Background: Amoebiasis is an intestinal and tissue parasitic infection caused by the protozoan Entamoeba histolytica. Despite significant medical importance and worldwide dispersion, little is known about the epidemiology and distinct geographical distribution of various clinical forms of amoebiasis in the world. In this study, we present an amoebiasis case series referred to Avicenne Hospital (Bobigny, France) from 2010 to 2022 followed by an overview of the released literature to explore diverse clinico-pathology of amoebiasis and to update the actual epidemiological situation of this parasitosis worldwide.Methods: The referred patients underwent a combination of clinical and parasitological examinations and imaging. The study was followed by an overview of released literature performed based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline.Results: A total of 15 patients with amoebiasis were diagnosed with an average age of 48.5 years old at the occurrence time of infection. Men (78%) were the most affected patients. Most of the cases were reported following a trip to endemic regions, such as Mali, India, Nepal, Algeria, Cameroon or Congo. All of the processed patients exhibited a hepatic amoebiasis. Amoebic abscess was observed in all cases with an average size of 6.3 cm. Of these patients, seven cases (46.7%) benefited from drainage following a risk of rupture or superinfection of the abscess. A compilation of findings extracted from 390 scientific publications via seven major medical databases, allowed us to update the main epidemiological and clinical events that has led to the current worldwide expansion of amoebiasis. We presented a clinical and epidemiological overview of the amoebiasis accompanied with a worldwide illustrative map displaying the current distribution of known amoebiasis foci in each geographical ecozone of Asia, Europe, Africa, Americas, and Australia.Conclusions: Although Metropolitan France is not known as an endemic region of amoebiasis, amoebic liver abscess was the most frequent clinical form observed among our 15 patients processed. Most of infected patients had a history of travel to or lived-in endemic areas before arriving in France.(c) 2022 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

We aimed to assess the prognostic value of the pre-operative GRADE score for long-term survival among older adults undergoing major surgery for digestive or non-breast gynaecological cancers. Between 2013 and 2019, 136 consecutive older adults with cancer were prospectively recruited from the PF-EC cohort study before major cancer surgery and underwent a geriatric assessment. The GRADE score includes weight loss, gait speed at the threshold of 0.8 m/s, cancer site and cancer extension. The primary outcome was post-operative 5-year mortality. Patients were classified as low risk (GRADE ≤ 8) or high risk (GRADE > 8) on the basis of the median score. A Cox multivariate proportional hazards regression model was performed to assess the association between pre-operative factors and 5-year mortality expressed by adjusted hazard ratio (aHR) and 95% CI. The median age was 80 years, 52% were men, 73% had colorectal cancer. The 30-day post-operative severe complication rate (Clavien-Dindo ≥ 3) was 37%. The 5-year post-operative mortality rate was 34.5%. A GRADE score ≥ 8 (aHR = 2.64 [1.34–5.21], p = 0.0002) was associated with post-operative mortality after adjustment for Body Mass Index < 21 kg/m2 and Instrumental Activities of Daily Living <3/4. By combining very simple geriatric and cancer parameters, the pre-operative GRADE score provides a discriminant prognosis and could help to choose the most suitable treatment strategy for older cancer patients, avoiding under or over-treatment.

