We report a follow-up axion haloscope search near 1.036 GHz that completes and extends our previous work [Ahn et al. Phys. Rev. X 14, 031023 (2024)PRXHAE2160-330810.1103/PhysRevX.14.031023], in which a portion of the HEMT-based data could not be analyzed due to unrecorded experimental information. While recovering this dataset, we identified an excess near 1.036 GHz that satisfied our candidate-selection criteria, motivating dedicated validation studies, including independent cross-checks and reexamination with the original apparatus. The excess did not persist under these investigations and was not confirmed as an axion dark-matter signal. We subsequently extended the search over a 20-MHz band surrounding the candidate using a quantum-noise-limited amplifier, achieving sensitivity close to the Dine-Fischler-Srednicki-Zhitnitsky benchmark. In the absence of a confirmed signal, we set improved 90% confidence-level upper limits on the axion-photon coupling over the frequency range 1.026-1.045 GHz. This Letter highlights the importance of robust candidate-validation strategies as haloscope searches approach discovery-level sensitivity.

We report an axion dark matter search in the mass range of 15.30–15.85 μeV using a broadly tunable high-temperature superconducting (HTS) haloscope. By soldering substrate-stripped rare-earth barium copper oxide (REBCO) films onto a copper shell, we achieved a quality factor 3–4 times higher than in copper cavities across its tuning band in an 8-T magnetic field. We set robust Frequentist 90% confidence-level exclusion limits on the axion–photon coupling down to 1.3 times the KSVZ coupling, while a complementary Bayesian analysis achieves KSVZ-level sensitivity.

Axion haloscopes use radio-frequency cavities immersed in a magnetic field to search for dark-matter axions, which could resolve two central puzzles in fundamental physics: the strong charge-parity problem in quantum chromodynamics and the nature of dark matter. Multi-tesla fields trigger axion-to-photon conversion but induce severe vortex dissipation in standard superconductors, whereas copper cavities are limited by the anomalous skin effect (Q ≲ 10^5). Here, we overcome these barriers by introducing a pole-to-pole 3-dimensional cavity architecture constructed from strain-controlled, mechanically delaminated rare-earth barium copper oxide (REBCO) tapes. By selectively stripping the lossy metallic substrate while utilizing the copper stabilizer as a "conductive backing" we convert the longitudinal assembly gaps into waveguides below cutoff, effectively suppressing cross-seam RF leakage. Employing a two-track strategy, we first unveiled the intrinsic high-field potential of the material with a 5.4 GHz resonant cavity, achieving an unloaded quality-factor (Q_0) of 1.4 × 10^7 in an 8 T magnetic field, exceeding conventional copper baselines by two orders of magnitude. Second, prioritizing practical haloscope integration, we engineered a tunable, volume-maximized 2.3 GHz pathfinder cavity. Deployed in the Pilot Axion Cavity Experiment at the Center for Axion and Precision Physics Research (CAPP-PACE), this system achieved a 180 mK noise temperature and a 5-fold Q enhancement over copper, cumulatively delivering a ∼8.4-fold scan-rate acceleration.

The axion quark nugget (AQN) model is an emerging candidate for cold dark matter, and proposes that dark matter consists of (anti)quarks in a color superconducting state enclosed by an axion domain wall. We performed the first dedicated AQN experiment using an axion haloscope, based on the scenario that antimatter AQNs could annihilate with Earth matter and release relativistic axions. This experiment employed a high-temperature superconducting microwave cavity that achieved a quality factor exceeding one million in a strong magnetic field, alongside a quantum-noise-limited Josephson parametric amplifier. Combined with an additional experiment using a large-volume copper cavity, our investigation focused on the range of axion rest mass between 1.9 mu eV and 9.3 mu eV, and attempted to detect the daily modulation of the signal predicted by the model. While no definitive signals were detected, this study establishes the initial groundwork for exploring broader parameter spaces in future experiments.

Two outstanding problems of particle physics and cosmology, namely the strong-CP problem and the nature of dark matter, can be solved with the discovery of a single new particle, the axion. The modular high magnetic field and flux hybrid magnet platform of LNCMI-Grenoble, which was recently put in operation up to 42 T, offers unique opportunities for axion/axion-like particle search using Sikivie-type haloscopes. In this paper, the focus will be on the 350–600 MHz frequency range corresponding to the 1–3 μeV axion mass range requiring a large-bore RF-cavity. It will be built by DMAG and integrated within the large-bore superconducting hybrid magnet outsert, providing a central magnetic field up to 9 T in 812 mm warm bore diameter. The progress achieved by Néel Institute in the design of the complex cryostat with its double dilution refrigerators to cooldown below 50 mK the ultra-light Cu RF-cavity of 650 mm inner diameter and the first stage of the RF measurement chain are presented. Perspectives for the targeted sensitivity, assuming less than 2-year integration time, are recalled.

