In recent years, software infrastructures for the run-time instrumentation of programs have begun to emerge. The paper presents and evaluates prototypes of dynamic instrumentation and dynamic control of instrumentation for parallel mixed MPI/OpenMP applications. An overview of the technology behind these approaches is presented. Prototypes of dynamic instrumentation and dynamic control of instrumentation for use with the Vampir/Guide View (VGV) toolset (GmbH. Pallas, 2002) are discussed. Instrumentation evaluations using the ASCI kernel benchmarks are used for proof of concept on a cluster of SMPs. The results demonstrate that a mix of dynamic instrumentation and dynamic control of instrumentation can be an effective performance analysis alternative to the traditional static instrumentation of applications.

Thirty-four random DNA probes from the terminal half of the human chromosome 4 short arm were further localized within 4pter----p15.1. A panel of somatic cell hybrid lines defining six chromosomal regions within 4pter----p15.1 was constructed using human cell lines containing translocation or deletion chromosomes. The vast majority of the DNA sequences, 32 of 34 or 94%, mapped to the three most proximal regions comprising 4p16.1----4p15.1. Only two probes were localized distal to 4p16.1: one in the region 4p16.3----4p16.1 and one in 4p16.3. D4S10, a polymorphic DNA marker linked to the Huntington's disease defect, has previously been mapped to the terminal region of 4p with conflicting assignments to 4p16.1 and 4p16.3. Analysis of restriction fragment length polymorphisms demonstrated hemizygosity for D4S10 in a patient with Wolf-Hirschhorn syndrome resulting from an unbalanced translocation t(4;8)(p16.3;p23.1), supporting the 4p16.3 localization. Our panel of somatic cell hybrids provides a rapid method for mapping new probes to the same vicinity as that of D4S10. However, the relative paucity of such DNA segments identified here suggests that a more directed approach may be required to generate additional markers near the HD gene.

Annals of the New York Academy of SciencesVolume 450, Issue 1 p. 25-31 Genetic Linkage Map for Chromosome 21a JAMES F. GUSELLA, JAMES F. GUSELLA Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorRUDOLPH E. TANZI, RUDOLPH E. TANZI Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorPAUL C. WATKINS, PAUL C. WATKINS Integrated Genetics, Inc. Framingham, Massachusetts 01701Search for more papers by this authorKERIN T. GIBBONS, KERIN T. GIBBONS Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorWENDY J. HOBBS, WENDY J. HOBBS Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorANNE G. FARYNIARZ, ANNE G. FARYNIARZ Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorSTEVEN T. HEALEY, STEVEN T. HEALEY Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorMARY ANNE ANDERSON, MARY ANNE ANDERSON Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this author JAMES F. GUSELLA, JAMES F. GUSELLA Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorRUDOLPH E. TANZI, RUDOLPH E. TANZI Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorPAUL C. WATKINS, PAUL C. WATKINS Integrated Genetics, Inc. Framingham, Massachusetts 01701Search for more papers by this authorKERIN T. GIBBONS, KERIN T. GIBBONS Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorWENDY J. HOBBS, WENDY J. HOBBS Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorANNE G. FARYNIARZ, ANNE G. FARYNIARZ Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorSTEVEN T. HEALEY, STEVEN T. HEALEY Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this authorMARY ANNE ANDERSON, MARY ANNE ANDERSON Genetics Unit and Neurology Service Massachusetts General Hospital, and Department of Genetics Harvard Medical School Boston, Massachusetts 02114Search for more papers by this author First published: June 1985 https://doi.org/10.1111/j.1749-6632.1985.tb21480.xCitations: 3 † This work was supported in part by Grants NS16367 (Huntington's Disease Center without Walls) and NS20012, from the National Institute for Neurological and Communication Disorders, by a grant from the Hereditary Disease Foundation, and by the Julieanne Dorn Fund for Neurological Research. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume450, Issue1Adenosine Molecular Structure of the Number 21 chromosome and Down SyndromeJune 1985Pages 25-31 RelatedInformation