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1Исследование Безопасности Неионных Рентгеноконтрастных Средств И Их Влияния На Функциональные И Метаболические Показатели У Детей С Нефропатиями

Elena N. Tsygina,И. Е. Смирнов,А. Г. Кучеренко,G. F. Zadkova,О Ф Лукина, О,Т Е Сорокина,М И Баканов,S.N. Zorkin,С. П. Яцык,А.Н. Цыгин

A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy. After contrast media use we observed elevation of cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation were identified. The results obtained indicate that renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy. Increased serum cystatin C reflects adverse impact of contrast agents on renal function. Hypocoagulation effect requires that coagulation disorders must be excluded before use of contast media. Key words: children, contrast-induced nephropathy, renal function, cystatin C, endothelin, hemostasis. (Pediatric Pharmacology. – 2010; 7(2):78-82)

2010Педиатрическая фармакология（2010）引用：23

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2STUDIES OF SAFETY AND FUNCTIONAL AND METABOLIC EFFECTS OF NON-IONIC CONTRAST MEDIA IN CHILDREN WITH NEPHROPATHIES

E.N. Tsygina,I.E. Smirnov,A.G. Kucherenko,G.F. Zadkova,O.F. Lukina,O.O. Kupriyanova,T.E. Sorokina,M.I. Bakanov,S.N. Zorkin,S.P. Yatsyk,A.N. Tsygin

A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy. After contrast media use we observed elevation of cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation were identified. The results obtained indicate that renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy. Increased serum cystatin C reflects adverse impact of contrast agents on renal function. Hypocoagulation effect requires that coagulation disorders must be excluded before use of contast media.Key words: children, contrast-induced nephropathy, renal function, cystatin C, endothelin, hemostasis. (Pediatric Pharmacology. – 2010; 7(2):78-82)

2010Pediatričeskaâ Farmakologiâ（2010）

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3Оксид Азота При Хронических Воспалительных Заболеваниях Легких У Детей

Т. Е. Сорокина,И. Е. Смирнов,А. Г. Кучеренко

2006Вопросы современной педиатрии

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4ОКСИД АЗОТА ПРИ ХРОНИЧЕСКИХ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЯХ ЛЕГКИХ У ДЕТЕЙ

т е сорокина,и е смирнов,а г кучеренко

2006引用：23

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