A collaboration between CNRS-Grenoble and IBS-CAPP Daejeon plans to build a Sikivie’s type haloscope for axion/ALPs dark matter search at the Dine-Fischler-Srednicki-Zhitnitskii sensitivity for the 300–600 MHz range. It will be based on the large-bore superconducting “outsert” coil of the Grenoble hybrid magnet, providing a central magnetic field up to 9 T in an 810-mm warm bore diameter. This magnet has recently been successfully powered up to 8.5 T, achieving the first step of the electrical commissioning phase. The design principles of the cryostat with its double dilution refrigerators to cool below 50 mK, the light Cu RF cavity of 700-mm diameter, and its tuning rod(s) and the first stages of the measurement chain are presented. Perspectives for the targeted sensitivity assuming less than a 2-year integration time are given.

We report an extensive high-sensitivity search for axion dark matter above 1\,GHz at the Center for Axion and Precision Physics Research (CAPP). The cavity resonant search, exploiting the coupling between axions and photons, explored the frequency (mass) range of 1.025\,GHz (4.24\,$\mu$eV) to 1.185\,GHz (4.91\,$\mu$eV). We have introduced a number of innovations in this field, demonstrating the practical approach of optimizing all the relevant parameters of axion haloscopes, extending presently available technology. The CAPP 12\,T magnet with an aperture of 320\,mm made of Nb$_3$Sn and NbTi superconductors surrounding a 37-liter ultralight-weight copper cavity is expected to convert DFSZ axions into approximately $10^2$ microwave photons per second. A powerful dilution refrigerator, capable of keeping the core system below 40\,mK, combined with quantum-noise limited readout electronics, achieved a total system noise of about 200\,mK or below, which corresponds to a background of roughly $4\times 10^3$ photons per second within the axion bandwidth. The combination of all those improvements provides unprecedented search performance, imposing the most stringent exclusion limits on axion--photon coupling in this frequency range to date. These results also suggest an experimental capability suitable for highly-sensitive searches for axion dark matter above 1\,GHz.

The complement system is a major component of the innate immune system that works through the cytolytic effect of the membrane attack complex (MAC). Complement component 7 (C7) is essential for MAC assembly and its precisely regulated expression level is crucial for the cytolytic activity of MAC. We show that C7 is specifically expressed by the stromal cells in both mouse and human prostates. The expression level of C7 inversely correlates with clinical outcomes in prostate cancer. C7 is positively regulated by androgen signaling in the mouse prostate stromal cells. The androgen receptor directly transcriptionally regulates the mouse and human C7. Increasing C7 expression in the C57Bl/6 syngeneic RM-1 and Pten-Kras allografts suppresses tumor growth in vivo. Conversely, C7 haploinsufficiency promotes tumor growth in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Interestingly, replenishing C7 in androgen-sensitive Pten-Kras tumors during androgen depletion only slightly enhances cellular apoptosis, highlighting the diverse mechanisms employed by tumors to counteract complement activity. Collectively, our research indicates that augmenting complement activity could be a promising therapeutic approach to impede the development of castration resistance in prostate cancer.

Targeting immune suppressive mechanisms in the tumor microenvironment has revolutionized cancer treatment. Although immune checkpoint inhibition (ICI) has yielded meaningful responses across many cancer types, the ICI efficacy is still limited for prostate cancer. We generated a mouse model with prostate epithelial specific expression of Foxf2, a Forkhead box transcription factor. Foxf2 overexpression suppressed tumor growth in two mouse models for prostate cancer with prostate specific Pten deletion or TRAMP. Foxf2 expression strongly induced tumor cell-intrinsic immune responses by recruiting and activating CD8+ T cells and switching the polarization of macrophages from an immunosuppressive M2-like phenotype to a more inflammatory M1-like state in both syngeneic and autochthonous mouse prostate cancer models in an immunocompetent context. Furthermore, we showed that overexpression of Foxf2 in mouse and human prostate cells repressed the expression of FGL1, a major ligand of LAG-3 that mediates T cell suppression. In this study, we take a combination of bioinformatic, molecular, cellular, and genetic approaches and reveal that Foxf2 overexpression in prostate cancer suppresses tumor progression by activating antitumor immunity. Citation Format: Deyong Jia, Zhicheng Zhou, OhJoon Kwon, Li Xin. Foxf2 activates antitumor immunity to repress the progression of prostate cancer by repressing Fgl1 [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr B029.

