Deep venous thrombosis (DVT) in the lower extremities is a serious postpartum complication in women with pregnancy-induced hypertension (PIH), often resulting in significant morbidity if not diagnosed early. This study aimed to evaluate the diagnostic utility of vascular color Doppler ultrasound in combination with plasma Ddimer (D-D) and antithrombin III (ATIII) levels for detecting DVT in postpartum women with PIH. A retrospective analysis was conducted on 88 postpartum women with PIH, divided into DVT-positive and DVT-negative groups based on Doppler ultrasound findings. Clinical data, vascular imaging results, and laboratory parameters were compared between the groups. The study found that increased limb vessel diameter, decreased blood flow velocity, and elevated levels of D-D and ATIII were significantly associated with DVT. Multivariate analysis confirmed these as independent risk factors. Receiver operating characteristic (ROC) curve analysis demonstrated that combining Doppler ultrasound with D-D and ATIII measurements yielded superior diagnostic accuracy (AUC = 0.876), with a specificity of 96.57 %. These findings suggest that integrating vascular imaging with plasma biomarkers can enhance the early detection of DVT in high-risk postpartum populations. This combined diagnostic approach may provide a valuable, non-invasive strategy for improving maternal outcomes in clinical practice.

OBJECTIVE:This study aimed to evaluate the sonographic features of giant fetal hepatic hemangioma (GFHH) as predictors of complications and outcomes. METHODS:We conducted a retrospective analysis of prenatally diagnosed GFHH cases between 2014 and 2024, reviewing ultrasonographic features, complications, and neonatal outcomes. RESULTS:Among 36 fetuses, 38.9% exhibited homogeneous masses and 61.1% showed heterogeneous masses. Peripheral annular or semi-annular blood flow was observed in 88.9% of cases. Heterogeneous echogenicity was more frequent in the complicated group (93.3%, 14/15) than in the uncomplicated group (38.1%, 8/21) (p < 0.01). Significant differences were identified between the complicated and uncomplicated groups regarding the presence of vascularity, arteriovenous fistula (AVF), hepatic artery peak systolic velocity (HAPSV) (> 106 cm/s), and hepatic vein dilation (≥ 3 veins) (all p < 0.05). The survival rate was 100% among the 21 fetuses in the uncomplicated group, compared with 73.3% among the 15 fetuses in the complicated group. CONCLUSION:The typical presentation of GFHH is a well-defined hypoechoic mass with peripheral circular or semicircular vascularity. Homogeneous masses are predictive of favorable outcomes, whereas within heterogeneous masses, features such as hypervascularity, AVF, HAPSV > 106 cm/s, and dilation of three hepatic veins are closely correlated with an increased risk of complications.

Purpose: Based on bioinformatics and molecular docking, this study explores the mechanism of promoting blood circulation, removing blood stasis, and unblocking collaterals through the TGF-B1/Smads/CTGF signaling pathway to regulate tubal inflammatory infertility. Methods: Collect data from OMIM database, RefSeq Gene database, TTD database, CTD database, and Genecards database. Collect 12 medicinal ingredients and targets of modified prescriptions for promoting blood circulation, removing blood stasis, and unblocking collaterals using the TCMSP database. Collect common targets using Venn diagram and perform GO and KEGG analysis. Select relevant representative targets and corresponding components for molecular docking. Results： There are 37,176 target points for tubal inflammatory infertility disease. Through pharmacological analysis, there are 343 corresponding targets for 14 related traditional Chinese medicine herbs using the method of promoting blood circulation, removing blood stasis, and unblocking collaterals. There are 326 common targets with tubal inflammatory infertility disease. The top 20 key targets including AKT1, TNF, IL6, IL1B, TP53, EGFR, ESR1, PTGS2, STAT3, SRC, CASP3, BCL2, NFKB1, HIF1A, MMP9, CTNNB1, IFNG, ICAM1, STAT1, and NFKBIA were obtained through Cytoscape software analysis. It involves signaling pathways such as WP5434, hsa05417, hsa05208, WP5420, WP5470, WP2882, WP4298, hsa05207, WP4396, hsa05418, etc. Conclusion: The method of promoting blood circulation, removing blood stasis, and unblocking collaterals can regulate tubal inflammatory infertility through multiple targets and pathways, including the TGF-B1/Smads/CTGF signaling pathway.

