Background Childhood stunting remains a major public health problem in the Northern Province of Rwanda, where approximately 27.1% of children 1-36 months five are stunted. While many risk factors are documented, less is known about social and parenting processes in high-risk child conditions of undernutrition. We aimed to explore parental experiences and understandings of the risk of childhood stunting in the Northern Province of Rwanda. Methods We conducted a qualitative study using focus group discussions (FGDs) with 120 parents, mothers and fathers separated, of children aged 1–36 months across all five districts of Northern Province. We analysed data using a reflexive thematic analysis approach. Results Parents described interconnected household and caregiving processes perceived to influence children's nutrition and growth. Thematically, household power struggles and resource diversion, vulnerabilities during the first 1,000 days, a paradox whereby food and livestock assets did not always benefit children, and fragile substitute-care arrangements when mothers must go out for work, highlighted how intra-household allocation of resources, caregiving practices, and competing economic priorities shaped children's nutritional environments. The themes indicated that parents see intra-household resource allocation and caregiving as affecting the link between food resources and child growth. Conclusion Parents in Rwanda's Northern Province of Rwanda see childhood growth as shaped by interconnected household power relations, caregiving, and resource allocation practices in the first 1,000 days. Policies should give more decision-making power and resources to infants by promoting shared household decisions, empowering mothers, aligning livestock and market incentives with infant nutrition, and restoring reliable substitute care via public platforms.

Abstract Background Childhood stunting, defined as a height-for-age Z-score below − 2 standard deviations, remains a major public health issue in Rwanda, with one in three children under-five affected. Although national prevalence of stunting has declined over the past two decades, less is known about how trends compare across population groups. This study assessed trends in childhood stunting inequalities in Rwanda from 2000 to 2019 using absolute and relative inequality measures across five equity dimensions (wealth, women’s education, place of residence, sex, and regions or provinces). Methods We analyzed data from five rounds of the Rwanda Demographic and Health Surveys (2000–2019). Stunting prevalence was disaggregated by wealth quintiles, women’s education, place of residence, child’s gender, and region/province. Absolute and relative inequality measures included the slope index of inequality (SII), concentration index (CIX), absolute difference, and the weighted mean difference to the mean (WMDM). Population attributable risk (PAR) and population attributable fraction (PAF) were estimated to assess public health impact. Results Stunting prevalence in Rwanda decreased by 31.0% from 2000 (47.9%) to 2019 (33.1%). However, inequalities widened, with faster progress among the wealthiest, reaching their peak in 2019 (SII = -41.7, CIX = -21.9). Women’s education inequalities persisted in favor of the highly educated (SII = − 29.7 and CIX worsening to -9.2 in 2019), urban areas (16-point absolute difference), and boys (7.8-point absolute difference). Regional disparities were relatively stable, with WMDM around 5.0% points, Kigali having the lowest rate. The measures of impact show wealth had the strongest effect, with a PAR of 23.2% points and PAF of 69.0%; respectively reflecting the amount of stunting rates that are attributable to being in the poorest categories and what could be eliminated if all children were in the wealthiest categories. Conclusion Despite overall national progress in reducing stunting, social and economic inequalities remained apparent and widened between 2000 and 2019. Children from the poorest households and those with less educated mothers remain disproportionately affected. To achieve the global nutrition target by 2030, Rwanda must strengthen equity-focused interventions to reach the most vulnerable groups.

Despite national progress, stunting remains prevalent in specific regions of Rwanda, highlighting the limitations of coarse-resolution data for effective mapping and intervention planning. This study explored optimal spatial resolution and analytical approach to capture localised dynamics and the multifactorial nature of stunting. A cross-sectional, population-based study was conducted in the Northern Province of Rwanda, focusing on children aged 1-36 months. Data were collected using structured questionnaires covering socio-demographic, economic, health, childcare, livestock factors and anthropometric measurements. Environmental characteristics were obtained from national datasets, while household geographic coordinates were captured using a customized mobile geodata platform (emGeo). After data cleaning, predictors were analysed using univariable and multivariable logistic regression as well as geographically weighted logistic regression (GWLR) to account for spatial heterogeneity. Among 601 children, stunting prevalence was 27% (boys 33.8%; girls 20.9%). GWLR improved model fit, increasing adjusted deviance explained from 34% to 39%. Significant predictors included child age (adjusted OR = 2.46; 95% CI: 1.78-3.39), male sex (OR = 2.83; 95% CI: 1.65-4.86), birthweight (OR = 0.71; 95% CI: 0.54-0.94), maternal autonomy (ability to refuse sexual intercourse; OR = 0.48; 95% CI: 0.27-0.86), inconsistent maternal social support (OR = 2.30; 95% CI: 1.20-4.42), household electricity access (OR = 0.48; 95% CI: 0.27-0.84) and handwashing facilities (OR = 0.21; 95% CI: 0.07-0.67). GWLR revealed substantial spatial heterogeneity in these factors, delineating areas where each factor matters most. This household-level, spatially explicit analysis reveals localised risk patterns often masked by aggregated national data. Prioritising context-specific interventions (such as electrification, hygiene promotion, and enhanced maternal social support), can enhance effectiveness. The proposed analytical workflow provides a model for addressing persistent stunting in other resource-limited settings.

