In Xenon Polarization Transfer Constant (XTC) imaging, saturation pulses are applied at DP Xe frequencies for red blood cell (RBC) and tissue plasma (TP), but, due to their high power, are not perfectly selective, often depolarizing both DP frequencies instead of only the one intended. We used XTC spectroscopy to explore how various saturation pulse parameters, primarily pulse power, affects saturation selectivity. The generated graphs plot depolarization as a function of saturation frequency. They demonstrate that as pulse power increases, the contribution of gas-phase depolarization due to off-resonance saturation increases, compromising selectivity.