In the present study, the density (ρ) and dynamic viscosity (η) of binary liquid mixtures such as glycerol (GLY) + isomers of butanol (1-butanol (1-BU), 2-butanol (2-BU), and tert-butanol (T-BU)) were experimentally measured as a function of glycerol mole fraction at T = (293.15 to 318.15) K and a pressure of 0.1 MPa. Using these experimental data, the deviation in viscosity (∆η), molar volume ( V_m ), excess molar volume ( V_m^E ), apparent molar volumes ( V_m,∅ ,1 and V_m,∅ ,2 ), partial molar volumes ( V_m,1 and V_m,2 ), and excess partial molar volumes ( V_m,1^E and V_m,2^E) values were calculated. The observed V_m^E and ∆η results were associated with the Redlich–Kister (R-K) model. Further, the V_m^E values were interpreted using the Prigogine–Flory–Patterson (PFP) model. The obtained V_m^E showed a negative deviation, and ∆η showed a positive deviation over the entire composition range of glycerol. The derived parameters in binary mixtures are affected by H-bonding. Moreover, the development of new H-bonding interactions between unlike molecules was further described using 1H-NMR spectroscopy studies.

We have synthesized some novel derivatives of 4-(1-(2, 4-dinitrophenyl)-3-phenyl-1H-pyrazol-4-yl)-7,7-dimet hyl-2-(methylamino)-3nitro-6,7,8,8a-tetrahydro-4H-chromen-5(4aH)-one by the multicomponent reaction of pyrazole aldehydes derivatives, N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) and 5,5-dimethylcyclohexane-1,3-dione. The synthesised compounds are confirmed by 1H NMR, IR and Mass Spectroscopy and they were then tested for antioxidant activities. In terms of antioxidant activity, compounds C-7 and C-1 were found to have the greatest and lowest levels respectively. Against Enterobacter aerogenes, compound C-5 exhibited the lowest minimum inhibitory concentration value.

The peculiar one-pot reaction involving Carbaldehydes, malononitrile, and indane 1,3-dione was used to explain the alternative synthesis of indeno-pyridine and indeno-pyran derivatives. The synthesis of indeno-pyridine or indeno-pyran derivatives has been examined based on an effective modification in the Michael addition of indane 1,3-dione or malononitrile on Knoevenagel product throughout the reaction process. The reaction required up to 30 min to complete utilizing CuO nanoparticles (NPs) in water at room temperature, making the approach innovative and environmentally benign. All of the produced compounds have been validated using spectroscopic data. And they were then tested for their antimicrobial activities. All tested compounds showing greater efficacy against Sertaconazol and Chloramphenicol.

The multi-step synthesis and structural determination by H-1 and C-13 NMR, IR, and mass spectroscopic investigations of certain new piperidinyl-pyridines 10a-o are described in this article. Compounds 10e , 10g , 10h , 10i , 10j , and 10n show greater efficacy with Doxorubicin, which is employed as a positive control, when tested for anti-cancer activity in vitro against two cancer cell lines, A549 and MCF-7. The compound 10g shows promising action over A549 and MCF-7, with IC50 values of 16.3 and 12.3 M respectively. Other IC50 values indicate towards strong potential and were in the good promise range.

The synthesis of some new isoxazole-piperidine-1,2,3-triazoles (4a-4j) have been achieved using Sharpless Cu(I) catalyzed [3+2] cycloaddition as a key approach. The in vitro anticancer screening of all the compounds against four human cancer cell lines including MCF-7, HeLa, A549 and IMR32 has revealed that the compounds 4c and 4f exhibited promising activity against all the cell lines as compared to etoposide. Rest of the compounds have shown good to zero activity against specific cell line when compared with the positive control. Predominantly, the compound 4c is showing superior activity against IMR32 which posses IC50 value 3.2 +/- 0.3 mu M.

We define and study a class of analytic functions in the unit disc by using a modification of the well-known Silverman and Silvia analytic formula for starlike functions with respect to a boundary point. The representation theorem, as well as growth and distortion theorems are established for the new class of functions. Further, early coefficients of the new class of functions are also estimated.

A series of novel (1-aryl-1 H -1,2,3-triazol-4-yl)methyl 3-acetamido-1-phenyl-1 H -benzo[ f ]chromene-2-carboxylates were synthesized from prop-2-yn-1-yl 3-acetamido-1-phenyl-1 H -benzo[ f ]chromene-2-carbox­ylate. 3-Amino-1-phenyl-1 H -benzo[ f ]chromene-2-carbonitrile and 2-amino-4-phenyl-4a,5,6,7,8,8a-hexahydro-4 H -chromene-3-carbonitrile were prepared by three-component condensation of benzaldehyde, β-naphthol or cyclohexanol, and malononitrile. The synthesized compounds were evaluated for their antibacterial and anti­fungal activities in comparison to chloramphenicol and amphotericin B as reference antibiotics.