Microvascular invasion (MVI) is a critical factor in predicting the recurrence and prognosis of hepatocellular carcinoma (HCC) after liver transplantation (LT). However, there is a lack of reliable preoperative predictors for MVI. The purpose of this study is to evaluate the potential of an 18F-FDG PET/CT-based nomogram in predicting MVI before LT for HCC. 83 HCC patients who obtained 18F-FDG PET/CT before LT were included in this retrospective research. To determine the parameters connected to MVI and to create a nomogram for MVI prediction, respectively, Logistic and Cox regression models were applied. Analyses of the calibration curve and receiver operating characteristic (ROC) curves were used to assess the model's capability to differentiate between clinical factors and metabolic data from PET/CT images. Among the 83 patients analyzed, 41

Microangiogenesis is an important prognostic factor in various cancers, including hepatocellular carcinoma (HCC). The Vascular Endothelial Growth Factor (VEGF) has been shown to contribute to tumor angiogenesis. Recently, several studies have investigated the regulation of VEGF production by a single gene, with few researchers exploring all genes that affect VEGF production. In this study, we comprehensively analyzed all genes affecting VEGF production in HCC and developed a risk model and gene-based risk score based on VEGF production. Moreover, the model's predictive capacity on prognosis of HCCs was verified using training and validation datasets. The developed model showed good prediction of the overall survival rate. Patients with a higher risk score experienced poor outcomes compared to those with a lower risk score. Furthermore, we identified the immunological causes of the poor prognosis of patients with high-risk scores comparing with those with low-risk scores.

Background: We aimed to evaluate the impact of pain on patients during Hysterosalpingography (HSG). Methods: PubMed, PMC and other journals were searched for randomized controlled trials (RCTS) on HSG. Appropriate articles were selected for inclusion and reasonable exclusion according to keywords. Following a thorough review of the relevant literature, the process of literature screening was conducted in accordance with the aforementioned criteria. The methodological quality of the studies was assessed using the risk of bias assessment tool developed by the Cochrane Collaboration. Meta -analysis was conducted using RevMan 5.4.1 software. Results: Twelve studies were included, including 1530 cases in the experimental group and 1545 cases in the control group. The literature summarizes the basic information of patients during HSG and makes statistics on the differences in visual analog scale (VAS) and pain perception. The findings from the HSG examination revealed a lack of significant association between patients' pain sensation and their age and BMI. However, the duration of pregnancy in patients decreased following HSG treatment (95%CI (-18.84 to -3.58), P=0.004).Compared with conventional testing, HSG could effectively reduce the pregnancy time of patients (95%CI (-18.84, -3.58), P=0.004), reduce the VAS of patients (95%CI (-4.73, -1.51), P=0.0001), and increase the number of patients without pain (95%CI (1.80, 10.43), P=0.001). Conclusion: During the HSG examination, acceptable pain avoidance is generated and can be relieved over time. At present, there is no effective alternative method, so the patient should cooperate with the doctor to complete the examination, to relieve the pain.

Evidence displays that circular RNAs (circRNAs) are considerable mediators of numerous processes in cancer development. Given that many circRNAs are not functionally characterized, our aim was to explore the function and mechanisms of circ_0051428 in thyroid cancer (TC). The analysis of circ_0051428, miR-1248 and FN1 mRNA expression was conducted using real-time quantitative polymerase chain reaction. Cell growth was observed using CCK-8 and colony formation assays. Cell migration was investigated using wound healing assay. Cell apoptosis was identified by the expression of apoptosis-related proteins (Bax and Bcl-2) using Western blotting. Animal models were established to testify the role of circ_0051428 in vivo. The assumed binding between miR-1248 and circ_0051428 or FN1 was identified using dual-luciferase reporter or RIP assay. circ_0051428 exhibits an abnormally elevated expression in TC. circ_0051428 deficiency caused inhibition of TC cell proliferation, migration, clonogenic capacity, and inhibition of tumor growth in vivo. circ_0051428 directly targeted miR-1248, and FN1 was a target downstream of circ_0051428/miR-1248 axis. circ_0051428 could sponge miR-1248 to upregulate FN1. Furthermore, miR-1248 downregulation recovered circ_0051428 deficiency-suppressed cancer cell proliferation, survival and migration. Besides, the repressive effects of FN1 knockdown on cancer cell growth, survival and migration were also partly abolished by miR-1248 downregulation. circ_0051428 targeted miR-1248 to modulate FN1 expression, thereby facilitating the malignant progression of TC, which contributed to the understanding of the molecular mechanism of TC development.

