This work investigates the system-level performance impact of read disturbance in modern NAND flash-based SSDs, aiming to provide new insights that can help develop better storage architectures and optimize system software. Continuous improvement in storage density over decades has led NAND flash memory to play a vital role in modern computing systems, but it also comes at a cost of significant reliability degradation. Among various error sources, read disturbance has gained growing attention as a major reliability concern due to its rapidly increasing impact, which can significantly affect system I/O performance by exacerbating SSD-internal reliability-management overheads. Although a large body of prior work has focused on device-level characterizations and optimizations, the system-level performance impact of read disturbance still remains largely uninvestigated. To address this gap, this work conducts a rigorous experimental study using 15 modern NVMe SSDs from 10 major vendors in two ways. First, we comprehensively analyze the system-level performance impact of read disturbance under diverse workloads and operating conditions. Second, to highlight the importance of efficient read-disturbance management, we showcase a new possible SSD-performance attack as a case study, demonstrating that an adversary can significantly degrade the I/O performance of other concurrently running processes by exploiting read disturbance alone in commodity SSDs. Based on our experimental study, we make 16 new observations and 7 takeaway lessons, which lead to 6 key directions for future improvements at the host-system and SSD-architecture levels to better cope with read disturbance.

Modern distributed file systems rely on uncoordinated, per node page caches that replicate hot data locally across the cluster. While ensuring fast local access, this architecture underutilizes aggregate cluster DRAM capacity through massive data redundancy and incurs prohibitive coherence overhead via heavyweight, lock-based protocols. In this paper, we focus on the design of a distributed page cache that treats the entire cluster's main memory as a single cache budget while preserving standard file-system interfaces and semantics. We present Distributed Page Cache (DPC), an OS-level, distributed page cache built on top of Compute Express Link (CXL) 3.0 memory semantics. DPC enforces a single-copy invariant at page granularity: each file page has exactly one owner node holding the sole resident DRAM copy, and other nodes access it via CXL-based remote mappings rather than creating replicas of the page. DPC is implemented end-to-end on a CXL-based emulation framework that models multi-host CXL 3.0 memory fabrics, enabling detailed evaluation in the absence of widespread hardware. Across real-world and representative data-sharing workloads, DPC delivers speedups of up to 12.4X, with a geometric-mean speedup of 5.6X.

The development of on-device large language models (LLMs) is driven by the need for privacy and fast response times. Energy-intensive data transfer on mobile devices makes Processing-in-Memory (PIM) an effective solution. Due to stringent DRAM cost constraints, limited physical footprint on circuit boards, and the interaction between applications and LLMs, it is imperative for the CPU and PIM to operate concurrently within a shared memory space. However, challenges such as bank conflicts and bus congestion can arise, potentially diminishing the performance and energy benefits of PIM. To address this challenge, we introduce COSM, a cooperative scheduling framework designed to facilitate the concurrent operation of PIM and CPU tasks on mobile platforms. Our key innovations include: 1) a low-interference PIM control interface that generates the maximum number of PIM commands without disrupting CPU memory accesses; 2) an idleness-aware scheduling method that integrates PIM commands into available idle time windows within the CPU's access sequence. COSM not only hides PIM execution latency from the CPU, but also overlaps PIM execution with data transfer. Experiments on concurrent execution of LLMs and mobile workloads, including mobile applications and compute-intensive kernels, demonstrate that COSM improves PIM throughput by up to 2.8x compared to the baseline scheduling method with less than 2.0

This work investigates the potential benefits and technical challenges of using high- bandwidth flash (HBF) for large language model (LLM) inference. HBF has gained increasing attention as a promising solution to mitigate memory-capacity bottlenecks in modern LLM-serving systems, but its benefits and challenges remain largely uninvestigated. To address this gap, we thoroughly analyze HBF-based LLM-serving systems under diverse system configurations and operating scenarios in which HBF serves as a main GPU-memory component to handle both reads and writes. Our analysis shows that, despite its limited write performance, HBF can significantly improve the batch size, throughput, and flexibility of LLM-serving systems while reducing the minimum GPU requirements, but realizing these benefits critically depends on sustaining HBM-comparable read bandwidth and requires significant endurance improvements.