Background Protein intake among children in resource-rich countries often exceeds current recommendations. Higher protein consumption during infancy has been associated with an increased risk of obesity later in life. Objectives We conducted a secondary analysis of a randomized controlled trial where 250 infants were randomly assigned to receive either a protein-reduced Nordic diet or a conventional Swedish complementary diet. Our aims were to examine the metabolic responses to the intervention using plasma metabolomics and to test the pathways proposed by the Early Protein Hypothesis by linking cumulative protein intake to circulating branched-chain amino acids (BCAAs), insulin-like growth factor-1 (IGF-1), and growth outcomes using structural equation modeling (SEM). Methods Targeted proton nuclear magnetic resonance (1H-NMR) metabolomics was performed on plasma samples collected at 12 and 18 mo. Two SEM models were constructed: one modeled body weight and the other modeled BMI as growth outcomes using data collected up to age 18 mo. Model fit indices were assessed, and path diagrams were used to visualize relationships. Results The Nordic diet led to reduced-protein intake and a distinct infant plasma metabolomic profile. Circulating BCAAs and their catabolites were significantly lower in the reduced-protein Nordic diet compared with the conventional diet. Cumulative protein intake positively correlated with plasma IGF-1 concentrations {weight-based SEM: β = 0.40 [95% confidence interval (CI): 0.03, 0.48]; BMI-based SEM: β = 0.43 [95% CI: 0.05, 0.50]}. Plasma total BCAAs were positively associated with plasma IGF-1 levels [weight-based SEM: β = 0.16 (95% CI: 0.00, 0.76); BMI-based SEM: β = 0.17 (95% CI: 0.02, 0.78)]. After accounting for metabolite-mediated effects on IGF-1 and insulin, cumulative protein intake remained significantly associated with infant body weight [β=0.36 (95% CI: 0.02, 0.99)], but not BMI. Conclusions Complementary feeding during infancy substantially shapes the plasma metabolome. Reducing protein intake from complementary feeding helps attenuate rapid infant weight gain, a well-established early-life predictor of later obesity.

BACKGROUND:To enhance the quality of life for individuals with type 1 diabetes and mitigate the risks of complications, new methods for insulin delivery and glucose monitoring are being developed. The ability to monitor a child's glucose levels via a mobile phone can provide parents with a feeling of security, potentially leading to improved sleep quality. However, constant monitoring could lead to increased stress both for youths and parents. AIM:The aim of the study was to explore how youths with type 1 diabetes and their parents experienced using insulin pumps and continuous glucose monitoring devices (CGM) and the support from the diabetes team. Further, to explore their opinions about the glucose target HbA1c ≤ 48 mmol/mol (6.5%) and other glucose metabolic measurements. METHOD:Sixteen individual interviews were performed with eight youths with type 1 diabetes and their parents. Qualitative content analysis was done according to Graneheim and Lundman. RESULTS:The participants described increased satisfaction, security, strengthened independence and increased freedom. The parents described improved sleep at night leading to increased quality of life. The participants had not reflected so much over the change when the glucose target was lowered in 2017, but they found time in tight range to be more useful. They had a positive experience of healthcare with easy accessibility and continuity, and they described technical support as important. CONCLUSION:Insulin pumps and CGM facilitate everyday life for both youths and their parents, and the opportunity to follow their youth's glucose values does not seem to be a problem to neither youths nor parents. The lowering of the glucose target is not something that parents and youth had much concern about, and they consider the gluco-metabolic measurement time in tight range to be more useful.