Objective: To investigate the clinical efficacy of polydocartanol foam sclerotherapy and conventional surgery in the treatment of varicose veins in lower extremities.Methods: 112 cases of VVLE patients hospitalized in the vascular surgery department of our hospital from September 2017 to August 2019 were included and divided into experimental group and control group according to different surgical methods, with 56 cases in each group. Both groups of VVLE patients received routine preoperative surgical examination and epidural anesthesia, in which the control group received conventional surgical treatment (high ligation and stripping of the great saphenous vein), and the experimental group received polydocartanol foam sclerosis. The operative time, length of hospital stay, intraoperative blood loss, subjective feeling improvement, postoperative pain (whether there is local pain, whether to take painkillers), and incidence of symptoms were observed and analyzed in each group.Results: Compared with the control group and experimental group, the operative time, hospital stay, and intraoperative blood loss were significantly reduced (P<0.05). Compared with the control group, there was no statistically significant difference in the subjective feelings of VVLE patients in the experimental group (P>0.05). Of the 56 VVLE patients in the experimental group (101 affected limbs), 32 (31.68%) had local pain, and 6 (10.71%) needed to take painkillers. Among the 56 patients with VVLE in the control group (105 affected limbs), 69 (65.71%) had local tenderness, and 21 (37.50%) needed a painkiller. The difference in the local pain rate and the painkiller rate between the two groups was statistically significant compared with the control group (P<0.05). In the experimental group, 3 (5.36%) cases of thrombophlebitis, 4 (7.14%) cases of skin pigmentation, and 3 (5.36%) cases of varicose vein residue occurred in VVLE patients, with a total incidence of 17.86%. In the control group, there were 6 (10.71%) cases of thrombophlebitis, 6 (10.71%) cases of skin pigmentation, 4 (7.14%) cases of varicose vein residue, and 7 (12.50%) cases of skin paresthesia, for a total of 41.07%. The difference in the postoperative complication rate between the two groups of VVLE patients was statistically significant (P<0.05).Conclusion: Polydocaryl foam sclerotherapy can effectively promote the recovery of VVLE patients and relieve their pain with higher safety and reliability. Compared with traditional surgical treatment, polydocaryl foam sclerotherapy has significant advantages, strong practicability, and is expected to be a new treatment method to replace traditional surgery.

目的 探讨与对比血氧水平依赖功能磁共振(blood oxygen level dependent function,Bold-fMRI)及弥散加权成像(diffusion weighted imaging,DWI)检查对烧伤伴脑组织损伤的诊断价值.方法 收集2015年12月-2018年12月在武汉市第三医院就诊的烧伤伴脑组织损伤患者72例影像学资料,所有患者均进行头颅MRI检查,包括平扫、Bold-fMRI及DWI,统计分析其影像学特征并评估对比Bold-fMRI及DWI两者的诊断价值.结果 所有患者脑损伤部位Bold-fMRI与DWI信号采集图像清晰,其中M1区受累63例,运动前区(pre-Motor Area,PMA)区受累10例,额外运动区(supplementary motor area,SMA)区受累24例,受累区可表现为损伤部位脑组织水肿,移位及信号强度异常;损伤部位脑组织的表观扩散系数(apparent diffusion coefficient,ADC)值与分数各向异性(fractional anisotropy,FA)值也显著高于对称性的健侧部位(P＜0.05).Bold-fMRI检出脑组织损伤72例,检出率为100.0％;DWI检出脑组织损伤70例,检出率为97.2％,对比差异无统计学意义(P＞0.05).结论 Bold-fMRI及DWI检查对烧伤伴脑组织损伤的检出均具有很高的效用价值,可全面了解烧伤所致脑损伤的高发损伤部位特点及其表现,以及与邻近组织的关系,为临床对病情判断、治疗与预后提供更全面的参考.

