 ± 0.39) than the patients without placental pathologies (0.74 ± 0.21) (P = 0.001). An underlying abnormal placental pathology was found to be higher in patients showing preterm labor symptoms and in the patients particularly who deliver in early time periods. With this study, it's shown for the first time that the placental lesions prosecuted for preterm delivery were associated with antenatal UtA blood flows.