Les plaies des voies biliaires (PVB) au cours de la cholécystectomie sont une complication grave nécessitant souvent une réparation chirurgicale. Le but de cette étude était de rapporter les résultats de la réparation chirurgicale des PVB à court terme et à long terme.Tous les patients ayant eu une réparation de PVB, entre août 2007 and septembre 2017, ont été rétrospectivement inclus dans cette étude. La classification de McDonald était utilisée pour évaluer les résultats à long terme. Les facteurs de risque de résultats à long terme, peu satisfaisants, étaient analysés de manière uni- et multivariée.Au total, 228 patients ont eu une anastomose hépaticojéjunale que anse en Y. La chomécystectomie par laparotomie était la principale cause de PVB (61 %). Le délai médian de la réparation de la PVB était de 6 mois. Les types de PVB selon la classification de Strasberg étaient comme suit : E1 chez 13 (5,7 %), E2 chez 68 (29,82 %), E3 chez 108 (47,36 %), E4 chez 28 (12,28 %), and E5 chez 11 (4,82 %) patients. La morbidité et la mortalité postopératoires étaient respectivement de 25 % et 1,31 %. Après un suivi médian de 58 mois, 90 % patients avaient de bons à excellents résultats. Une sténose récidivante a été observée chez 6 (3 %) patients. L’analyse multivariée a montré que l’intervalle entre la PVB et la réparation et les tentatives de réparation avant transfert du patient étaient des facteurs de risque indépendants de résultats peu satisfaisants à long terme.La réparation chirurgicale des PVB offre de bons à excellents résultats chez la majorité des patients. Comme le long délai du transfert dans un centre expert et les tentatives de réparation avant transfert sont des facteurs de mauvais résultats à long terme, il paraît important de transférer rapidement les patients dans des centres experts en chirurgie hépatobiliaire.Bile duct injury (BDI) after cholecystectomy is a serious complication. It often requires surgical repair. The aim of this study was to report on the short and long-term outcomes of surgery for post-cholecystectomy BDI.All the patients, who underwent surgery for post-cholecystectomy BDI between August 2007 and September 2017, were retrospectively reviewed. McDonald grading system was used to assess the long-term outcome. The risk factors for unsatisfactory longterm outcome were analyzed by univariate and multivatiate logistic regression analysis.In total, 228 patients had a Roux-en-Y hepaticojejunostomy. Open cholecystectomy was the major cause of BDI (61%). The median time from injury to definitive repair was 6 months. The types of BDI were as follows: E1 in 13 (5.7%), E2 in 68 (29.82%), E3 in 108 (47.36%), E4 in 28 (12.28%), and E5 in 11 (4.82%) patients respectively. Postoperative morbidity and mortality were 25% and 1.31% respectively. After a median follow-up of 58 months, 90% patients had excellent to good outcome. Recurrent stricture developed in 6 (3%) patients. On multivariate analysis, long injury-repair interval and previous attempt at repair were independent predictors of unsatisfactory long-term outcome.Surgical reconstruction affords excellent to good results for majority of the patients with post-cholecystectomy BDI. As longer delay in definitive repair and previous attempt at repair were associated with unsatisfactory long-term outcome, early referral to a specialized hepatobiliary surgery unit is recommended.

The goal of this study was to evaluate the prognostic role of four preservation solutions in liver transplantation (LT).This is a retrospective study originating from 22 French centers performing LT, registered in the prospective databank of the Cristal Biomedicine Agency between 2008 and 2013. The preservation solutions used were Celsior (CS), Institut Georges Lopez (IGL)-1, Solution de Conservation des Organes et des Tissus (SCOT) 15 and University of Wisconsin (UW) solutions. Exclusion criteria were preservation with unknown or inhomogeneous solutions, or Histidine-tryptophan-ketoglutarate (HTK) solution (representing only 3% of LT). Patient survival was the main endpoint. Secondary endpoints were graft survival and duration of stay in intensive care.Of 6347 LT performed, 4928 were included in this study, for which the distribution of preservation solution was CS (30%), IGL-1 (44%), SCOT 15 (10%) and UW (16%). Patient survival was 86%, 80% and 74% at 1, 3 and 5 years after LT, respectively, without any statistically significant difference between the four solutions (P = 0.78). Graft survival was 82%, 75% and 69% at 1, 3 and 5 years after LT, respectively, without any statistically significant difference between the four solutions (P = 0.80). Duration of intensive care was different according to the solution used in univariate analysis (P < 0.001), but this effect disappeared in multivariate analysis when the center performing the transplantation was accounted for.The type of preservation solution used (CS, IGL-1, SCOT 15 or UW) did not have any influence on patient or graft survival after LT.