BACKGROUND: We evaluated the improvement in the gray and white matter functional areas in children with cerebral palsy (CP) after common carotid artery sympathetic neural network ablation. We also analyzed the relationship between the values of the diffusion kurtosis imaging (DKI) parameters and clinical signs in children with CP. METHODS: We collected data from 22 children with unilateral spastic CP who had undergone common carotid sympathetic neural network ablation in our hospital from January 1, 2014 to December 1, 2018, using magnetic resonance kurtosis imaging technology parameters. RESULTS: The study found that the changes from pre-operatively to postoperatively in the kurtosis fractional anisotropy (KFA) values for the frontal lobe, parietal lobe, temporal lobe, internal sac forelimb, and corpus callosum were statistically significant. However, the changes in the internal sac forelimb, corpus callosum, and KFA values were not statistically significant. The changes from preoperatively to postoperatively in the mean kurtosis (MK) values for the frontal lobe, parietal lobe, temporal lobe, hindlimb of the internal capsule, corpus callosum, and caudate nucleus were statistically significant. However, the MK values for the forelimb, corpus callosum, and thalamus were not statistically significant. The 66-item gross motor function measure scores correlated negatively with the KFA value and positively with the MK value. CONCLUSION: Therefore, it can be concluded that DKI technology can more accurately reflect the gray and white matter damage in children with CP, and the DKI parameters can be used as a monitoring and evaluation index for children with CP.

BACKGROUND:Lung cancer is among the most common cancers worldwide, responsible for 13% of all new cancer cases. Also, it is the leading cause of cancer death among both men and women. In this scenario, an effective and efficient treatment is required.OBJECTIVE:Production of two gold nanoparticles: 198Au and 99mTc-Au. The first one has been produced from irradiation of the 197Au in order to produce a beta-emitter gold nanoparticle for cancer therapy. The second one has been produced from the radiolabeling of gold nanoparticles with technetium 99 metastable in order to produce imaging nanoagent.METHODS:The 198Au nanoparticles were produced by irradiation and identified by hyper-purity germanium (HPGe). They were then evaluated in vitro in order to confirm the behavior on cell proliferation of lung cancer cell lines by the MTT methodology using A549 cells. The 99mTc-Au nanoparticles were produced by directradiolabeling with 99mTc and evaluated in vivo as intralesional nanoagent.RESULTS:The results showed that in both cases, all the nanoparticles have performed their duties with excellence. The 198Au nanoparticles were capable to kill lung cancer cells, while 99mTc-Au was capable to image the tumor after intralesional injection. In addition, 99mTc-Au nanoparticles were useful for biodistribution assay imaging, showing the main organs responsible for the nanoparticle uptake in healthy animals.CONCLUSION:Both gold nanoparticles showed to be a highly efficient nanoagent for both: therapy and diagnosing of lung cancer.

BACKGROUND Lung cancer is among the most common cancers worldwide, responsible for 13% of all new cancer cases. Also, is the leading cause of cancer death among both men and women. In this scenario, an effective and efficient treatment is required. OBJECTIVE Production of two gold nanoparticles: 198Au and 99mTc-Au. The first one has been directed produced from irradiation of the 197Au in order to produce a beta-emitter gold nanoparticle for cancer therapy. The second one, has been directed produced from the radiolabeling of gold nanoparticles with technetium 99 metastable in order to produce imaging nanoagent. METHODS The 198Au Nanoparticles were produced by irradiation and identified by hyper-purity germanium (HPGe). Then were evaluated in vitro in order to confirm the behavior on cell proliferation of lung cancer cell line, by the MTT methodology using A549 cells. The 99mTc-Au nanoparticles were produced by direct-radiolabeling with 99mTc and evaluated in vivo as intralesional nanoagent. RESULTS The results showed that in both cases, all the nanoparticles have performed their duties with excellence. The 198Au nanoparticles were capable to kill lung cancer cells, while and 99mTc-Au was capable to image the tumor after intralesional injection. Also, 99mTc-Au nanoparticles were useful for biodistribution assay imaging, showing the main organs responsible for the nanoparticle uptake in healthy animals. CONCLUSION The both gold nanoparticles showed to be a highly efficient nanoagent for both: therapy and diagnosing of lung cancer.

