This report consolidates scientific evidence substantiating that there is no Environmental Tobacco Smoke (ETS) emitted during use of Philip Morris International’s (PMI) Electrically Heated Tobacco System (EHTS, also known as the Tobacco Heating System 2.2 and marketed in various countries under the brand name IQOS) and that EHTS use has no adverse effect on the air quality according to threshold limits established by existing air quality guidelines and when used in a setting where regulatory norms of adequate ventilation are respected.

Philip Morris International (PMI) supports scientific data transparency, data sharing and actively encourages the conduct of independent studies on IQOS that are aimed at advancing scientific and medical knowledge or verifying the results we obtained through our assessment program described by Smith et al. To date we have published over 30 peer-reviewed articles describing studies specifically conducted with IQOS. We have also submitted a Modified Risk Tobacco Product (MRTP) application with the U.S. FDA. It is important that independent studies are conducted with a high degree of scientific rigor, the same degree of rigor that is expected from our company. Key standards for scientific research are:

Three d-glucose based bolaamphiphiles have been synthesized by a simple and efficient synthetic methodology utilizing the free C-3 hydroxyl group of diisopropylidene glucose. The resulting bolaamphiphiles showed unique aggregation behavior in aqueous solution, e.g. transformation of vesicle to tubular morphology on aging. The chiral hydrophobic interior of these vesicles was utilized as tiny reaction vessels to carry out 1,3-dipolar nitrone cycloadditions in water. The corresponding isoxazolidine derivatives were formed with high diastereoselectivity in several cases. The bolaamphiphile with 12 carbon spacer (5c) showed better diastereoselectivity among the rest with just 2 mol% of catalyst loading and can be reused.