Empowered by advanced on-board sensors, high-performance optics packages and ever-increasing computational power, smartphones have democratized data generation, collection, and analysis. Building on this capacity, many platforms have been developed to enable its use as an optical sensing platform for colorimetric and fluorescence measurements. In this paper, we report the ability to enable a smartphone to perform laboratory quality time-resolved analysis of luminescent samples via the exploitation of the rolling shutter mechanism of the native CMOS imager. We achieve this by leveraging the smartphone's standard image capture applications, commercially available image analysis software, and housing the device within a UV-LED containing case. These low-cost modifications enable us to demonstrate the smartphone's analytical potential by performing tasks ranging from authentication and encryption to the interrogation of packaging, compounds, and physical phenomena. This approach underscores the power of repurposing existing technologies to extend the reach and inclusivity of scientific exploration, opening new avenues for data collection and analysis.

Fluorescence quenching of poly(phenylene ethynylene) (PPE) particles by a Cy-5 labeled oligonucleotide is 2 orders of magnitude more sensitive than direct excitation of the Cy-5 fluorophore.

Nomadics and Professor Timothy Swager have collaborated extensively on the development of Amplifying Fluorescent Polymer (AFP) sensing technologies. AFPs are fully conjugated polymers which link many fluorphores into what is in effect, a molecular wire. Once linked, the ensemble of fluorophores will respond to a transduction event at any individual fluorophore. As a result, each individual analyte interaction will produce an effect in a much larger ensemble of fluorphores, amplifying each sensing event. Nomadics capitalized on this effect to construct a handheld landmine detector, which can identify buried landmines by sensing the trace signature of TNT vapor emanating from a mine. This presentation will describe efforts of Nomadics and the Swager group to leverage the intrinsic amplification of AFP systems for bioanalyte detection.

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Poly(p-phenyleneethynylene) with a Highly Emissive Aggregated PhaseRobert Deans, Jinsang Kim, Michelle R. Machacek, and Timothy M. SwagerView Author Information Department of Chemistry Massachusetts Institute of Technology Cambridge, Massachusetts 02139 Cite this: J. Am. Chem. Soc. 2000, 122, 35, 8565–8566Publication Date (Web):August 19, 2000Publication History Received29 February 2000Published online19 August 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/ja0007298https://doi.org/10.1021/ja0007298rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1941Altmetric-Citations242LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absorption,Aggregation,Polymer films,Polymers,Thin films Get e-Alerts