Perioperative outcomes of repeat laparoscopic colorectal resection (LCRR) have not been extensively reported. Patients who underwent LCRR from 2010 to 2018 in an expert center were retrieved from a prospectively collected database and compared to 2:1 matched sample. Matching was based on demographics, surgical indication [colorectal cancer (CRC) or benign condition], and type of resection (right-sided resection or left-sided resection or proctectomy). Twenty-three patients underwent repeat LCRR with a median time of 36 months between the primary and the repeat LCRR. They were 12 (52%) men with a mean age of 64.9 years (31–87) and a median BMI of 21.4 kg/m2 (17.7–34). Indication for repeat LCRR was CRC, dysplasia, anastomotic stricture, and inflammatory bowel disease in 11 (48%), 5 (22%), 4 (17%), and 3 (13%) patients, respectively. A right-sided resection, a left-sided resection, and proctectomy were reported in 11 (48%), 8 (35%), and 4 (17%) patients, respectively. Median blood loss reached 211 mL (range 0–2000 mL). Thirteen (57%) patients required conversion to laparotomy including 12 for intense adhesions. The median length of hospital stay was 7.5 days (5–20). Two (9%) major complications (Clavien–Dindo ≥ 3) were reported: 1 (4%) anastomotic fistula and 1 (4%) postoperative hemorrhage, without mortality. Among patients who underwent repeat LCRR for CRC, histopathological examination showed R0 resection in all patients, with at least 12 lymph nodes harvested in ten (91%) patients. After matched case–control analysis that compared to primary LCRR, conversion rate (p = 0.03), operative time (p = 0.03), and intraoperative blood loss (p = 0.0016) were significantly increased in repeat LCRR, without impact on postoperative outcomes. Repeat LCRR seems to be feasible and safe in expert hands without compromising the oncologic outcomes. Intense postoperative adhesions and misidentification of blood supply might lead to conversion to laparotomy. Real benefits of laparoscopic approach for repeat LCRR should be assessed in further studies.

As the most appropriate laparoscopic approach for adrenalectomy is still a matter of debate, we present a modified technique of laparoscopic transmesocolic approach for left adrenalectomy. All demographics, intraoperative and postoperative data of patients who underwent laparoscopic transmesocolic left adrenalectomy from 2009 to 2015 in Avicenne Hospital were recorded. Thirty-three consecutive patients underwent laparoscopic transmesocolic left adrenalectomy. We observed no conversion, negligible blood loss, no red cell transfusion or intraoperative complication. Mean operative time reached 96 min (range: 40–200 min). Postoperatively, the median length of hospital stay was 5 days (range: 3–8 days), mortality was nil, and six (19%) patients suffered from complication, including one major complication (Clavien–Dindo III–IV, an abdominal collection treated with radiologic drainage). R0 resection was achieved in all patients. Laparoscopic left adrenalectomy using semi-lateral transperitoneal transmesocolic approach is feasible and safe with acceptable intraoperative and perioperative outcomes. This technique could be considered as a routine approach and should be compared in further studies.