目的 通过对国际骨循环研究会(ARCO)Ⅱ期股骨头坏死组和正常对照组关节软骨、骨微结构的磁共振(MR)T2 map进行形态学、定量学分析评估其临床应用价值.方法 收集确诊20髋股骨头坏死(ARCOⅡ期)为试验组及20髋正常股骨头为对照组,比较2组软骨、骨微结构的磁共振成像(MRI)、T2 map伪彩图形态学结构变化及定量学指标.结果 2组间软骨及骨微结构的T2 map定量学指标差异无统计学意义(P>0.05),但坏死组关节软骨T2 map值总体稍高.2组间软骨及骨微结构在MRI、T2 map伪彩图的形态结构表现不同.结论正常股骨头关节软骨的T2 map的数值可界定为(50±8),临床上可将此区间值作为可能性参考标准,同时通过形态学主要观察髋关节MR及T2 map伪彩图软骨、骨微结构形态及颜色变化亦有一定价值.

BACKGROUND:This study aimed to investigate the image quality and adverse events (AEs) of ethiodized poppyseed oil (EPO) compared with ioversol as contrast agents in hysterosalpingography (HSG). METHODS:Two hundred twenty-eight patients underwent HSG were consecutively recruited in this prospective cohort study, and were accordingly divided into EPO group (N = 165) and ioversol group (N = 63). The quality of image was assessed according to the European Guidelines on quality criteria for diagnostic radiographic images. AEs during, within 2 h and at 1-month post-HSG were recorded. RESULTS:EPO displayed elevated image quality compared with ioversol including the total image quality score (P < 0.001), the cervical canal display score (P < 0.001), shape and outline of uterus score (P < 0.01), cervical mucosa or folds score (P < 0.001), oviduct isthmus score (P < 0.001), ampulla and fimbriae of oviduct score (P < 0.001) and celiac diffuse image score (P < 0.001). Multivariate linear regression displayed that EPO (P < 0.001) was an independent predictive factor for increased total image quality score. AEs were similar between EPO group and ioversol group during and within 2 h post-HSG (all P > 0.05). However, at 1-month post-HSG, the number of patients had unchanged and faded menstrual blood color decreased but the proportion of patients with deepened menstrual color increased in EPO group compared with ioversol group (P = 0.007). In addition, the number of patients had iodine residue in uterine cavity was elevated in EPO group compared with ioversol group (P < 0.001). CONCLUSION:EPO is more efficient in image quality and equally tolerant compared to ioversol as contrast agents in HSG.

目的 观察介入治疗糖尿病患者下肢血管病变的临床疗效,并探讨其临床价值.方法 收集并分析42例行介入治疗的糖尿病下肢血管病变患者作为观察组,38例行常规保守治疗的糖尿病下肢血管病变患者作为对照组,对比两组患者治疗后血清TC,TG,LDL,HDL及D-二聚体的表达情况,评估两组患者的临床疗效,并进行对比分析.结果 两组患者在年龄、性别、吸烟史、病程及Fontaine分期中均未见显著差异,提示具有可比性.两组患者在静息疼痛、足面溃烂、四肢发冷及间歇跛行中存在显著差异,在其他症状中未见显著异常,在血清TC,TG,LDL,HDL及D-二聚体中存在显著差异.术后疗效对比结果显示:两组患者治愈率、无效率及总有效率比较差异具有统计学意义,有效率比较差异无统计学意义.结论 介入治疗能够有效缓解糖尿病患者下肢血管病变的临床症状,降低血清TC,TG,LDL和D-二聚体水平,升高HDL水平,提高总体有效率,具有良好的临床疗效.

目的 基于影像学分析骨髓水肿与股骨头坏死的关系.方法 选择股骨头坏死患者125例221髋,髋关节骨髓水肿分级0级73髋、Ⅰ级32髋、Ⅱ级61髋、Ⅲ级55髋.所有患者行X线、CT、MRI检查,记录硬化带、塌陷、关节腔积液及坏死区方位情况.评价这些影像学指标与骨髓水肿的关系.结果 股骨头坏死区塌陷、髋关节积液、股骨头坏死方位与骨髓水肿分级有关(P<0.05),表现为股骨头坏死区出现塌陷及股骨头坏死位于股骨头上方、前上方承重区时出现骨髓水肿的概率更高,并且随着髋关节积液增多,骨髓水肿逐渐加重.股骨头坏死区硬化带与骨髓水肿分级无关(P>0.05).结论 骨髓水肿与股骨头坏死区塌陷、髋关节积液及股骨头坏死方位有关,可提示病情进展,临床应予重视.