We report the results of an axion dark matter search over an axion mass range of 9.39-9.51  μeV. A flux-driven Josephson parametric amplifier (JPA) was added to the cryogenic receiver chain. A system noise temperature of as low as 200 mK was achieved, which is the lowest recorded noise among published axion cavity experiments with phase-insensitive JPA operation. In addition, we developed a two-stage scanning method which boosted the scan speed by 26%. As a result, a range of two-photon coupling in a plausible model for the QCD axion was excluded with an order of magnitude higher in sensitivity than existing limits.

We report an axion dark matter search at Dine-Fischler-Srednicki-Zhitnitskii sensitivity with the CAPP-12TB haloscope, assuming axions contribute 100% of the local dark matter density. The search excluded the axion-photon coupling g_{aγγ} down to about 6.2×10^{-16}  GeV^{-1} over the axion mass range between 4.51 and 4.59  μeV at a 90% confidence level. The achieved experimental sensitivity can also exclude Kim-Shifman-Vainshtein-Zakharov axion dark matter that makes up just 13% of the local dark matter density. The CAPP-12TB haloscope will continue the search over a wide range of axion masses.

Cancer-associated fibroblasts (CAFs) mediate an immunosuppressive effect, but the underlying mechanism remains incompletely defined. Here we show that increasing prostatic stromal Foxf2 suppresses the growth and progression of both syngeneic and autochthonous mouse prostate cancer models in an immunocompetent context. Mechanistically, Foxf2 moderately attenuates the CAF phenotype and transcriptionally downregulates Cxcl5, which diminish the immunosuppressive myeloid cells and enhance T cell cytotoxicity. Increasing prostatic stromal Foxf2 sensitizes prostate cancer to the immune checkpoint blockade therapies. Augmenting lung stromal Foxf2 also mediates an immunosuppressive milieu and inhibits lung colonization of prostate cancer. FOXF2 is expressed higher in the stroma of human transition zone (TZ) than peripheral zone (PZ) prostate. The stromal FOXF2 expression level in primary prostate cancers inversely correlates with the Gleason grade. Our study establishes Foxf2 as a stromal transcription factor modulating the tumor immune microenvironment and potentially explains why cancers are relatively rare and indolent in the TZ prostate.

We report an axion dark matter search at Dine-Fischler-Srednicki-Zhitnitskii sensitivity with the CAPP-12TB haloscope, assuming axions contribute 100% of the local dark matter density. The search excluded the axion–photon coupling g aγγ down to about 6 . 2 × 10 − 16 GeV − 1 over the axion mass range between 4.51 and 4.59 µ eV at a 90% confidence level. The achieved experimental sensitivity can also exclude Kim-Shifman-Vainshtein-Zakharov axion dark matter that makes up just 13% of the local dark matter density. The CAPP-12TB haloscope will continue the search over a wide range of axion masses.

Macrophages are increased in human benign prostatic hyperplasia and prostate cancer. We generate a Pb-Csf1 mouse model with prostate-specific overexpression of macrophage colony-stimulating factor (M-Csf/Csf1). Csf1 overexpression promotes immune cell infiltration into the prostate, modulates the macrophage polarity in a lobe-specific manner, and induces senescence and low-grade prostatic intraepithelial neoplasia (PIN). The Pb-Csf1 prostate luminal cells exhibit increased stem cell features and undergo an epithelial-to-mesenchymal transition. Human prostate cancer patients with high CSF-1 expression display similar transcriptional alterations with the Pb-Csf1 model. P53 knockout alleviates senescence but fails to progress PIN lesions. Ablating epithelial Gp130 but not Il1r1 substantially blocks PIN lesion formation. The androgen receptor (AR) is downregulated in Pb-Csf1 mice. ChIP-Seq analysis reveals altered AR binding in 2482 genes although there is no significant widespread change in global AR transcriptional activity. Collectively, our study demonstrates that increased macrophage infiltration causes PIN formation but fails to transform prostate cells.