La prise en charge de patients en oncologie digestive est parfois complexe, du fait d’antécédents thérapeutiques lourds (chirurgie, radiofréquence, radiothérapie). L’objectif est d’évaluer l’apport du TEP/MR dans le bilan des récidives des tumeurs abdominopelviennes. Vingt-neuf patients du service d’oncologie digestive de l’hôpital Avicenne étaient inclus prospectivement, entre février 2016 et mai 2017, dans un contexte d’élévation des marqueurs ou d’apparition de nouvelles lésions durant le suivi. Tous les patients ont eu un TEP/MR qui a suivi un bilan conventionnel associant un scanner (n = 18/29), une IRM (n = 14/29) et un TEP/TDM au FDG (n = 29/29). Le TEP/IRM était réalisé à la suite du TEP/TDM comprenant les séquences suivantes : Dixon (correction d’atténuation), axiales T2, DWI et T1 W post-contraste. Les dossiers des patients ont été discutés en RCP de chirurgie digestive. Les constatations en imagerie et les décisions thérapeutiques durant la RCP disposant des informations du bilan conventionnel ont été relevées. Dans un second temps, après introduction dans la discussion des résultats du TEP/IRM, les changements dans les décisions thérapeutiques ont été notés. Le TEP/MR a apporté des informations supplémentaires chez 11/29 (38 %) patients : négativation de lésions suspectes hépatiques (3/11), ganglionnaires ou péritonéales (2/11) ou extra-abdominales (3/11) ; lésions additionnelles ganglionnaires et/ou péritonéales (2/11) et extra-abdominale (1/11). L’introduction des résultats de TEP/MR pendant la RCP a conduit à un changement de décision thérapeutique chez 4 patients (14 %) : chirurgie à la place d’une chimiothérapie (n = 1), changement considéré comme pertinent car confirmé par la chirurgie (lésion hépatique suspecte décrite comme stéatose en TEP/IRM) ; chirurgie à la place de la chimiothérapie, changement non pertinent du fait des constatations opératoires infirmant le TEP/IRM (carcinose non vue en imagerie) ; chirurgie à la place de la radiothérapie vertébrale, changement considéré comme pertinent (lésion vertébrale suspecte, décrite comme bénigne en TEP/IRM) ; chimiothérapie à la place de la chirurgie chez un patient avec carcinose péritonéale décrite comme répondant à la chimiothérapie en TEP/IRM. Dans les dossiers complexes d’oncologie digestive, le TEP/MR peut apporter des informations supplémentaires, pouvant conduire à des modifications des stratégies thérapeutiques chez un nombre significatif de patients.

Analyser la survie après résection de récidive ganglionnaire d’un cancer colorectal. Étude monocentrique rétrospective (2007–2017) observationnelle incluant tous les patients ayant été réséqués d’une récidive ganglionnaire d’un cancer colorectal. Un total de 7 patients dont 4 femmes d’un âge médian de 60 ans (38 à 69 ans) étaient inclus. Les tumeurs étaient classées T3 (71 %) ou T4 (28 %), dont 86 % de N+ et 43 % de métastases synchrones. Toutes les récidives ganglionnaires étaient lombo-aortiques (86 %) ou pelviennes, suspectées sur des scanners et Pet-scans consécutifs, affirmées sur les pièces opératoires. Le délai médian entre la résection du primitif et celle de la récidive ganglionnaire était de 29 mois (8 à 57 mois). Une seule complication était associée à la résection ganglionnaire (fistule colo-vésicale). Tous les patients ont bénéficié d’un traitement adjuvant associant chimiothérapie et radiothérapie ; 3 (43 %) patients ont finalement récidivé, 1 (14 %) patient est décédé après 25 mois, pour une survie médiane sans récidive 36 mois (0 à 117 mois) et une survie globale de 69 mois (25 à 117 mois). La résection chirurgicale d’une récidive ganglionnaire d’un cancer colorectal peut s’intégrer dans une prise en charge multimodale, offrant une survie prolongée.

BACKGROUND:Hepatectomy remains the only curative option in patients presenting with colorectal liver metastases (CLM). Although laparoscopic approach has improved postoperative morbidity and mortality rates, its suitability for patients of all age groups has yet to be confirmed. The aim of this study was to analyze postoperative outcomes following laparoscopic liver resection (LLR) in different age groups of patients presenting with CLM. METHODS:All patients who underwent LLR for CLM from 2008 to 2017 were reviewed. Patients were divided into four age groups: < 55, 55-65 years, 65-75 and > 75 years. Baseline and intraoperative characteristics as well as postoperative morbidity and mortality were compared between all four groups. RESULTS:Overall, 335 patients were included with 34 (10%), 113 (34%), 136 (41%) and 52 (15%) in < 55, 55-65, 65-75 and > 75 years subgroups. Baseline characteristics were similar between all four groups except for elevated pressure, dyslipidemia and ASA score which were higher in older patients. Regarding surgical procedures, major hepatectomy, uni- or bisegmentectomy and wedge resection were performed in 122 (36%), 87 (26%) and 126 (38%) patients, respectively, with no significant differences between age groups. Overall, 90-day postoperative mortality rate was nil and postoperative morbidity was similar between all four groups except for biliary fistula occurrence, which was higher in < 55 years patients (p = 0.006). CONCLUSION:Short-term postoperative outcome following LLR for CLM does not seem to be affected by age. Curative laparoscopic treatment should therefore be considered whenever possible, regardless of patient age.