We experimentally demonstrate that it is possible to generate unique, repeatable, and device-specific signatures suitable for use as Physical Unclonable Function (PUF) responses in commercial off-the-shelf (COTS) DRAM chips by leveraging simultaneous multiple-row activation (SiMRA). Based on a rigorous experimental characterization of 112 modern DDR4 DRAM chips (from 10 modules), we introduce SiMRA-PUF, the first DRAM-based PUF that uses SiMRA-generated signatures as PUF responses. We analyze SiMRA-PUF in terms of reliability, uniqueness, and evaluation latency for varying numbers of simultaneously activated DRAM rows (i.e., 2, 4, 8, 16, and 32), DRAM chip density & die revision, and evaluate how temperature affects the similarity of SiMRA-generated responses. Among our 8 key experimental observations, we highlight two major results. First, SiMRA-PUF provides average intra-Jaccard indices of 89.02%, 89.81%, 93.03%, 94.06%, and 94.86%, and average inter-Jaccard indices of 3.98%, 2.37%, 3.44%, 2.92%, and 3.24% for 2-, 4-, 8-, 16-, and 32-row activations, respectively, showing that SiMRA-generated signatures are both repeatable within a device and unique across devices. Second, 2-row activation-based SiMRA-PUF provides 5.75% lower evaluation latency than the state-of-the-art DRAM-based PUF. We open-source our infrastructure and datasets at https://github.com/CMU-SAFARI/SiMRA-PUF.

Cryptographic algorithms such as AES-128 and SHA-256 are fundamental to ensuring data security and integrity. Although these algorithms are computationally efficient, their performance is often constrained by the processor-centric architectures (e.g., CPUs, GPUs), primarily due to the memory bottleneck. This constraint leads to increased latency and higher energy consumption, particularly when handling large volumes of data. To overcome these challenges, Processing-in-Memory (PIM) has emerged as a promising architectural paradigm, allowing computation to occur directly within or near memory units. By minimizing data movement between the processor and memory units, PIM can significantly accelerate cryptographic algorithms while improving energy efficiency. Several pieces of prior work have demonstrated the effectiveness of PIM at fundamentally accelerating cryptographic algorithms. However, none of the prior works have extensively demonstrated the potential of a real-world PIM system. In this paper, we want to investigate the potential and limitations of real-world PIM in accelerating cryptographic algorithms. As part of our methodology, the UPMEM PIM architecture is used to assess the scalability of cryptographic algorithms. When these algorithms operate on a single rank, their performance remains below that of modern CPUs. However, distributing the computation across multiple ranks significantly enhances performance. When all available ranks are utilized, real-world PIM can accelerate cryptographic algorithms more effectively.

We provide the first experimental demonstration of DejaVu, a phenomenon where the data previously written to DRAM cells affects DRAM's vulnerability to read disturbance. Our experimental characterization using 112 COTS DDR4 DRAM chips from all three major manufacturers shows that, compared to the baseline where we initialize the victim row by writing to it only once, 1) overwriting it with the opposite data reduces ACmin, the minimum aggressor row activation count to induce a bitflip, and 2) writing the same data twice increases ACmin. We provide two hypotheses to explain DejaVu. First, we hypothesize that overwriting the victim row with opposite data values causes under-restoration of charge in DRAM cells. Second, we hypothesize that overwriting the victim row changes charge trap states in the active region, affecting read-disturbance-induced cell leakage current. We conduct controlled characterization to provide insight into these hypotheses. We further characterize the reliability of Processing-Using-DRAM (PUD) operations with DRAM rows initialized with DejaVu patterns. Our characterization of 32-row MAJ-3 operation shows that overwriting the DRAM rows used in the operation reduces the number of bitlines that fail to reliably perform MAJ-3 by 32.7