A high-quality factor microwave resonator in the presence of a strong magnetic field could have a wide range of applications, such as axion dark matter searches where the two aspects must coexist to enhance the experimental sensitivity. We introduce a polygon-shaped cavity design with bi-axially textured YBa$_{2}$Cu$_{3}$O$_{7-x}$ superconducting tapes covering the entire inner wall. Using a 12-sided polygon cavity, we obtain substantially improved quality factors of the TM$_{010}$ mode at 6.9 GHz at 4 K with respect to a copper cavity and observe no considerable degradation in the presence of magnetic fields up to 8 T. This corresponds to the first demonstration of practical applications of superconducting radio frequency technology for axion and other research areas requiring low loss in a strong magnetic field. We address the importance of the successful demonstration and discuss further improvements.

The cell-type continuous electromagnetic radiation system is a demonstration device capable of generating high-power millimeter electromagnetic waves of a specific wavelength and observing their effects on living organisms. It irradiates a biological sample placed in a 30 × 30 × 50 cm3 cell with electromagnetic waves in the 3.15-mm-wavelength region (with an output of ≥1 W) and analyzes the temperature change of the sample. A vacuum electronic device-based coupled-cavity backward-wave oscillator converts the electron energy of the electron beam into radiofrequency (RF) energy and radiates it to the target through an antenna, increasing the temperature through the absorption of RF energy in the skin. The system causes pain and ultimately reduces combat power. A cell-type continuous electromagnetic radiation system consisting of four parts—an electromagnetic-wave generator, a high-voltage power supply, a test cell, and a system controller—generates an RF signal of ≥1 W in a continuous waveform at a 95-GHz center frequency, as well as a chemical solution with a dielectric constant similar to that of the skin of a living organism. An increase of 5 °C lasting approximately 10 s was confirmed through an experiment.

Introduction The Wnt proteins play key roles in the development, homeostasis, and disease progression of many organs including the prostate. However, the spatiotemporal expression patterns of Wnt proteins in prostate cell lineages at different developmental stages and in prostate cancer remain inadequately characterized. Methods We isolated the epithelial and stromal cells in the developing and mature mouse prostate by flow cytometry and determined the expression levels of Wnt ligands. We used Visium spatial gene expression analysis to determine the spatial distribution of Wnt ligands in the mouse prostatic glands. Using laser-capture microscopy in combination with gene expression analysis, we also determined the expression patterns of Wnt signaling components in stromal and cancer cells in advanced human prostate cancer specimens. To investigate how the stroma-derived Wnt ligands affect prostate development and homeostasis, we used a Col1a2-CreER(T2) mouse model to disrupt the Wnt transporter Wntless specifically in prostate stromal cells. Results We showed that the prostate stromal cells are a major source of several Wnt ligands. Visium spatial gene expression analysis revealed a distinct spatial distribution of Wnt ligands in the prostatic glands. We also showed that Wnt signaling components are highly expressed in the stromal compartment of primary and advanced human prostate cancer. Blocking stromal Wnt secretion attenuated prostate epithelial proliferation and regeneration but did not affect cell survival and lineage maintenance. Discussion Our study demonstrates a critical role of stroma-derived Wnt ligands in prostate development and homeostasis.

High-power microwave sources applied to a directed-energy weapon can lead to permanent damage by radiating concentrated energy in a specific direction to disturb or overload electronic equipment. The effect analysis on the target, such as electronics exposed to electromagnetic pulse, should be considered as an important factor in determining the performance of high-power microwave sources and conducting experimental evaluations. In this study, a magnetically insulated transmission line oscillator, one of the representative high-power microwave sources based on vacuum electronics device, was constructed and experimental analysis with respect to electromagnetic pulse effects was performed. The specification of the magnetically insulated transmission line oscillator used in this study corresponded to 3 GW of high-power electromagnetic wave pulses operating at L-band. The power efficiency was approximately 10 – 15%. For effective targeting, a Vlasov antenna that converts TM01 mode to TE11 mode was designed and fabricated. The radiation pattern was confirmed via fluorescent lamps, and to confirm the effect of the directed-energy weapon on the target, an effect analysis was performed using a portable electronic device as a sample. Furthermore, the electric field was measured with a D-dot probe and quantified and compared. This study presents a future blueprint of the value of the directed-energy weapon by predicting the radiant output power of the weapon in the far-field region after it is mounted on a movable ground vehicle or unmanned aerial vehicle.