Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near Dongshan Island in East China Sea. Structures of these compounds were elucidated by in-depth spectral and chemical methods, including 2D-NMR, HR-ESI-ESI-MS spectra, and acidic hydrolysis. For the first time, acetamido-glucose moiety is being reported from a gorgonian. The B-ring aromatized steroid aglycone of compound 3 is also rare in marine natural products. Compounds 1-3 exhibited moderate cytotoxic activity with IC50 values of 26.8-45.6 mu M against human tumor cells Bel-7402 and K562.
柳珊瑚一直是海洋天然产物研究的热点,从中分离得到的化合物包括甾醇类、萜类、含氮化合物类等多种类型,活性筛选实验表明,这些化合物普遍具有抗炎、抗菌、抗肿瘤和抗结核等多方面的生理活性.本文对2003年以来中国海域包括台湾海域柳珊瑚新的化学成分及其生理活性做一总结,为柳珊瑚的化学成分和活性研究提供参考.
The low polar components and antilipemic activity of Haliplanella luciae,a kind of fouling organisms of aquaculture,were analyzed.△4,5-(E),△8,9-(E)-Sphingol-hexadecamide(1) and cholester(2) were first obtained from H.luciae.Analysis on the relative content of fatty acids of H.luciae oil demonstrated that the content of EPA and EDA reached 61.9%.And the result of the antilipemic activity of the H.luciae oil in mice revealed that the high-dose group could significantly lower the level of TC、TG and HDL-C.The H.luciae oil was expected to be a new source of HUFAs and the relevant research would lead to new antilipemic drugs or food.