Cycle-level DRAM simulators provide accurate and flexible models for DRAM and memory controller operations and enable research on current and future memory systems. Therefore, they are critical for improving the performance, efficiency, and robustness of DRAM-based memory systems. Ramulator 2.0 (successor of Ramulator) is a highly modular and extensible cycle-accurate DRAM simulator that enables rapid exploration of new ideas in DRAM-based memory systems. A MICRO 2024 best paper runner-up publication, A Mess of Memory System Benchmarking, Simulation and Application Profiling, which we refer to as "the Mess paper," with all three artifact badges awarded (including "Reproducible"), proposes a new benchmark to evaluate real and simulated memory system performance. While doing so, it makes strong negative claims about Ramulator 2.0 and shows unexpected results. In this talk and the associated extended abstract, we demonstrate that these results and claims in the Mess paper are incorrect and are due to configuration and simulator usage errors made in the Mess paper. We describe four best practices to aid users and developers of simulation tools to avoid such issues in the future. We emphasize the importance of contacting simulator authors and developers when unexpected results are observed (especially and importantly before publishing such results), to ensure these simulators are used with correct configurations and as intended. Our investigation also aims to stimulate discussion on artifact evaluation practices and on mechanisms for correcting results and artifacts after publication. To aid future works and reproduction of all our results, we open source all our code and scripts at https://github.com/CMU-SAFARI/Cleaning-up-the-Mess. We refer the reader to our full ISPASS 2026 paper and its artifact for the complete analysis, detailed methodology, and extended results.

Ramulator 2.1 is a major overhaul of Ramulator 2.0 that substantially improves the simulator in three directions: 1) support of modern and emerging DRAM and memory-controller features, 2) better usability and extensibility of the simulator, and 3) more comprehensive tests and validation workflows. Ramulator 2.1 adds support for advanced features in recent and emerging DRAM standards and memory controllers, including HBM3/4, LPDDR5/6, and GDDR7. To improve usability and extensibility, Ramulator 2.1 introduces a Python-based modeling and configuration interface backed by a two-way code-generation framework that 1) hides low-level C++ code behind high-level DRAM specifications written in Python, and 2) automatically creates Python proxies for all components of the simulator. Doing so enables users to rapidly create variants of DRAM standards and automate design-space-exploration workflows. To improve trustworthiness in simulation results, Ramulator 2.1 provides a comprehensive testing and validation infrastructure that covers both 1) fine-grained validation of specific DRAM timing constraints and memory-controller scheduling behavior, and 2) system-level performance evaluation using latency-throughput curves. To aid performance analysis and debugging, Ramulator 2.1 also includes an easy-to-use and high-performance DRAM command trace visualizer. Ramulator 2.1 is open-source on GitHub and under active development.

Modern high-performance computing (HPC) environments rely on hybrid storage systems (HSS) that combine multiple storage devices with diverse latency, bandwidth, endurance, and capacity characteristics to meet the performance, capacity, and cost requirements of data-intensive applications. The performance of an HSS highly depends on two key data-management policies: (1) data placement, which determines the most suitable storage device to store application data, and (2) data migration, which dynamically reorganizes previously-stored data across storage devices (i.e., prefetching hot data and evicting cold data) to sustain high HSS performance. These policies are tightly interdependent, and thus, improving one without considering the other leads to suboptimal HSS performance. Unfortunately, prior works focus on optimizing only one of the policies. Our goal is to design a holistic data-management technique that optimizes both data-placement and data-migration policies to fully exploit the potential of an HSS. To this end, we propose Harmonia, a multi-agent reinforcement learning (RL)-based data-management technique. Harmonia employs two lightweight autonomous RL agents, a data-placement agent and a data-migration agent, that adapt their policies for the current workload and HSS configuration while coordinating with each other. We evaluate Harmonia on real HSS configurations with up to four heterogeneous storage devices and 25 data-intensive workloads. On a performance- (cost-) optimized HSS with two heterogeneous storage devices, Harmonia outperforms the best-performing prior approach by 29.3