Childhood stunting, defined as height-for-age below − 2 standard deviations (SD), disproportionately affects the Northern Province of Rwanda. We investigated risk factors contributing to stunting in this region at individual, household, and societal/community levels to inform future interventions. We conducted a population-based, cross-sectional study using a quantitative questionnaire in households with children aged 1–36 months in the Northern Province. Anthropometric measurements of children and mothers were taken to estimate nutritional status. Multivariable logistic regressions were performed to identify independent risk factors of stunting, reporting odds ratios, 95

Background: In Rwanda, various intervention initiatives have led to progress in reducing maternal and child undernutrition. However, the rate of stunting, the chronic form of malnutrition, remains high with about 33% of children under five years stunted countrywide, especially in the Northern Province where the stunting rate is 40.5%. This study aimed to sample and analyse spatially-explicit undernutrition determinants in Northern Rwanda through a multidisciplinary approach. Methods: A multidisciplinary team of experts in public health, geographical information science, epidemiology, animal science and veterinary medicine conducted a population-based cross-sectional study in five districts of the Northern Province of Rwanda. Targeting households with mothers of children aged 1-36 months, we used a structured household-level questionnaire to collect information on socio-demographic and economic factors, child health, childcare practices, presence of violence against children and mothers, maternal health, livestock production and animal health. In addition to child and maternal anthropometric measurements, we collected rectal swabs and blood samples from children to identify potential gastrointestinal pathogens and estimate haemoglobin levels. Data on environmental and physical characteristics of the study area were obtained from existing national datasets. To capture GPS coordinates of each visited household, we customized a web-based geodata management platform into a mobile application for in-field data collection (emGeo). To analyse the determinants underlying stunting, we used the following key techniques: feature selection using random forest to identify 26 most pertinent predictors, univariable and multivariable logistic regression analyses, and geographically weighted logistic regression (GWLR) to account for spatial variation. Results: The multivariable logistic regression accounted for 30% (R2 = 0.30) of the variation in stunting, with higher odds with increase in child’s age and sex, mother’s decision-making autonomy in major household purchases, having a friend to assist the mother when ill, access to electricity, having a home garden, and handwashing practices. The geographically weighted logistics regression improved explanatory power to 35%, highlighting spatial heterogeneity in the predictors' effects across the study area. Conclusion: A multidisciplinary approach is essential to tackle multifaceted challenges like stunting. Combining logistic regression and geospatial statistics enabled us to identify areas with high stunting risk factors and guide policymakers toward geographically targeted interventions, particularly in limited settings, including Rwanda.

BACKGROUND: Childhood stunting remains a public health challenge, especially in sub-Saharan Africa. In Rwanda, it is the highest in the Northern province, with a prevalence of 40.5% in children under five. Given that poverty is a key determinant of stunting, we aimed to investigate wealth inequalities in childhood stunting and to identify its contributing determinants in the province. METHODS: We included 601 children aged 1 to 36 months. We estimated the concentration index to quantify wealth-related inequalities in stunting, which we further decomposed it by applying the Wagstaff decomposition approach. RESULTS: The overall concentration index of child stunting was relatively high (-0.190; 95% CI: -0.295, -0.084), suggesting that stunting was concentrated in poorer households. Its decomposition revealed that socio-economic determinants (147.9%), namely wealth index, partner’s unemployment or non-skilled occupation, and household food insecurity, contributed most to the wealth inequalities of childhood stunting. The demographic determinants contributed in the second order, especially living in Musanze district. Psychosocial determinants came last, namely maternal social support. CONCLUSION: This study revealed significant wealth inequalities in childhood stunting in the Northern Province of Rwanda, with socio-economic factors being the primary contributors to these inequalities. Targeted interventions, such as household economic strengthening programs, robust food security policies, improved conditions and salaries in non-skilled jobs, and social support programs for the most disadvantaged communities, are essential to reducing these disparities.

