Figure S1 - PDF file 4805K, Fig. S1. CONSORT trial flow diagram

Supplementary Figure S1. Typical staining of CDK4 pathway-related proteins Supplementary Figure S2. Sensitivity of acral melanoma cells to CDK4/6 inhibitors. Supplementary Figure S3. Western blotting assays of total Rb and phosphorylated Rb (pRb) in cell lines after CDK4/6 inhibitor treatments Supplementary Figure S4. Representative images of tumor nodules after the treatments. Supplementary Figure S5. Rb inactivation status in PDX models after AT7519 and PD0332991 treatments.

Supplementary Figures S1-S8; Supplementary Tables S1-S3.

Supplementary Figure Legend - PDF file 46K, Supplementary Figure Legends for Supplemental Figure S1

PDF file - 2243K, Figure S3. Genetic mutations in exon 18 of PDGFRA.

Background: Cross-linked polyethylene (HXLPE) liners have been used for total hip arthroplasty (THA) to address the problem of osteolysis and revision surgery associated with conventional polyethylene (CPE) liners. This systematic review and meta-analysis investigated the long-term efficacy of HXLPE in preventing revision surgery and radiological osteolysis in comparison to CPE. Materials and Methods: A comprehensive search of PubMed, Embase, and the Cochrane Library from their respective inception to September 2018 was conducted to identify potential candidate articles. Data were pooled using Stata software 14.0. The quality of randomized controlled trials (RCTs) and observational studies was assessed by two different authors using the Cochrane risk-of-bias tool and the Newcastle-Ottawa scale (NOS), respectively. Results: Eight RCTs and six observational studies were included in this review. The pooled results significantly favored HXLPE over CPE in terms of total number of revisions and radiological osteolysis, with a risk reduction of 78% (95% confidence interval [CI] 0.13-0.36; p < 0.001) and 80% (95% CI 0.13-0.29; p < 0.001), respectively. Additionally, subgroup analyses of pooled data from RCTs and observational studies both showed the efficacy of HXLPE in the prevention of revision and osteolysis. Polyethylene wear in the HXLPE group was significantly less than that in the CPE group in terms of linear wear rates and head penetration rates (both p < 0.001). No significant differences were observed with regard to functional outcomes. Conclusions: The current evidence shows that HXLPE significantly improved the clinical and radiographic outcomes, but not the functional outcomes, in comparison to CPE in long-term follow-up.

Pre-treatment to increase cellulose enzymatic hydrolyzability is a prerequisite step for bioconversion of lignocellulosic biomass. The final objective of pre-treatment is to increase cellulose accessibility to cellulase enzymes, which can be done by either removing hemicelluloses or delignification or modifying lignin structure. Organosolv fractionating pre-treatment (OFP) achieves a fractionation of biomass in a one-pot process with greatly increased cellulose digestibility. In this review, the research progress in recent years on the acid and alkali-catalyzed OFP processes has been discussed, in terms of the process modes, chemistry, pre-treatment kinetics as well as substrate structures. It is concluded that OFP not only improves cellulose digestibility but also shows great promise as an entry to biomass biorefining for co-producing various chemicals and fuels; however, the economic feasibility of the OFP process has to be improved by reducing the energy consumption for solvent recovery and developing more products with higher added values. Finally, the challenge and perspective of OFP are further discussed. (C) 2017 Society of Chemical Industry and John Wiley & Sons, Ltd

The cover image, by Xuebing Zhao et al., is based on the Review Organosolv fractionating pre‐treatment of lignocellulosic biomass for efficient enzymatic saccharification: chemistry, kinetics, and substrate structures, DOI: 10.1002/bbb.1768. image

Diurnal metabolic rhythms add an important temporal dimension to metabolic homeostasis in mammals. Although it remains a challenge to untangle the intricate networks of crosstalk among the body clock, nutrient signalling and tissue metabolism, there is little doubt that the rhythmic nature of nutrient and energy metabolism is a central aspect of metabolic physiology. Disruption of the synchrony between clock and metabolism has been causally linked to diverse pathophysiological states. As such, restoring the rhythmicity of body physiology and therapeutic targeting directed at specific time windows during the day may have important implications in human health and medicine. In this review, we summarize recent findings on the integration of hepatic glucose metabolism and the body clock through a regulatory network centred on the PPARγ coactivator 1 (PGC-1) transcriptional coactivators. In addition, we discuss the transcriptional mechanisms underlying circadian control of the autophagy gene programme and autophagy in the liver.

Enterprise education is an important component of higher education. In order to develop the enterprise education effectively, cultivating the students with creative personality, the colleges should reinforce the structure of the group of the teachers, reform the curriculum system and the mode of teaching, and insist on the way of cooperation between the enterprise and the college, the combination of the learning and practicing, positively establishing the steady practicing base for the enterprise education.

Industrial pollution and environmental impacts The Pearl River Delta has had for centuries the reputation of a rice growing and fish breeding region. Men started to settle in the Northern limit of the Delta thousands of years ago. Since then, urbanization has played an important role in the Pearl River Delta. Canton, Shenzhen and Dongguan are cities with today a population greater than 10 million inhabitants. The farming soils of the Pearl River Delta have rapidly given way to urbanization and industry. These sudden urban and economical developments have heavily pressured the regional environment. Moreover this growth took place in a quite anarchist way, local collectivities of the region competing one against another to attract foreign and national investments. The very fragmentary structure of the governance of the Pearl River Delta economic zone makes difficult, if not impossible, all coordination of measures aiming at treating the delta environmental problems.

The vortex-induced motions (VIM) of semi-submersibles depends on the shape of the submerged structure, small changes in column geometries may have a significant impact on the VIM response of the platform. The study on the effect of column rounded ratios on the VIM of semisubmersible platforms has important guiding significance for the design of platforms. In the present study, numerical simulations of the VIM characteristics of a semi-submersible platform with different column corner radius at 45° current heading have been carried out by naoeFOAM-SJTU. SST-DDES was used for modeling the massively separated turbulent flows. The displacements and hydrodynamic forces information in three DOFs including sway, surge and yaw motion are obtained. Based on the advantages of CFD method, the mechanism of the influence of the column rounded corner on the VIM of the semisubmersible platform is studied. Vortex shedding patterns and other flow field information are given for further analysis.