High-performance Host processors can integrate Processing-In-Memory (PIM) devices, which can accelerate memory-intensive kernels of Machine Learning (ML) models, including Large Language Models (LLMs), by leveraging the large memory bandwidth available at PIM cores. However, Host processor needs consecutive elements distributed across DRAM banks, while PIM cores need consecutive elements within their local banks. This necessitates data rearrangements in ML kernel execution that pose significant performance and programmability challenges, further exacerbated by the need to support diverse PIM devices. Current compilation approaches lack systematic optimization for diverse ML kernels and multiple PIM devices, and may largely ignore data rearrangement costs during the compute code optimization step. We show that data rearrangements and compute code optimization are interdependent, and need to be jointly optimized during the tuning process. Therefore, we design DCC, the first data-centric ML compiler for PIM systems that jointly co-optimizes data rearrangements and compute code in a unified tuning process. DCC integrates a multi-layer PIM abstraction to support multiple PIM backends. DCC enables effective co-optimization of data partitioning strategies with compute loop partitioning schemes. DCC applies PIM-specific code optimizations, and leverages a fast and accurate performance prediction model to select the bestperforming code schedule for a given kernel on a target PIM architecture. Our evaluations in various individual ML kernels show that DCC achieves up to 7.68x speedup (2.21x average) on HBM-PIM, and up to 13.17x speedup (3.92x average) on AttAcc PIM, over GPU-only execution. In end-to-end LLM inference, DCC on AttAcc accelerates GPT-3 and LLaMA-2 by 4.52x average (up to 7.71x in LLaMA-2) over GPU. DCC is open-sourced at https://github.com/SPIN-Research-Group/DCC.

Processing-using-DRAM (PuD) is a promising computation paradigm that alleviates frequent data movement between main memory and processing units by using each DRAM column as a computation engine via simultaneous multiple-row activation (SiMRA). Unfortunately, DRAM density scaling may hinder PuD's benefits: denser cell arrays bring rows and columns closer, making regular DRAM operations susceptible to noise and interference from neighboring cells. Yet no prior work investigates whether interference from rows or columns not intended to participate in computation can compromise PuD robustness. In this work, we reveal PuDGhost, an interference phenomenon where a PuD operation in a given column produces erroneous results due to interference from 1) data in non-activated DRAM rows and 2) data in other columns that compute concurrently under the same SiMRA operation. PuDGhost violates the ideal picture that each column's computation depends solely on its own operand data, threatening future PuD systems. We present the first extensive characterization of PuDGhost using 96 real DDR4 DRAM chips from 12 modules, quantifying these two interference sources under various conditions. Among our 15 new empirical observations, we highlight two major results: 1) data in adjacent non-activated rows affects SiMRA outputs by up to 10

Homomorphic encryption (HE) enables computation over encrypted data, offering strong privacy guarantees for untrusted computing environments. Practical adoption remains limited by high computational complexity, large ciphertext sizes, and substantial data movement. Processor-centric architectures (CPUs, GPUs, ASICs) hit fundamental bottlenecks on HE workloads because ciphertexts are large, data locality is low, and primitives such as relinearization and bootstrapping repeatedly access large auxiliary metadata. Processing-In-Memory (PIM) is a promising mitigation by computing near or inside memory. Prior PIM proposals for HE either do not target real-world PIM systems or cover only a narrow set of operations. We comprehensively characterize HE operations on a real-world, general-purpose PIM system. We implement a complete set of HE kernels used by emerging applications (databases, machine learning) on the UPMEM PIM system, evaluate performance and scalability, compare against CPU and GPU baselines, and discuss implications for future PIM hardware. Our results demonstrate four major findings. (1) HE-based applications expose distinct bottlenecks across execution stages: some kernels are compute-bound due to modular arithmetic, while others are memory-bound due to large ciphertexts and intermediate data. These bottlenecks are exacerbated by limited per-core compute and per-bank capacity, which force frequent data movement. (2) The dominant compute bottleneck is the lack of native 64-bit modular integer multiplication, a key HE primitive. (3) Limited per-bank memory capacity is the second major bottleneck, since HE ciphertexts and auxiliary metadata do not fit and require inter-bank movement. (4) Despite these limits, PIM can be a viable alternative to state-of-the-art CPU and GPU systems for HE when equipped with native modular multiplication and efficient inter-PIM data movement.