A series of novel (1-phenyl-1H-1,2,3-triazol-4-yl)methyl-2-acetamido-1-phenyl-1H-benzo[f] benzo[f]chromene-3carboxylate 6a-i compounds have been synthesised from prop-2-yn-1yl-3-acetamido-1-phenyl-1H-benzo[f]chromene-2carboxylate 5. 3-Amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile and 2-amino-4-phenyl-4a,5,6,7,8,8a-hexahydro-4Hchromene-3-carbonitrile (1 and 2a) are generated when benzaldehyde, 0-naphthol, (or) cyclohexanol, and malononitrile are incorporated into the mixture. Activity of two conventional antibiotics, Chloramphenicol and Amphotericin-B, have been compared to the antibacterial and antifungal properties of the prepared synthetic compounds. A study has been conducted on the spectroscopic properties of Schlenter products.

Synthesis of new series of chromen-2-one-1,2,3-Triazoles (6a-6j) was reported using the help of key methods such as [3+2]-cycloaddition and ultrasound. All compounds were further evaluated for their in vitro anticancer activity profile in three human cancer cell lines MCF-7(breast), A-549 (lungs), and HeLa (cervical). Among all, three compounds namely 6c, 6f, and 6j showed the most promising activity against three lines, when compared with the etoposide.

Pyran was formed by reacting methyl 3‐methoxyacrylate (1) with 2‐benzylidenemalanonitrile to form compound 2 . The pyrano derivatives 3–6 were obtained by reacting the second molecule with 2‐benzylidenemalanonitrile, carbon disulfide, formamide, and benzylidene cyclohexanone. Compound (2) interacted with ethyl chloroacetate to form compound 8 , which then cyclized in the presence of sodium ethoxide to form compound 9 . Compound 7 was formed when compound (2) was treated with acetic acid in the presence of sulfuric acid and reacted with ethylchloroacetate to form compound 10 and then was converted to compound 11 by the addition of sodium ethoxide. Analytical and spectral data have been used to determine the structures of the newly synthesized substances and they were then tested for their antibacterial and antioxidant activities. In terms of antioxidant activity, compounds 2 and 8 were found to have the greatest and lowest levels, respectively, against Enterobacter aerogenes.

In this context, we describe the efficiency of this catalyst towards green organic synthesis has been studied by carrying out a mixture of 1-fluoro-4-isocyanobenzene (1), 6-aminonicotinic acid (2)and substituted 1H-indole-3- carbaldehyde (3a-i) in distilled water, porous Au/TiO2nanospheres were added at room temperature in H2O. It proceeds yielding the corresponding isubstituted-3-((4-fluorophenyl) amino)-2-(1H-indol-3-yl)imidazo [1,2- a]pyridine-6-carboxylic acid derivative in good to excellent yield viz one-pot multi-component reaction. All the title compounds were also screened for Anti- proliferation activity screened for their in vitro anticancer activity against four human cancer cell lines MCF-7, HeLa, HEK 293T and IMR 32. Among them 4a (having 4-OCH3 substituent) has shown promising activity with IC50 (µM) 16.74±1.86 (MCF-7), 40.68 ± 1.25(HeLa), 50.61±4.64 (HEK 293T) and 26.58±1.68 (IMR32) has shown IC50 (µM) and these results are close to that of standard drug Doxorubicin.

The application of agro-waste in the form of compost is an ecofriendly approach to minimize the use of chemicals for crop improvement. Hence, compost was prepared by the Indore method from banana spathe obtained from five popular varieties of banana cultivated in Tamil Nadu, India, and its growth promoting ability was tested on the rice cultivar CO-51. The banana spathe was applied as both an aqueous extract and compost to evaluate the growth parameters in bioassays and pot culture experiments. The compost improved the growth in terms of root length, shoot length, biomass, tillers, length, and width of flag leaf and yield in CO-51 rice cultivar significantly (p < 0.001%) when compared to the untreated control and fertilizer-treated plants. The maximum yield was observed in the treatment with Rasthali spathe. Biochemical analysis of the compost-treated rice plants showed an increase in chlorophyll, carotenoid, carbohydrate, protein, and amino acid content when compared to the untreated control plants. The results from the study suggest that the banana spathe compost could be used as an effective organic fertilizer for the growth of rice plants thus providing a strategy to reduce landfills, as well as the use of fertilizers, thereby further helping to protect the agroecosystem.

