Objective: To explore the pharmacological basis and anti-inflammatory mechanism of persimmon leaf flavonoids（PLF） in preventing and treating oral ulcer. Methods: The analgesic and anti-inflammatory effects of PLF were evaluated by writhing test, pain threshold test, auricle swelling test and toe swelling test in mice. Moreover, based on rat oral uclcer model（acetic acid method）, the effects of PLF on the expressions of p38 mitogen activated protein kinases（p38MAPK）, phosphorylated p38MAPK（P-P38MAPK） and matrix metalloproteinase-2/9（MMP-2/9） in oral ulcer tissues were investigated by immunoboltting. Results: PLF could significantly reduce the number of writhing, increase the pain threshold, reduce the auricle swelling induced by xylene and inhibit the toe swelling induced by egg white. In addition, PLF could down regulate the expression of MMP-2/9 protein and inhibit the phosphorylation of p38MAPK. Conclusion: PLF has clear analgesic and anti-inflammatory effects. The therapeutic effects of PLF on oral ulcer may be through inhibiting MAPK signaling pathway and down-regulating expression of MMP-2/9.

目的 探讨柿叶黄酮在口腔溃疡大鼠中的抗氧化抗炎作用.方法 建立口腔溃疡大鼠模型(醋酸法),用桂林西瓜霜和不同剂量(20 mg·kg-1,40 mg·kg-1,80 mg·kg-1)的柿叶黄酮进行干预.观察血清和溃疡组织中的超氧化物歧化酶(SOD)和丙二醛(MDA)的变化;H-E染色观察组织病理形态学变化.结果 柿叶黄酮(20 mg·kg-1,40 mg·kg-1,80 mg·kg-1)可提高模型大鼠血清和溃疡组织中SOD活性、降低MDA含量(P<0.05);桂林西瓜霜和减轻溃疡组织的炎性浸润.结论 柿叶黄酮对醋酸诱导的口腔溃疡有一定的治疗作用,其机制与抗氧化损伤和降低炎症反应有关.

复发性口腔溃疡(以下简称RAU)属于口腔科常见的口腔黏膜疾病,并有高病发率、病发原因复杂、易复发、自愈性等特征,对病人日常生活造成了一定的影响.本文以RAU的病因病机分析为出发点,对目前国内外学者的研究成果进行了综述,并在此基础上探讨了治疗措施和新的研究进展,通过本文的研究希望能进一步明确RAU的病发机制,从而采取更为有效的临床治疗措施.

Objective:To study the gender characteristics and changes with aging of the length of upper lips and the width of angulus oris in Shandong to provide effective basis for treating and prognosis of prosthodontics and orthodontics. Methods:852 subjects with normal occlusion from Shandong were selected randomly. They were divided into 3 groups ac-cording to ages(18 ~ 36 years old,37 ~ 55 years old,56 ~ 74 years old)and the number of male and female in each group was 142 . These subjects,face were recorded and the images were measured in order to analysis among the groups. Results:The length of upper lips and the width of angulous oris were significantly different among the groups(P < 0. 01);the width of angulous oris was significantly different between the male and female in the same group(P < 0. 01);the length of upper lips was statistically different between the male and the female among the groups(P < 0. 05);there is positively correlated between age and all measurement items and the average value was increased with age. Conclusion:The relationship be-tween all measurement items and age is positively correlated,the length of upper lips and the width of angulous oris in-creased with age and there were gender differences at the same age.