Due to the challenges of analyzing and storing massive volumes of genomic and metagenomic sequence data, significant efforts have been made to accelerate (meta)genomic analyses and store sequence data compressed. Despite the benefits of these techniques, we identify two major outstanding problems in accessing stored sequence data and supplying it to the analysis units: (i) the data movement bottleneck due to moving large amounts of low-reuse data from storage and the unnecessary burden on the rest of the system, and (ii) the data preparation bottleneck, where compressed sequence data needs to be first decompressed and formatted before analysis. We present customized storage-centric systems, which efficiently (i) analyze (meta)genomic data inside storage, and (ii) enable highly-compressed storage and high-performance access of large-scale sequence data, thereby alleviating the overheads of data movement, computation, and data preparation. First, we introduce GenStore, an in-storage processing system that filters genomic data not requiring expensive computation directly inside storage. Second, we propose MegIS, an in-storage processing system that significantly reduces the data movement overhead of metagenomic analysis. Third, we introduce GRAINS, a storage-centric system for analysis on large-scale (meta)genomic graphs in storage. Fourth, we propose SAGe, an algorithm-architecture co-design for highly-compressed storage and high-performance access of sequence data. We demonstrate that the proposed systems significantly (e.g., by one to two orders of magnitude) improve performance, energy efficiency, and cost-efficiency, all at the same time. We hope these systems facilitate broader adoption of (meta)genomics and inspire research on other data-intensive domains in health and life sciences.

A MICRO 2024 best paper runner-up publication (the Mess paper) with all three artifact badges awarded (including “Reproducible”) proposes a new benchmark to evaluate real and simulated memory system performance. The publication contends that Ramulator 2.0 and DAMOV (ZSim+Ramulator) (along with other existing memory system simulators) “poorly resemble the actual system performance” and asserts that their simulator is better. In this paper, we show that the Mess paper has 1) demonstrable technical misconfigurations, 2) methodological errors in interpreting simulation statistics, and 3) an incomplete artifact that makes its key results irreproducible. We demonstrate that the Ramulator 2.0 simulation results reported in the Mess paper are incorrect due to multiple configuration errors instead of inherent simulation inaccuracy claimed by the Mess paper. We show that by correctly configuring Ramulator 2.0, Ramulator 2.0's simulated memory system performance actually resembles real system characteristics well, and thus a key claimed contribution of the Mess paper is factually incorrect. We also identify that the DAMOV simulation results in the Mess paper use wrong simulation statistics that are unrelated to the simulated DRAM performance. We show that DAMOV's simulated DRAM latency is not constant, in contrast to the Mess paper's claim. Moreover, the Mess paper's artifact repository lacks the necessary sources to fully reproduce all the Mess paper's results. We find that the experiment scripts use simulator executables and other resources that are neither described in the Mess paper nor found in the artifact repository. We strongly encourage the computer architecture community to consider our corrections to the Ramulator 2.0 and DAMOV results of the Mess paper to prevent the propagation of inaccurate and misleading results and to maintain the reliability of the scientific record.

Genome sequencing has become a central focus in computational biology. A genome study typically begins with sequencing, which produces millions to billions of short DNA fragments known as reads. Read mapping aligns these reads to a reference genome. Read mapping for short reads comes in two forms: single-end and paired-end, with the latter being more prevalent due to its higher accuracy and support for advanced analysis. Read mapping remains a major performance bottleneck in genome analysis due to expensive dynamic programming. Prior efforts have attempted to mitigate this cost by employing filters to identify and potentially discard computationally expensive matches and leveraging hardware accelerators to speed up the computations. While partially effective, these approaches have limitations. In particular, existing filters are often ineffective for paired-end reads, as they evaluate each read independently and exhibit relatively low filtering ratios. In this work, we propose GenPairX, a hardware-algorithm co-designed accelerator that efficiently minimizes the computational load of paired-end read mapping while enhancing the throughput of memory-intensive operations. GenPairX introduces: (1) a novel filtering algorithm that jointly considers both reads in a pair to improve filtering effectiveness, and a lightweight alignment algorithm to replace most of the computationally expensive dynamic programming operations, and (2) two specialized hardware mechanisms to support the proposed algorithms. Our evaluations show that GenPairX delivers substantial performance improvements over state-of-the-art solutions, achieving 1575x and 1.43x higher throughput per watt compared to leading CPU-based and accelerator-based read mappers, respectively, all without compromising accuracy.

AirLift is the first read remapping tool that enables users to quickly and comprehensively map a read set, that had been previously mapped to one reference genome, to another similar reference. Users can then quickly run downstream analysis of read sets for each latest reference release. Compared to the state-of-the-art method for remapping reads (i.e., full mapping), AirLift reduces the overall execution time to remap read sets between two reference genome versions by up to 27.4×. We validate our remapping results with GATK and find that AirLift provides high accuracy in identifying ground truth SNP/INDEL variants.Code AvailabilityAirLift source code and readme describing how to reproduce our results are available athttps://github.com/CMU-SAFARI/AirLift.