The current article presents the experimental density (rho) and viscosity (eta) values were re ported as a function of mole fraction for the binary liquid mixtures of isoamyl alcohol (IAA) + heterocyclic components (NCHC) namely; piperidine, pyrrole, pyridine, morpholine, and quinoline at the temperatures T = (293.15 to 313.15) K with 10 K intervals under atmospheric pressure (0.1 MPa). Based on experimental data, the excess molar volume (V-E), viscosity deviation (Delta eta) was calculated. These values were correlated to the Redlich-Kister (R-K) model at measured temperatures. The obtained excess molar volume was negative deviations and deviation in viscosity was positive at the above said temperatures. From these results, the new H-bond, OH-pi interaction, and molecules fitting in studied unlike molecules had been determined. Further, the influence of temperature on rho, eta, V-E and Delta eta were also reported.

Herein we described the synthesis of indazole derivatives through C-N cyclization and evaluated for their anticancer activities against three human cancer cell lines such as HeLa, MCF-7, and SKOV3 using MTT assay.The synthesized indazole hybrids are characterized based on 1H NMR, 13C NMR spectral data, and elemental analysis.The results indicated that the most potent molecule in this series is compound 3b against MCF-7, compound 3h against HeLa, and compound 3d against SKOV3, which showed the highest activity with an IC50 value of 32.92 µg/ml, 12.08 µg/ml, and 29.06 µg/ml respectively.

The simple and more reliable one-pot synthesis of some novel compounds of allyl/Benzyl quinazolinone (4aa-4bd) with good yields from readily available derivatives of anthranilic acid and benzoyl chloride was also reported. Interestingly, as compared to Diclofenac sodium, compounds 4ac, 4ad, 4ba, 4bc and 4bd displayed remarkable anti-inflammatory activity (Scheme 1 & Table 2).

A concise and highly efficient procedure has been described for the synthesis of 9-aryl-6-(2-naphthyl)[1,2,4] triazolo[4,3-a][1,8]naphthyridines-8 by the oxidation of the corresponding aryl aldehydel-[3-(2-naphthyl) [1,8]naphthyridin-2-yl]hydrazones 7 using silica gel supported ferric chloride (SiO2-FeCl3) in solvent-free conditions under microwave irradiation. The desired products are obtained in very good yields and in a state of high purity. The structure of compounds 3-8 have been confirmed by their spectroscopic (IR, H-1 NMR and MS) and analytical data. The compounds 8a-j have been screened for their antibacterial activity.

The synthesis of some new 5 alpha-cholestan-pyrazole hybrids from the reaction of 5 alpha-cholestan-6-one-thiosemicarbazone derivatives with several amides using POCl3 is demonstrated. The structures of newly synthesized hybrids were characterized by H-1 and C-13 NMR and mass spectral analysis. These compounds were screened for their in vitro anticancer activity over few human cancer cell lines such as ACHN, MCF-7, and A375 using doxorubicin as a positive control. Among them, compounds 3h and 3i have shown slightly higher activity than the positive control. The rest of the compounds have displayed moderate to good in vitro anticancer activity against all the tested cell lines as compared to the positive control. The IC50 values for more active 3h and 3i compounds were found to be ranging between 0.71 to 5.48 mu M.[GRAPHICS]

- Inflammation is the primary host defense mechanism against all forms of injury. Excessive or inadequate activation of the system can have serious effects, as can the failure of inactivation mechanisms. Coumarins can reduce tissue edema and inflammation and inhibit prostaglandin biosynthesis, which involves fatty acid hydroperoxy intermediates.In this paper we would like to discuss the anti-inflammatory activity some substituted coumarin derivatives by means of LD50 using Diclofenac sodium as standard .

Let (p, q) ∈ (0, 1). Let the function f be analytic in |z| < 1. Further, let the (p, q) be differential operator defined as \( {\displaystyle } {{\partial _{p,q}}}f \left ( z \right ) = \frac {{f\left ( pz \right ) - f\left ( {qz} \right )}}{{z\left ( {p - q} \right )}}, \quad |z|<1. \) In the current investigation, the authors apply the (p, q)-differential operator for few subclasses of univalent functions defined by quasi-subordination. Initial coefficient bounds for the defined new classes are obtained.

1 Department of Chemistry , Chaitanya Post Graduate college (Autonomous), 2 Kakatiya University , Warangal , Telangana State -506009. Abstract-The pyrazole derivatives have been also used in the field of agriculture as fungicides, insecticides, pesticides and herbicides. 2,4-Dihydro-2,5-disubstituted-3H-pyrazol-3-ones (fig-1) 1 condense readily with aromatic aldehydes (2) both in acidic and basic media. The reaction is when carried out in the presence of acetic acid, it yields 4-arylmethylene-2,4-dihydro-2,5-disubstituted-3Hpyrazol-3-one(3) (Scheme-1).