Introduction This study aimed to investigate if individuals with childhood-onset type 1 diabetes having a parent with the same condition (parental diabetes) had worse metabolic control and an increased risk of death and renal failure compared with those with parents without type 1 diabetes (sporadic diabetes).Research design and methods We conducted a population-based cohort study using data from the Swedish Childhood Diabetes Register, including cases with onset of type 1 diabetes before the age of 15 and recorded between 1977 and 2010. The cohort was linked to national registers to compare mortality, renal failure, and glycated hemoglobin (HBA1c) levels.Results We identified 16 572 incident cases of childhood-onset type 1 diabetes. Of these, 15 701 had data on parental diabetes status, with 1390 (8.9%) having at least one parent with this condition. HbA1c data were available in 9105 individuals at 20–30 years of age, with the parental group showing higher levels compared with the sporadic diabetes group (8.4% (68 mmol/mol) vs 8.2% (66 mmol/mol), p=0.004). The Cox proportional HR for death in parental diabetes was 1.33 (95% CI 1.00 to 1.75), and the competing risk HR for renal failure was 1.27 (95% CI 1.08 to 1.50). Women in the parental diabetes group had a higher risk of early death (HR 1.79, 95% CI 1.17 to 2.72) compared with the sporadic diabetes group.Conclusions Individuals with parental diabetes had slightly higher HbA1c and elevated risks of renal failure and death compared with those with sporadic diabetes, especially pronounced in women. Although the exact mechanisms behind these differences are unclear, we suggest that individualized care may benefit individuals with parental type 1 diabetes.

Background: In Northern Province, Rwanda, stunting is common among children aged under 5 years. However, previous studies on spatial analysis of childhood stunting in Rwanda did not assess its randomness and clustering, and none were conducted in Northern Province. We conducted a spatial-pattern analysis of childhood undernutrition to identify stunting clusters and hotspots for targeted interventions in Northern Province. Methods: Using a household population-based questionnaire survey of the characteristics and causes of undernutrition in households with biological mothers of children aged 1–36 months, we collected anthropometric measurements of the children and their mothers and captured the coordinates of the households. Descriptive statistics were computed for the sociodemographic characteristics and anthropometric measurements. Spatial patterns of childhood stunting were determined using global and local Moran's I and Getis-Ord Gi* statistics, and the corresponding maps were produced. Results: The z-scores of the three anthropometric measurements were normally distributed, but the z-scores of height-for-age were generally lower than those of weight-for-age and weight-for-height, prompting us to focus on height-for-age for the spatial analysis. The estimated incidence of stunting among 601 children aged 1–36 months was 27.1 %. The sample points were interpolated to the administrative level of the sector. The global Moran's I was positive and significant (Moran's I = 0.403, p < 0.001, z-score = 7.813), indicating clustering of childhood stunting across different sectors of Northern Province. The local Moran's I and hotspot analysis based on the Getis-Ord Gi* statistic showed statistically significant hotspots, which were strongest within Musanze district, followed by Gakenke and Gicumbi districts. Conclusion: Childhood stunting in Northern Province showed statistically significant hotspots in Musanze, Gakenke, and Gicumbi districts. Factors associated with such clusters and hotspots should be assessed to identify possible geographically targeted interventions.

Aims/Hypotheses: To investigate the frequency and characteristics of partial remission in Swedish children with type 1 diabetes and whether the insulin delivery method, that is, continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDIs), affects incidence and duration of this period, 2007-2011. Factors that increase the proportion of subjects who enter partial remission and extend this period can improve long-term metabolic control and reduce the risk of severe hypoglycemia, improve quality of life, and, in the long run, reduce late complications. Methods: Longitudinal data from 2007 to 2020 were extracted from the Swedish National Quality Register (SWEDIABKIDS) with all reported newly diagnosed children. Data on C-peptide from the participants in the Better Diabetes Diagnosis study from 2007 to 2010 were used. The definition of partial remission was insulin dose-adjusted HbA1c: HbA1c (%) + [4 × total daily insulin dose (U/kg/day)] ≤9. Results: Of the 3887 patients, 56% were boys. More boys than girls were in partial remission throughout the follow-up period until 24 months after diabetes onset. Fewer children 0-6 years old had partial remission at 3 and 12 months but not at 24 months compared with older age-groups. A larger proportion of patients using CSII at 12 and 24 months remained in partial remission compared with those with MDI (37% vs. 33%, P = 0.02 and 31% vs. 27%, P = 0.01, respectively). The level of C-peptide was higher in the group with partial remission and mean HbA1c was lower (both P < 0.001). Partial remission at 12 months after diabetes onset was associated with CSII (odds ratio [OR]: 1.39, confidence interval [CI]:1.13, 1.71), shorter diabetes duration (OR: 0.80, CI: 0.76, 0.84), and male sex (OR: 1.23, CI: 1.04, 1.46). Conclusions/Interpretation: Insulin through MDI, longer duration of diabetes, and female sex were associated with lower frequency of partial remission. Use of CSII seems to contribute to longer partial remission among Swedish children with type 1 diabetes.

