A Raleigh, NC, population of Drosophila melanogaster was sampled for the presence of enzyme null alleles at 25 loci. No nulls were found at any of five X-linked loci. Nulls were recovered at 13 of 20 autosomal loci; the weighted mean frequency for all 20 autosomal loci was estimated to be 0.0025. A consideration of the effects of these null alleles on viability strongly suggests that, although they may contribute to so-called polygenic variation, they are not representative of the entire genome.
Abundant proteins of 25 human kidneys were surveyed for genic variation by means of two-dimensional electrophoresis. Eighty-three (83) proteins were scored, and no genic variation was detected. This reduction in genic heterozygosity corroborates results determined with two-dimensional electrophoresis in mice and flies. These results suggest that previous estimates of electrophoretic variation may have been in error because of biased selection of loci.
Charles H. Langley合作论文数Laboratory of Molecular Genetics;National Institute of Environmental Health Sciences;Research Triangle Park;Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences2Rr Racine合作论文数1AJL BROWN合作论文数NIEHS,ANIM GENET LAB,RES TRIANGLE PK,NC 277091Ra Voelker合作论文数1Elizabeth Montgomery合作论文数1Seido Ohnishi合作论文数1Barbara Dickson合作论文数1