Background: Risk factors for pancreatic fistula (POPF) occurrence after pancreaticoduodectomy (PD) are mostly known. Identifying those that are linked to clinically relevant POPF (Grades B and C) (CR-POPF) is critical, as CR-POPF is associated with more complications and a higher mortality rate. Methods: From 2004 to 2016, 270 consecutive patients who underwent PD in two academic centers were compared retrospectively according to the occurrence of CR-POPF. Results: A series of patients with a median age of 64.5 years (range 30.6-88.7 years) underwent PD. They were allocated to two groups: CR-POPF (Grades B and C)(n = 74; 27.4%) and without clinically relevant POPF (cr-POPF) (no fistula formation or Grade A) (n = 196). Pancreatic ductal adenocarcinoma was the main indication for the procedure (58.5%). Post-operative complications Clavien-Dindo I/II and Clavien-Dindo III/IV and in-hospital death occurred in 109 (40.4%), 67 (24.8%), and 18 (6.7%) patients, respectively. After univariate analysis, CR-POPF was associated with a Body Mass Index (BMI) >25 kg/m2 (p < 0.0001), pancreatic duct diameter <3 mm (p = 0.047), soft pancreas texture to palpation (p = 0.037), and peri-operative transfusion (p < 0.001). After multivariate analysis, high BMI (p = 0.026), transfusion (p < 0.001), length of hospital stay (p < 0.0001), and in-hospital death (p = 0.004) were associated with CR-POPF. Conclusions: In-hospital death and length of hospital stay after PD are related to CR-POPF. A BMI >25 kg/m2 and peri-operative blood transfusion are objective risk factors for CR-POPF.