BACKGROUND:High intake of protein and low intake of plant-based foods during complementary feeding can contribute to negative long-term health effects.OBJECTIVES:To investigate the effects of a protein-reduced, Nordic complementary diet on body composition, growth, biomarkers, and dietary intake, compared with current Swedish dietary recommendations for infants at 12 and 18 mo.METHODS:Healthy, term infants (n = 250) were randomly allocated to either a Nordic group (NG) or a conventional group (CG). From 4 to 6 mo, NG participants received repeated exposures of Nordic taste portions. From 6 to 18 mo, NG was supplied with Nordic homemade baby food recipes, protein-reduced baby food products, and parental support. CG followed the current Swedish dietary recommendations. Measurements of body composition, anthropometry, biomarkers, and dietary intake were collected from baseline and at 12 and 18 mo.RESULTS:Of the 250 infants, 82% (n = 206) completed the study. There were no group differences in body composition or growth. In NG, protein intake, blood urea nitrogen and plasma IGF-1 were lower compared to CG at 12 and 18 mo. Infants in NG consumed 42% to 45% more fruits and vegetables compared to CG at 12 and 18 mo, which was reflected in a higher plasma folate at 12 and 18 mo. There were no between-group differences in EI or iron status.CONCLUSIONS:Introduction of a predominantly plant-based, protein-reduced diet as part of complementary feeding is feasible and can increase fruit and vegetable intake. This trial was registered at clinicaltrials.gov as NCT02634749.

Aims/hypothesis During the 1980s and 1990s, the incidence of childhood-onset type 1 diabetes more than doubled in Sweden, followed by a plateau. In the present 40 year follow-up, we investigated if the incidence remained stable and whether this could be explained by increased migration from countries reporting lower incidences. Methods We used 23,143 incident cases of childhood-onset type 1 diabetes reported between 1978 and 2019 to the nationwide, population-based Swedish Childhood Diabetes Registry and population data from Statistics Sweden. Generalised additive models and ANOVA were applied to analyse the effects of onset age, sex, time trends and parental country of birth and interaction effects between these factors. Results The flattening of the incidence increase seems to remain over the period 2005–2019. When comparing the incidence of type 1 diabetes for all children in Sweden with that for children with both parents born in Sweden, the trends were parallel but at a higher level for the latter. A comparison of the incidence trends between individuals with Swedish backgrounds (high diabetes trait) and Asian backgrounds (low diabetes trait) showed that the Asian subpopulation had a stable increase in incidence over time. Conclusions/interpretation In Sweden, the increase in incidence of childhood-onset type 1 diabetes in the late 20th century has been approaching a more stable albeit high level over the last two decades. Increased immigration from countries with lower incidences of childhood-onset type 1 diabetes does not provide a complete explanation for the observed levelling off. Graphical abstract

Abstract Introduction/aim: Young patients with Fontan circulation may have low serum 25-hydroxyvitamin D levels, an affected liver, and unhealthy body compositions. This study aimed to explore the association between vitamin D intake/levels, liver biomarkers, and body composition in young Fontan patients. Method: We collected prospective data in 2017 to 2018, obtained with food-frequency questionnaires, biochemical analyses of liver biomarkers, and dual-energy X-ray absorptiometry scans in 44 children with Fontan circulation. Body compositions were compared to matched controls (n = 38). Linear regression analyses were used to investigate associations of biomarkers, leg pain, and lean mass on serum levels of 25-hydroxyvitamin D. Biomarkers were converted to z scores and differences were evaluated within the Fontan patients. Results: Our Fontan patients had a daily mean vitamin D intake of 9.9 µg and a mean serum 25-hydroxyvitamin D of 56 nmol/L. These factors were not associated with fat or lean mass, leg pain, or biomarkers of liver status. The Fontan patients had significantly less lean mass, but higher fat mass than controls. Male adolescents with Fontan circulation had a greater mean abdominal fat mass than male controls and higher cholesterol levels than females with Fontan circulation. Conclusion: Vitamin D intake and serum levels were not associated with body composition or liver biomarkers in the Fontan group, but the Fontan group had lower lean mass and higher fat mass than controls. The more pronounced abdominal fat mass in male adolescents with Fontan circulation might increase metabolic risks later in life.