Graph-based representations of genome sequences have emerged as a powerful approach for representing massive genomic databases in an expressive and efficient way. Despite their benefits, analysis on large-scale genome graphs incurs significant data movement overhead from the storage system due to accessing large amounts of low-reuse data. Processing data directly inside the storage device can be a fundamental solution for mitigating this overhead. However, none of the existing tools for graph-based genome analysis can be efficiently used inside the storage system due to the limited internal hardware resources in modern SSDs. At the same time, prior storage-centric systems developed for (i) traditional, linear non-graph-based genome analysis or (ii) conventional, non-genomic graph analysis are not suitable for the unique data structures and access patterns of graph-based genome analysis. We propose GRAINS, the first system for analysis with large-scale genome graphs in storage. Through our detailed examination of typical analysis pipelines that operate on genome graphs, we perform storage-aware algorithm-architecture co-design to (i) make these pipelines more storage-friendly and (ii) further improve performance, energy-efficiency, and cost via in-storage and in-flash processing. GRAINS's co-design is based on three key aspects. First, we propose a new batching and execution flow, based on unique features of genome graphs. Second, via in-flash and in-storage processing, we avoid transferring low-reused flash pages. Third, to leverage the full parallelism of flash dies, we design an effective, yet lightweight, scheduling technique, enabled by re-purposing the existing SSD structures. GRAINS provides 2.7x-47.8x speedup (4.4x-31.6x energy reduction) over the state-of-the-art software baselines, and 1.5x-17.0x speedup (3.1x-20.7x energy reduction) over a hardware-accelerated baseline.

Prefetching and off-chip prediction are two techniques proposed to hide long memory access latencies in high-performance processors. In this work, we demonstrate that: (1) prefetching and off-chip prediction often provide complementary performance benefits, yet (2) naively combining them often fails to realize their full performance potential, and (3) existing prefetcher control policies leave significant room for performance improvement behind. Our goal is to design a holistic framework that can autonomously learn to coordinate an off-chip predictor with multiple prefetchers employed at various cache levels. To this end, we propose a new technique called Athena, which models the coordination between prefetchers and off-chip predictor (OCP) as a reinforcement learning (RL) problem. Athena acts as the RL agent that observes multiple system-level features (e.g., prefetcher/OCP accuracy, bandwidth usage) over an epoch of program execution, and uses them as state information to select a coordination action (i.e., enabling the prefetcher and/or OCP, and adjusting prefetcher aggressiveness). At the end of every epoch, Athena receives a numerical reward that measures the change in multiple system-level metrics (e.g., number of cycles taken to execute an epoch). Athena uses this reward to autonomously and continuously learn a policy to coordinate prefetchers with OCP. Our extensive evaluation using a diverse set of memory-intensive workloads shows that Athena consistently outperforms prior state-of-the-art coordination policies across a wide range of system configurations with various combinations of underlying prefetchers, OCPs, and main memory bandwidths, while incurring only modest storage overhead. Athena is freely available at https://github.com/CMU-SAFARI/Athena.

De Bruijn graphs are widely used in pangenome representation due to their numerous advantages and extensions, such as colored and compacted variants that enhance the representation of genetic variation. Although de Bruijn graphs are becoming increasingly adopted, their performance and energy impact have not been clearly studied. Such an overlooked understanding can lead to suboptimal designs for de Bruijn graph-based tools in addressing the computational challenges posed by pangenome data. To identify workflow bottlenecks and assess the efficiency of hardware utilization, we present an in-depth performance analysis of state-of-the-art de Bruijn graph-based read mapping tools on pangenomic datasets, focusing on scalability of execution time, hardware resource utilization, and energy consumption. We observe that the tools primarily prioritize data parallelism for processing read datasets, disregarding the increasing complexity of the pangenome graph, which hinders scalability. As the pangenome graph grows in size and complexity, cache miss rates also increase, leading to poor overall performance. By extensively analyzing sources of suboptimal performance, we pave the way for optimizing the existing and future tools to fully realize their potential in advancing pangenome research.