Fixed drug eruption (FDE) is a specific drug-induced dermatosis with a characteristic recurrence at the same sites of the skin or mucous membrane. FDE is frequently associated to non-steroid anti-inflammatory drugs exposure. This condition can mimic serious medical conditions such as Stevens-Johnson syndrome when bullae are present. We report a case of a 74-year-old woman, with a non-specified past cutaneous reaction to diclofenac, that developed generalized bullous fixed drug eruption caused by Naproxen.

Amyloidosis is a systemic disease, with an incidence of 5-12 people per million per year. Autopsy studies suggest a higher incidence(1). Is characterized by deposition of amyloid fibrils in extracellular tissue of various organs and systems, and therefore with multiple possible presentations. The causative amyloid fibril deposits are of monoclonal light chain (AL) or transthyretin (TTR) in most cases. TTR amyloidosis may be acquired, associated with wild type TTR or hereditary (associated with variants in TTR gene(2) (table 1). The AL amyloidosis condition can occur alone or associated with multiple myeloma or other B-cell dyscrasias(3). The main affected organs in AL amyloidosis are the heart, kidney, liver, gastrointestinal tract and the peripheral and autonomic nervous systems. Patients often present with non-specific symptoms, such as asthenia, weight loss, palpitations and syncopal attacks(4). Thus, diagnosis is usually delayed, and renal and cardiac failure can be forms of presentation. We report a case of a 68-year-old woman, who presented with new onset heart failure as the main presentation form of multiple myeloma with associated cardiac amyloidosis. This case highlights the need of a high level of suspicion in order establish an early diagnosis and initiate specific therapy, and therefore delay the development of this condition.

Amyloidosis is a systemic disease, with an incidence of 5-12 people per million per year. Autopsy studies suggest a higher incidence. Is characterized by deposition of amyloid fibrils in extracellular tissue of various organs and systems, and therefore with multiple possible presentations. The causative amyloid fibril deposits are of monoclonal light chain (AL) or transthyretin (TTR) in most cases. TTR amyloidosis may be acquired, associated with wild type TTR or hereditary (associated with variants in TTR gene (table 1). The AL amyloidosis condition can occur alone or associated with multiple myeloma or other B-cell dyscrasias. The main affected organs in AL amyloidosis are the heart, kidney, liver, gastrointestinal tract and the peripheral and autonomic nervous systems. Patients often present with non-specific symptoms, such as asthenia, weight loss, palpitations and syncopal attacks. Thus, diagnosis is usually delayed, and renal and cardiac failure can be forms of presentation. We report a case of a 68-year-old woman, who presented with new onset heart failure as the main presentation form of multiple myeloma with associated cardiac amyloidosis. This case highlights the need of a high level of suspicion in order establish an early diagnosis and initiate specific therapy, and therefore delay the development of this condition.