Objective This study aimed to compare metabolic control measured as hemoglobin A1c (HbA1c), the risk of severe hypoglycemia, and body composition measured as body mass index standard deviation scores (BMI-SDS) in a nationwide sample of children and adolescents with Type 1 diabetes with continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI), respectively. Research Design and Methods Longitudinal data from 2011 to 2016 were extracted from the Swedish National Quality Register (SWEDIABKIDS) with both cross-sectional (6 years) and longitudinal (4 years) comparisons. Main end points were changes in HbA1c, BMI-SDS, and incidence of severe hypoglycemia. Results Data were available from 35,624 patient-years (54% boys). In general, HbA1c decreased approximately 0.5% (2-5 mmol/mol) from 2011 to 2016 (p(trend) < 0.001) and the use of CSII increased in both sexes and all age groups. Mean HbA1c was 0.1% (0.7-1.5 mmol/mol) lower in the CSII treated group. Teenagers, especially girls, using CSII tended to have higher BMI-SDS. There was no difference in the number of hypoglycemias between CSII and MDI over the years 2011-2016. Conclusions There was a small decrease in HbA1c with CSII treatment but of little clinical relevance. Overall, mean HbA1c decreased in both sexes and all age groups without increasing the episodes of severe hypoglycemia, indicating that other factors than insulin method contributed to a better metabolic control.

Early life is critical for developing healthy eating patterns. This study aimed to investigate the effects of a Nordic, protein-reduced complementary diet (ND) compared to a diet following the current Swedish dietary guidelines on eating patterns and food acceptance. At 4–6 months (mo) of age infants were randomized to a Nordic group (NG, n = 41) or a Conventional group (CG, n = 40), and followed until 18 mo of age. Daily intake of fruits and vegetables (mean ± sd) at 12 mo was significantly higher in the NG compared to the CG: 341 ± 108 g/day vs. 220 ± 76 g/day (p < 0.001), respectively. From 12 to 18 mo, fruit and vegetable intake decreased, but the NG still consumed 32% more compared to the CG: 254 ± 99 g/day vs. 193 ± 67 g/day (p = 0.004). To assess food acceptance, both groups were tested with home exposure meals at 12 and 18 mo. No group differences in acceptance were found. We find that a ND with parental education initiates healthy eating patterns during infancy, but that the exposure meal used in the present study was insufficient to detect major differences in food acceptance. This is most likely explained by the preparation of the meal. Nordic produce offers high environmental sustainability and favorable taste composition to establish healthy food preferences during this sensitive period of early life.

AIMS/HYPOTHESIS:In persons with type 1 diabetes, the risk of cancer remains controversial. We wanted to examine the excess risk of cancer in a large population-based cohort diagnosed with type 1 diabetes before 15 years of age. STUDY POPULATION AND METHODS:From 1 July 1977 to 31 December 2013, we prospectively and on a national scale included 18,724 persons (53% men) with childhood-onset type 1 diabetes. For each person with type 1 diabetes, we selected four referents, matched for the date at birth and municipality of living at the time when the case developed diabetes. Cases and referents were linked to national registers of cancer and of the cause of death. RESULTS:A total of 125 persons (61% women) with diabetes had 135 different cancers, all diagnosed after the diabetes diagnosis. The median duration from diabetes diagnosis to first cancer diagnosis was 19 years (interquartile range 10-26). The median age at cancer diagnosis in the diabetes group was 28 years (interquartile range 20-35). The overall standardized incidence ratio (95%), using the Swedish general population as referents for women with diabetes was 1.28 (1.02, 1.58) and when comparing women with diabetes with matched referents, we found a hazard ratio of 1.42 (1.10, 1.85). No elevated risk was seen for men. Cancers of the breast and testis were the most common types in women and men respectively. CONCLUSIONS:Women with childhood-onset type 1 diabetes had a small but significantly elevated risk of cancer. No such tendency was seen for men. The reason behind this is unclear.