Obesity and its metabolic complications are characterized by subclinical systemic and tissue inflammation. In rodent models of obesity, inflammation and metabolic impairments are linked with intestinal barrier damage. However, whether intestinal permeability is altered in human obesity remains to be investigated. In a cohort of 122 severely obese and non-obese patients, we analyzed intestinal barrier function combining in vivo and ex vivo investigations. We found tight junction impairments in the jejunal epithelium of obese patients, evidenced by a reduction of occludin and tricellulin. Serum levels of zonulin and LPS binding protein, two markers usually associated with intestinal barrier alterations, were also increased in obese patients. Intestinal permeability per se was assessed in vivo by quantification of urinary lactitol/mannitol (L/M) and measured directly ex vivo on jejunal samples in Ussing chambers. In the fasting condition, L/M ratio and jejunal permeability were not significantly different between obese and non-obese patients, but high jejunal permeability to small molecules (0.4 kDa) was associated with systemic inflammation within the obese cohort. Altogether, these results suggest that intestinal barrier function is subtly compromised in obese patients. We thus tested whether this barrier impairment could be exacerbated by dietary lipids. To this end, we challenged jejunal samples with lipid micelles and showed that a single exposure increased permeability to macromolecules (4 kDa). Jejunal permeability after the lipid load was two-fold higher in obese patients compared to non-obese controls and correlated with systemic and intestinal inflammation. Moreover, lipid-induced permeability was an explicative variable of type 2 diabetes. In conclusion, intestinal barrier defects are present in human severe obesity and exacerbated by a lipid challenge. This paves the way to the development of novel therapeutic approaches to modulate intestinal barrier function or personalize nutrition therapy to decrease lipid-induced jejunal leakage in metabolic diseases. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Purposes: Accurately localizing colorectal cancer during surgery may be challenging due to intraoperative limitations. In the present study, localization of left-sided colon cancer (LCC) by CT scan is compared to colonoscopy. Material and methods: Consecutive patients with LCC located by colonoscopy and CT scan and undergoing left-hemicolectomy were included. Tumor distance from the anal verge (TDAV) was calculated by both CT-scan and colonoscopy, and then compared, using as reference TDAV measured intraoperatively. Statistical analysis was performed including (1) comparison of means between all three TDAVs, (2) comparison of mean differences between all three TDAVs, (3) comparison of number of patients with a difference between endoscopic TDAV and intraoperative TDAV ≤5 cm and the number of patients with a difference between CT scan TDAV and intraoperative TDAV ≤5 cm (4) statistical relationship between either CT scan and endoscopic and intraoperative TDAVs. Results: Both CT scan and endoscopy overestimate TDAV (25.8 ± 12.5 cm and 24.6 ± 10.6 cm vs. 21.5 ± 7.4 cm, p = 0.005), but CT scan TDAV resulted as being different from intraoperative TDAV (p < 0.01). Regression analysis reported an increasing divergence of measurements with increasing values of intraoperative TDAV, which resulted greater for CT. Tumors within 5 cm of intraoperative TDAV were 22/28 (78.6%) for endoscopy, and 17/28 (60.7%) for CT (p = 0.2448). Conclusions: Accuracy of both examinations seems poor, with a mean overestimation >3 cm and a significant number of tumors found at >5 cm from preoperative evaluation. Preoperative examinations' bias increase proportionally with TDAV length, decreasing their interest especially for tumors located at a greater distance from anal verge.

Although association between colorectal cancer (CRC) and metabolic syndrome (MetS) is established, specific features of CRC arising in patients presenting with MetS have not been clearly identified.

Abstract Complicated Meckel's diverticulum represents a common etiology of acute abdomen in children. However, this condition is less frequent in adults. We reviewed the records of adult patients who underwent the surgical removal of complicated Meckel's diverticulum between 2001 and 2017 at 2 tertiary French medical centers. We then analyzed the clinical characteristics, mode of presentation, and management for all patients. The Meckel's diverticulum was resected in 37 patients (24 males and 13 females). The mean patient age was 46.1 ± 21.4 years. The most common clinical presentations of complicated Meckel's diverticulum were diverticulitis (35.1%, n = 13), small-bowel obstruction (35.1%, n = 13), and gastrointestinal bleeding (29.8%, n = 11) (anemia, n = 1; hematochezia, n = 10). Age distribution was significantly different (P = .02) according to the 3 Meckel's diverticulum complications: patients with diverticulitis (P = .02) were statistically more frequently over 40 (P = .05), significantly older than patients with gastrointestinal bleeding who were more frequently <40 (P = .05). There was a preoperative diagnosis available for 15 of the 37 patients (40%). An exploratory laparoscopy was necessary to determine the cause of disease for the other 22 patients (60%). An intestinal resection was performed in 33 patients (89%) and diverticulectomy was performed in 4 patients (11%). There was heterotopic tissue found in only 6 patients (16%). Postoperative complications were as follows: 1 death by cardiac failure in a 92-year-old patient and 2 patients with postoperative wound infections. The follow-up time was 3 to 12 months. The correct diagnosis of complicated Meckel's diverticulum in adults is difficult due to the lack of specific clinical presentation. As a result, exploratory laparoscopy appears to play a central role in cases of acute abdomen with uncertain diagnosis.

With an increasing postoperative survival and prolonged follow-up, late complications following pancreaticoduodenectomy (PD) have yet to be thoroughly described and analyzed. Among those, pancreatic anastomosis stricture may lead to severe consequences.