目的 探讨阿替普酶(rt-PA)与尿激酶(UK)经导管接触性溶栓(CDT)治疗亚急性下肢动脉闭塞症(DVT)患者的临床疗效.方法 选择100例亚急性DVT患者,根据随机数字表法分为UK-CDT组(n=50)与Rt-PA-CDT组(n=50),比较两组患者治疗疗效、静脉通畅度评分、双下肢周径差及并发症发生情况.结果 rt-PA-CDT组患者治疗总有效率高于UK-CDT组(χ2=5.086,P=0.024);在治疗后Pos-1,Pos-2时,Rt-PA-CDT组患者的静脉通畅度评分及双侧大腿、小腿周径差均低于UK-CDT组(P<0.05);Rt-PA-CDT组患者轻度出血率高于UK-CDT组(χ2=9.756,P=0.002);Rt-PA-CDT组患者的血栓后综合征(PTS)发生率低于UK-CDT组(χ2=4.891,P=0.027);两组患者PTS严重程度比较差异无统计学意义(P>0.05).结论 经CDT联合rt-PA溶栓效果好,能够显著降低亚急性下肢动脉闭塞症患者PTS发生率.

目的 运用磁共振血氧水平依赖功能磁共振成像技术(Bold-fMRI)、弥散加权成像(DWI)及弥散张量成像(DTI)成像技术,探讨严重烧伤早期脑组织损伤的神经机制.方法 研究采用前瞻性实验设计,35只健康雄性新西兰大白兔随机分成对照组及烧伤组(烧伤后1h、2h、3h、4h、5h、6h).采用体表烫伤法制作兔严重烧伤模型.运用磁共振Bold-fMRI、DWI及DTI成像技术采集相关磁共振图像,最后计算各组的表观弥散系数(ADC值)、各向异性分数值(FA值)、烧伤前后全脑肯德尔系数(ReHo值)以及脑含水量的变化情况.分析烧伤后脑含水量与ADC值、FA值、ReHo值的相关性.结果 与对照组相比,烧伤后4～6h兔脑所测感兴趣区(ROI)范围内ADC值出现显著降低,两者间差异有统计学意义(P＜0.05);而烧伤后各时间节点的FA值未见明显变化,差异无统计学意义(P＞0.05).和正常对照组相比,烧伤后兔脑主要表现为双侧额叶、岛叶及左侧丘脑间的ReHo值显著上升;而在右侧楔前叶、海马旁回及双侧颞叶ReHo值显著下降.与正常对照组相比,烧伤后兔脑含水量明显增加,且在1～6h内呈缓慢升高的趋势,尤以烧伤后3h为著.进一步与影像学资料进行相关性分析后发现:烧伤后脑含水量与ADC值呈负相关(r=-0.867,P＜0.01),与FA值无明确相关性(r=0.147,P=0.524),而与ReHo值呈正相关(r=0.734,P＜0.01).结论 重度烧伤后出现神经功能损害的神经机制可能是由于细胞毒性脑水肿引起,为烧伤患者治疗方案的选择奠定了可靠地理论基础.

目的 通过收集股骨头坏死临床病例进行回顾性研究,将Harris评分、ARCO分期与骨髓水肿进行相关性研究分析.方法 采用有序分组资料的线性趋势检验,观察Harris评分、ARCO分期的临床指标与骨髓水肿之间是否有统计学相关性.结果 Harris评分、ARCO分期与骨髓水肿的发生存在相关关系.结论 骨髓水肿是股骨头坏死过程中病情进展及预后不良的一个指标,这对于深入研究骨髓水肿的发生机制及干预措施有着重要意义.

Objective A retrospective study of clinical cases of femoral head necrosis was carried out to study the correlation between age, gender, etiology and bone marrow edema. Methods The non parametric chi-square test was performed on the age, etiology and bone marrow edema grading, and the non parametric test of two independent samples was performed on sex and bone marrow edema. Results Age, gender, etiology and the occurrence of bone marrow edema in the femoral head were not significantly different. Conclusion Bone marrow edema is a kind of imaging signs in the process of femoral head necrosis. There is no significant correlation between age, gender, etiology and bone marrow edema, but from the chart analysis, the incidence of femoral head necrosis is the most common in the male youth, young and middle-aged, more than the time of ARCOII, ARCOII and III were more common in the di-agnosis of the disease.