Objective To examine the association between perinatal factors and hospitalisations for sepsis and bacterial meningitis in early childhood (from 28 days to 2 years of age). Design A population‐based cohort study. The Swedish Medical Birth Register was combined with the National Inpatient Register, the Cause of Death Register, the Total Population Register and the Longitudinal integration database for health insurance and labour market studies. Associations between perinatal factors and hospitalisations were examined using negative binomial regression models. Setting Sweden. Participants 1 406 547 children born in Sweden between 1997 and 2013. Main outcome measures Hospital admissions for sepsis and bacterial meningitis recorded between 28 days and 2 years of life. Results Gestational age was inversely associated with severe infections, that is, extreme prematurity was strongly associated with an increased risk of sepsis, adjusted incidence rate ratio (aIRR) 10.37 (95% CI 6.78 to 15.86) and meningitis aIRR 6.22 (95% CI 2.28 to 16.94). The presence of congenital malformation was associated with sepsis aIRR 3.89 (95% CI 3.17 to 4.77) and meningitis aIRR 1.69 (95% CI 1.09 to 2.62). Moreover, children born small or large for gestational age were more likely to be hospitalised for sepsis and children exposed to maternal smoking were more likely to be hospitalised for meningitis. Conclusions Prematurity and several other perinatal factors were associated with an increased risk of severe infections in young children. Therefore, clinical guidelines for risk assessment of infections in young children should consider perinatal factors.

Background Children report that they do not participate in their healthcare as much as they want, despite having the lawful right to form their own views and the right to express those views freely in all matters affecting them. Children and parents appeared to be more satisfied when healthcare professionals (HCP) use a participatory style in healthcare encounters. Aim To explore how children, adolescents and young adults with Juvenile Idiopathic Arthritis (JIA) and parents of children with JIA view their participation and communication in healthcare encounters with healthcare professionals. Methods Using a qualitative study design, participatory workshops were held separately for children and young adults with JIA and parents of children with JIA. The workshop data were analysed with Graneheim and Lundman's Qualitative Content Analysis resulting in one main theme and two subthemes. Results The theme "Feeling alienated or familiar with healthcare encounters" illuminates how children felt alienated at healthcare encounters if they found the encounters emotionally distressing. Children could withhold information regarding their health and function from both HCPs and their family and friends. The subtheme "Distancing oneself from healthcare" describe why children felt reluctant to engage in the healthcare encounters and experienced difficulty expressing how they really felt. The subtheme "Being a normal event in life" describe how children felt more comfortable over time engaging with HCPs when they knew what would happen, and felt that HCPs gave them the necessary support they needed to participate. Conclusions Children's participation in healthcare encounters varied depending if children felt alienated or familiar to the healthcare situations. Children distance themselves and are reluctant to engage in healthcare encounters if they find them emotionally distressing and feel disregarded. Over time, children can become more familiar and at ease with healthcare situations when they feel safe and experience personal and positive encounters. When the children are prepared for the encounter, provided with the space and support they want and receive tailored help they are more enabled to participate.

Background The study explores how healthcare professionals view participation of children and adolescents with juvenile idiopathic arthritis, in healthcare encounters.Methods This qualitative study includes focus groups of HCPs from different professions. The interviews were analysed with qualitative content analysis.Results The theme “Creating an enabling arena” illuminates how HCPs face possibilities and challenges when enabling children to communicate and participate in clinical encounters. HCPs, parents, and the healthcare system need to adjust to the child. The sub-theme “Bringing different perspectives” describes how children and their parents cooperate and complement each other during healthcare encounters. The sub-theme “Building a safe and comfortable setting” includes how HCPs address the child’s self-identified needs and make the child feel comfortable during encounters. The sub-theme “Facilitating methods in a limiting organisation” includes how HCPs’ working methods and organization may help or hinder child participation during encounters.Conclusions HCPs encourage children and adolescents to make their views known during healthcare encounters by creating an enabling arena. Collaboration and building good relationships between the child, the parents and the HCPs, before and during the healthcare encounters, can help the child express their wishes and experiences. Clinical examinations and use of technology, such as photos, films and web-bases questionnaires can be a good start for a better child communication in healthcare encounters.IMPLICATIONS FOR REHABILITATIONHealthcare professionals in JIA teams experience that they can facilitate communication and participation with children and adolescents in healthcare encounters.When healthcare professionals enable both children, adolescents and their parents to bring their perspectives, these views complement one another and enrich information during healthcare encounters.Children and adolescents are more empowered to participate, when healthcare professionals create a good relationship with the child and their parents, and strengthen the child’s knowledge, confidence and autonomy.