Gallstone ileus is an uncommon clinical presentation of complicated biliary lithiasis that mostly occurs in the elderly without specific signs. Various types of surgical management have been proposed: primary enterolithotomy, enterolithotomy, cholecystectomy and fistula closure (one stage), or enterolithotomy with delayed cholecystectomy (two stage). All are associated with a high complication rate. We present a video of a laparoscopic cololithotomy for gallstone ileus caused by a gallstone impacted in the sigmoid colon. As a safe and feasible procedure, enterolithotomy appears to be the treatment of choice based on the scientific literature, especially in frail patients. However, except in case of an impacted gallstone in a colorectal cancer, colon resection is not mandatory. Further surgery (such as cholecystectomy or colectomy in benign disease such as diverticulosis) may be selectively considered.

Background/Purpose In order to avoid consequences of total splenectomy (including severe postsplenectomy sepsis), partial splenectomy (PS) is increasingly reported. Without guidelines and indications concerning a rarely-indicated procedure, a review of literature should be an asset. Methods A systematic review of all PSs from 1960 to December 2017 was performed, with special focus on surgical indications, sites of resection, approaches and techniques of vascular dissection and parenchymal section/hemostasis of the spleen, perioperative morbidity/mortality, including complications compelling to perform total splenectomy. Results Among 2130 PSs, indications for resection were hematological disease in 1013 cases and nonhematological conditions in 1078, including various tumors in 142 and trauma in 184. Parenchymal transection was performed using several techniques through the years, most frequently after having induced partial ischemia by splenic hilum vascular dissection/ligation. 371 laparoscopic/robotic PSs were reported. Rescue total splenectomy was required in 75 patients. Conclusions Although good results are probably overestimated by such a retrospective review, PS should be considered as a procedure associated with a low morbidity/mortality. Nevertheless, severe complications are also reported, and the need of total splenectomy should not to be minimized. Laparoscopic/robotic procedures are increasingly performed, with good results and rare conversions. Type of study Systematic review. Level of evidence IV.

Among the criteria used to diagnose metabolic syndrome (MS), obesity and diabetes mellitus (DM) are associated with poor postoperative outcomes following colectomy. MS is also associated with colorectal cancer (CRC) and diverticulosis, both of which may be treated with colectomy. However, the effect of MS on postoperative outcomes following laparoscopic colectomy has yet to be clarified.

Background & aims: the obesity survival paradox is an emergent issue in oncology, but its existence remains unclear particularly in older cancer patients. We aimed to assess the obesity survival paradox in older cancer patients. Methods: all consecutive cancer outpatients 65 years and older referred for geriatric assessment (GA) before a decision on cancer treatment between November 2013 and September 2016 were enrolled in the PF-EC cohort study. The main outcome was 6-month mortality. A Cox univariate and multivariate proportional hazard regression models were performed with baseline GA, oncological variables (cancer site, extension and treatment modalities) and C-reactive protein (CRP). We assessed the prognostic value of body mass index categories (i.e. malnutrition <21, 21 <= normal weight <= 24.9, 25 <= overweight <= 29.9 and obesity >= 30 kg/m(2)) in the whole study population and according to the metastatic status. Results: 433 patients with a mean age of 81.2 +/- 6.0 years were included, 51% were women, 44.3% had digestive cancers, 18% breast cancer and 14.5% lung cancer and 45% metastatic cancers. Eighty-eight of these patients (20.3%) were obese at baseline. Mortality rate was 17% during the 6-month follow-up period. After adjustment for sex, gait speed, Mini-Mental State Examination, cancer site and exclusive supportive care, obesity (compared to normal weight) was independently and negatively associated with 6-month mortality only in metastatic patients (aHR 0.17, 95% CI [0.03-0.92], P = 0.04). Conclusion: our study confirms the obesity survival paradox in older cancer patients only in the metastatic group. (C) 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.